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Protein

Tolloid-like protein 2

Gene

TLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi242Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Active sitei243PROSITE-ProRule annotation1
Metal bindingi246Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Metal bindingi252Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Metalloprotease, Protease
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2214320 Anchoring fibril formation
R-HSA-2243919 Crosslinking of collagen fibrils

Protein family/group databases

MEROPSiM12.018

Names & Taxonomyi

Protein namesi
Recommended name:
Tolloid-like protein 2 (EC:3.4.24.-)
Gene namesi
Name:TLL2
Synonyms:KIAA0932
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000095587.8
HGNCiHGNC:11844 TLL2
MIMi606743 gene
neXtProtiNX_Q9Y6L7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7093
OpenTargetsiENSG00000095587
PharmGKBiPA36546

Chemistry databases

DrugBankiDB01989 Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome

Polymorphism and mutation databases

BioMutaiTLL2
DMDMi74762080

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000004603626 – 1491 PublicationAdd BLAST124
ChainiPRO_0000046037150 – 1015Tolloid-like protein 2Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi192 ↔ 348PROSITE-ProRule annotation
Disulfide bondi212 ↔ 234PROSITE-ProRule annotation
Disulfide bondi214 ↔ 215PROSITE-ProRule annotation
Disulfide bondi351 ↔ 377By similarity
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi404 ↔ 426By similarity
Disulfide bondi464 ↔ 490By similarity
Disulfide bondi517 ↔ 539By similarity
Disulfide bondi580 ↔ 592By similarity
Disulfide bondi588 ↔ 601By similarity
Disulfide bondi603 ↔ 616By similarity
Disulfide bondi620 ↔ 646By similarity
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi673 ↔ 695By similarity
Disulfide bondi736 ↔ 747By similarity
Disulfide bondi743 ↔ 756By similarity
Disulfide bondi758 ↔ 771By similarity
Disulfide bondi776 ↔ 802By similarity
Glycosylationi805N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi829 ↔ 851By similarity
Disulfide bondi889 ↔ 919By similarity
Disulfide bondi946 ↔ 968By similarity
Modified residuei963Omega-N-methylarginineBy similarity1
Modified residuei966Omega-N-methylarginineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Methylation, Zymogen

Proteomic databases

MaxQBiQ9Y6L7
PaxDbiQ9Y6L7
PeptideAtlasiQ9Y6L7
PRIDEiQ9Y6L7
ProteomicsDBi86720

PTM databases

GlyConnecti1820
iPTMnetiQ9Y6L7
PhosphoSitePlusiQ9Y6L7

Expressioni

Gene expression databases

BgeeiENSG00000095587 Expressed in 102 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TLL2
GenevisibleiQ9Y6L7 HS

Interactioni

Protein-protein interaction databases

BioGridi112948, 1 interactor
STRINGi9606.ENSP00000350630

Structurei

3D structure databases

ProteinModelPortaliQ9Y6L7
SMRiQ9Y6L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 349Peptidase M12APROSITE-ProRule annotationAdd BLAST201
Domaini351 – 463CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini464 – 576CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini576 – 617EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini620 – 732CUB 3PROSITE-ProRule annotationAdd BLAST113
Domaini732 – 772EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini776 – 888CUB 4PROSITE-ProRule annotationAdd BLAST113
Domaini889 – 1005CUB 5PROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiQ9Y6L7
KOiK13047
OMAiSSMFLRF
OrthoDBiEOG091G009U
PhylomeDBiQ9Y6L7
TreeFamiTF314351

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PF07645 EGF_CA, 1 hit
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6L7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRATALGAL VSLLLLLPLP RGAGGLGERP DATADYSELD GEEGTEQQLE
60 70 80 90 100
HYHDPCKAAV FWGDIALDED DLKLFHIDKA RDWTKQTVGA TGHSTGGLEE
110 120 130 140 150
QASESSPDTT AMDTGTKEAG KDGRENTTLL HSPGTLHAAA KTFSPRVRRA
160 170 180 190 200
TTSRTERIWP GGVIPYVIGG NFTGSQRAIF KQAMRHWEKH TCVTFIERTD
210 220 230 240 250
EESFIVFSYR TCGCCSYVGR RGGGPQAISI GKNCDKFGIV AHELGHVVGF
260 270 280 290 300
WHEHTRPDRD QHVTIIRENI QPGQEYNFLK MEAGEVSSLG ETYDFDSIMH
310 320 330 340 350
YARNTFSRGV FLDTILPRQD DNGVRPTIGQ RVRLSQGDIA QARKLYKCPA
360 370 380 390 400
CGETLQDTTG NFSAPGFPNG YPSYSHCVWR ISVTPGEKIV LNFTSMDLFK
410 420 430 440 450
SRLCWYDYVE VRDGYWRKAP LLGRFCGDKI PEPLVSTDSR LWVEFRSSSN
460 470 480 490 500
ILGKGFFAAY EATCGGDMNK DAGQIQSPNY PDDYRPSKEC VWRITVSEGF
510 520 530 540 550
HVGLTFQAFE IERHDSCAYD YLEVRDGPTE ESALIGHFCG YEKPEDVKSS
560 570 580 590 600
SNRLWMKFVS DGSINKAGFA ANFFKEVDEC SWPDHGGCEH RCVNTLGSYK
610 620 630 640 650
CACDPGYELA ADKKMCEVAC GGFITKLNGT ITSPGWPKEY PTNKNCVWQV
660 670 680 690 700
VAPAQYRISL QFEVFELEGN DVCKYDFVEV RSGLSPDAKL HGRFCGSETP
710 720 730 740 750
EVITSQSNNM RVEFKSDNTV SKRGFRAHFF SDKDECAKDN GGCQHECVNT
760 770 780 790 800
FGSYLCRCRN GYWLHENGHD CKEAGCAHKI SSVEGTLASP NWPDKYPSRR
810 820 830 840 850
ECTWNISSTA GHRVKLTFNE FEIEQHQECA YDHLEMYDGP DSLAPILGRF
860 870 880 890 900
CGSKKPDPTV ASGSSMFLRF YSDASVQRKG FQAVHSTECG GRLKAEVQTK
910 920 930 940 950
ELYSHAQFGD NNYPSEARCD WVIVAEDGYG VELTFRTFEV EEEADCGYDY
960 970 980 990 1000
MEAYDGYDSS APRLGRFCGS GPLEEIYSAG DSLMIRFRTD DTINKKGFHA
1010
RYTSTKFQDA LHMKK
Length:1,015
Mass (Da):113,557
Last modified:November 1, 1999 - v1
Checksum:i25F5B23065861593
GO

Sequence cautioni

The sequence BAA76776 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495T → M in BAA76776 (PubMed:10231032).Curated1
Sequence conflicti576 – 593EVDEC…EHRCV → GKKKKKKKKKKKKKKKKK in AAH13871 (PubMed:15489334).CuratedAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059516 mRNA Translation: AAD42979.1
AB023149 mRNA Translation: BAA76776.2 Different initiation.
AL138765 Genomic DNA No translation available.
AL136181 Genomic DNA No translation available.
AL391136 Genomic DNA No translation available.
BC013871 mRNA Translation: AAH13871.1
BC112341 mRNA Translation: AAI12342.1
BC112366 mRNA Translation: AAI12367.1
BC113577 mRNA Translation: AAI13578.1
CCDSiCCDS7449.1
RefSeqiNP_036597.1, NM_012465.3
UniGeneiHs.154296

Genome annotation databases

EnsembliENST00000357947; ENSP00000350630; ENSG00000095587
GeneIDi7093
KEGGihsa:7093
UCSCiuc001kml.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059516 mRNA Translation: AAD42979.1
AB023149 mRNA Translation: BAA76776.2 Different initiation.
AL138765 Genomic DNA No translation available.
AL136181 Genomic DNA No translation available.
AL391136 Genomic DNA No translation available.
BC013871 mRNA Translation: AAH13871.1
BC112341 mRNA Translation: AAI12342.1
BC112366 mRNA Translation: AAI12367.1
BC113577 mRNA Translation: AAI13578.1
CCDSiCCDS7449.1
RefSeqiNP_036597.1, NM_012465.3
UniGeneiHs.154296

3D structure databases

ProteinModelPortaliQ9Y6L7
SMRiQ9Y6L7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112948, 1 interactor
STRINGi9606.ENSP00000350630

Chemistry databases

DrugBankiDB01989 Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome

Protein family/group databases

MEROPSiM12.018

PTM databases

GlyConnecti1820
iPTMnetiQ9Y6L7
PhosphoSitePlusiQ9Y6L7

Polymorphism and mutation databases

BioMutaiTLL2
DMDMi74762080

Proteomic databases

MaxQBiQ9Y6L7
PaxDbiQ9Y6L7
PeptideAtlasiQ9Y6L7
PRIDEiQ9Y6L7
ProteomicsDBi86720

Protocols and materials databases

DNASUi7093
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357947; ENSP00000350630; ENSG00000095587
GeneIDi7093
KEGGihsa:7093
UCSCiuc001kml.3 human

Organism-specific databases

CTDi7093
DisGeNETi7093
EuPathDBiHostDB:ENSG00000095587.8
GeneCardsiTLL2
H-InvDBiHIX0009074
HGNCiHGNC:11844 TLL2
MIMi606743 gene
neXtProtiNX_Q9Y6L7
OpenTargetsiENSG00000095587
PharmGKBiPA36546
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiQ9Y6L7
KOiK13047
OMAiSSMFLRF
OrthoDBiEOG091G009U
PhylomeDBiQ9Y6L7
TreeFamiTF314351

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2214320 Anchoring fibril formation
R-HSA-2243919 Crosslinking of collagen fibrils

Miscellaneous databases

ChiTaRSiTLL2 human
GeneWikiiTLL2
GenomeRNAii7093
PROiPR:Q9Y6L7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095587 Expressed in 102 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TLL2
GenevisibleiQ9Y6L7 HS

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PF07645 EGF_CA, 1 hit
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLL2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6L7
Secondary accession number(s): A6NDK0
, Q2M1H1, Q6PJN5, Q9UQ00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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