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Protein

Solute carrier organic anion transporter family member 1B1

Gene

SLCO1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5661182 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.5 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B1
Alternative name(s):
Liver-specific organic anion transporter 1
Short name:
LST-1
OATP-C
Sodium-independent organic anion-transporting polypeptide 2
Short name:
OATP-2
Solute carrier family 21 member 6
Gene namesi
Name:SLCO1B1
Synonyms:LST1, OATP1B1, OATP2, OATPC, SLC21A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134538.2
HGNCiHGNC:10959 SLCO1B1
MIMi604843 gene
neXtProtiNX_Q9Y6L6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini49 – 67ExtracellularSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 94CytoplasmicSequence analysis6
Transmembranei95 – 119Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini120 – 168ExtracellularSequence analysisAdd BLAST49
Transmembranei169 – 197Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 255ExtracellularSequence analysisAdd BLAST18
Transmembranei256 – 280Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini281 – 331CytoplasmicSequence analysisAdd BLAST51
Transmembranei332 – 353Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini354 – 373ExtracellularSequence analysisAdd BLAST20
Transmembranei374 – 397Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini398 – 401CytoplasmicSequence analysis4
Transmembranei402 – 425Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini426 – 537ExtracellularSequence analysisAdd BLAST112
Transmembranei538 – 560Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini561 – 569CytoplasmicSequence analysis9
Transmembranei570 – 595Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini596 – 629ExtracellularSequence analysisAdd BLAST34
Transmembranei630 – 647Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini648 – 691CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
See also OMIM:237450

Organism-specific databases

DisGeNETi10599
GeneReviewsiSLCO1B1
MalaCardsiSLCO1B1
MIMi237450 phenotype
OpenTargetsiENSG00000134538
Orphaneti3111 Rotor syndrome
413696 Statin toxicity
PharmGKBiPA134865839

Chemistry databases

ChEMBLiCHEMBL1697668
DrugBankiDB06151 Acetylcysteine
DB06403 Ambrisentan
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB06626 Axitinib
DB01053 Benzylpenicillin
DB01393 Bezafibrate
DB06772 Cabazitaxel
DB00520 Caspofungin
DB00439 Cerivastatin
DB02659 Cholic Acid
DB01211 Clarithromycin
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB05804 dehydroepiandrosterone sulfate
DB00509 Dextrothyroxine
DB00390 Digoxin
DB00917 Dinoprostone
DB04881 Elacridar
DB06210 Eltrombopag
DB09272 Eluxadoline
DB00783 Estradiol
DB00655 Estrone
DB00973 Ezetimibe
DB00950 Fexofenadine
DB01095 Fluvastatin
DB08884 Gadoxetic acid
DB01241 Gemfibrozil
DB11575 Grazoprevir
DB01892 Hyperforin
DB09054 Idelalisib
DB00224 Indinavir
DB00762 Irinotecan
DB00583 L-Carnitine
DB13153 Levomenol
DB13139 Levosalbutamol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB02691 N-Cholylglycine
DB00220 Nelfinavir
DB00275 Olmesartan
DB01092 Ouabain
DB00213 Pantoprazole
DB13154 Parachlorophenol
DB06589 Pazopanib
DB00859 Penicillamine
DB01132 Pioglitazone
DB08860 Pitavastatin
DB00175 Pravastatin
DB00908 Quinidine
DB00912 Repaglinide
DB01045 Rifampicin
DB08864 Rilpivirine
DB00503 Ritonavir
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB09292 Sacubitril
DB01232 Saquinavir
DB11362 Selexipag
DB06290 Simeprevir
DB00641 Simvastatin
DB00877 Sirolimus
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB09137 Technetium Tc 99m Mebrofenin
DB00197 Troglitazone
DB00177 Valsartan
DB00661 Verapamil
GuidetoPHARMACOLOGYi1220

Polymorphism and mutation databases

BioMutaiSLCO1B1
DMDMi12643959

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910501 – 691Solute carrier organic anion transporter family member 1B1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi516N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi617N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei672PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y6L6
PaxDbiQ9Y6L6
PeptideAtlasiQ9Y6L6
PRIDEiQ9Y6L6
ProteomicsDBi86719

PTM databases

iPTMnetiQ9Y6L6
PhosphoSitePlusiQ9Y6L6

Expressioni

Tissue specificityi

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.3 Publications

Gene expression databases

BgeeiENSG00000134538 Expressed in 29 organ(s), highest expression level in right lobe of liver
CleanExiHS_LST1
HS_SLCO1B1
ExpressionAtlasiQ9Y6L6 baseline and differential
GenevisibleiQ9Y6L6 HS

Organism-specific databases

HPAiHPA050892

Interactioni

Protein-protein interaction databases

BioGridi115847, 11 interactors
STRINGi9606.ENSP00000256958

Chemistry databases

BindingDBiQ9Y6L6

Structurei

3D structure databases

ProteinModelPortaliQ9Y6L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 508Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9Y6L6
KOiK05043
OMAiIDRACMK
OrthoDBiEOG091G08QD
PhylomeDBiQ9Y6L6
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS
60 70 80 90 100
SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL
160 170 180 190 200
NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA
210 220 230 240 250
KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT
260 270 280 290 300
DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE
310 320 330 340 350
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS
360 370 380 390 400
SYIGAFTYVF KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF
410 420 430 440 450
KLNTVGIAKF SCFTAVMSLS FYLLYFFILC ENKSVAGLTM TYDGNNPVTS
460 470 480 490 500
HRDVPLSYCN SDCNCDESQW EPVCGNNGIT YISPCLAGCK SSSGNKKPIV
510 520 530 540 550
FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI QVLNLFFSAL
560 570 580 590 600
GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI
610 620 630 640 650
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK
660 670 680 690
YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH C
Length:691
Mass (Da):76,449
Last modified:December 1, 2000 - v2
Checksum:iD13D5130189383A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01507073F → L1 PublicationCorresponds to variant dbSNP:rs56101265Ensembl.1
Natural variantiVAR_01507182V → A1 PublicationCorresponds to variant dbSNP:rs56061388Ensembl.1
Natural variantiVAR_015072130N → D6 PublicationsCorresponds to variant dbSNP:rs2306283EnsemblClinVar.1
Natural variantiVAR_057724151N → S. Corresponds to variant dbSNP:rs2306282Ensembl.1
Natural variantiVAR_015073152R → K3 Publications1
Natural variantiVAR_015074155P → T Decreased transport activity. 3 PublicationsCorresponds to variant dbSNP:rs11045819EnsemblClinVar.1
Natural variantiVAR_015075156E → G Decreased transport activity. 1 PublicationCorresponds to variant dbSNP:rs72559745Ensembl.1
Natural variantiVAR_015076174V → A Decreased transport activity. 2 PublicationsCorresponds to variant dbSNP:rs4149056EnsemblClinVar.1
Natural variantiVAR_015077193L → R Strongly decreases expression at the plasma membrane; abolishes transport activity. 1 PublicationCorresponds to variant dbSNP:rs72559746Ensembl.1
Natural variantiVAR_015078241D → N3 Publications1
Natural variantiVAR_060108245I → V. Corresponds to variant dbSNP:rs11045852EnsemblClinVar.1
Natural variantiVAR_015079353I → T1 PublicationCorresponds to variant dbSNP:rs55901008Ensembl.1
Natural variantiVAR_015080432N → D1 PublicationCorresponds to variant dbSNP:rs56387224Ensembl.1
Natural variantiVAR_015081462D → G1 PublicationCorresponds to variant dbSNP:rs72559748Ensembl.1
Natural variantiVAR_015082488G → A1 PublicationCorresponds to variant dbSNP:rs59502379EnsemblClinVar.1
Natural variantiVAR_057725643L → F. Corresponds to variant dbSNP:rs34671512EnsemblClinVar.1
Natural variantiVAR_015083655D → G1 PublicationCorresponds to variant dbSNP:rs56199088Ensembl.1
Natural variantiVAR_015084667E → G1 PublicationCorresponds to variant dbSNP:rs55737008Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060500 mRNA Translation: AAD38323.1
AF205071 mRNA Translation: AAF20212.1
AJ132573 mRNA Translation: CAB62577.1
AB026257 mRNA Translation: BAA78639.1
AJ400749
, AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA Translation: CAB97007.1
AY945934 Genomic DNA Translation: AAX20114.1
AK312970 mRNA Translation: BAG35809.1
CH471094 Genomic DNA Translation: EAW96420.1
BC114376 mRNA Translation: AAI14377.1
CCDSiCCDS8685.1
RefSeqiNP_006437.3, NM_006446.4
UniGeneiHs.449738

Genome annotation databases

EnsembliENST00000256958; ENSP00000256958; ENSG00000134538
GeneIDi10599
KEGGihsa:10599
UCSCiuc001req.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060500 mRNA Translation: AAD38323.1
AF205071 mRNA Translation: AAF20212.1
AJ132573 mRNA Translation: CAB62577.1
AB026257 mRNA Translation: BAA78639.1
AJ400749
, AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA Translation: CAB97007.1
AY945934 Genomic DNA Translation: AAX20114.1
AK312970 mRNA Translation: BAG35809.1
CH471094 Genomic DNA Translation: EAW96420.1
BC114376 mRNA Translation: AAI14377.1
CCDSiCCDS8685.1
RefSeqiNP_006437.3, NM_006446.4
UniGeneiHs.449738

3D structure databases

ProteinModelPortaliQ9Y6L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115847, 11 interactors
STRINGi9606.ENSP00000256958

Chemistry databases

BindingDBiQ9Y6L6
ChEMBLiCHEMBL1697668
DrugBankiDB06151 Acetylcysteine
DB06403 Ambrisentan
DB00345 Aminohippuric acid
DB01076 Atorvastatin
DB06626 Axitinib
DB01053 Benzylpenicillin
DB01393 Bezafibrate
DB06772 Cabazitaxel
DB00520 Caspofungin
DB00439 Cerivastatin
DB02659 Cholic Acid
DB01211 Clarithromycin
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB05804 dehydroepiandrosterone sulfate
DB00509 Dextrothyroxine
DB00390 Digoxin
DB00917 Dinoprostone
DB04881 Elacridar
DB06210 Eltrombopag
DB09272 Eluxadoline
DB00783 Estradiol
DB00655 Estrone
DB00973 Ezetimibe
DB00950 Fexofenadine
DB01095 Fluvastatin
DB08884 Gadoxetic acid
DB01241 Gemfibrozil
DB11575 Grazoprevir
DB01892 Hyperforin
DB09054 Idelalisib
DB00224 Indinavir
DB00762 Irinotecan
DB00583 L-Carnitine
DB13153 Levomenol
DB13139 Levosalbutamol
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00227 Lovastatin
DB00563 Methotrexate
DB00688 Mycophenolate mofetil
DB02691 N-Cholylglycine
DB00220 Nelfinavir
DB00275 Olmesartan
DB01092 Ouabain
DB00213 Pantoprazole
DB13154 Parachlorophenol
DB06589 Pazopanib
DB00859 Penicillamine
DB01132 Pioglitazone
DB08860 Pitavastatin
DB00175 Pravastatin
DB00908 Quinidine
DB00912 Repaglinide
DB01045 Rifampicin
DB08864 Rilpivirine
DB00503 Ritonavir
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB09292 Sacubitril
DB01232 Saquinavir
DB11362 Selexipag
DB06290 Simeprevir
DB00641 Simvastatin
DB00877 Sirolimus
DB00669 Sumatriptan
DB04348 Taurocholic Acid
DB09137 Technetium Tc 99m Mebrofenin
DB00197 Troglitazone
DB00177 Valsartan
DB00661 Verapamil
GuidetoPHARMACOLOGYi1220

Protein family/group databases

TCDBi2.A.60.1.5 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ9Y6L6
PhosphoSitePlusiQ9Y6L6

Polymorphism and mutation databases

BioMutaiSLCO1B1
DMDMi12643959

Proteomic databases

EPDiQ9Y6L6
PaxDbiQ9Y6L6
PeptideAtlasiQ9Y6L6
PRIDEiQ9Y6L6
ProteomicsDBi86719

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256958; ENSP00000256958; ENSG00000134538
GeneIDi10599
KEGGihsa:10599
UCSCiuc001req.5 human

Organism-specific databases

CTDi10599
DisGeNETi10599
EuPathDBiHostDB:ENSG00000134538.2
GeneCardsiSLCO1B1
GeneReviewsiSLCO1B1
HGNCiHGNC:10959 SLCO1B1
HPAiHPA050892
MalaCardsiSLCO1B1
MIMi237450 phenotype
604843 gene
neXtProtiNX_Q9Y6L6
OpenTargetsiENSG00000134538
Orphaneti3111 Rotor syndrome
413696 Statin toxicity
PharmGKBiPA134865839
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9Y6L6
KOiK05043
OMAiIDRACMK
OrthoDBiEOG091G08QD
PhylomeDBiQ9Y6L6
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5661182 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRSiSLCO1B1 human
GeneWikiiSLCO1B1
GenomeRNAii10599
PROiPR:Q9Y6L6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134538 Expressed in 29 organ(s), highest expression level in right lobe of liver
CleanExiHS_LST1
HS_SLCO1B1
ExpressionAtlasiQ9Y6L6 baseline and differential
GenevisibleiQ9Y6L6 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSO1B1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6L6
Secondary accession number(s): B2R7G2
, Q29R64, Q9NQ37, Q9UBF3, Q9UH89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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