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Protein

Casein kinase I isoform gamma-3

Gene

CSNK1G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).By similarity

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei72ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei162Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi49 – 57ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: ParkinsonsUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y6M4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Casein kinase I isoform gamma-3 (EC:2.7.11.1)
Short name:
CKI-gamma 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSNK1G3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151292.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2456 CSNK1G3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604253 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6M4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1456

Open Targets

More...
OpenTargetsi
ENSG00000151292

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26956

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5084

Drug and drug target database

More...
DrugBanki
DB04751 Purvalanol A

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117932

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001928461 – 447Casein kinase I isoform gamma-3Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Isoform 6 (identifier: Q9Y6M4-6)
Modified residuei254PhosphoserineCombined sources1
Isoform 5 (identifier: Q9Y6M4-5)
Modified residuei291PhosphoserineCombined sources1
Isoform 3 (identifier: Q9Y6M4-3)
Modified residuei366PhosphoserineCombined sources1
Isoform 4 (identifier: Q9Y6M4-4)
Modified residuei367PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6M4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6M4

PeptideAtlas

More...
PeptideAtlasi
Q9Y6M4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6M4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86730
86731 [Q9Y6M4-2]
86732 [Q9Y6M4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6M4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6M4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y6M4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151292 Expressed in 227 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_CSNK1G3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6M4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6M4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027010

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107840, 48 interactors

Protein interaction database and analysis system

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IntActi
Q9Y6M4, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000353904

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y6M4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y6M4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y6M4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y6M4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni117 – 125Inhibitors binding9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1165 Eukaryota
ENOG410XNXP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160646

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000182054

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000176

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6M4

KEGG Orthology (KO)

More...
KOi
K08958

Identification of Orthologs from Complete Genome Data

More...
OMAi
MELHSGH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F3Z

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6M4

TreeFam database of animal gene trees

More...
TreeFami
TF313349

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12605 CK1gamma_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6M4-1) [UniParc]FASTAAdd to basket
Also known as: 3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG
60 70 80 90 100
CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP
110 120 130 140 150
QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM
160 170 180 190 200
EYVHSKNLIY RDVKPENFLI GRPGNKTQQV IHIIDFGLAK EYIDPETKKH
210 220 230 240 250
IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ
260 270 280 290 300
GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD
310 320 330 340 350
YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH
360 370 380 390 400
QHRDKMQQSK NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN
410 420 430 440
GELNTDDPTA GRSNAPITAP TEVEVMDETK CCCFFKRRKR KTIQRHK
Length:447
Mass (Da):51,389
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FAEDD605579ED3A
GO
Isoform 2 (identifier: Q9Y6M4-2) [UniParc]FASTAAdd to basket
Also known as: 3L, CSNK1G3L

The sequence of this isoform differs from the canonical sequence as follows:
     430-430: K → NCQKVLNMW

Show »
Length:455
Mass (Da):52,378
Checksum:i23C1F32F3559120F
GO
Isoform 3 (identifier: Q9Y6M4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:423
Mass (Da):48,898
Checksum:i786AA3787897A4C5
GO
Isoform 4 (identifier: Q9Y6M4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-282: E → EE
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:424
Mass (Da):49,027
Checksum:i0D2C64F25039E090
GO
Isoform 5 (identifier: Q9Y6M4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:348
Mass (Da):40,729
Checksum:i5AEB20AED88A1240
GO
Isoform 6 (identifier: Q9Y6M4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.
     282-282: E → EE
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:311
Mass (Da):36,492
Checksum:i9A87163AF2FC9AFF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBN6H0YBN6_HUMAN
Casein kinase I isoform gamma-3
CSNK1G3
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91K → E in AAH47567 (PubMed:15489334).Curated1
Sequence conflicti174G → R in AAD26525 (PubMed:9925945).Curated1
Sequence conflicti174G → R in AAD26526 (PubMed:9925945).Curated1
Sequence conflicti241Y → C in BAH14390 (PubMed:14702039).Curated1
Sequence conflicti302D → E in AAD26525 (PubMed:9925945).Curated1
Sequence conflicti302D → E in AAD26526 (PubMed:9925945).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470531 – 113Missing in isoform 6. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0470541 – 75Missing in isoform 5. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_047055282E → EE in isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_010256363 – 394Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_004749430K → NCQKVLNMW in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF049089 mRNA Translation: AAD26525.1
AF049090 mRNA Translation: AAD26526.1
AK289405 mRNA Translation: BAF82094.1
AK299739 mRNA Translation: BAG61634.1
AK316019 mRNA Translation: BAH14390.1
AC008541 Genomic DNA No translation available.
AC026422 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48872.1
BC047567 mRNA Translation: AAH47567.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34218.1 [Q9Y6M4-3]
CCDS4135.1 [Q9Y6M4-1]
CCDS43355.1 [Q9Y6M4-2]
CCDS59491.1 [Q9Y6M4-4]
CCDS59492.1 [Q9Y6M4-5]
CCDS59493.1 [Q9Y6M4-6]

NCBI Reference Sequences

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RefSeqi
NP_001026982.1, NM_001031812.3 [Q9Y6M4-3]
NP_001038188.1, NM_001044723.2 [Q9Y6M4-2]
NP_001257501.1, NM_001270572.1 [Q9Y6M4-4]
NP_001257502.1, NM_001270573.1 [Q9Y6M4-5]
NP_001257503.1, NM_001270574.1 [Q9Y6M4-6]
NP_004375.2, NM_004384.4 [Q9Y6M4-1]
XP_005271949.1, XM_005271892.2 [Q9Y6M4-2]
XP_005271951.1, XM_005271894.2 [Q9Y6M4-1]
XP_005271952.1, XM_005271895.2 [Q9Y6M4-4]
XP_016864558.1, XM_017009069.1 [Q9Y6M4-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.129206
Hs.741716

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000345990; ENSP00000334735; ENSG00000151292 [Q9Y6M4-3]
ENST00000360683; ENSP00000353904; ENSG00000151292 [Q9Y6M4-2]
ENST00000361991; ENSP00000354942; ENSG00000151292 [Q9Y6M4-1]
ENST00000510842; ENSP00000423838; ENSG00000151292 [Q9Y6M4-4]
ENST00000511130; ENSP00000421385; ENSG00000151292 [Q9Y6M4-6]
ENST00000512718; ENSP00000421998; ENSG00000151292 [Q9Y6M4-5]
ENST00000521364; ENSP00000429412; ENSG00000151292 [Q9Y6M4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1456

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1456

UCSC genome browser

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UCSCi
uc003ktn.5 human [Q9Y6M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049089 mRNA Translation: AAD26525.1
AF049090 mRNA Translation: AAD26526.1
AK289405 mRNA Translation: BAF82094.1
AK299739 mRNA Translation: BAG61634.1
AK316019 mRNA Translation: BAH14390.1
AC008541 Genomic DNA No translation available.
AC026422 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48872.1
BC047567 mRNA Translation: AAH47567.1
CCDSiCCDS34218.1 [Q9Y6M4-3]
CCDS4135.1 [Q9Y6M4-1]
CCDS43355.1 [Q9Y6M4-2]
CCDS59491.1 [Q9Y6M4-4]
CCDS59492.1 [Q9Y6M4-5]
CCDS59493.1 [Q9Y6M4-6]
RefSeqiNP_001026982.1, NM_001031812.3 [Q9Y6M4-3]
NP_001038188.1, NM_001044723.2 [Q9Y6M4-2]
NP_001257501.1, NM_001270572.1 [Q9Y6M4-4]
NP_001257502.1, NM_001270573.1 [Q9Y6M4-5]
NP_001257503.1, NM_001270574.1 [Q9Y6M4-6]
NP_004375.2, NM_004384.4 [Q9Y6M4-1]
XP_005271949.1, XM_005271892.2 [Q9Y6M4-2]
XP_005271951.1, XM_005271894.2 [Q9Y6M4-1]
XP_005271952.1, XM_005271895.2 [Q9Y6M4-4]
XP_016864558.1, XM_017009069.1 [Q9Y6M4-4]
UniGeneiHs.129206
Hs.741716

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CHLX-ray1.95A35-362[»]
2IZRX-ray1.30A35-362[»]
2IZSX-ray1.95A35-362[»]
2IZTX-ray2.00A35-362[»]
2IZUX-ray1.85A35-362[»]
4G16X-ray2.30A34-362[»]
4G17X-ray2.10A34-362[»]
4HGLX-ray2.40A34-362[»]
4HGSX-ray2.40A34-362[»]
6GROX-ray1.45A33-362[»]
ProteinModelPortaliQ9Y6M4
SMRiQ9Y6M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107840, 48 interactors
IntActiQ9Y6M4, 10 interactors
STRINGi9606.ENSP00000353904

Chemistry databases

BindingDBiQ9Y6M4
ChEMBLiCHEMBL5084
DrugBankiDB04751 Purvalanol A

PTM databases

iPTMnetiQ9Y6M4
PhosphoSitePlusiQ9Y6M4
SwissPalmiQ9Y6M4

Polymorphism and mutation databases

DMDMi47117932

Proteomic databases

EPDiQ9Y6M4
PaxDbiQ9Y6M4
PeptideAtlasiQ9Y6M4
PRIDEiQ9Y6M4
ProteomicsDBi86730
86731 [Q9Y6M4-2]
86732 [Q9Y6M4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1456
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345990; ENSP00000334735; ENSG00000151292 [Q9Y6M4-3]
ENST00000360683; ENSP00000353904; ENSG00000151292 [Q9Y6M4-2]
ENST00000361991; ENSP00000354942; ENSG00000151292 [Q9Y6M4-1]
ENST00000510842; ENSP00000423838; ENSG00000151292 [Q9Y6M4-4]
ENST00000511130; ENSP00000421385; ENSG00000151292 [Q9Y6M4-6]
ENST00000512718; ENSP00000421998; ENSG00000151292 [Q9Y6M4-5]
ENST00000521364; ENSP00000429412; ENSG00000151292 [Q9Y6M4-3]
GeneIDi1456
KEGGihsa:1456
UCSCiuc003ktn.5 human [Q9Y6M4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1456
DisGeNETi1456
EuPathDBiHostDB:ENSG00000151292.17

GeneCards: human genes, protein and diseases

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GeneCardsi
CSNK1G3
HGNCiHGNC:2456 CSNK1G3
HPAiHPA027010
MIMi604253 gene
neXtProtiNX_Q9Y6M4
OpenTargetsiENSG00000151292
PharmGKBiPA26956

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1165 Eukaryota
ENOG410XNXP LUCA
GeneTreeiENSGT00940000160646
HOGENOMiHOG000182054
HOVERGENiHBG000176
InParanoidiQ9Y6M4
KOiK08958
OMAiMELHSGH
OrthoDBiEOG091G0F3Z
PhylomeDBiQ9Y6M4
TreeFamiTF313349

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9Y6M4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSNK1G3 human
EvolutionaryTraceiQ9Y6M4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1456

Protein Ontology

More...
PROi
PR:Q9Y6M4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151292 Expressed in 227 organ(s), highest expression level in kidney
CleanExiHS_CSNK1G3
ExpressionAtlasiQ9Y6M4 baseline and differential
GenevisibleiQ9Y6M4 HS

Family and domain databases

InterProiView protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12605 CK1gamma_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKC1G3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6M4
Secondary accession number(s): A8K040
, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2004
Last modified: December 5, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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