CEPT1

Functionⁱ

Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.2 Publications

Catalytic activityⁱ

a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
CDP-ethanolamine
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
CMP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine."
  Henneberry A.L., McMaster C.R.
  Biochem. J. 339:291-298(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR, TISSUE SPECIFICITY.
EC:2.7.8.1
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine."
  Henneberry A.L., McMaster C.R.
  Biochem. J. 339:291-298(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR, TISSUE SPECIFICITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycerol
zoom
+
CDP-ethanolamine
zoom
=
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
zoom
+
CMP
zoom
+
H⁺
zoom
a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
CDP-choline
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
a 1,2-diacyl-sn-glycero-3-phosphocholine
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
CMP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine."
  Henneberry A.L., McMaster C.R.
  Biochem. J. 339:291-298(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR, TISSUE SPECIFICITY.
EC:2.7.8.2
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine."
  Henneberry A.L., McMaster C.R.
  Biochem. J. 339:291-298(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR, TISSUE SPECIFICITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycerol
zoom
+
CDP-choline
zoom
=
a 1,2-diacyl-sn-glycero-3-phosphocholine
zoom
+
CMP
zoom
+
H⁺
zoom

Cofactorⁱ

Mg²⁺1 Publication, Mn²⁺1 Publication

Kineticsⁱ

Pathwayⁱ: phosphatidylethanolamine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Ethanolamine kinase 1 (ETNK1), Choline/ethanolamine kinase (CHKB), Choline kinase alpha (CHKA), Ethanolamine kinase 2 (ETNK2)
Ethanolamine-phosphate cytidylyltransferase (PCYT2)
Choline/ethanolaminephosphotransferase 1 (CEPT1), Ethanolaminephosphotransferase 1 (SELENOI)

This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Pathwayⁱ: phosphatidylcholine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Choline-phosphate cytidylyltransferase B (PCYT1B), Choline-phosphate cytidylyltransferase A (PCYT1A)
Choline/ethanolaminephosphotransferase 1 (CEPT1), Cholinephosphotransferase 1 (CHPT1)

This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

GO - Molecular functionⁱ

diacylglycerol cholinephosphotransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ethanolaminephosphotransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
phosphotransferase activity, for other substituted phosphate groups
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10191259
phosphatidylcholine biosynthetic process Source: Reactome
phosphatidylethanolamine biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
Ligand	Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05844-MONOMER
Reactomeⁱ	R-HSA-1483191 Synthesis of PC R-HSA-1483213 Synthesis of PE
SABIO-RKⁱ	Q9Y6K0
UniPathwayⁱ	UPA00558;UER00743 UPA00753;UER00740

Protein family/group databases

TCDBⁱ	4.F.1.1.1 the choline/ethanolaminephosphotransferase 1 (cept1) family

TCDBⁱ

4.F.1.1.1 the choline/ethanolaminephosphotransferase 1 (cept1) family

Chemistry databases

SwissLipidsⁱ	SLP:000000137

SwissLipidsⁱ

SLP:000000137

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Choline/ethanolaminephosphotransferase 1 (EC:2.7.8.1, EC:2.7.8.2) Short name: hCEPT1
Gene namesⁱ	Name:CEPT1 ORF Names:PRO1101
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134255.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24289 CEPT1
MIMⁱ	616751 gene
neXtProtⁱ	NX_Q9Y6K0

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	87 – 107	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	115 – 135	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	186 – 206	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	209 – 229	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	239 – 259	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	283 – 303	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	317 – 337	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	365 – 385	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	138	K → M: Induces a reduction in both cholinephosphotransferase and ethanolaminephosphotransferase activities.	1
Mutagenesisⁱ	144	N → G: No effect. 1 Publication	1
Mutagenesisⁱ	146	S → Q or C: No effect. 1 Publication	1
Mutagenesisⁱ	156	G → C, S or A: Induces a reduction in cholinephosphotransferase activity and abolishes ethanolaminephosphotransferase activity. 1 Publication	1
Mutagenesisⁱ	214	T → A: Alters the profile of diacylglycerol utilization and results in modest reduction in enzyme activity. 1 Publication	1
Mutagenesisⁱ	215	E → A or D: Induces a strong reduction in enzyme activity without altering diacylglycerol specificity. 1 Publication	1
Mutagenesisⁱ	215	E → Q: Induces a strong reduction in enzyme activity and alters diacylglycerol specificity. 1 Publication	1
Mutagenesisⁱ	216	V → A: Alters the profile of diacylglycerol utilization and results in modest reduction in enzyme activity. 1 Publication	1
Mutagenesisⁱ	221	I → A: Alters the profile of diacylglycerol utilization and results in modest reduction in enzyme activity. 1 Publication	1
Mutagenesisⁱ	226	L → A: Does not affect either the enzyme activity or the diacylglycerol specificity. 1 Publication	1
Mutagenesisⁱ	228	V → A: Does not affect either the enzyme activity or the diacylglycerol specificity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10390
Open Targets More...OpenTargetsⁱ	ENSG00000134255
PharmGKBⁱ	PA134892657

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00122 Choline

DrugBankⁱ

DB00122 Choline

Polymorphism and mutation databases

BioMutaⁱ	CEPT1
DMDMⁱ	74753524

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000289245	1 – 416	Choline/ethanolaminephosphotransferase 1Add BLAST		416

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	PhosphoserineCombined sources	1
Modified residueⁱ	40	PhosphothreonineCombined sources	1
Glycosylationⁱ	144	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y6K0
jPOSTⁱ	Q9Y6K0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y6K0
PaxDbⁱ	Q9Y6K0
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6K0
PRIDEⁱ	Q9Y6K0
ProteomicsDBⁱ	86708

PTM databases

iPTMnetⁱ	Q9Y6K0
PhosphoSitePlusⁱ	Q9Y6K0
SwissPalmⁱ	Q9Y6K0

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134255 Expressed in 221 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasⁱ	Q9Y6K0 baseline and differential
Genevisibleⁱ	Q9Y6K0 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115662, 34 interactors
IntActⁱ	Q9Y6K0, 33 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y6K0
STRINGⁱ	9606.ENSP00000349696

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y6K0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2877 Eukaryota COG5050 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154001
HOGENOMⁱ	HOG000034808
HOVERGENⁱ	HBG107647
InParanoidⁱ	Q9Y6K0
KEGG Orthology (KO) More...KOⁱ	K13644
OMAⁱ	WGLQFAH
Database of Orthologous Groups More...OrthoDBⁱ	847100at2759
PhylomeDBⁱ	Q9Y6K0
TreeFamⁱ	TF313270

Family and domain databases

InterProⁱ	View protein in InterPro IPR000462 CDP-OH_P_trans IPR014472 CHOPT
PANTHERⁱ	PTHR10414 PTHR10414, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01066 CDP-OH_P_transf, 1 hit
PIRSFⁱ	PIRSF015665 CHOPT, 1 hit
PROSITEⁱ	View protein in PROSITE PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y6K0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGHRSTRKR CGDSHPESPV GFGHMSTTGC VLNKLFQLPT PPLSRHQLKR 
        60         70         80         90        100
LEEHRYQSAG RSLLEPLMQG YWEWLVRRVP SWIAPNLITI IGLSINICTT 
       110        120        130        140        150
ILLVFYCPTA TEQAPLWAYI ACACGLFIYQ SLDAIDGKQA RRTNSSSPLG 
       160        170        180        190        200
ELFDHGCDSL STVFVVLGTC IAVQLGTNPD WMFFCCFAGT FMFYCAHWQT 
       210        220        230        240        250
YVSGTLRFGI IDVTEVQIFI IIMHLLAVIG GPPFWQSMIP VLNIQMKIFP 
       260        270        280        290        300
ALCTVAGTIF SCTNYFRVIF TGGVGKNGST IAGTSVLSPF LHIGSVITLA 
       310        320        330        340        350
AMIYKKSAVQ LFEKHPCLYI LTFGFVSAKI TNKLVVAHMT KSEMHLHDTA 
       360        370        380        390        400
FIGPALLFLD QYFNSFIDEY IVLWIALVFS FFDLIRYCVS VCNQIASHLH 
       410 
IHVFRIKVST AHSNHH

Length:416

Mass (Da):46,554

Last modified:November 1, 1999 - v1

Checksum:ⁱA25FED1193342FD9

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0C4DGS9	A0A0C4DGS9_HUMAN		Choline/ethanolaminephosphotransfer... Choline/ethanolaminephosphotransferase 1	CEPT1	280	Annotation score:

Sequence cautionⁱ

The sequence AAF61194 differs from that shown. Reason: Frameshift at position 276.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF068302 mRNA Translation: AAD25170.1 AF138862 mRNA Translation: AAF61194.1 Frameshift. AL355816 Genomic DNA No translation available. BC032610 mRNA Translation: AAH32610.1 BC049196 mRNA Translation: AAH49196.1 AL833102 mRNA Translation: CAH10403.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS830.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001007795.1, NM_001007794.2 NP_001317672.1, NM_001330743.1 NP_006081.1, NM_006090.4
UniGeneⁱ	Hs.363572 Hs.636850

Genome annotation databases

Ensemblⁱ	ENST00000357172; ENSP00000349696; ENSG00000134255 ENST00000545121; ENSP00000441980; ENSG00000134255
GeneIDⁱ	10390
KEGGⁱ	hsa:10390
UCSC genome browser More...UCSCⁱ	uc001eah.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6K0	Choline/ethanolamine phosphotransferase 1, isoform CRA_b		HUMAN		416	UniRef100_Q9Y6K0
CEPT1 isoform 1		PANTR		416
CEPT1 isoform 1		PONAB		416
Choline/ethanolamine phosphotransferase 1		COLAP		416
Choline/ethanolamine phosphotransferase 1		CERAT		416
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6K0	Choline/ethanolamine phosphotransferase 1, isoform CRA_b		HUMAN		416	UniRef90_Q9Y6K0
CEPT1 isoform 1		PANTR		416
CEPT1 isoform 1		PONAB		416
Choline/ethanolamine phosphotransferase 1		COLAP		416
Choline/ethanolamine phosphotransferase 1		CERAT		416
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6K0	Choline/ethanolamine phosphotransferase 1, isoform CRA_b		HUMAN		416	UniRef50_Q9Y6K0
CEPT1 isoform 1		PANTR		416
CEPT1 isoform 1		PONAB		416
Choline/ethanolamine phosphotransferase 1		COLAP		416
Choline/ethanolamine phosphotransferase 1		CERAT		416
+235

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF068302 mRNA Translation: AAD25170.1 AF138862 mRNA Translation: AAF61194.1 Frameshift. AL355816 Genomic DNA No translation available. BC032610 mRNA Translation: AAH32610.1 BC049196 mRNA Translation: AAH49196.1 AL833102 mRNA Translation: CAH10403.1
CCDSⁱ	CCDS830.1
RefSeqⁱ	NP_001007795.1, NM_001007794.2 NP_001317672.1, NM_001330743.1 NP_006081.1, NM_006090.4
UniGeneⁱ	Hs.363572 Hs.636850

3D structure databases

ProteinModelPortalⁱ	Q9Y6K0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115662, 34 interactors
IntActⁱ	Q9Y6K0, 33 interactors
MINTⁱ	Q9Y6K0
STRINGⁱ	9606.ENSP00000349696

Chemistry databases

DrugBankⁱ	DB00122 Choline
SwissLipidsⁱ	SLP:000000137

Protein family/group databases

TCDBⁱ	4.F.1.1.1 the choline/ethanolaminephosphotransferase 1 (cept1) family

TCDBⁱ

4.F.1.1.1 the choline/ethanolaminephosphotransferase 1 (cept1) family

PTM databases

iPTMnetⁱ	Q9Y6K0
PhosphoSitePlusⁱ	Q9Y6K0
SwissPalmⁱ	Q9Y6K0

Polymorphism and mutation databases

BioMutaⁱ	CEPT1
DMDMⁱ	74753524

Proteomic databases

EPDⁱ	Q9Y6K0
jPOSTⁱ	Q9Y6K0
MaxQBⁱ	Q9Y6K0
PaxDbⁱ	Q9Y6K0
PeptideAtlasⁱ	Q9Y6K0
PRIDEⁱ	Q9Y6K0
ProteomicsDBⁱ	86708

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10390
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357172; ENSP00000349696; ENSG00000134255 ENST00000545121; ENSP00000441980; ENSG00000134255
GeneIDⁱ	10390
KEGGⁱ	hsa:10390
UCSCⁱ	uc001eah.1 human

Organism-specific databases

CTDⁱ	10390
DisGeNETⁱ	10390
EuPathDBⁱ	HostDB:ENSG00000134255.13
GeneCardsⁱ	CEPT1
HGNCⁱ	HGNC:24289 CEPT1
MIMⁱ	616751 gene
neXtProtⁱ	NX_Q9Y6K0
OpenTargetsⁱ	ENSG00000134255
PharmGKBⁱ	PA134892657
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2877 Eukaryota COG5050 LUCA
GeneTreeⁱ	ENSGT00940000154001
HOGENOMⁱ	HOG000034808
HOVERGENⁱ	HBG107647
InParanoidⁱ	Q9Y6K0
KOⁱ	K13644
OMAⁱ	WGLQFAH
OrthoDBⁱ	847100at2759
PhylomeDBⁱ	Q9Y6K0
TreeFamⁱ	TF313270

Enzyme and pathway databases

UniPathwayⁱ	UPA00558;UER00743 UPA00753;UER00740
BioCycⁱ	MetaCyc:HS05844-MONOMER
Reactomeⁱ	R-HSA-1483191 Synthesis of PC R-HSA-1483213 Synthesis of PE
SABIO-RKⁱ	Q9Y6K0

Miscellaneous databases

ChiTaRSⁱ	CEPT1 human
GenomeRNAiⁱ	10390
Protein Ontology More...PROⁱ	PR:Q9Y6K0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134255 Expressed in 221 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasⁱ	Q9Y6K0 baseline and differential
Genevisibleⁱ	Q9Y6K0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000462 CDP-OH_P_trans IPR014472 CHOPT
PANTHERⁱ	PTHR10414 PTHR10414, 1 hit
Pfamⁱ	View protein in Pfam PF01066 CDP-OH_P_transf, 1 hit
PIRSFⁱ	PIRSF015665 CHOPT, 1 hit
PROSITEⁱ	View protein in PROSITE PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEPT1_HUMAN
Accessionⁱ	Q9Y6K0Primary (citable) accession number: Q9Y6K0 Secondary accession number(s): Q69YJ9, Q9P0Y8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	November 1, 1999
	Last modified:	February 13, 2019
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y6K0 (CEPT1_HUMAN)

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Choline/ethanolaminephosphotransferase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylethanolamine biosynthesis

Pathwayi: phosphatidylcholine biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Endoplasmic reticulum

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

Kineticsⁱ

Pathwayⁱ: phosphatidylethanolamine biosynthesis

Pathwayⁱ: phosphatidylcholine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ