Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase I isoform gamma-3

Gene

CSNK1G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).By similarity

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72ATPPROSITE-ProRule annotation1
Active sitei162Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 57ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9Y6M4

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-3 (EC:2.7.11.1)
Short name:
CKI-gamma 3
Gene namesi
Name:CSNK1G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000151292.17
HGNCiHGNC:2456 CSNK1G3
MIMi604253 gene
neXtProtiNX_Q9Y6M4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1456
OpenTargetsiENSG00000151292
PharmGKBiPA26956

Chemistry databases

ChEMBLiCHEMBL5084
DrugBankiDB04751 Purvalanol A

Polymorphism and mutation databases

DMDMi47117932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928461 – 447Casein kinase I isoform gamma-3Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Isoform 6 (identifier: Q9Y6M4-6)
Modified residuei254PhosphoserineCombined sources1
Isoform 5 (identifier: Q9Y6M4-5)
Modified residuei291PhosphoserineCombined sources1
Isoform 3 (identifier: Q9Y6M4-3)
Modified residuei366PhosphoserineCombined sources1
Isoform 4 (identifier: Q9Y6M4-4)
Modified residuei367PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6M4
PaxDbiQ9Y6M4
PeptideAtlasiQ9Y6M4
PRIDEiQ9Y6M4
ProteomicsDBi86730
86731 [Q9Y6M4-2]
86732 [Q9Y6M4-3]

PTM databases

iPTMnetiQ9Y6M4
PhosphoSitePlusiQ9Y6M4
SwissPalmiQ9Y6M4

Expressioni

Gene expression databases

BgeeiENSG00000151292 Expressed in 227 organ(s), highest expression level in kidney
CleanExiHS_CSNK1G3
ExpressionAtlasiQ9Y6M4 baseline and differential
GenevisibleiQ9Y6M4 HS

Organism-specific databases

HPAiHPA027010

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi107840, 48 interactors
IntActiQ9Y6M4, 10 interactors
STRINGi9606.ENSP00000353904

Chemistry databases

BindingDBiQ9Y6M4

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6M4
SMRiQ9Y6M4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6M4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 125Inhibitors binding9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1165 Eukaryota
ENOG410XNXP LUCA
GeneTreeiENSGT00920000148988
HOGENOMiHOG000182054
HOVERGENiHBG000176
InParanoidiQ9Y6M4
KOiK08958
OMAiTYKHLQG
OrthoDBiEOG091G0F3Z
PhylomeDBiQ9Y6M4
TreeFamiTF313349

Family and domain databases

InterProiView protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12605 CK1gamma_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9Y6M4-1) [UniParc]FASTAAdd to basket
Also known as: 3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG
60 70 80 90 100
CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP
110 120 130 140 150
QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM
160 170 180 190 200
EYVHSKNLIY RDVKPENFLI GRPGNKTQQV IHIIDFGLAK EYIDPETKKH
210 220 230 240 250
IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ
260 270 280 290 300
GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD
310 320 330 340 350
YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH
360 370 380 390 400
QHRDKMQQSK NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN
410 420 430 440
GELNTDDPTA GRSNAPITAP TEVEVMDETK CCCFFKRRKR KTIQRHK
Length:447
Mass (Da):51,389
Last modified:May 10, 2004 - v2
Checksum:i6FAEDD605579ED3A
GO
Isoform 2 (identifier: Q9Y6M4-2) [UniParc]FASTAAdd to basket
Also known as: 3L, CSNK1G3L

The sequence of this isoform differs from the canonical sequence as follows:
     430-430: K → NCQKVLNMW

Show »
Length:455
Mass (Da):52,378
Checksum:i23C1F32F3559120F
GO
Isoform 3 (identifier: Q9Y6M4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:423
Mass (Da):48,898
Checksum:i786AA3787897A4C5
GO
Isoform 4 (identifier: Q9Y6M4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-282: E → EE
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:424
Mass (Da):49,027
Checksum:i0D2C64F25039E090
GO
Isoform 5 (identifier: Q9Y6M4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:348
Mass (Da):40,729
Checksum:i5AEB20AED88A1240
GO
Isoform 6 (identifier: Q9Y6M4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.
     282-282: E → EE
     363-394: Missing.
     430-430: K → NCQKVLNMW

Show »
Length:311
Mass (Da):36,492
Checksum:i9A87163AF2FC9AFF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBN6H0YBN6_HUMAN
Casein kinase I isoform gamma-3
CSNK1G3
164Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91K → E in AAH47567 (PubMed:15489334).Curated1
Sequence conflicti174G → R in AAD26525 (PubMed:9925945).Curated1
Sequence conflicti174G → R in AAD26526 (PubMed:9925945).Curated1
Sequence conflicti241Y → C in BAH14390 (PubMed:14702039).Curated1
Sequence conflicti302D → E in AAD26525 (PubMed:9925945).Curated1
Sequence conflicti302D → E in AAD26526 (PubMed:9925945).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470531 – 113Missing in isoform 6. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0470541 – 75Missing in isoform 5. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_047055282E → EE in isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_010256363 – 394Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_004749430K → NCQKVLNMW in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049089 mRNA Translation: AAD26525.1
AF049090 mRNA Translation: AAD26526.1
AK289405 mRNA Translation: BAF82094.1
AK299739 mRNA Translation: BAG61634.1
AK316019 mRNA Translation: BAH14390.1
AC008541 Genomic DNA No translation available.
AC026422 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48872.1
BC047567 mRNA Translation: AAH47567.1
CCDSiCCDS34218.1 [Q9Y6M4-3]
CCDS4135.1 [Q9Y6M4-1]
CCDS43355.1 [Q9Y6M4-2]
CCDS59491.1 [Q9Y6M4-4]
CCDS59492.1 [Q9Y6M4-5]
CCDS59493.1 [Q9Y6M4-6]
RefSeqiNP_001026982.1, NM_001031812.3 [Q9Y6M4-3]
NP_001038188.1, NM_001044723.2 [Q9Y6M4-2]
NP_001257501.1, NM_001270572.1 [Q9Y6M4-4]
NP_001257502.1, NM_001270573.1 [Q9Y6M4-5]
NP_001257503.1, NM_001270574.1 [Q9Y6M4-6]
NP_004375.2, NM_004384.4 [Q9Y6M4-1]
XP_005271949.1, XM_005271892.2 [Q9Y6M4-2]
XP_005271951.1, XM_005271894.2 [Q9Y6M4-1]
XP_005271952.1, XM_005271895.2 [Q9Y6M4-4]
XP_016864558.1, XM_017009069.1 [Q9Y6M4-4]
UniGeneiHs.129206
Hs.741716

Genome annotation databases

EnsembliENST00000345990; ENSP00000334735; ENSG00000151292 [Q9Y6M4-3]
ENST00000360683; ENSP00000353904; ENSG00000151292 [Q9Y6M4-2]
ENST00000361991; ENSP00000354942; ENSG00000151292 [Q9Y6M4-1]
ENST00000510842; ENSP00000423838; ENSG00000151292 [Q9Y6M4-4]
ENST00000511130; ENSP00000421385; ENSG00000151292 [Q9Y6M4-6]
ENST00000512718; ENSP00000421998; ENSG00000151292 [Q9Y6M4-5]
ENST00000521364; ENSP00000429412; ENSG00000151292 [Q9Y6M4-3]
GeneIDi1456
KEGGihsa:1456
UCSCiuc003ktn.5 human [Q9Y6M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049089 mRNA Translation: AAD26525.1
AF049090 mRNA Translation: AAD26526.1
AK289405 mRNA Translation: BAF82094.1
AK299739 mRNA Translation: BAG61634.1
AK316019 mRNA Translation: BAH14390.1
AC008541 Genomic DNA No translation available.
AC026422 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48872.1
BC047567 mRNA Translation: AAH47567.1
CCDSiCCDS34218.1 [Q9Y6M4-3]
CCDS4135.1 [Q9Y6M4-1]
CCDS43355.1 [Q9Y6M4-2]
CCDS59491.1 [Q9Y6M4-4]
CCDS59492.1 [Q9Y6M4-5]
CCDS59493.1 [Q9Y6M4-6]
RefSeqiNP_001026982.1, NM_001031812.3 [Q9Y6M4-3]
NP_001038188.1, NM_001044723.2 [Q9Y6M4-2]
NP_001257501.1, NM_001270572.1 [Q9Y6M4-4]
NP_001257502.1, NM_001270573.1 [Q9Y6M4-5]
NP_001257503.1, NM_001270574.1 [Q9Y6M4-6]
NP_004375.2, NM_004384.4 [Q9Y6M4-1]
XP_005271949.1, XM_005271892.2 [Q9Y6M4-2]
XP_005271951.1, XM_005271894.2 [Q9Y6M4-1]
XP_005271952.1, XM_005271895.2 [Q9Y6M4-4]
XP_016864558.1, XM_017009069.1 [Q9Y6M4-4]
UniGeneiHs.129206
Hs.741716

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CHLX-ray1.95A35-362[»]
2IZRX-ray1.30A35-362[»]
2IZSX-ray1.95A35-362[»]
2IZTX-ray2.00A35-362[»]
2IZUX-ray1.85A35-362[»]
4G16X-ray2.30A34-362[»]
4G17X-ray2.10A34-362[»]
4HGLX-ray2.40A34-362[»]
4HGSX-ray2.40A34-362[»]
6GROX-ray1.45A33-362[»]
ProteinModelPortaliQ9Y6M4
SMRiQ9Y6M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107840, 48 interactors
IntActiQ9Y6M4, 10 interactors
STRINGi9606.ENSP00000353904

Chemistry databases

BindingDBiQ9Y6M4
ChEMBLiCHEMBL5084
DrugBankiDB04751 Purvalanol A

PTM databases

iPTMnetiQ9Y6M4
PhosphoSitePlusiQ9Y6M4
SwissPalmiQ9Y6M4

Polymorphism and mutation databases

DMDMi47117932

Proteomic databases

EPDiQ9Y6M4
PaxDbiQ9Y6M4
PeptideAtlasiQ9Y6M4
PRIDEiQ9Y6M4
ProteomicsDBi86730
86731 [Q9Y6M4-2]
86732 [Q9Y6M4-3]

Protocols and materials databases

DNASUi1456
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345990; ENSP00000334735; ENSG00000151292 [Q9Y6M4-3]
ENST00000360683; ENSP00000353904; ENSG00000151292 [Q9Y6M4-2]
ENST00000361991; ENSP00000354942; ENSG00000151292 [Q9Y6M4-1]
ENST00000510842; ENSP00000423838; ENSG00000151292 [Q9Y6M4-4]
ENST00000511130; ENSP00000421385; ENSG00000151292 [Q9Y6M4-6]
ENST00000512718; ENSP00000421998; ENSG00000151292 [Q9Y6M4-5]
ENST00000521364; ENSP00000429412; ENSG00000151292 [Q9Y6M4-3]
GeneIDi1456
KEGGihsa:1456
UCSCiuc003ktn.5 human [Q9Y6M4-1]

Organism-specific databases

CTDi1456
DisGeNETi1456
EuPathDBiHostDB:ENSG00000151292.17
GeneCardsiCSNK1G3
HGNCiHGNC:2456 CSNK1G3
HPAiHPA027010
MIMi604253 gene
neXtProtiNX_Q9Y6M4
OpenTargetsiENSG00000151292
PharmGKBiPA26956
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1165 Eukaryota
ENOG410XNXP LUCA
GeneTreeiENSGT00920000148988
HOGENOMiHOG000182054
HOVERGENiHBG000176
InParanoidiQ9Y6M4
KOiK08958
OMAiTYKHLQG
OrthoDBiEOG091G0F3Z
PhylomeDBiQ9Y6M4
TreeFamiTF313349

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9Y6M4

Miscellaneous databases

ChiTaRSiCSNK1G3 human
EvolutionaryTraceiQ9Y6M4
GenomeRNAii1456
PROiPR:Q9Y6M4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151292 Expressed in 227 organ(s), highest expression level in kidney
CleanExiHS_CSNK1G3
ExpressionAtlasiQ9Y6M4 baseline and differential
GenevisibleiQ9Y6M4 HS

Family and domain databases

InterProiView protein in InterPro
IPR022247 Casein_kinase-1_gamma_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12605 CK1gamma_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKC1G3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M4
Secondary accession number(s): A8K040
, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again