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Protein

Solute carrier organic anion transporter family member 1B1

Gene

SLCO1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • bile acid and bile salt transport Source: GO_Central
  • organic anion transport Source: ProtInc
  • sodium-independent organic anion transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159418 Recycling of bile acids and salts
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5661182 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.5 the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B1
Alternative name(s):
Liver-specific organic anion transporter 1
Short name:
LST-1
OATP-C
Sodium-independent organic anion-transporting polypeptide 2
Short name:
OATP-2
Solute carrier family 21 member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO1B1
Synonyms:LST1, OATP1B1, OATP2, OATPC, SLC21A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134538.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10959 SLCO1B1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604843 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6L6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 48Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini49 – 67ExtracellularSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 94CytoplasmicSequence analysis6
Transmembranei95 – 119Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini120 – 168ExtracellularSequence analysisAdd BLAST49
Transmembranei169 – 197Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 255ExtracellularSequence analysisAdd BLAST18
Transmembranei256 – 280Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini281 – 331CytoplasmicSequence analysisAdd BLAST51
Transmembranei332 – 353Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini354 – 373ExtracellularSequence analysisAdd BLAST20
Transmembranei374 – 397Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini398 – 401CytoplasmicSequence analysis4
Transmembranei402 – 425Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini426 – 537ExtracellularSequence analysisAdd BLAST112
Transmembranei538 – 560Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini561 – 569CytoplasmicSequence analysis9
Transmembranei570 – 595Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini596 – 629ExtracellularSequence analysisAdd BLAST34
Transmembranei630 – 647Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini648 – 691CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
See also OMIM:237450

Organism-specific databases

DisGeNET

More...
DisGeNETi
10599

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLCO1B1

MalaCards human disease database

More...
MalaCardsi
SLCO1B1
MIMi237450 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134538

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3111 Rotor syndrome
413696 Statin toxicity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134865839

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1697668

Drug and drug target database

More...
DrugBanki
DB06151 Acetylcysteine
DB06403 Ambrisentan
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB06626 Axitinib
DB01053 Benzylpenicillin
DB01393 Bezafibrate
DB06772 Cabazitaxel
DB00520 Caspofungin
DB00439 Cerivastatin
DB02659 Cholic Acid
DB01211 Clarithromycin
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB05804 dehydroepiandrosterone sulfate
DB00509 Dextrothyroxine
DB00390 Digoxin
DB00917 Dinoprostone
DB04881 Elacridar
DB06210 Eltrombopag
DB09272 Eluxadoline
DB00783 Estradiol
DB00655 Estrone
DB00973 Ezetimibe
DB00950 Fexofenadine
DB01095 Fluvastatin
DB08884 Gadoxetic acid
DB01241 Gemfibrozil
DB11575 Grazoprevir
DB01892 Hyperforin
DB09054 Idelalisib
DB00224 Indinavir
DB00762 Irinotecan
DB00583 L-Carnitine
DB13153 Levomenol
DB13139 Levosalbutamol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB02691 N-Cholylglycine
DB00220 Nelfinavir
DB00275 Olmesartan
DB01092 Ouabain
DB00213 Pantoprazole
DB13154 Parachlorophenol
DB06589 Pazopanib
DB00859 Penicillamine
DB01132 Pioglitazone
DB08860 Pitavastatin
DB00175 Pravastatin
DB00908 Quinidine
DB00912 Repaglinide
DB01045 Rifampicin
DB08864 Rilpivirine
DB00503 Ritonavir
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB09292 Sacubitril
DB01232 Saquinavir
DB11362 Selexipag
DB06290 Simeprevir
DB00641 Simvastatin
DB00877 Sirolimus
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB09137 Technetium Tc 99m Mebrofenin
DB00197 Troglitazone
DB00177 Valsartan
DB00661 Verapamil

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1220

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO1B1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643959

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910501 – 691Solute carrier organic anion transporter family member 1B1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi516N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi617N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei672PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6L6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6L6

PeptideAtlas

More...
PeptideAtlasi
Q9Y6L6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6L6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86719

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6L6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6L6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134538 Expressed in 29 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_LST1
HS_SLCO1B1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6L6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6L6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115847, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000256958

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y6L6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y6L6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini453 – 508Kazal-likePROSITE-ProRule annotationAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626 Eukaryota
ENOG410XRSF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231269

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063896

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6L6

KEGG Orthology (KO)

More...
KOi
K05043

Identification of Orthologs from Complete Genome Data

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OMAi
LFSKMYV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08QD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6L6

TreeFam database of animal gene trees

More...
TreeFami
TF317540

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388 PTHR11388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805 oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y6L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS
60 70 80 90 100
SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL
160 170 180 190 200
NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA
210 220 230 240 250
KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT
260 270 280 290 300
DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE
310 320 330 340 350
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS
360 370 380 390 400
SYIGAFTYVF KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF
410 420 430 440 450
KLNTVGIAKF SCFTAVMSLS FYLLYFFILC ENKSVAGLTM TYDGNNPVTS
460 470 480 490 500
HRDVPLSYCN SDCNCDESQW EPVCGNNGIT YISPCLAGCK SSSGNKKPIV
510 520 530 540 550
FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI QVLNLFFSAL
560 570 580 590 600
GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI
610 620 630 640 650
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK
660 670 680 690
YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH C
Length:691
Mass (Da):76,449
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD13D5130189383A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01507073F → L1 PublicationCorresponds to variant dbSNP:rs56101265Ensembl.1
Natural variantiVAR_01507182V → A1 PublicationCorresponds to variant dbSNP:rs56061388Ensembl.1
Natural variantiVAR_015072130N → D6 PublicationsCorresponds to variant dbSNP:rs2306283EnsemblClinVar.1
Natural variantiVAR_057724151N → S. Corresponds to variant dbSNP:rs2306282Ensembl.1
Natural variantiVAR_015073152R → K3 Publications1
Natural variantiVAR_015074155P → T Decreased transport activity. 3 PublicationsCorresponds to variant dbSNP:rs11045819EnsemblClinVar.1
Natural variantiVAR_015075156E → G Decreased transport activity. 1 PublicationCorresponds to variant dbSNP:rs72559745Ensembl.1
Natural variantiVAR_015076174V → A Decreased transport activity. 2 PublicationsCorresponds to variant dbSNP:rs4149056EnsemblClinVar.1
Natural variantiVAR_015077193L → R Strongly decreases expression at the plasma membrane; abolishes transport activity. 1 PublicationCorresponds to variant dbSNP:rs72559746Ensembl.1
Natural variantiVAR_015078241D → N3 Publications1
Natural variantiVAR_060108245I → V. Corresponds to variant dbSNP:rs11045852EnsemblClinVar.1
Natural variantiVAR_015079353I → T1 PublicationCorresponds to variant dbSNP:rs55901008Ensembl.1
Natural variantiVAR_015080432N → D1 PublicationCorresponds to variant dbSNP:rs56387224Ensembl.1
Natural variantiVAR_015081462D → G1 PublicationCorresponds to variant dbSNP:rs72559748Ensembl.1
Natural variantiVAR_015082488G → A1 PublicationCorresponds to variant dbSNP:rs59502379EnsemblClinVar.1
Natural variantiVAR_057725643L → F. Corresponds to variant dbSNP:rs34671512EnsemblClinVar.1
Natural variantiVAR_015083655D → G1 PublicationCorresponds to variant dbSNP:rs56199088Ensembl.1
Natural variantiVAR_015084667E → G1 PublicationCorresponds to variant dbSNP:rs55737008Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF060500 mRNA Translation: AAD38323.1
AF205071 mRNA Translation: AAF20212.1
AJ132573 mRNA Translation: CAB62577.1
AB026257 mRNA Translation: BAA78639.1
AJ400749
, AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA Translation: CAB97007.1
AY945934 Genomic DNA Translation: AAX20114.1
AK312970 mRNA Translation: BAG35809.1
CH471094 Genomic DNA Translation: EAW96420.1
BC114376 mRNA Translation: AAI14377.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8685.1

NCBI Reference Sequences

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RefSeqi
NP_006437.3, NM_006446.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.449738

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000256958; ENSP00000256958; ENSG00000134538

Database of genes from NCBI RefSeq genomes

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GeneIDi
10599

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10599

UCSC genome browser

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UCSCi
uc001req.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060500 mRNA Translation: AAD38323.1
AF205071 mRNA Translation: AAF20212.1
AJ132573 mRNA Translation: CAB62577.1
AB026257 mRNA Translation: BAA78639.1
AJ400749
, AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA Translation: CAB97007.1
AY945934 Genomic DNA Translation: AAX20114.1
AK312970 mRNA Translation: BAG35809.1
CH471094 Genomic DNA Translation: EAW96420.1
BC114376 mRNA Translation: AAI14377.1
CCDSiCCDS8685.1
RefSeqiNP_006437.3, NM_006446.4
UniGeneiHs.449738

3D structure databases

ProteinModelPortaliQ9Y6L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115847, 11 interactors
STRINGi9606.ENSP00000256958

Chemistry databases

BindingDBiQ9Y6L6
ChEMBLiCHEMBL1697668
DrugBankiDB06151 Acetylcysteine
DB06403 Ambrisentan
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB06626 Axitinib
DB01053 Benzylpenicillin
DB01393 Bezafibrate
DB06772 Cabazitaxel
DB00520 Caspofungin
DB00439 Cerivastatin
DB02659 Cholic Acid
DB01211 Clarithromycin
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB05804 dehydroepiandrosterone sulfate
DB00509 Dextrothyroxine
DB00390 Digoxin
DB00917 Dinoprostone
DB04881 Elacridar
DB06210 Eltrombopag
DB09272 Eluxadoline
DB00783 Estradiol
DB00655 Estrone
DB00973 Ezetimibe
DB00950 Fexofenadine
DB01095 Fluvastatin
DB08884 Gadoxetic acid
DB01241 Gemfibrozil
DB11575 Grazoprevir
DB01892 Hyperforin
DB09054 Idelalisib
DB00224 Indinavir
DB00762 Irinotecan
DB00583 L-Carnitine
DB13153 Levomenol
DB13139 Levosalbutamol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB02691 N-Cholylglycine
DB00220 Nelfinavir
DB00275 Olmesartan
DB01092 Ouabain
DB00213 Pantoprazole
DB13154 Parachlorophenol
DB06589 Pazopanib
DB00859 Penicillamine
DB01132 Pioglitazone
DB08860 Pitavastatin
DB00175 Pravastatin
DB00908 Quinidine
DB00912 Repaglinide
DB01045 Rifampicin
DB08864 Rilpivirine
DB00503 Ritonavir
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB09292 Sacubitril
DB01232 Saquinavir
DB11362 Selexipag
DB06290 Simeprevir
DB00641 Simvastatin
DB00877 Sirolimus
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB09137 Technetium Tc 99m Mebrofenin
DB00197 Troglitazone
DB00177 Valsartan
DB00661 Verapamil
GuidetoPHARMACOLOGYi1220

Protein family/group databases

TCDBi2.A.60.1.5 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ9Y6L6
PhosphoSitePlusiQ9Y6L6

Polymorphism and mutation databases

BioMutaiSLCO1B1
DMDMi12643959

Proteomic databases

EPDiQ9Y6L6
PaxDbiQ9Y6L6
PeptideAtlasiQ9Y6L6
PRIDEiQ9Y6L6
ProteomicsDBi86719

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256958; ENSP00000256958; ENSG00000134538
GeneIDi10599
KEGGihsa:10599
UCSCiuc001req.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10599
DisGeNETi10599
EuPathDBiHostDB:ENSG00000134538.2

GeneCards: human genes, protein and diseases

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GeneCardsi
SLCO1B1
GeneReviewsiSLCO1B1
HGNCiHGNC:10959 SLCO1B1
HPAiHPA050892
MalaCardsiSLCO1B1
MIMi237450 phenotype
604843 gene
neXtProtiNX_Q9Y6L6
OpenTargetsiENSG00000134538
Orphaneti3111 Rotor syndrome
413696 Statin toxicity
PharmGKBiPA134865839

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00940000153279
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9Y6L6
KOiK05043
OMAiLFSKMYV
OrthoDBiEOG091G08QD
PhylomeDBiQ9Y6L6
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5661182 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLCO1B1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLCO1B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10599

Protein Ontology

More...
PROi
PR:Q9Y6L6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134538 Expressed in 29 organ(s), highest expression level in right lobe of liver
CleanExiHS_LST1
HS_SLCO1B1
ExpressionAtlasiQ9Y6L6 baseline and differential
GenevisibleiQ9Y6L6 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO1B1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6L6
Secondary accession number(s): B2R7G2
, Q29R64, Q9NQ37, Q9UBF3, Q9UH89
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: December 5, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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