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Entry version 148 (13 Feb 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Choline/ethanolaminephosphotransferase 1

Gene

CEPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=37 µM for CDP-choline2 Publications
  2. KM=101 µM for CDP-ethanolamine2 Publications
  1. Vmax=10.5 nmol/min/mg enzyme with CDP-choline as substrate2 Publications
  2. Vmax=4.35 nmol/min/mg enzyme with CDP-ethanolamine as substrate2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ethanolamine kinase 1 (ETNK1), Choline/ethanolamine kinase (CHKB), Choline kinase alpha (CHKA), Ethanolamine kinase 2 (ETNK2)
  2. Ethanolamine-phosphate cytidylyltransferase (PCYT2)
  3. Choline/ethanolaminephosphotransferase 1 (CEPT1), Ethanolaminephosphotransferase 1 (SELENOI)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Choline-phosphate cytidylyltransferase B (PCYT1B), Choline-phosphate cytidylyltransferase A (PCYT1A)
  2. Choline/ethanolaminephosphotransferase 1 (CEPT1), Cholinephosphotransferase 1 (CHPT1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05844-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483191 Synthesis of PC
R-HSA-1483213 Synthesis of PE

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9Y6K0

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00558;UER00743

UPA00753;UER00740

Protein family/group databases

Transport Classification Database

More...
TCDBi
4.F.1.1.1 the choline/ethanolaminephosphotransferase 1 (cept1) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000137

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Choline/ethanolaminephosphotransferase 1 (EC:2.7.8.1, EC:2.7.8.2)
Short name:
hCEPT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEPT1
ORF Names:PRO1101
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134255.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24289 CEPT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616751 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6K0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi138K → M: Induces a reduction in both cholinephosphotransferase and ethanolaminephosphotransferase activities. 1
Mutagenesisi144N → G: No effect. 1 Publication1
Mutagenesisi146S → Q or C: No effect. 1 Publication1
Mutagenesisi156G → C, S or A: Induces a reduction in cholinephosphotransferase activity and abolishes ethanolaminephosphotransferase activity. 1 Publication1
Mutagenesisi214T → A: Alters the profile of diacylglycerol utilization and results in modest reduction in enzyme activity. 1 Publication1
Mutagenesisi215E → A or D: Induces a strong reduction in enzyme activity without altering diacylglycerol specificity. 1 Publication1
Mutagenesisi215E → Q: Induces a strong reduction in enzyme activity and alters diacylglycerol specificity. 1 Publication1
Mutagenesisi216V → A: Alters the profile of diacylglycerol utilization and results in modest reduction in enzyme activity. 1 Publication1
Mutagenesisi221I → A: Alters the profile of diacylglycerol utilization and results in modest reduction in enzyme activity. 1 Publication1
Mutagenesisi226L → A: Does not affect either the enzyme activity or the diacylglycerol specificity. 1 Publication1
Mutagenesisi228V → A: Does not affect either the enzyme activity or the diacylglycerol specificity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10390

Open Targets

More...
OpenTargetsi
ENSG00000134255

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134892657

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00122 Choline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEPT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753524

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002892451 – 416Choline/ethanolaminephosphotransferase 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei40PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6K0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6K0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y6K0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6K0

PeptideAtlas

More...
PeptideAtlasi
Q9Y6K0

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6K0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86708

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6K0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6K0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y6K0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134255 Expressed in 221 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6K0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6K0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115662, 34 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y6K0, 33 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6K0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349696

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y6K0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2877 Eukaryota
COG5050 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034808

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107647

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6K0

KEGG Orthology (KO)

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KOi
K13644

Identification of Orthologs from Complete Genome Data

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OMAi
WGLQFAH

Database of Orthologous Groups

More...
OrthoDBi
847100at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6K0

TreeFam database of animal gene trees

More...
TreeFami
TF313270

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000462 CDP-OH_P_trans
IPR014472 CHOPT

The PANTHER Classification System

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PANTHERi
PTHR10414 PTHR10414, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF015665 CHOPT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y6K0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGHRSTRKR CGDSHPESPV GFGHMSTTGC VLNKLFQLPT PPLSRHQLKR
60 70 80 90 100
LEEHRYQSAG RSLLEPLMQG YWEWLVRRVP SWIAPNLITI IGLSINICTT
110 120 130 140 150
ILLVFYCPTA TEQAPLWAYI ACACGLFIYQ SLDAIDGKQA RRTNSSSPLG
160 170 180 190 200
ELFDHGCDSL STVFVVLGTC IAVQLGTNPD WMFFCCFAGT FMFYCAHWQT
210 220 230 240 250
YVSGTLRFGI IDVTEVQIFI IIMHLLAVIG GPPFWQSMIP VLNIQMKIFP
260 270 280 290 300
ALCTVAGTIF SCTNYFRVIF TGGVGKNGST IAGTSVLSPF LHIGSVITLA
310 320 330 340 350
AMIYKKSAVQ LFEKHPCLYI LTFGFVSAKI TNKLVVAHMT KSEMHLHDTA
360 370 380 390 400
FIGPALLFLD QYFNSFIDEY IVLWIALVFS FFDLIRYCVS VCNQIASHLH
410
IHVFRIKVST AHSNHH
Length:416
Mass (Da):46,554
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA25FED1193342FD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGS9A0A0C4DGS9_HUMAN
Choline/ethanolaminephosphotransfer...
CEPT1
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF61194 differs from that shown. Reason: Frameshift at position 276.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF068302 mRNA Translation: AAD25170.1
AF138862 mRNA Translation: AAF61194.1 Frameshift.
AL355816 Genomic DNA No translation available.
BC032610 mRNA Translation: AAH32610.1
BC049196 mRNA Translation: AAH49196.1
AL833102 mRNA Translation: CAH10403.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS830.1

NCBI Reference Sequences

More...
RefSeqi
NP_001007795.1, NM_001007794.2
NP_001317672.1, NM_001330743.1
NP_006081.1, NM_006090.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.363572
Hs.636850

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357172; ENSP00000349696; ENSG00000134255
ENST00000545121; ENSP00000441980; ENSG00000134255

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10390

UCSC genome browser

More...
UCSCi
uc001eah.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068302 mRNA Translation: AAD25170.1
AF138862 mRNA Translation: AAF61194.1 Frameshift.
AL355816 Genomic DNA No translation available.
BC032610 mRNA Translation: AAH32610.1
BC049196 mRNA Translation: AAH49196.1
AL833102 mRNA Translation: CAH10403.1
CCDSiCCDS830.1
RefSeqiNP_001007795.1, NM_001007794.2
NP_001317672.1, NM_001330743.1
NP_006081.1, NM_006090.4
UniGeneiHs.363572
Hs.636850

3D structure databases

ProteinModelPortaliQ9Y6K0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115662, 34 interactors
IntActiQ9Y6K0, 33 interactors
MINTiQ9Y6K0
STRINGi9606.ENSP00000349696

Chemistry databases

DrugBankiDB00122 Choline
SwissLipidsiSLP:000000137

Protein family/group databases

TCDBi4.F.1.1.1 the choline/ethanolaminephosphotransferase 1 (cept1) family

PTM databases

iPTMnetiQ9Y6K0
PhosphoSitePlusiQ9Y6K0
SwissPalmiQ9Y6K0

Polymorphism and mutation databases

BioMutaiCEPT1
DMDMi74753524

Proteomic databases

EPDiQ9Y6K0
jPOSTiQ9Y6K0
MaxQBiQ9Y6K0
PaxDbiQ9Y6K0
PeptideAtlasiQ9Y6K0
PRIDEiQ9Y6K0
ProteomicsDBi86708

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10390
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357172; ENSP00000349696; ENSG00000134255
ENST00000545121; ENSP00000441980; ENSG00000134255
GeneIDi10390
KEGGihsa:10390
UCSCiuc001eah.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10390
DisGeNETi10390
EuPathDBiHostDB:ENSG00000134255.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CEPT1
HGNCiHGNC:24289 CEPT1
MIMi616751 gene
neXtProtiNX_Q9Y6K0
OpenTargetsiENSG00000134255
PharmGKBiPA134892657

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2877 Eukaryota
COG5050 LUCA
GeneTreeiENSGT00940000154001
HOGENOMiHOG000034808
HOVERGENiHBG107647
InParanoidiQ9Y6K0
KOiK13644
OMAiWGLQFAH
OrthoDBi847100at2759
PhylomeDBiQ9Y6K0
TreeFamiTF313270

Enzyme and pathway databases

UniPathwayi
UPA00558;UER00743

UPA00753;UER00740

BioCyciMetaCyc:HS05844-MONOMER
ReactomeiR-HSA-1483191 Synthesis of PC
R-HSA-1483213 Synthesis of PE
SABIO-RKiQ9Y6K0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEPT1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10390

Protein Ontology

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PROi
PR:Q9Y6K0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134255 Expressed in 221 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ9Y6K0 baseline and differential
GenevisibleiQ9Y6K0 HS

Family and domain databases

InterProiView protein in InterPro
IPR000462 CDP-OH_P_trans
IPR014472 CHOPT
PANTHERiPTHR10414 PTHR10414, 1 hit
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF015665 CHOPT, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEPT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6K0
Secondary accession number(s): Q69YJ9, Q9P0Y8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 1, 1999
Last modified: February 13, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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