UniProtKB - Q9Y6M7 (S4A7_HUMAN)

>sp|Q9Y6M7|S4A7_HUMAN Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2
MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHR
HRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELC
YRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRA
STLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKK
HSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCT
TPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALK
GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR
KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ
YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS
VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF
KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ
PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT
RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA
QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS
FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW
IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV
MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG
LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW
KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE
SKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFE
DEPRKKYVDAETSL

Entry version 172 (02 Jun 2021)
Sequence version 2 (05 May 2009)
Previous versions | rss

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Protein

Sodium bicarbonate cotransporter 3

Gene

SLC4A7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na⁺:HCO3^- 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.

2 Publications

Activity regulationⁱ

Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. PubMed:10347222 states it is inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA).

Keywordsⁱ

Biological process	Ion transport, Sodium transport, Symport, Transport
Ligand	Sodium

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y6M7
Reactomeⁱ	R-HSA-425381, Bicarbonate transporters

Protein family/group databases

TCDBⁱ	2.A.31.2.11, the anion exchanger (ae) family

TCDBⁱ

2.A.31.2.11, the anion exchanger (ae) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium bicarbonate cotransporter 3 Alternative name(s): Electroneutral Na/HCO(3) cotransporter Sodium bicarbonate cotransporter 2 Sodium bicarbonate cotransporter 2b Short name: Bicarbonate transporter Solute carrier family 4 member 7
Gene namesⁱ	Name:SLC4A7 Synonyms:BT, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4A6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11033, SLC4A7
MIMⁱ	603353, gene
neXtProtⁱ	NX_Q9Y6M7
VEuPathDBⁱ	HostDB:ENSG00000033867.16

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 608	ExtracellularSequence analysisAdd BLAST	608
Transmembraneⁱ	609 – 629	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	630 – 637	CytoplasmicSequence analysis	8
Transmembraneⁱ	638 – 658	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	659 – 695	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	696 – 716	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	717 – 725	CytoplasmicSequence analysis	9
Transmembraneⁱ	726 – 746	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	747 – 817	ExtracellularSequence analysisAdd BLAST	71
Transmembraneⁱ	818 – 838	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	839 – 861	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	862 – 882	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	883 – 908	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	909 – 929	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	930 – 954	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	955 – 975	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	976 – 1011	ExtracellularSequence analysisAdd BLAST	36
Transmembraneⁱ	1012 – 1032	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1033 – 1034	CytoplasmicSequence analysis	2
Transmembraneⁱ	1035 – 1055	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1056 – 1092	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	1093 – 1113	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1114 – 1214	CytoplasmicSequence analysisAdd BLAST	101

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1135 – 1136	DD → NN: Loss of interaction with CA2. Loss of regulation by CA2. 1 Publication	2
Mutagenesisⁱ	1163 – 1165	DDD → NNN: No effect on interaction with CA2. No effect on regulation by CA2. 1 Publication	3
Mutagenesisⁱ	1214	L → G: Loss of interaction with ATP6V1B1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9497
Open Targets More...OpenTargetsⁱ	ENSG00000033867
PharmGKBⁱ	PA35899

Miscellaneous databases

Pharosⁱ	Q9Y6M7, Tbio

Pharosⁱ

Q9Y6M7, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL3774290
Drug and drug target database More...DrugBankⁱ	DB01390, Sodium bicarbonate

Genetic variation databases

BioMutaⁱ	SLC4A7
DMDMⁱ	229462789

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079233	1 – 1214	Sodium bicarbonate cotransporter 3Add BLAST		1214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	52	PhosphoserineBy similarity	1
Modified residueⁱ	55	PhosphoserineCombined sources	1
Modified residueⁱ	84	PhosphoserineBy similarity	1
Modified residueⁱ	150	PhosphoserineBy similarity	1
Glycosylationⁱ	171	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	233	PhosphoserineBy similarity	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Glycosylationⁱ	269	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	382	PhosphoserineBy similarity	1
Glycosylationⁱ	398	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	400	PhosphoserineBy similarity	1
Modified residueⁱ	403	PhosphoserineCombined sources	1
Glycosylationⁱ	406	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	407	PhosphoserineCombined sources	1
Modified residueⁱ	556	PhosphoserineCombined sources	1
Modified residueⁱ	557	PhosphothreonineCombined sources	1
Disulfide bondⁱ	766 ↔ 768	By similarity
Glycosylationⁱ	776	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	786	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	791	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	802 ↔ 814	By similarity
Modified residueⁱ	1167	PhosphothreonineCombined sources	1
Modified residueⁱ	1176	PhosphoserineCombined sources	1
Modified residueⁱ	1213	PhosphoserineCombined sources	1
Isoform 3 (identifier: Q9Y6M7-3)
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	168	PhosphoserineCombined sources	1
Modified residueⁱ	1007	PhosphoserineCombined sources	1
Modified residueⁱ	1010	PhosphoserineCombined sources	1
Modified residueⁱ	1016	PhosphoserineCombined sources	1
Isoform 4 (identifier: Q9Y6M7-4)
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	168	PhosphoserineCombined sources	1
Isoform 2 (identifier: Q9Y6M7-2)
Modified residueⁱ	255	PhosphoserineCombined sources	1
Modified residueⁱ	258	PhosphoserineCombined sources	1
Isoform 6 (identifier: Q9Y6M7-6)
Modified residueⁱ	260	PhosphoserineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1
Modified residueⁱ	1073	PhosphoserineCombined sources	1
Modified residueⁱ	1102	PhosphoserineCombined sources	1
Modified residueⁱ	1105	PhosphoserineCombined sources	1
Modified residueⁱ	1111	PhosphoserineCombined sources	1
Isoform 9 (identifier: Q9Y6M7-9)
Modified residueⁱ	260	PhosphoserineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1
Isoform 11 (identifier: Q9Y6M7-11)
Modified residueⁱ	260	PhosphoserineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1
Isoform 13 (identifier: Q9Y6M7-13)
Modified residueⁱ	264	PhosphoserineCombined sources	1
Modified residueⁱ	267	PhosphoserineCombined sources	1
Modified residueⁱ	1077	PhosphoserineCombined sources	1
Modified residueⁱ	1106	PhosphoserineCombined sources	1
Modified residueⁱ	1109	PhosphoserineCombined sources	1
Modified residueⁱ	1115	PhosphoserineCombined sources	1
Isoform 14 (identifier: Q9Y6M7-14)
Modified residueⁱ	264	PhosphoserineCombined sources	1
Modified residueⁱ	267	PhosphoserineCombined sources	1
Isoform 5 (identifier: Q9Y6M7-5)
Modified residueⁱ	742	PhosphoserineCombined sources	1
Modified residueⁱ	771	PhosphoserineCombined sources	1
Modified residueⁱ	774	PhosphoserineCombined sources	1
Modified residueⁱ	780	PhosphoserineCombined sources	1
Isoform 8 (identifier: Q9Y6M7-8)
Modified residueⁱ	1188	PhosphoserineCombined sources	1
Modified residueⁱ	1217	PhosphoserineCombined sources	1
Modified residueⁱ	1220	PhosphoserineCombined sources	1
Modified residueⁱ	1226	PhosphoserineCombined sources	1
Isoform 7 (identifier: Q9Y6M7-7)
Modified residueⁱ	1201	PhosphoserineCombined sources	1
Modified residueⁱ	1230	PhosphoserineCombined sources	1
Modified residueⁱ	1233	PhosphoserineCombined sources	1
Modified residueⁱ	1239	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y6M7
jPOSTⁱ	Q9Y6M7
MassIVEⁱ	Q9Y6M7
PaxDbⁱ	Q9Y6M7
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6M7
PRIDEⁱ	Q9Y6M7
ProteomicsDBⁱ	12778 3404 5941 5942 6243 6244 86734 [Q9Y6M7-1] 86735 [Q9Y6M7-2] 86736 [Q9Y6M7-3] 86737 [Q9Y6M7-4] 86738 [Q9Y6M7-5]

PTM databases

GlyGenⁱ	Q9Y6M7, 8 sites
iPTMnetⁱ	Q9Y6M7
PhosphoSitePlusⁱ	Q9Y6M7
SwissPalmⁱ	Q9Y6M7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000033867, Expressed in oocyte and 229 other tissues
ExpressionAtlasⁱ	Q9Y6M7, baseline and differential
Genevisibleⁱ	Q9Y6M7, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000033867, Tissue enhanced (intestine)

HPAⁱ

ENSG00000033867, Tissue enhanced (intestine)

Interactionⁱ

Subunit structureⁱ

Interacts with CFTR through SLC9A3R1/EBP50.

Interacts with USH1C.

Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50.

Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.

4 Publications

Binary interactionsⁱ

Hide details

Q9Y6M7

With	#Exp.	IntAct
CIAO1 [O76071]	3	EBI-1044546,EBI-725145
KRTAP4-5 [Q9BYR2]	3	EBI-1044546,EBI-11993254

Protein-protein interaction databases

BioGRIDⁱ	114876, 72 interactors
IntActⁱ	Q9Y6M7, 39 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y6M7
STRINGⁱ	9606.ENSP00000295736

Miscellaneous databases

RNActⁱ	Q9Y6M7, protein

RNActⁱ

Q9Y6M7, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9Y6M7
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 22	DisorderedSequence analysisAdd BLAST	22
Regionⁱ	52 – 93	DisorderedSequence analysisAdd BLAST	42
Regionⁱ	289 – 346	DisorderedSequence analysisAdd BLAST	58
Regionⁱ	362 – 408	DisorderedSequence analysisAdd BLAST	47
Regionⁱ	552 – 572	DisorderedSequence analysisAdd BLAST	21
Regionⁱ	1134 – 1136	CA2-binding	3
Regionⁱ	1144 – 1169	DisorderedSequence analysisAdd BLAST	26

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1211 – 1214	PDZ-binding		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1 – 16	Basic and acidic residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	53 – 72	Basic residuesSequence analysisAdd BLAST	20
Compositional biasⁱ	312 – 334	Polar residuesSequence analysisAdd BLAST	23
Compositional biasⁱ	375 – 408	Polar residuesSequence analysisAdd BLAST	34

Domainⁱ

The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C.1 Publication

Sequence similaritiesⁱ

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1172, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157045
HOGENOMⁱ	CLU_002289_0_0_1
InParanoidⁱ	Q9Y6M7
OMAⁱ	WSPIIAV
Database of Orthologous Groups More...OrthoDBⁱ	863978at2759
PhylomeDBⁱ	Q9Y6M7
TreeFamⁱ	TF313630

Family and domain databases

Gene3Dⁱ	3.40.930.10, 2 hits
InterProⁱ	View protein in InterPro IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr
PANTHERⁱ	PTHR11453, PTHR11453, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit
PRINTSⁱ	PR01231, HCO3TRNSPORT
SUPFAMⁱ	SSF55804, SSF55804, 2 hits
TIGRFAMsⁱ	TIGR00834, ae, 1 hit

Sequences (14+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 14 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 14 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y6M7-1) [UniParc]FASTA Add to basket

Also known as: mNBC3, NBCn1-A

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERFRLEKKL PGPDEEAVVD LGKTSSTVNT KFEKEELESH RAVYIGVHVP 
        60         70         80         90        100
FSKESRRRHR HRGHKHHHRR RKDKESDKED GRESPSYDTP SQRVQFILGT 
       110        120        130        140        150
EDDDEEHIPH DLFTEMDELC YRDGEEYEWK ETARWLKFEE DVEDGGDRWS 
       160        170        180        190        200
KPYVATLSLH SLFELRSCIL NGTVMLDMRA STLDEIADMV LDNMIASGQL 
       210        220        230        240        250
DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK HSDPHLLERN 
       260        270        280        290        300
GEGLSASRHS LRTGLSASNL SLRGESPLSL LLGHLLPSSR AGTPAGSRCT 
       310        320        330        340        350
TPVPTPQNSP PSSPSISRLT SRSSQESQRQ APELLVSPAS DDIPTVVIHP 
       360        370        380        390        400
PEEDLEAALK GEEQKNEENV DLTPGILASP QSAPGNLDNS KSGEIKGNGS 
       410        420        430        440        450
GGSRENSTVD FSKVDMNFMR KIPTGAEASN VLVGEVDFLE RPIIAFVRLA 
       460        470        480        490        500
PAVLLTGLTE VPVPTRFLFL LLGPAGKAPQ YHEIGRSIAT LMTDEIFHDV 
       510        520        530        540        550
AYKAKDRNDL LSGIDEFLDQ VTVLPPGEWD PSIRIEPPKS VPSQEKRKIP 
       560        570        580        590        600
VFHNGSTPTL GETPKEAAHH AGPELQRTGR LFGGLILDIK RKAPFFLSDF 
       610        620        630        640        650
KDALSLQCLA SILFLYCACM SPVITFGGLL GEATEGRISA IESLFGASLT 
       660        670        680        690        700
GIAYSLFAGQ PLTILGSTGP VLVFEKILYK FCRDYQLSYL SLRTSIGLWT 
       710        720        730        740        750
SFLCIVLVAT DASSLVCYIT RFTEEAFAAL ICIIFIYEAL EKLFDLGETY 
       760        770        780        790        800
AFNMHNNLDK LTSYSCVCTE PPNPSNETLA QWKKDNITAH NISWRNLTVS 
       810        820        830        840        850
ECKKLRGVFL GSACGHHGPY IPDVLFWCVI LFFTTFFLSS FLKQFKTKRY 
       860        870        880        890        900
FPTKVRSTIS DFAVFLTIVI MVTIDYLVGV PSPKLHVPEK FEPTHPERGW 
       910        920        930        940        950
IISPLGDNPW WTLLIAAIPA LLCTILIFMD QQITAVIINR KEHKLKKGAG 
       960        970        980        990       1000
YHLDLLMVGV MLGVCSVMGL PWFVAATVLS ISHVNSLKVE SECSAPGEQP 
      1010       1020       1030       1040       1050
KFLGIREQRV TGLMIFILMG LSVFMTSVLK FIPMPVLYGV FLYMGVSSLK 
      1060       1070       1080       1090       1100
GIQLFDRIKL FGMPAKHQPD LIYLRYVPLW KVHIFTVIQL TCLVLLWVIK 
      1110       1120       1130       1140       1150
VSAAAVVFPM MVLALVFVRK LMDLCFTKRE LSWLDDLMPE SKKKKEDDKK 
      1160       1170       1180       1190       1200
KKEKEEAERM LQDDDDTVHL PFEGGSLLQI PVKALKYSPD KPVSVKISFE 
      1210 
DEPRKKYVDA ETSL

Length:1,214

Mass (Da):136,044

Last modified:May 5, 2009 - v2

Checksum:ⁱ7B4ADA1E3F26813C

Isoform 2 (identifier: Q9Y6M7-2) [UniParc]FASTA Add to basket

Also known as: NBCn1-F

The sequence of this isoform differs from the canonical sequence as follows:
251-374: Missing.

« Hide

        10         20         30         40         50
MERFRLEKKL PGPDEEAVVD LGKTSSTVNT KFEKEELESH RAVYIGVHVP 
        60         70         80         90        100
FSKESRRRHR HRGHKHHHRR RKDKESDKED GRESPSYDTP SQRVQFILGT 
       110        120        130        140        150
EDDDEEHIPH DLFTEMDELC YRDGEEYEWK ETARWLKFEE DVEDGGDRWS 
       160        170        180        190        200
KPYVATLSLH SLFELRSCIL NGTVMLDMRA STLDEIADMV LDNMIASGQL 
       210        220        230        240        250
DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK HSDPHLLERN 
       260        270        280        290        300
GILASPQSAP GNLDNSKSGE IKGNGSGGSR ENSTVDFSKV DMNFMRKIPT 
       310        320        330        340        350
GAEASNVLVG EVDFLERPII AFVRLAPAVL LTGLTEVPVP TRFLFLLLGP 
       360        370        380        390        400
AGKAPQYHEI GRSIATLMTD EIFHDVAYKA KDRNDLLSGI DEFLDQVTVL 
       410        420        430        440        450
PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN GSTPTLGETP KEAAHHAGPE 
       460        470        480        490        500
LQRTGRLFGG LILDIKRKAP FFLSDFKDAL SLQCLASILF LYCACMSPVI 
       510        520        530        540        550
TFGGLLGEAT EGRISAIESL FGASLTGIAY SLFAGQPLTI LGSTGPVLVF 
       560        570        580        590        600
EKILYKFCRD YQLSYLSLRT SIGLWTSFLC IVLVATDASS LVCYITRFTE 
       610        620        630        640        650
EAFAALICII FIYEALEKLF DLGETYAFNM HNNLDKLTSY SCVCTEPPNP 
       660        670        680        690        700
SNETLAQWKK DNITAHNISW RNLTVSECKK LRGVFLGSAC GHHGPYIPDV 
       710        720        730        740        750
LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK VRSTISDFAV FLTIVIMVTI 
       760        770        780        790        800
DYLVGVPSPK LHVPEKFEPT HPERGWIISP LGDNPWWTLL IAAIPALLCT 
       810        820        830        840        850
ILIFMDQQIT AVIINRKEHK LKKGAGYHLD LLMVGVMLGV CSVMGLPWFV 
       860        870        880        890        900
AATVLSISHV NSLKVESECS APGEQPKFLG IREQRVTGLM IFILMGLSVF 
       910        920        930        940        950
MTSVLKFIPM PVLYGVFLYM GVSSLKGIQL FDRIKLFGMP AKHQPDLIYL 
       960        970        980        990       1000
RYVPLWKVHI FTVIQLTCLV LLWVIKVSAA AVVFPMMVLA LVFVRKLMDL 
      1010       1020       1030       1040       1050
CFTKRELSWL DDLMPESKKK KEDDKKKKEK EEAERMLQDD DDTVHLPFEG 
      1060       1070       1080       1090
GSLLQIPVKA LKYSPDKPVS VKISFEDEPR KKYVDAETSL

Show »

Length:1,090

Mass (Da):123,081

Checksum:ⁱ541839CC9B565896

Isoform 3 (identifier: Q9Y6M7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-118: SQRVQFILGTEDDDEEHIPHDLFTEMDE → MAVTQFIHFREEIMGNMFFIIIFSTKDK
     251-374: Missing.
     1189-1214: PDKPVSVKISFEDEPRKKYVDAETSL → GDPSIGNISDEMAKTAQWKALSMNTENAKVTRSNMSPDKPVSVK

« Hide

        10         20         30         40         50
MAVTQFIHFR EEIMGNMFFI IIFSTKDKLC YRDGEEYEWK ETARWLKFEE 
        60         70         80         90        100
DVEDGGDRWS KPYVATLSLH SLFELRSCIL NGTVMLDMRA STLDEIADMV 
       110        120        130        140        150
LDNMIASGQL DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK 
       160        170        180        190        200
HSDPHLLERN GILASPQSAP GNLDNSKSGE IKGNGSGGSR ENSTVDFSKV 
       210        220        230        240        250
DMNFMRKIPT GAEASNVLVG EVDFLERPII AFVRLAPAVL LTGLTEVPVP 
       260        270        280        290        300
TRFLFLLLGP AGKAPQYHEI GRSIATLMTD EIFHDVAYKA KDRNDLLSGI 
       310        320        330        340        350
DEFLDQVTVL PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN GSTPTLGETP 
       360        370        380        390        400
KEAAHHAGPE LQRTGRLFGG LILDIKRKAP FFLSDFKDAL SLQCLASILF 
       410        420        430        440        450
LYCACMSPVI TFGGLLGEAT EGRISAIESL FGASLTGIAY SLFAGQPLTI 
       460        470        480        490        500
LGSTGPVLVF EKILYKFCRD YQLSYLSLRT SIGLWTSFLC IVLVATDASS 
       510        520        530        540        550
LVCYITRFTE EAFAALICII FIYEALEKLF DLGETYAFNM HNNLDKLTSY 
       560        570        580        590        600
SCVCTEPPNP SNETLAQWKK DNITAHNISW RNLTVSECKK LRGVFLGSAC 
       610        620        630        640        650
GHHGPYIPDV LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK VRSTISDFAV 
       660        670        680        690        700
FLTIVIMVTI DYLVGVPSPK LHVPEKFEPT HPERGWIISP LGDNPWWTLL 
       710        720        730        740        750
IAAIPALLCT ILIFMDQQIT AVIINRKEHK LKKGAGYHLD LLMVGVMLGV 
       760        770        780        790        800
CSVMGLPWFV AATVLSISHV NSLKVESECS APGEQPKFLG IREQRVTGLM 
       810        820        830        840        850
IFILMGLSVF MTSVLKFIPM PVLYGVFLYM GVSSLKGIQL FDRIKLFGMP 
       860        870        880        890        900
AKHQPDLIYL RYVPLWKVHI FTVIQLTCLV LLWVIKVSAA AVVFPMMVLA 
       910        920        930        940        950
LVFVRKLMDL CFTKRELSWL DDLMPESKKK KEDDKKKKEK EEAERMLQDD 
       960        970        980        990       1000
DDTVHLPFEG GSLLQIPVKA LKYSGDPSIG NISDEMAKTA QWKALSMNTE 
      1010 
NAKVTRSNMS PDKPVSVK

Show »

Length:1,018

Mass (Da):114,205

Checksum:ⁱA37799D93A1E30BC

Isoform 4 (identifier: Q9Y6M7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-118: SQRVQFILGTEDDDEEHIPHDLFTEMDE → MAVTQFIHFREEIMGNMFFIIIFSTKDK
     251-374: Missing.

« Hide

        10         20         30         40         50
MAVTQFIHFR EEIMGNMFFI IIFSTKDKLC YRDGEEYEWK ETARWLKFEE 
        60         70         80         90        100
DVEDGGDRWS KPYVATLSLH SLFELRSCIL NGTVMLDMRA STLDEIADMV 
       110        120        130        140        150
LDNMIASGQL DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK 
       160        170        180        190        200
HSDPHLLERN GILASPQSAP GNLDNSKSGE IKGNGSGGSR ENSTVDFSKV 
       210        220        230        240        250
DMNFMRKIPT GAEASNVLVG EVDFLERPII AFVRLAPAVL LTGLTEVPVP 
       260        270        280        290        300
TRFLFLLLGP AGKAPQYHEI GRSIATLMTD EIFHDVAYKA KDRNDLLSGI 
       310        320        330        340        350
DEFLDQVTVL PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN GSTPTLGETP 
       360        370        380        390        400
KEAAHHAGPE LQRTGRLFGG LILDIKRKAP FFLSDFKDAL SLQCLASILF 
       410        420        430        440        450
LYCACMSPVI TFGGLLGEAT EGRISAIESL FGASLTGIAY SLFAGQPLTI 
       460        470        480        490        500
LGSTGPVLVF EKILYKFCRD YQLSYLSLRT SIGLWTSFLC IVLVATDASS 
       510        520        530        540        550
LVCYITRFTE EAFAALICII FIYEALEKLF DLGETYAFNM HNNLDKLTSY 
       560        570        580        590        600
SCVCTEPPNP SNETLAQWKK DNITAHNISW RNLTVSECKK LRGVFLGSAC 
       610        620        630        640        650
GHHGPYIPDV LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK VRSTISDFAV 
       660        670        680        690        700
FLTIVIMVTI DYLVGVPSPK LHVPEKFEPT HPERGWIISP LGDNPWWTLL 
       710        720        730        740        750
IAAIPALLCT ILIFMDQQIT AVIINRKEHK LKKGAGYHLD LLMVGVMLGV 
       760        770        780        790        800
CSVMGLPWFV AATVLSISHV NSLKVESECS APGEQPKFLG IREQRVTGLM 
       810        820        830        840        850
IFILMGLSVF MTSVLKFIPM PVLYGVFLYM GVSSLKGIQL FDRIKLFGMP 
       860        870        880        890        900
AKHQPDLIYL RYVPLWKVHI FTVIQLTCLV LLWVIKVSAA AVVFPMMVLA 
       910        920        930        940        950
LVFVRKLMDL CFTKRELSWL DDLMPESKKK KEDDKKKKEK EEAERMLQDD 
       960        970        980        990       1000
DDTVHLPFEG GSLLQIPVKA LKYSPDKPVS VKISFEDEPR KKYVDAETSL

Show »

Length:1,000

Mass (Da):112,448

Checksum:ⁱ50FAA40A31468223

Isoform 5 (identifier: Q9Y6M7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-450: Missing.
     451-465: PAVLLTGLTEVPVPT → MEVVEAEKIVLLTSA
     1188-1188: S → SVDPSIVNISDEMAKTAQWKALSMNTENAKVTRSNMS

« Hide

        10         20         30         40         50
MEVVEAEKIV LLTSARFLFL LLGPAGKAPQ YHEIGRSIAT LMTDEIFHDV 
        60         70         80         90        100
AYKAKDRNDL LSGIDEFLDQ VTVLPPGEWD PSIRIEPPKS VPSQEKRKIP 
       110        120        130        140        150
VFHNGSTPTL GETPKEAAHH AGPELQRTGR LFGGLILDIK RKAPFFLSDF 
       160        170        180        190        200
KDALSLQCLA SILFLYCACM SPVITFGGLL GEATEGRISA IESLFGASLT 
       210        220        230        240        250
GIAYSLFAGQ PLTILGSTGP VLVFEKILYK FCRDYQLSYL SLRTSIGLWT 
       260        270        280        290        300
SFLCIVLVAT DASSLVCYIT RFTEEAFAAL ICIIFIYEAL EKLFDLGETY 
       310        320        330        340        350
AFNMHNNLDK LTSYSCVCTE PPNPSNETLA QWKKDNITAH NISWRNLTVS 
       360        370        380        390        400
ECKKLRGVFL GSACGHHGPY IPDVLFWCVI LFFTTFFLSS FLKQFKTKRY 
       410        420        430        440        450
FPTKVRSTIS DFAVFLTIVI MVTIDYLVGV PSPKLHVPEK FEPTHPERGW 
       460        470        480        490        500
IISPLGDNPW WTLLIAAIPA LLCTILIFMD QQITAVIINR KEHKLKKGAG 
       510        520        530        540        550
YHLDLLMVGV MLGVCSVMGL PWFVAATVLS ISHVNSLKVE SECSAPGEQP 
       560        570        580        590        600
KFLGIREQRV TGLMIFILMG LSVFMTSVLK FIPMPVLYGV FLYMGVSSLK 
       610        620        630        640        650
GIQLFDRIKL FGMPAKHQPD LIYLRYVPLW KVHIFTVIQL TCLVLLWVIK 
       660        670        680        690        700
VSAAAVVFPM MVLALVFVRK LMDLCFTKRE LSWLDDLMPE SKKKKEDDKK 
       710        720        730        740        750
KKEKEEAERM LQDDDDTVHL PFEGGSLLQI PVKALKYSVD PSIVNISDEM 
       760        770        780        790        800
AKTAQWKALS MNTENAKVTR SNMSPDKPVS VKISFEDEPR KKYVDAETSL

Show »

Length:800

Mass (Da):89,745

Checksum:ⁱD7FB5D3479BB0935

Isoform 6 (identifier: Q9Y6M7-6) [UniParc]FASTA Add to basket

Also known as: NBCn1-G

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MERFRLEKKLP → MEADGAGEQMRPLLTR
     251-374: Missing.
     1188-1188: S → SVDPSIVNISDEMAKTAQWKALSMNTENAKVTRSNMS

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYI 
        60         70         80         90        100
GVHVPFSKES RRRHRHRGHK HHHRRRKDKE SDKEDGRESP SYDTPSQRVQ 
       110        120        130        140        150
FILGTEDDDE EHIPHDLFTE MDELCYRDGE EYEWKETARW LKFEEDVEDG 
       160        170        180        190        200
GDRWSKPYVA TLSLHSLFEL RSCILNGTVM LDMRASTLDE IADMVLDNMI 
       210        220        230        240        250
ASGQLDESIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA DIGKKHSDPH 
       260        270        280        290        300
LLERNGILAS PQSAPGNLDN SKSGEIKGNG SGGSRENSTV DFSKVDMNFM 
       310        320        330        340        350
RKIPTGAEAS NVLVGEVDFL ERPIIAFVRL APAVLLTGLT EVPVPTRFLF 
       360        370        380        390        400
LLLGPAGKAP QYHEIGRSIA TLMTDEIFHD VAYKAKDRND LLSGIDEFLD 
       410        420        430        440        450
QVTVLPPGEW DPSIRIEPPK SVPSQEKRKI PVFHNGSTPT LGETPKEAAH 
       460        470        480        490        500
HAGPELQRTG RLFGGLILDI KRKAPFFLSD FKDALSLQCL ASILFLYCAC 
       510        520        530        540        550
MSPVITFGGL LGEATEGRIS AIESLFGASL TGIAYSLFAG QPLTILGSTG 
       560        570        580        590        600
PVLVFEKILY KFCRDYQLSY LSLRTSIGLW TSFLCIVLVA TDASSLVCYI 
       610        620        630        640        650
TRFTEEAFAA LICIIFIYEA LEKLFDLGET YAFNMHNNLD KLTSYSCVCT 
       660        670        680        690        700
EPPNPSNETL AQWKKDNITA HNISWRNLTV SECKKLRGVF LGSACGHHGP 
       710        720        730        740        750
YIPDVLFWCV ILFFTTFFLS SFLKQFKTKR YFPTKVRSTI SDFAVFLTIV 
       760        770        780        790        800
IMVTIDYLVG VPSPKLHVPE KFEPTHPERG WIISPLGDNP WWTLLIAAIP 
       810        820        830        840        850
ALLCTILIFM DQQITAVIIN RKEHKLKKGA GYHLDLLMVG VMLGVCSVMG 
       860        870        880        890        900
LPWFVAATVL SISHVNSLKV ESECSAPGEQ PKFLGIREQR VTGLMIFILM 
       910        920        930        940        950
GLSVFMTSVL KFIPMPVLYG VFLYMGVSSL KGIQLFDRIK LFGMPAKHQP 
       960        970        980        990       1000
DLIYLRYVPL WKVHIFTVIQ LTCLVLLWVI KVSAAAVVFP MMVLALVFVR 
      1010       1020       1030       1040       1050
KLMDLCFTKR ELSWLDDLMP ESKKKKEDDK KKKEKEEAER MLQDDDDTVH 
      1060       1070       1080       1090       1100
LPFEGGSLLQ IPVKALKYSV DPSIVNISDE MAKTAQWKAL SMNTENAKVT 
      1110       1120       1130 
RSNMSPDKPV SVKISFEDEP RKKYVDAETS L

Show »

Length:1,131

Mass (Da):127,359

Checksum:ⁱD3DC49DE4DD7F133

Isoform 7 (identifier: Q9Y6M7-7) [UniParc]FASTA Add to basket

Also known as: NBCn1-D

The sequence of this isoform differs from the canonical sequence as follows:
1-11: MERFRLEKKLP → MEADGAGEQMRPLLTRVTSR
1188-1188: S → SVDPSIVNISDEMAKTAQWKALSMNTENAKVTRSNMS

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRVTSR GPDEEAVVDL GKTSSTVNTK FEKEELESHR 
        60         70         80         90        100
AVYIGVHVPF SKESRRRHRH RGHKHHHRRR KDKESDKEDG RESPSYDTPS 
       110        120        130        140        150
QRVQFILGTE DDDEEHIPHD LFTEMDELCY RDGEEYEWKE TARWLKFEED 
       160        170        180        190        200
VEDGGDRWSK PYVATLSLHS LFELRSCILN GTVMLDMRAS TLDEIADMVL 
       210        220        230        240        250
DNMIASGQLD ESIRENVREA LLKRHHHQNE KRFTSRIPLV RSFADIGKKH 
       260        270        280        290        300
SDPHLLERNG EGLSASRHSL RTGLSASNLS LRGESPLSLL LGHLLPSSRA 
       310        320        330        340        350
GTPAGSRCTT PVPTPQNSPP SSPSISRLTS RSSQESQRQA PELLVSPASD 
       360        370        380        390        400
DIPTVVIHPP EEDLEAALKG EEQKNEENVD LTPGILASPQ SAPGNLDNSK 
       410        420        430        440        450
SGEIKGNGSG GSRENSTVDF SKVDMNFMRK IPTGAEASNV LVGEVDFLER 
       460        470        480        490        500
PIIAFVRLAP AVLLTGLTEV PVPTRFLFLL LGPAGKAPQY HEIGRSIATL 
       510        520        530        540        550
MTDEIFHDVA YKAKDRNDLL SGIDEFLDQV TVLPPGEWDP SIRIEPPKSV 
       560        570        580        590        600
PSQEKRKIPV FHNGSTPTLG ETPKEAAHHA GPELQRTGRL FGGLILDIKR 
       610        620        630        640        650
KAPFFLSDFK DALSLQCLAS ILFLYCACMS PVITFGGLLG EATEGRISAI 
       660        670        680        690        700
ESLFGASLTG IAYSLFAGQP LTILGSTGPV LVFEKILYKF CRDYQLSYLS 
       710        720        730        740        750
LRTSIGLWTS FLCIVLVATD ASSLVCYITR FTEEAFAALI CIIFIYEALE 
       760        770        780        790        800
KLFDLGETYA FNMHNNLDKL TSYSCVCTEP PNPSNETLAQ WKKDNITAHN 
       810        820        830        840        850
ISWRNLTVSE CKKLRGVFLG SACGHHGPYI PDVLFWCVIL FFTTFFLSSF 
       860        870        880        890        900
LKQFKTKRYF PTKVRSTISD FAVFLTIVIM VTIDYLVGVP SPKLHVPEKF 
       910        920        930        940        950
EPTHPERGWI ISPLGDNPWW TLLIAAIPAL LCTILIFMDQ QITAVIINRK 
       960        970        980        990       1000
EHKLKKGAGY HLDLLMVGVM LGVCSVMGLP WFVAATVLSI SHVNSLKVES 
      1010       1020       1030       1040       1050
ECSAPGEQPK FLGIREQRVT GLMIFILMGL SVFMTSVLKF IPMPVLYGVF 
      1060       1070       1080       1090       1100
LYMGVSSLKG IQLFDRIKLF GMPAKHQPDL IYLRYVPLWK VHIFTVIQLT 
      1110       1120       1130       1140       1150
CLVLLWVIKV SAAAVVFPMM VLALVFVRKL MDLCFTKREL SWLDDLMPES 
      1160       1170       1180       1190       1200
KKKKEDDKKK KEKEEAERML QDDDDTVHLP FEGGSLLQIP VKALKYSVDP 
      1210       1220       1230       1240       1250
SIVNISDEMA KTAQWKALSM NTENAKVTRS NMSPDKPVSV KISFEDEPRK 

KYVDAETSL

Show »

Length:1,259

Mass (Da):140,766

Checksum:ⁱDDE8C01EB6C6E00F

Isoform 8 (identifier: Q9Y6M7-8) [UniParc]FASTA Add to basket

Also known as: NBCn1-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MERFRLEKKLP → MEADGAGEQMRPLLTRVTSR
     238-250: Missing.
     1188-1188: S → SVDPSIVNISDEMAKTAQWKALSMNTENAKVTRSNMS

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRVTSR GPDEEAVVDL GKTSSTVNTK FEKEELESHR 
        60         70         80         90        100
AVYIGVHVPF SKESRRRHRH RGHKHHHRRR KDKESDKEDG RESPSYDTPS 
       110        120        130        140        150
QRVQFILGTE DDDEEHIPHD LFTEMDELCY RDGEEYEWKE TARWLKFEED 
       160        170        180        190        200
VEDGGDRWSK PYVATLSLHS LFELRSCILN GTVMLDMRAS TLDEIADMVL 
       210        220        230        240        250
DNMIASGQLD ESIRENVREA LLKRHHHQNE KRFTSRIPLV RSFADIGEGL 
       260        270        280        290        300
SASRHSLRTG LSASNLSLRG ESPLSLLLGH LLPSSRAGTP AGSRCTTPVP 
       310        320        330        340        350
TPQNSPPSSP SISRLTSRSS QESQRQAPEL LVSPASDDIP TVVIHPPEED 
       360        370        380        390        400
LEAALKGEEQ KNEENVDLTP GILASPQSAP GNLDNSKSGE IKGNGSGGSR 
       410        420        430        440        450
ENSTVDFSKV DMNFMRKIPT GAEASNVLVG EVDFLERPII AFVRLAPAVL 
       460        470        480        490        500
LTGLTEVPVP TRFLFLLLGP AGKAPQYHEI GRSIATLMTD EIFHDVAYKA 
       510        520        530        540        550
KDRNDLLSGI DEFLDQVTVL PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN 
       560        570        580        590        600
GSTPTLGETP KEAAHHAGPE LQRTGRLFGG LILDIKRKAP FFLSDFKDAL 
       610        620        630        640        650
SLQCLASILF LYCACMSPVI TFGGLLGEAT EGRISAIESL FGASLTGIAY 
       660        670        680        690        700
SLFAGQPLTI LGSTGPVLVF EKILYKFCRD YQLSYLSLRT SIGLWTSFLC 
       710        720        730        740        750
IVLVATDASS LVCYITRFTE EAFAALICII FIYEALEKLF DLGETYAFNM 
       760        770        780        790        800
HNNLDKLTSY SCVCTEPPNP SNETLAQWKK DNITAHNISW RNLTVSECKK 
       810        820        830        840        850
LRGVFLGSAC GHHGPYIPDV LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK 
       860        870        880        890        900
VRSTISDFAV FLTIVIMVTI DYLVGVPSPK LHVPEKFEPT HPERGWIISP 
       910        920        930        940        950
LGDNPWWTLL IAAIPALLCT ILIFMDQQIT AVIINRKEHK LKKGAGYHLD 
       960        970        980        990       1000
LLMVGVMLGV CSVMGLPWFV AATVLSISHV NSLKVESECS APGEQPKFLG 
      1010       1020       1030       1040       1050
IREQRVTGLM IFILMGLSVF MTSVLKFIPM PVLYGVFLYM GVSSLKGIQL 
      1060       1070       1080       1090       1100
FDRIKLFGMP AKHQPDLIYL RYVPLWKVHI FTVIQLTCLV LLWVIKVSAA 
      1110       1120       1130       1140       1150
AVVFPMMVLA LVFVRKLMDL CFTKRELSWL DDLMPESKKK KEDDKKKKEK 
      1160       1170       1180       1190       1200
EEAERMLQDD DDTVHLPFEG GSLLQIPVKA LKYSVDPSIV NISDEMAKTA 
      1210       1220       1230       1240 
QWKALSMNTE NAKVTRSNMS PDKPVSVKIS FEDEPRKKYV DAETSL

Show »

Length:1,246

Mass (Da):139,254

Checksum:ⁱDEA67883267065E6

Isoform 9 (identifier: Q9Y6M7-9) [UniParc]FASTA Add to basket

Also known as: NBCn1-E

The sequence of this isoform differs from the canonical sequence as follows:
1-11: MERFRLEKKLP → MEADGAGEQMRPLLTR
251-374: Missing.

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYI 
        60         70         80         90        100
GVHVPFSKES RRRHRHRGHK HHHRRRKDKE SDKEDGRESP SYDTPSQRVQ 
       110        120        130        140        150
FILGTEDDDE EHIPHDLFTE MDELCYRDGE EYEWKETARW LKFEEDVEDG 
       160        170        180        190        200
GDRWSKPYVA TLSLHSLFEL RSCILNGTVM LDMRASTLDE IADMVLDNMI 
       210        220        230        240        250
ASGQLDESIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA DIGKKHSDPH 
       260        270        280        290        300
LLERNGILAS PQSAPGNLDN SKSGEIKGNG SGGSRENSTV DFSKVDMNFM 
       310        320        330        340        350
RKIPTGAEAS NVLVGEVDFL ERPIIAFVRL APAVLLTGLT EVPVPTRFLF 
       360        370        380        390        400
LLLGPAGKAP QYHEIGRSIA TLMTDEIFHD VAYKAKDRND LLSGIDEFLD 
       410        420        430        440        450
QVTVLPPGEW DPSIRIEPPK SVPSQEKRKI PVFHNGSTPT LGETPKEAAH 
       460        470        480        490        500
HAGPELQRTG RLFGGLILDI KRKAPFFLSD FKDALSLQCL ASILFLYCAC 
       510        520        530        540        550
MSPVITFGGL LGEATEGRIS AIESLFGASL TGIAYSLFAG QPLTILGSTG 
       560        570        580        590        600
PVLVFEKILY KFCRDYQLSY LSLRTSIGLW TSFLCIVLVA TDASSLVCYI 
       610        620        630        640        650
TRFTEEAFAA LICIIFIYEA LEKLFDLGET YAFNMHNNLD KLTSYSCVCT 
       660        670        680        690        700
EPPNPSNETL AQWKKDNITA HNISWRNLTV SECKKLRGVF LGSACGHHGP 
       710        720        730        740        750
YIPDVLFWCV ILFFTTFFLS SFLKQFKTKR YFPTKVRSTI SDFAVFLTIV 
       760        770        780        790        800
IMVTIDYLVG VPSPKLHVPE KFEPTHPERG WIISPLGDNP WWTLLIAAIP 
       810        820        830        840        850
ALLCTILIFM DQQITAVIIN RKEHKLKKGA GYHLDLLMVG VMLGVCSVMG 
       860        870        880        890        900
LPWFVAATVL SISHVNSLKV ESECSAPGEQ PKFLGIREQR VTGLMIFILM 
       910        920        930        940        950
GLSVFMTSVL KFIPMPVLYG VFLYMGVSSL KGIQLFDRIK LFGMPAKHQP 
       960        970        980        990       1000
DLIYLRYVPL WKVHIFTVIQ LTCLVLLWVI KVSAAAVVFP MMVLALVFVR 
      1010       1020       1030       1040       1050
KLMDLCFTKR ELSWLDDLMP ESKKKKEDDK KKKEKEEAER MLQDDDDTVH 
      1060       1070       1080       1090 
LPFEGGSLLQ IPVKALKYSP DKPVSVKISF EDEPRKKYVD AETSL

Show »

Length:1,095

Mass (Da):123,409

Checksum:ⁱA3CD8C2972A7DFB3

Isoform 10 (identifier: Q9Y6M7-10) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MERFRLEKKLP → MEADGAGEQMRPLLTR
     238-250: Missing.
     581-582: LF → VQ
     583-1214: Missing.

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYI 
        60         70         80         90        100
GVHVPFSKES RRRHRHRGHK HHHRRRKDKE SDKEDGRESP SYDTPSQRVQ 
       110        120        130        140        150
FILGTEDDDE EHIPHDLFTE MDELCYRDGE EYEWKETARW LKFEEDVEDG 
       160        170        180        190        200
GDRWSKPYVA TLSLHSLFEL RSCILNGTVM LDMRASTLDE IADMVLDNMI 
       210        220        230        240        250
ASGQLDESIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA DIGEGLSASR 
       260        270        280        290        300
HSLRTGLSAS NLSLRGESPL SLLLGHLLPS SRAGTPAGSR CTTPVPTPQN 
       310        320        330        340        350
SPPSSPSISR LTSRSSQESQ RQAPELLVSP ASDDIPTVVI HPPEEDLEAA 
       360        370        380        390        400
LKGEEQKNEE NVDLTPGILA SPQSAPGNLD NSKSGEIKGN GSGGSRENST 
       410        420        430        440        450
VDFSKVDMNF MRKIPTGAEA SNVLVGEVDF LERPIIAFVR LAPAVLLTGL 
       460        470        480        490        500
TEVPVPTRFL FLLLGPAGKA PQYHEIGRSI ATLMTDEIFH DVAYKAKDRN 
       510        520        530        540        550
DLLSGIDEFL DQVTVLPPGE WDPSIRIEPP KSVPSQEKRK IPVFHNGSTP 
       560        570 
TLGETPKEAA HHAGPELQRT GRVQ

Show »

Length:574

Mass (Da):63,699

Checksum:ⁱ57ECD93FDB48A158

Isoform 11 (identifier: Q9Y6M7-11) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MERFRLEKKLP → MEADGAGEQMRPLLTR
     251-374: Missing.
     581-582: LF → VQ
     583-1214: Missing.

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYI 
        60         70         80         90        100
GVHVPFSKES RRRHRHRGHK HHHRRRKDKE SDKEDGRESP SYDTPSQRVQ 
       110        120        130        140        150
FILGTEDDDE EHIPHDLFTE MDELCYRDGE EYEWKETARW LKFEEDVEDG 
       160        170        180        190        200
GDRWSKPYVA TLSLHSLFEL RSCILNGTVM LDMRASTLDE IADMVLDNMI 
       210        220        230        240        250
ASGQLDESIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA DIGKKHSDPH 
       260        270        280        290        300
LLERNGILAS PQSAPGNLDN SKSGEIKGNG SGGSRENSTV DFSKVDMNFM 
       310        320        330        340        350
RKIPTGAEAS NVLVGEVDFL ERPIIAFVRL APAVLLTGLT EVPVPTRFLF 
       360        370        380        390        400
LLLGPAGKAP QYHEIGRSIA TLMTDEIFHD VAYKAKDRND LLSGIDEFLD 
       410        420        430        440        450
QVTVLPPGEW DPSIRIEPPK SVPSQEKRKI PVFHNGSTPT LGETPKEAAH 
       460 
HAGPELQRTG RVQ

Show »

Length:463

Mass (Da):52,249

Checksum:ⁱBFD9ACB2B9362149

Isoform 12 (identifier: Q9Y6M7-12) [UniParc]FASTA Add to basket

Also known as: NBCn1-H

The sequence of this isoform differs from the canonical sequence as follows:
1-11: MERFRLEKKLP → MEADGAGEQMRPLLTR
238-250: Missing.

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYI 
        60         70         80         90        100
GVHVPFSKES RRRHRHRGHK HHHRRRKDKE SDKEDGRESP SYDTPSQRVQ 
       110        120        130        140        150
FILGTEDDDE EHIPHDLFTE MDELCYRDGE EYEWKETARW LKFEEDVEDG 
       160        170        180        190        200
GDRWSKPYVA TLSLHSLFEL RSCILNGTVM LDMRASTLDE IADMVLDNMI 
       210        220        230        240        250
ASGQLDESIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA DIGEGLSASR 
       260        270        280        290        300
HSLRTGLSAS NLSLRGESPL SLLLGHLLPS SRAGTPAGSR CTTPVPTPQN 
       310        320        330        340        350
SPPSSPSISR LTSRSSQESQ RQAPELLVSP ASDDIPTVVI HPPEEDLEAA 
       360        370        380        390        400
LKGEEQKNEE NVDLTPGILA SPQSAPGNLD NSKSGEIKGN GSGGSRENST 
       410        420        430        440        450
VDFSKVDMNF MRKIPTGAEA SNVLVGEVDF LERPIIAFVR LAPAVLLTGL 
       460        470        480        490        500
TEVPVPTRFL FLLLGPAGKA PQYHEIGRSI ATLMTDEIFH DVAYKAKDRN 
       510        520        530        540        550
DLLSGIDEFL DQVTVLPPGE WDPSIRIEPP KSVPSQEKRK IPVFHNGSTP 
       560        570        580        590        600
TLGETPKEAA HHAGPELQRT GRLFGGLILD IKRKAPFFLS DFKDALSLQC 
       610        620        630        640        650
LASILFLYCA CMSPVITFGG LLGEATEGRI SAIESLFGAS LTGIAYSLFA 
       660        670        680        690        700
GQPLTILGST GPVLVFEKIL YKFCRDYQLS YLSLRTSIGL WTSFLCIVLV 
       710        720        730        740        750
ATDASSLVCY ITRFTEEAFA ALICIIFIYE ALEKLFDLGE TYAFNMHNNL 
       760        770        780        790        800
DKLTSYSCVC TEPPNPSNET LAQWKKDNIT AHNISWRNLT VSECKKLRGV 
       810        820        830        840        850
FLGSACGHHG PYIPDVLFWC VILFFTTFFL SSFLKQFKTK RYFPTKVRST 
       860        870        880        890        900
ISDFAVFLTI VIMVTIDYLV GVPSPKLHVP EKFEPTHPER GWIISPLGDN 
       910        920        930        940        950
PWWTLLIAAI PALLCTILIF MDQQITAVII NRKEHKLKKG AGYHLDLLMV 
       960        970        980        990       1000
GVMLGVCSVM GLPWFVAATV LSISHVNSLK VESECSAPGE QPKFLGIREQ 
      1010       1020       1030       1040       1050
RVTGLMIFIL MGLSVFMTSV LKFIPMPVLY GVFLYMGVSS LKGIQLFDRI 
      1060       1070       1080       1090       1100
KLFGMPAKHQ PDLIYLRYVP LWKVHIFTVI QLTCLVLLWV IKVSAAAVVF 
      1110       1120       1130       1140       1150
PMMVLALVFV RKLMDLCFTK RELSWLDDLM PESKKKKEDD KKKKEKEEAE 
      1160       1170       1180       1190       1200
RMLQDDDDTV HLPFEGGSLL QIPVKALKYS PDKPVSVKIS FEDEPRKKYV 

DAETSL

Show »

Length:1,206

Mass (Da):134,860

Checksum:ⁱ8A29DF5AD5ECE7E6

Isoform 13 (identifier: Q9Y6M7-13) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MERFRLEKKLP → MEADGAGEQMRPLLTRVTSR
     251-374: Missing.
     1188-1188: S → SVDPSIVNISDEMAKTAQWKALSMNTENAKVTRSNMS

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRVTSR GPDEEAVVDL GKTSSTVNTK FEKEELESHR 
        60         70         80         90        100
AVYIGVHVPF SKESRRRHRH RGHKHHHRRR KDKESDKEDG RESPSYDTPS 
       110        120        130        140        150
QRVQFILGTE DDDEEHIPHD LFTEMDELCY RDGEEYEWKE TARWLKFEED 
       160        170        180        190        200
VEDGGDRWSK PYVATLSLHS LFELRSCILN GTVMLDMRAS TLDEIADMVL 
       210        220        230        240        250
DNMIASGQLD ESIRENVREA LLKRHHHQNE KRFTSRIPLV RSFADIGKKH 
       260        270        280        290        300
SDPHLLERNG ILASPQSAPG NLDNSKSGEI KGNGSGGSRE NSTVDFSKVD 
       310        320        330        340        350
MNFMRKIPTG AEASNVLVGE VDFLERPIIA FVRLAPAVLL TGLTEVPVPT 
       360        370        380        390        400
RFLFLLLGPA GKAPQYHEIG RSIATLMTDE IFHDVAYKAK DRNDLLSGID 
       410        420        430        440        450
EFLDQVTVLP PGEWDPSIRI EPPKSVPSQE KRKIPVFHNG STPTLGETPK 
       460        470        480        490        500
EAAHHAGPEL QRTGRLFGGL ILDIKRKAPF FLSDFKDALS LQCLASILFL 
       510        520        530        540        550
YCACMSPVIT FGGLLGEATE GRISAIESLF GASLTGIAYS LFAGQPLTIL 
       560        570        580        590        600
GSTGPVLVFE KILYKFCRDY QLSYLSLRTS IGLWTSFLCI VLVATDASSL 
       610        620        630        640        650
VCYITRFTEE AFAALICIIF IYEALEKLFD LGETYAFNMH NNLDKLTSYS 
       660        670        680        690        700
CVCTEPPNPS NETLAQWKKD NITAHNISWR NLTVSECKKL RGVFLGSACG 
       710        720        730        740        750
HHGPYIPDVL FWCVILFFTT FFLSSFLKQF KTKRYFPTKV RSTISDFAVF 
       760        770        780        790        800
LTIVIMVTID YLVGVPSPKL HVPEKFEPTH PERGWIISPL GDNPWWTLLI 
       810        820        830        840        850
AAIPALLCTI LIFMDQQITA VIINRKEHKL KKGAGYHLDL LMVGVMLGVC 
       860        870        880        890        900
SVMGLPWFVA ATVLSISHVN SLKVESECSA PGEQPKFLGI REQRVTGLMI 
       910        920        930        940        950
FILMGLSVFM TSVLKFIPMP VLYGVFLYMG VSSLKGIQLF DRIKLFGMPA 
       960        970        980        990       1000
KHQPDLIYLR YVPLWKVHIF TVIQLTCLVL LWVIKVSAAA VVFPMMVLAL 
      1010       1020       1030       1040       1050
VFVRKLMDLC FTKRELSWLD DLMPESKKKK EDDKKKKEKE EAERMLQDDD 
      1060       1070       1080       1090       1100
DTVHLPFEGG SLLQIPVKAL KYSVDPSIVN ISDEMAKTAQ WKALSMNTEN 
      1110       1120       1130 
AKVTRSNMSP DKPVSVKISF EDEPRKKYVD AETSL

Show »

Length:1,135

Mass (Da):127,803

Checksum:ⁱ77E065DA75256869

Isoform 14 (identifier: Q9Y6M7-14) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MERFRLEKKLP → MEADGAGEQMRPLLTRVTSR
     251-374: Missing.
     581-582: LF → VQ
     583-1214: Missing.

« Hide

        10         20         30         40         50
MEADGAGEQM RPLLTRVTSR GPDEEAVVDL GKTSSTVNTK FEKEELESHR 
        60         70         80         90        100
AVYIGVHVPF SKESRRRHRH RGHKHHHRRR KDKESDKEDG RESPSYDTPS 
       110        120        130        140        150
QRVQFILGTE DDDEEHIPHD LFTEMDELCY RDGEEYEWKE TARWLKFEED 
       160        170        180        190        200
VEDGGDRWSK PYVATLSLHS LFELRSCILN GTVMLDMRAS TLDEIADMVL 
       210        220        230        240        250
DNMIASGQLD ESIRENVREA LLKRHHHQNE KRFTSRIPLV RSFADIGKKH 
       260        270        280        290        300
SDPHLLERNG ILASPQSAPG NLDNSKSGEI KGNGSGGSRE NSTVDFSKVD 
       310        320        330        340        350
MNFMRKIPTG AEASNVLVGE VDFLERPIIA FVRLAPAVLL TGLTEVPVPT 
       360        370        380        390        400
RFLFLLLGPA GKAPQYHEIG RSIATLMTDE IFHDVAYKAK DRNDLLSGID 
       410        420        430        440        450
EFLDQVTVLP PGEWDPSIRI EPPKSVPSQE KRKIPVFHNG STPTLGETPK 
       460 
EAAHHAGPEL QRTGRVQ

Show »

Length:467

Mass (Da):52,692

Checksum:ⁱ80F478ACDCBA905A

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PFN4	E9PFN4_HUMAN	Anion exchange protein Anion exchange protein	SLC4A7	1,210	Annotation score:
C9JRP1	C9JRP1_HUMAN	Anion exchange protein Anion exchange protein	SLC4A7	1,051	Annotation score:
H7C3C4	H7C3C4_HUMAN	Anion exchange protein Anion exchange protein	SLC4A7	801	Annotation score:
A0A0A0MST8	A0A0A0MST8_HUMAN	Anion exchange protein Anion exchange protein	SLC4A7	1,201	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055317	326	E → K2 PublicationsCorresponds to variant dbSNP:rs3755652Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047838	1 – 450	Missing in isoform 5. 1 PublicationAdd BLAST	450
Alternative sequenceⁱVSP_047839	1 – 90	Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST	90
Alternative sequenceⁱVSP_047840	1 – 11	MERFRLEKKLP → MEADGAGEQMRPLLTR in isoform 6, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST	11
Alternative sequenceⁱVSP_047841	1 – 11	MERFRLEKKLP → MEADGAGEQMRPLLTRVTSR in isoform 7, isoform 8, isoform 13 and isoform 14. 2 PublicationsAdd BLAST	11
Alternative sequenceⁱVSP_047842	91 – 118	SQRVQ…TEMDE → MAVTQFIHFREEIMGNMFFI IIFSTKDK in isoform 3 and isoform 4. 2 PublicationsAdd BLAST	28
Alternative sequenceⁱVSP_047843	238 – 250	Missing in isoform 8, isoform 10 and isoform 12. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_047844	251 – 374	Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 9, isoform 11, isoform 13 and isoform 14. 5 PublicationsAdd BLAST	124
Alternative sequenceⁱVSP_047845	451 – 465	PAVLL…VPVPT → MEVVEAEKIVLLTSA in isoform 5. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_047846	581 – 582	LF → VQ in isoform 10, isoform 11 and isoform 14. 2 Publications	2
Alternative sequenceⁱVSP_047847	583 – 1214	Missing in isoform 10, isoform 11 and isoform 14. 2 PublicationsAdd BLAST	632
Alternative sequenceⁱVSP_047848	1188	S → SVDPSIVNISDEMAKTAQWK ALSMNTENAKVTRSNMS in isoform 5, isoform 6, isoform 7, isoform 8 and isoform 13. 3 Publications	1
Alternative sequenceⁱVSP_047849	1189 – 1214	PDKPV…AETSL → GDPSIGNISDEMAKTAQWKA LSMNTENAKVTRSNMSPDKP VSVK in isoform 3. 1 PublicationAdd BLAST	26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012130 mRNA Translation: BAA25898.1 AF047033 mRNA Translation: AAD38322.1 AF089726 mRNA Translation: AAG16773.1 AF053755 mRNA Translation: AAF21720.1 EU499349 mRNA Translation: ACB47400.1 EU934246 mRNA Translation: ACH61958.1 EU934248 mRNA Translation: ACH61960.1 EU934249 mRNA Translation: ACH61961.1 EU934250 mRNA Translation: ACH61962.1 FJ178574 mRNA Translation: ACI24740.1 FJ178575 mRNA Translation: ACI24741.1 FJ178576 mRNA Translation: ACI24742.1 GU354307 mRNA Translation: ADC32649.1 GU354308 mRNA Translation: ADC32650.1 GU354309 mRNA Translation: ADC32651.1 GU354310 mRNA Translation: ADC32652.1 CR627428 mRNA Translation: CAH10515.1 AC099535 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64382.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33721.1 [Q9Y6M7-1] CCDS58819.1 [Q9Y6M7-2] CCDS58820.1 [Q9Y6M7-6] CCDS82747.1 [Q9Y6M7-7] CCDS82749.1 [Q9Y6M7-8] CCDS82750.1 [Q9Y6M7-9] CCDS82751.1 [Q9Y6M7-12]
PIRⁱ	JE0160
NCBI Reference Sequences More...RefSeqⁱ	NP_001245308.1, NM_001258379.1 [Q9Y6M7-6] NP_001245309.1, NM_001258380.1 [Q9Y6M7-2] NP_001308032.1, NM_001321103.1 [Q9Y6M7-7] NP_001308033.1, NM_001321104.1 [Q9Y6M7-8] NP_001308034.1, NM_001321105.1 NP_001308035.1, NM_001321106.1 [Q9Y6M7-12] NP_001308036.1, NM_001321107.1 [Q9Y6M7-9] NP_001308037.1, NM_001321108.1 [Q9Y6M7-13] NP_003606.3, NM_003615.4 [Q9Y6M7-1] XP_016863017.1, XM_017007528.1 [Q9Y6M7-5] XP_016863018.1, XM_017007529.1 [Q9Y6M7-5]

Genome annotation databases

Ensemblⁱ	ENST00000295736; ENSP00000295736; ENSG00000033867 [Q9Y6M7-1] ENST00000428386; ENSP00000416368; ENSG00000033867 [Q9Y6M7-2] ENST00000437179; ENSP00000394252; ENSG00000033867 [Q9Y6M7-9] ENST00000437266; ENSP00000409418; ENSG00000033867 [Q9Y6M7-11] ENST00000438530; ENSP00000407304; ENSG00000033867 [Q9Y6M7-10] ENST00000440156; ENSP00000414797; ENSG00000033867 [Q9Y6M7-8] ENST00000446700; ENSP00000406605; ENSG00000033867 [Q9Y6M7-12] ENST00000454389; ENSP00000390394; ENSG00000033867 [Q9Y6M7-7] ENST00000455077; ENSP00000407382; ENSG00000033867 [Q9Y6M7-6] ENST00000457377; ENSP00000408323; ENSG00000033867 [Q9Y6M7-11]
GeneIDⁱ	9497
KEGGⁱ	hsa:9497
UCSC genome browser More...UCSCⁱ	uc003cdu.6, human [Q9Y6M7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6M7-5	Anion exchange protein (Fragment)		HUMAN		801	UniRef100_Q9Y6M7-5

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6M7	Anion exchange protein		MYODS		1305	UniRef90_Q9Y6M7
Solute carrier family 4, sodium bicarbonate cotransporter, member 7 (Fragment)		MUSPF		81
Anion exchange protein		OCTDE		1272
Eye sodium bicarbonate cotransport protein NBC2 (Fragment)		RABIT		88
Anion exchange protein		MYOBR		1263
+444
Q9Y6M7-5	Anion exchange protein (Fragment)		HUMAN		801	UniRef90_Q9Y6M7-5
Anion exchange protein (Fragment)		PONAB		801
Anion exchange protein (Fragment)		PANTR		801
Q9Y6M7-9	Anion exchange protein		PHACI		1328	UniRef90_Q9Y6M7-9
Anion exchange protein		SARHA		1268
Anion exchange protein		VOMUR		1250
Anion exchange protein		MONDO		1245
Anion exchange protein		CANLF		1212
+44
Q9Y6M7-10	SLC4A7 isoform 10		PANTR		578	UniRef90_Q9Y6M7-10
SLC4A7 isoform 8		PONAB		574
Isoform 14 of Sodium bicarbonate cotransporter 3		HUMAN		467
Solute carrier family 4 member 7		RHIFE		463
SLC4A7 isoform 14		PANTR		463
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6M7	Anion exchange protein		MYODS		1305	UniRef50_Q9Y6M7
Solute carrier family 4, sodium bicarbonate cotransporter, member 7 (Fragment)		MUSPF		81
Anion exchange protein		OCTDE		1272
Eye sodium bicarbonate cotransport protein NBC2 (Fragment)		RABIT		88
Anion exchange protein		MYOBR		1263
+709
Q9Y6M7-3	Anion exchange protein		VICPA		975	UniRef50_Q9Y6M7-3
Anion exchange protein (Fragment)		Aegotheles bennettii		992
Anion exchange protein (Fragment)		AREIN		911
Anion exchange protein (Fragment)		Struthio camelus australis		992
Serine/threonine-protein kinase Nek10		CRIGR		1120
+15
Q9Y6M7-4	Isoform 12 of Sodium bicarbonate cotransporter 3		HUMAN		1206	UniRef50_Q9Y6M7-12
Anion exchange protein		PIPKU		1205
Anion exchange protein		PONAB		1206
Anion exchange protein		CALMI		1017
Uncharacterized protein		Monterrey platyfish		1138
+52
Q9Y6M7-5	Anion exchange protein (Fragment)		HUMAN		801	UniRef50_Q9Y6M7-5
Anion exchange protein (Fragment)		PONAB		801
Anion exchange protein (Fragment)		PANTR		801
Anion exchange protein (Fragment)		bluefin notho		831
Anion exchange protein		HIPCM		920
+25
Q9Y6M7-6	Sodium bicarbonate cotransporter 3		MOUSE		1034	UniRef50_Q9Y6M7-6
Anion exchange protein		PIG		1034
Anion exchange protein		MYOMY		1131
Anion exchange protein		GORGO		1153
Anion exchange protein		SHEEP		1254
+163
Q9Y6M7-10	SLC4A7 isoform 10		PANTR		578	UniRef50_Q9Y6M7-10
SLC4A7 isoform 8		PONAB		574
Isoform 14 of Sodium bicarbonate cotransporter 3		HUMAN		467
Solute carrier family 4 member 7		RHIFE		463
Sodium-driven chloride bicarbonate exchanger-like		Sinocyclocheilus anshuiensis		465
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012130 mRNA Translation: BAA25898.1 AF047033 mRNA Translation: AAD38322.1 AF089726 mRNA Translation: AAG16773.1 AF053755 mRNA Translation: AAF21720.1 EU499349 mRNA Translation: ACB47400.1 EU934246 mRNA Translation: ACH61958.1 EU934248 mRNA Translation: ACH61960.1 EU934249 mRNA Translation: ACH61961.1 EU934250 mRNA Translation: ACH61962.1 FJ178574 mRNA Translation: ACI24740.1 FJ178575 mRNA Translation: ACI24741.1 FJ178576 mRNA Translation: ACI24742.1 GU354307 mRNA Translation: ADC32649.1 GU354308 mRNA Translation: ADC32650.1 GU354309 mRNA Translation: ADC32651.1 GU354310 mRNA Translation: ADC32652.1 CR627428 mRNA Translation: CAH10515.1 AC099535 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64382.1
CCDSⁱ	CCDS33721.1 [Q9Y6M7-1] CCDS58819.1 [Q9Y6M7-2] CCDS58820.1 [Q9Y6M7-6] CCDS82747.1 [Q9Y6M7-7] CCDS82749.1 [Q9Y6M7-8] CCDS82750.1 [Q9Y6M7-9] CCDS82751.1 [Q9Y6M7-12]
PIRⁱ	JE0160
RefSeqⁱ	NP_001245308.1, NM_001258379.1 [Q9Y6M7-6] NP_001245309.1, NM_001258380.1 [Q9Y6M7-2] NP_001308032.1, NM_001321103.1 [Q9Y6M7-7] NP_001308033.1, NM_001321104.1 [Q9Y6M7-8] NP_001308034.1, NM_001321105.1 NP_001308035.1, NM_001321106.1 [Q9Y6M7-12] NP_001308036.1, NM_001321107.1 [Q9Y6M7-9] NP_001308037.1, NM_001321108.1 [Q9Y6M7-13] NP_003606.3, NM_003615.4 [Q9Y6M7-1] XP_016863017.1, XM_017007528.1 [Q9Y6M7-5] XP_016863018.1, XM_017007529.1 [Q9Y6M7-5]

3D structure databases

SMRⁱ	Q9Y6M7
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	114876, 72 interactors
IntActⁱ	Q9Y6M7, 39 interactors
MINTⁱ	Q9Y6M7
STRINGⁱ	9606.ENSP00000295736

Chemistry databases

ChEMBLⁱ	CHEMBL3774290
DrugBankⁱ	DB01390, Sodium bicarbonate

Protein family/group databases

TCDBⁱ	2.A.31.2.11, the anion exchanger (ae) family

TCDBⁱ

2.A.31.2.11, the anion exchanger (ae) family

PTM databases

GlyGenⁱ	Q9Y6M7, 8 sites
iPTMnetⁱ	Q9Y6M7
PhosphoSitePlusⁱ	Q9Y6M7
SwissPalmⁱ	Q9Y6M7

Genetic variation databases

BioMutaⁱ	SLC4A7
DMDMⁱ	229462789

Proteomic databases

EPDⁱ	Q9Y6M7
jPOSTⁱ	Q9Y6M7
MassIVEⁱ	Q9Y6M7
PaxDbⁱ	Q9Y6M7
PeptideAtlasⁱ	Q9Y6M7
PRIDEⁱ	Q9Y6M7
ProteomicsDBⁱ	12778 3404 5941 5942 6243 6244 86734 [Q9Y6M7-1] 86735 [Q9Y6M7-2] 86736 [Q9Y6M7-3] 86737 [Q9Y6M7-4] 86738 [Q9Y6M7-5]

Protocols and materials databases

Antibodypediaⁱ	45253, 177 antibodies
The DNASU plasmid repository More...DNASUⁱ	9497

Genome annotation databases

Organism-specific databases

CTDⁱ	9497
DisGeNETⁱ	9497
GeneCardsⁱ	SLC4A7
HGNCⁱ	HGNC:11033, SLC4A7
HPAⁱ	ENSG00000033867, Tissue enhanced (intestine)
MIMⁱ	603353, gene
neXtProtⁱ	NX_Q9Y6M7
OpenTargetsⁱ	ENSG00000033867
PharmGKBⁱ	PA35899
VEuPathDBⁱ	HostDB:ENSG00000033867.16
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1172, Eukaryota
GeneTreeⁱ	ENSGT00940000157045
HOGENOMⁱ	CLU_002289_0_0_1
InParanoidⁱ	Q9Y6M7
OMAⁱ	WSPIIAV
OrthoDBⁱ	863978at2759
PhylomeDBⁱ	Q9Y6M7
TreeFamⁱ	TF313630

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y6M7
Reactomeⁱ	R-HSA-425381, Bicarbonate transporters

Miscellaneous databases

BioGRID-ORCSⁱ	9497, 236 hits in 1003 CRISPR screens
ChiTaRSⁱ	SLC4A7, human
GeneWikiⁱ	SLC4A7
GenomeRNAiⁱ	9497
Pharosⁱ	Q9Y6M7, Tbio
Protein Ontology More...PROⁱ	PR:Q9Y6M7
RNActⁱ	Q9Y6M7, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000033867, Expressed in oocyte and 229 other tissues
ExpressionAtlasⁱ	Q9Y6M7, baseline and differential
Genevisibleⁱ	Q9Y6M7, HS

Family and domain databases

Gene3Dⁱ	3.40.930.10, 2 hits
InterProⁱ	View protein in InterPro IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr
PANTHERⁱ	PTHR11453, PTHR11453, 1 hit
Pfamⁱ	View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit
PRINTSⁱ	PR01231, HCO3TRNSPORT
SUPFAMⁱ	SSF55804, SSF55804, 2 hits
TIGRFAMsⁱ	TIGR00834, ae, 1 hit
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Entry informationⁱ

Entry nameⁱ	S4A7_HUMAN
Accessionⁱ	Q9Y6M7Primary (citable) accession number: Q9Y6M7 Secondary accession number(s): A6NIA8 Q9UIB9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
	Last sequence update:	May 5, 2009
	Last modified:	June 2, 2021
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9Y6M7 (S4A7_HUMAN)

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Sodium bicarbonate cotransporter 3

SLC4A7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Plasma Membrane

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Keywords - Cellular componenti

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Proteomic databases

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Gene expression databases

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Q9Y6M7

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3D structure databases

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Keywords - Coding sequence diversityi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ