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Entry version 174 (22 Apr 2020)
Sequence version 2 (03 Mar 2009)
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Protein

Insulin-like growth factor 2 mRNA-binding protein 2

Gene

IGF2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.By similarity2 Publications

Miscellaneous

Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Translation regulation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor 2 mRNA-binding protein 2
Short name:
IGF2 mRNA-binding protein 2
Short name:
IMP-2
Alternative name(s):
Hepatocellular carcinoma autoantigen p62
IGF-II mRNA-binding protein 2
VICKZ family member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGF2BP2
Synonyms:IMP2, VICKZ2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28867 IGF2BP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608289 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6M1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi211K → E: Significantly impaired binding to ACTB transcript, but little effect on MYC transcript binding, accumulation in the nucleus; when associated with E-292. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-292; 445-E-E-446 and 526-E-E-527. 1 Publication1
Mutagenesisi292K → E: Significantly impaired binding to ACTB transcript, but little effect on MYC transcript binding, accumulation in the nucleus; when associated with E-211. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-211; 445-E-E-445 and 526-E-E-527. 1 Publication1
Mutagenesisi445 – 446KK → EE: Significantly impaired binding to ACTB and MYC transcripts; when associated with 527-E-E-528. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-211; E-292 and 527-E-E-528. 1 Publication2
Mutagenesisi527 – 528KG → EE: Significantly impaired binding to ACTB and MYC transcripts; when associated with 445-E-E-446. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-211; E-292 and 445-E-E-446. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
10644

MalaCards human disease database

More...
MalaCardsi
IGF2BP2

Open Targets

More...
OpenTargetsi
ENSG00000073792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394577

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6M1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGF2BP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
224471831

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002444961 – 599Insulin-like growth factor 2 mRNA-binding protein 2Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei550PhosphothreonineBy similarity1
Isoform 6 (identifier: Q9Y6M1-6)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6M1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y6M1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y6M1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y6M1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6M1

PeptideAtlas

More...
PeptideAtlasi
Q9Y6M1

PRoteomics IDEntifications database

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PRIDEi
Q9Y6M1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
86724 [Q9Y6M1-2]
86725 [Q9Y6M1-1]
86726 [Q9Y6M1-3]
86727 [Q9Y6M1-4]
86728 [Q9Y6M1-5]
86729 [Q9Y6M1-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6M1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6M1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y6M1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000073792 Expressed in kidney and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6M1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6M1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000073792 Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner.

Interacts with HNRPD and IGF2BP1.

Interacts with ELAVL1, DHX9 and HNRNPU.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115888, 137 interactors

Database of interacting proteins

More...
DIPi
DIP-35539N

Protein interaction database and analysis system

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IntActi
Q9Y6M1, 47 interactors

Molecular INTeraction database

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MINTi
Q9Y6M1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371634

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y6M1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y6M1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y6M1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 76RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini82 – 157RRM 2PROSITE-ProRule annotationAdd BLAST76
Domaini193 – 258KH 1PROSITE-ProRule annotationAdd BLAST66
Domaini274 – 341KH 2PROSITE-ProRule annotationAdd BLAST68
Domaini427 – 492KH 3PROSITE-ProRule annotationAdd BLAST66
Domaini509 – 575KH 4PROSITE-ProRule annotationAdd BLAST67

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM IMP/VICKZ family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2193 Eukaryota
ENOG410ZKB4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020744_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6M1

KEGG Orthology (KO)

More...
KOi
K17392

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6M1

TreeFam database of animal gene trees

More...
TreeFami
TF320229

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12626 RRM1_IGF2BP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1370.10, 2 hits
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028743 IGF2BP2
IPR034843 IGF2BP2_RRM1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR10288:SF93 PTHR10288:SF93, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00013 KH_1, 4 hits
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00322 KH, 4 hits
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791 SSF54791, 4 hits
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50084 KH_TYPE_1, 4 hits
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6M1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW
60 70 80 90 100
AIRAIETLSG KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG
110 120 130 140 150
LLAQYGTVEN VEQVNTDTET AVVNVTYATR EEAKIAMEKL SGHQFENYSF
160 170 180 190 200
KISYIPDEEV SSPSPPQRAQ RGDHSSREQG HAPGGTSQAR QIDFPLRILV
210 220 230 240 250
PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK PVTIHATPEG
260 270 280 290 300
TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
310 320 330 340 350
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE
360 370 380 390 400
NDMLAVNQQA NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT
410 420 430 440 450
THSGYFSSLY PHHQFGPFPH HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI
460 470 480 490 500
KQLARFAGAS IKIAPAEGPD VSERMVIITG PPEAQFKAQG RIFGKLKEEN
510 520 530 540 550
FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS AEVIVPRDQT
560 570 580 590
PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK
Length:599
Mass (Da):66,121
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA656F8733BBB39A
GO
Isoform 2 (identifier: Q9Y6M1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-400: Missing.

Show »
Length:556
Mass (Da):61,842
Checksum:i1EDEFB100443DDC4
GO
Isoform 3 (identifier: Q9Y6M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MMNKLYIGNL...VDYSVSKKLR → MFSCPGHYHVDGFLNPG

Show »
Length:536
Mass (Da):59,001
Checksum:i733536C7BDAD8AF5
GO
Isoform 4 (identifier: Q9Y6M1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MMNKLYIGNL...VDYSVSKKLR → MFSCPGHYHVDGFLNPG
     113-113: Q → QVFAFSL

Show »
Length:542
Mass (Da):59,666
Checksum:iF1D98409DD8AE45D
GO
Isoform 5 (identifier: Q9Y6M1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MMNKLYIGNL...VDYSVSKKLR → MFSCPGHYHVDGFLNPG
     358-400: Missing.

Show »
Length:493
Mass (Da):54,722
Checksum:i36BF971E2C4296F7
GO
Isoform 6 (identifier: Q9Y6M1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Generated by alternative initiation at Met-69.Curated
Show »
Length:531
Mass (Da):58,578
Checksum:i1F5FD1AC97743530
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W930F8W930_HUMAN
Insulin-like growth factor 2 mRNA-b...
IGF2BP2
605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21290 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0365501 – 80MMNKL…SKKLR → MFSCPGHYHVDGFLNPG in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0436991 – 68Missing in isoform 6. CuratedAdd BLAST68
Alternative sequenceiVSP_036552113Q → QVFAFSL in isoform 4. 1 Publication1
Alternative sequenceiVSP_036553358 – 400Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF057352 mRNA Translation: AAD31596.1
EU408701 mRNA Translation: ACB86625.1
EU408702 mRNA Translation: ACB86626.1
EU408703 mRNA Translation: ACB86627.1
AC016961 Genomic DNA No translation available.
AC108670 Genomic DNA No translation available.
BC021290 mRNA Translation: AAH21290.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3273.2 [Q9Y6M1-2]
CCDS33903.1 [Q9Y6M1-1]
CCDS77869.1 [Q9Y6M1-3]

NCBI Reference Sequences

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RefSeqi
NP_001007226.1, NM_001007225.2 [Q9Y6M1-1]
NP_001278801.1, NM_001291872.2 [Q9Y6M1-4]
NP_001278802.1, NM_001291873.2 [Q9Y6M1-3]
NP_001278803.1, NM_001291874.2 [Q9Y6M1-5]
NP_001278804.1, NM_001291875.2
NP_006539.3, NM_006548.5 [Q9Y6M1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000346192; ENSP00000320204; ENSG00000073792 [Q9Y6M1-1]
ENST00000382199; ENSP00000371634; ENSG00000073792 [Q9Y6M1-2]
ENST00000421047; ENSP00000413787; ENSG00000073792 [Q9Y6M1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10644

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10644

UCSC genome browser

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UCSCi
uc003fpo.4 human [Q9Y6M1-2]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057352 mRNA Translation: AAD31596.1
EU408701 mRNA Translation: ACB86625.1
EU408702 mRNA Translation: ACB86626.1
EU408703 mRNA Translation: ACB86627.1
AC016961 Genomic DNA No translation available.
AC108670 Genomic DNA No translation available.
BC021290 mRNA Translation: AAH21290.1 Different initiation.
CCDSiCCDS3273.2 [Q9Y6M1-2]
CCDS33903.1 [Q9Y6M1-1]
CCDS77869.1 [Q9Y6M1-3]
RefSeqiNP_001007226.1, NM_001007225.2 [Q9Y6M1-1]
NP_001278801.1, NM_001291872.2 [Q9Y6M1-4]
NP_001278802.1, NM_001291873.2 [Q9Y6M1-3]
NP_001278803.1, NM_001291874.2 [Q9Y6M1-5]
NP_001278804.1, NM_001291875.2
NP_006539.3, NM_006548.5 [Q9Y6M1-2]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQHNMR-A2-81[»]
6ROLX-ray2.10A/B/C/D426-588[»]
SMRiQ9Y6M1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115888, 137 interactors
DIPiDIP-35539N
IntActiQ9Y6M1, 47 interactors
MINTiQ9Y6M1
STRINGi9606.ENSP00000371634

PTM databases

iPTMnetiQ9Y6M1
PhosphoSitePlusiQ9Y6M1
SwissPalmiQ9Y6M1

Polymorphism and mutation databases

BioMutaiIGF2BP2
DMDMi224471831

Proteomic databases

EPDiQ9Y6M1
jPOSTiQ9Y6M1
MassIVEiQ9Y6M1
MaxQBiQ9Y6M1
PaxDbiQ9Y6M1
PeptideAtlasiQ9Y6M1
PRIDEiQ9Y6M1
ProteomicsDBi86724 [Q9Y6M1-2]
86725 [Q9Y6M1-1]
86726 [Q9Y6M1-3]
86727 [Q9Y6M1-4]
86728 [Q9Y6M1-5]
86729 [Q9Y6M1-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33841 578 antibodies

The DNASU plasmid repository

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DNASUi
10644

Genome annotation databases

EnsembliENST00000346192; ENSP00000320204; ENSG00000073792 [Q9Y6M1-1]
ENST00000382199; ENSP00000371634; ENSG00000073792 [Q9Y6M1-2]
ENST00000421047; ENSP00000413787; ENSG00000073792 [Q9Y6M1-3]
GeneIDi10644
KEGGihsa:10644
UCSCiuc003fpo.4 human [Q9Y6M1-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10644
DisGeNETi10644

GeneCards: human genes, protein and diseases

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GeneCardsi
IGF2BP2
HGNCiHGNC:28867 IGF2BP2
HPAiENSG00000073792 Tissue enhanced (placenta)
MalaCardsiIGF2BP2
MIMi608289 gene
neXtProtiNX_Q9Y6M1
OpenTargetsiENSG00000073792
PharmGKBiPA128394577

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2193 Eukaryota
ENOG410ZKB4 LUCA
GeneTreeiENSGT00940000154913
HOGENOMiCLU_020744_1_0_1
InParanoidiQ9Y6M1
KOiK17392
PhylomeDBiQ9Y6M1
TreeFamiTF320229

Enzyme and pathway databases

ReactomeiR-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IGF2BP2 human
EvolutionaryTraceiQ9Y6M1

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IGF2BP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10644
PharosiQ9Y6M1 Tbio

Protein Ontology

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PROi
PR:Q9Y6M1
RNActiQ9Y6M1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000073792 Expressed in kidney and 203 other tissues
ExpressionAtlasiQ9Y6M1 baseline and differential
GenevisibleiQ9Y6M1 HS

Family and domain databases

CDDicd12626 RRM1_IGF2BP2, 1 hit
Gene3Di3.30.1370.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR028743 IGF2BP2
IPR034843 IGF2BP2_RRM1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10288:SF93 PTHR10288:SF93, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 4 hits
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 4 hits
SM00360 RRM, 2 hits
SUPFAMiSSF54791 SSF54791, 4 hits
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 4 hits
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF2B2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6M1
Secondary accession number(s): A0A4Z0
, B3FTN2, B3FTN3, B3FTN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 3, 2009
Last modified: April 22, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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