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Protein

Insulin-like growth factor 2 mRNA-binding protein 2

Gene

IGF2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.By similarity2 Publications

Miscellaneous

Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • mRNA 5'-UTR binding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • translation regulator activity Source: BHF-UCL

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • mRNA transport Source: UniProtKB-KW
  • negative regulation of translation Source: BHF-UCL
  • regulation of cytokine biosynthetic process Source: BHF-UCL
  • regulation of mRNA stability Source: Reactome

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Translation regulation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor 2 mRNA-binding protein 2
Short name:
IGF2 mRNA-binding protein 2
Short name:
IMP-2
Alternative name(s):
Hepatocellular carcinoma autoantigen p62
IGF-II mRNA-binding protein 2
VICKZ family member 2
Gene namesi
Name:IGF2BP2
Synonyms:IMP2, VICKZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000073792.15
HGNCiHGNC:28867 IGF2BP2
MIMi608289 gene
neXtProtiNX_Q9Y6M1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi211K → E: Significantly impaired binding to ACTB transcript, but little effect on MYC transcript binding, accumulation in the nucleus; when associated with E-292. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-292; 445-E-E-446 and 526-E-E-527. 1 Publication1
Mutagenesisi292K → E: Significantly impaired binding to ACTB transcript, but little effect on MYC transcript binding, accumulation in the nucleus; when associated with E-211. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-211; 445-E-E-445 and 526-E-E-527. 1 Publication1
Mutagenesisi445 – 446KK → EE: Significantly impaired binding to ACTB and MYC transcripts; when associated with 527-E-E-528. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-211; E-292 and 527-E-E-528. 1 Publication2
Mutagenesisi527 – 528KG → EE: Significantly impaired binding to ACTB and MYC transcripts; when associated with 445-E-E-446. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-211; E-292 and 445-E-E-446. 1 Publication2

Organism-specific databases

DisGeNETi10644
MalaCardsiIGF2BP2
OpenTargetsiENSG00000073792
PharmGKBiPA128394577

Polymorphism and mutation databases

BioMutaiIGF2BP2
DMDMi224471831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444961 – 599Insulin-like growth factor 2 mRNA-binding protein 2Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei550PhosphothreonineBy similarity1
Isoform 6 (identifier: Q9Y6M1-6)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6M1
MaxQBiQ9Y6M1
PaxDbiQ9Y6M1
PeptideAtlasiQ9Y6M1
PRIDEiQ9Y6M1
ProteomicsDBi86724
86725 [Q9Y6M1-1]
86726 [Q9Y6M1-3]
86727 [Q9Y6M1-4]
86728 [Q9Y6M1-5]
86729 [Q9Y6M1-6]

PTM databases

iPTMnetiQ9Y6M1
PhosphoSitePlusiQ9Y6M1
SwissPalmiQ9Y6M1

Expressioni

Tissue specificityi

Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.2 Publications

Gene expression databases

BgeeiENSG00000073792 Expressed in 204 organ(s), highest expression level in kidney
CleanExiHS_IGF2BP2
ExpressionAtlasiQ9Y6M1 baseline and differential
GenevisibleiQ9Y6M1 HS

Organism-specific databases

HPAiCAB017126
HPA035145

Interactioni

Subunit structurei

Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with HNRPD and IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPDQ14103-44EBI-1024419,EBI-432545

Protein-protein interaction databases

BioGridi115888, 123 interactors
DIPiDIP-35539N
IntActiQ9Y6M1, 37 interactors
MINTiQ9Y6M1
STRINGi9606.ENSP00000371634

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6M1
SMRiQ9Y6M1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6M1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 76RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini82 – 157RRM 2PROSITE-ProRule annotationAdd BLAST76
Domaini193 – 258KH 1PROSITE-ProRule annotationAdd BLAST66
Domaini274 – 341KH 2PROSITE-ProRule annotationAdd BLAST68
Domaini427 – 492KH 3PROSITE-ProRule annotationAdd BLAST66
Domaini509 – 575KH 4PROSITE-ProRule annotationAdd BLAST67

Domaini

Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.2 Publications

Sequence similaritiesi

Belongs to the RRM IMP/VICKZ family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2193 Eukaryota
ENOG410ZKB4 LUCA
GeneTreeiENSGT00530000063171
HOGENOMiHOG000000675
HOVERGENiHBG052725
InParanoidiQ9Y6M1
KOiK17392
PhylomeDBiQ9Y6M1
TreeFamiTF320229

Family and domain databases

CDDicd12626 RRM1_IGF2BP2, 1 hit
Gene3Di3.30.1370.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR028743 IGF2BP2
IPR034843 IGF2BP2_RRM1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10288:SF93 PTHR10288:SF93, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 4 hits
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 4 hits
SM00360 RRM, 2 hits
SUPFAMiSSF54791 SSF54791, 4 hits
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 4 hits
PS50102 RRM, 2 hits

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6M1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW
60 70 80 90 100
AIRAIETLSG KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG
110 120 130 140 150
LLAQYGTVEN VEQVNTDTET AVVNVTYATR EEAKIAMEKL SGHQFENYSF
160 170 180 190 200
KISYIPDEEV SSPSPPQRAQ RGDHSSREQG HAPGGTSQAR QIDFPLRILV
210 220 230 240 250
PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK PVTIHATPEG
260 270 280 290 300
TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
310 320 330 340 350
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE
360 370 380 390 400
NDMLAVNQQA NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT
410 420 430 440 450
THSGYFSSLY PHHQFGPFPH HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI
460 470 480 490 500
KQLARFAGAS IKIAPAEGPD VSERMVIITG PPEAQFKAQG RIFGKLKEEN
510 520 530 540 550
FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS AEVIVPRDQT
560 570 580 590
PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK
Length:599
Mass (Da):66,121
Last modified:March 3, 2009 - v2
Checksum:iEA656F8733BBB39A
GO
Isoform 2 (identifier: Q9Y6M1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-400: Missing.

Show »
Length:556
Mass (Da):61,842
Checksum:i1EDEFB100443DDC4
GO
Isoform 3 (identifier: Q9Y6M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MMNKLYIGNL...VDYSVSKKLR → MFSCPGHYHVDGFLNPG

Show »
Length:536
Mass (Da):59,001
Checksum:i733536C7BDAD8AF5
GO
Isoform 4 (identifier: Q9Y6M1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MMNKLYIGNL...VDYSVSKKLR → MFSCPGHYHVDGFLNPG
     113-113: Q → QVFAFSL

Show »
Length:542
Mass (Da):59,666
Checksum:iF1D98409DD8AE45D
GO
Isoform 5 (identifier: Q9Y6M1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MMNKLYIGNL...VDYSVSKKLR → MFSCPGHYHVDGFLNPG
     358-400: Missing.

Show »
Length:493
Mass (Da):54,722
Checksum:i36BF971E2C4296F7
GO
Isoform 6 (identifier: Q9Y6M1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Generated by alternative initiation at Met-69.Combined sources
Show »
Length:531
Mass (Da):58,578
Checksum:i1F5FD1AC97743530
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W930F8W930_HUMAN
Insulin-like growth factor 2 mRNA-b...
IGF2BP2
605Annotation score:

Sequence cautioni

The sequence AAH21290 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0365501 – 80MMNKL…SKKLR → MFSCPGHYHVDGFLNPG in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0436991 – 68Missing in isoform 6. CuratedAdd BLAST68
Alternative sequenceiVSP_036552113Q → QVFAFSL in isoform 4. 1 Publication1
Alternative sequenceiVSP_036553358 – 400Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057352 mRNA Translation: AAD31596.1
EU408701 mRNA Translation: ACB86625.1
EU408702 mRNA Translation: ACB86626.1
EU408703 mRNA Translation: ACB86627.1
AC016961 Genomic DNA No translation available.
AC108670 Genomic DNA No translation available.
BC021290 mRNA Translation: AAH21290.1 Different initiation.
CCDSiCCDS3273.2 [Q9Y6M1-2]
CCDS33903.1 [Q9Y6M1-1]
CCDS77869.1 [Q9Y6M1-3]
RefSeqiNP_001007226.1, NM_001007225.2 [Q9Y6M1-1]
NP_001278801.1, NM_001291872.2 [Q9Y6M1-4]
NP_001278802.1, NM_001291873.2 [Q9Y6M1-3]
NP_001278803.1, NM_001291874.2 [Q9Y6M1-5]
NP_001278804.1, NM_001291875.2
NP_006539.3, NM_006548.5 [Q9Y6M1-2]
UniGeneiHs.293396
Hs.35354

Genome annotation databases

EnsembliENST00000346192; ENSP00000320204; ENSG00000073792 [Q9Y6M1-1]
ENST00000382199; ENSP00000371634; ENSG00000073792 [Q9Y6M1-2]
ENST00000421047; ENSP00000413787; ENSG00000073792 [Q9Y6M1-3]
GeneIDi10644
KEGGihsa:10644
UCSCiuc003fpo.4 human [Q9Y6M1-2]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057352 mRNA Translation: AAD31596.1
EU408701 mRNA Translation: ACB86625.1
EU408702 mRNA Translation: ACB86626.1
EU408703 mRNA Translation: ACB86627.1
AC016961 Genomic DNA No translation available.
AC108670 Genomic DNA No translation available.
BC021290 mRNA Translation: AAH21290.1 Different initiation.
CCDSiCCDS3273.2 [Q9Y6M1-2]
CCDS33903.1 [Q9Y6M1-1]
CCDS77869.1 [Q9Y6M1-3]
RefSeqiNP_001007226.1, NM_001007225.2 [Q9Y6M1-1]
NP_001278801.1, NM_001291872.2 [Q9Y6M1-4]
NP_001278802.1, NM_001291873.2 [Q9Y6M1-3]
NP_001278803.1, NM_001291874.2 [Q9Y6M1-5]
NP_001278804.1, NM_001291875.2
NP_006539.3, NM_006548.5 [Q9Y6M1-2]
UniGeneiHs.293396
Hs.35354

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQHNMR-A2-81[»]
ProteinModelPortaliQ9Y6M1
SMRiQ9Y6M1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115888, 123 interactors
DIPiDIP-35539N
IntActiQ9Y6M1, 37 interactors
MINTiQ9Y6M1
STRINGi9606.ENSP00000371634

PTM databases

iPTMnetiQ9Y6M1
PhosphoSitePlusiQ9Y6M1
SwissPalmiQ9Y6M1

Polymorphism and mutation databases

BioMutaiIGF2BP2
DMDMi224471831

Proteomic databases

EPDiQ9Y6M1
MaxQBiQ9Y6M1
PaxDbiQ9Y6M1
PeptideAtlasiQ9Y6M1
PRIDEiQ9Y6M1
ProteomicsDBi86724
86725 [Q9Y6M1-1]
86726 [Q9Y6M1-3]
86727 [Q9Y6M1-4]
86728 [Q9Y6M1-5]
86729 [Q9Y6M1-6]

Protocols and materials databases

DNASUi10644
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346192; ENSP00000320204; ENSG00000073792 [Q9Y6M1-1]
ENST00000382199; ENSP00000371634; ENSG00000073792 [Q9Y6M1-2]
ENST00000421047; ENSP00000413787; ENSG00000073792 [Q9Y6M1-3]
GeneIDi10644
KEGGihsa:10644
UCSCiuc003fpo.4 human [Q9Y6M1-2]

Organism-specific databases

CTDi10644
DisGeNETi10644
EuPathDBiHostDB:ENSG00000073792.15
GeneCardsiIGF2BP2
HGNCiHGNC:28867 IGF2BP2
HPAiCAB017126
HPA035145
MalaCardsiIGF2BP2
MIMi608289 gene
neXtProtiNX_Q9Y6M1
OpenTargetsiENSG00000073792
PharmGKBiPA128394577
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2193 Eukaryota
ENOG410ZKB4 LUCA
GeneTreeiENSGT00530000063171
HOGENOMiHOG000000675
HOVERGENiHBG052725
InParanoidiQ9Y6M1
KOiK17392
PhylomeDBiQ9Y6M1
TreeFamiTF320229

Enzyme and pathway databases

ReactomeiR-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Miscellaneous databases

ChiTaRSiIGF2BP2 human
EvolutionaryTraceiQ9Y6M1
GeneWikiiIGF2BP2
GenomeRNAii10644
PROiPR:Q9Y6M1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073792 Expressed in 204 organ(s), highest expression level in kidney
CleanExiHS_IGF2BP2
ExpressionAtlasiQ9Y6M1 baseline and differential
GenevisibleiQ9Y6M1 HS

Family and domain databases

CDDicd12626 RRM1_IGF2BP2, 1 hit
Gene3Di3.30.1370.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR028743 IGF2BP2
IPR034843 IGF2BP2_RRM1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10288:SF93 PTHR10288:SF93, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 4 hits
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 4 hits
SM00360 RRM, 2 hits
SUPFAMiSSF54791 SSF54791, 4 hits
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 4 hits
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIF2B2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M1
Secondary accession number(s): A0A4Z0
, B3FTN2, B3FTN3, B3FTN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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