KCNE2

Functionⁱ

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505).By similarity2 Publications

GO - Molecular functionⁱ

delayed rectifier potassium channel activity Source: Ensembl
inward rectifier potassium channel activity Source: Ensembl
ion channel binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
potassium channel regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19219384
protein homodimerization activity Source: Ensembl
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cardiac muscle cell action potential involved in contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239
cellular response to drug
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
membrane repolarization
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
membrane repolarization during action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239
membrane repolarization during ventricular cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239
negative regulation of delayed rectifier potassium channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19219384
positive regulation of proteasomal protein catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 22180649
positive regulation of voltage-gated calcium channel activity Source: Ensembl
potassium ion export
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
potassium ion import
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239
potassium ion transmembrane transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
regulation of cyclic nucleotide-gated ion channel activity Source: Ensembl
regulation of delayed rectifier potassium channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
regulation of heart rate by cardiac conduction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239
regulation of inward rectifier potassium channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
regulation of membrane repolarization
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
regulation of potassium ion transmembrane transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
regulation of ventricular cardiac muscle cell membrane repolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239
tongue development Source: Ensembl
ventricular cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10219239

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Potassium channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5576890 Phase 3 - rapid repolarisation R-HSA-5576893 Phase 2 - plateau phase

Reactomeⁱ

R-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium voltage-gated channel subfamily E member 2 Alternative name(s): MinK-related peptide 1 Minimum potassium ion channel-related peptide 1 Potassium channel subunit beta MiRP1
Gene namesⁱ	Name:KCNE2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159197.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6242 KCNE2
MIMⁱ	603796 gene
neXtProtⁱ	NX_Q9Y6J6

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	49 – 69	HelicalSequence analysisAdd BLAST		21
Topological domainⁱ	70 – 123	CytoplasmicSequence analysisAdd BLAST		54

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Long QT syndrome 6 (LQT6)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_074921	14	V → I in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs142153692EnsemblClinVar.	1
Natural variantⁱVAR_074922	20	I → N in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199473363EnsemblClinVar.	1
Natural variantⁱVAR_074923	27	R → H in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148968498EnsemblClinVar.	1
Natural variantⁱVAR_008377	54	M → T in LQT6; forms I(KR) channels that deactivate twice as fast as wild type. 2 PublicationsCorresponds to variant dbSNP:rs74315447EnsemblClinVar.	1
Natural variantⁱVAR_008378	57	I → T in LQT6; may affect KCNQ1/KCNE2 channel. 3 PublicationsCorresponds to variant dbSNP:rs74315448EnsemblClinVar.	1
Natural variantⁱVAR_029334	60	F → L in LQT6; may be a rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs16991654EnsemblClinVar.	1
Natural variantⁱVAR_074924	65	V → L in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199473364EnsemblClinVar.	1
Natural variantⁱVAR_015063	65	V → M in LQT6. 1 PublicationCorresponds to variant dbSNP:rs199473364EnsemblClinVar.	1
Natural variantⁱVAR_074925	77	R → Q in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199473365EnsemblClinVar.	1
Natural variantⁱVAR_035386	77	R → W in LQT6. 1 PublicationCorresponds to variant dbSNP:rs141423405EnsemblClinVar.	1
Natural variantⁱVAR_074926	94	E → G in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs74424227EnsemblClinVar.	1

Atrial fibrillation, familial, 4 (ATFB4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037795	27	R → C in ATFB4; gain-of-function mutation associated with the initiation and/or maintenance of AF. 1 PublicationCorresponds to variant dbSNP:rs74315449EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	75	K → H: Increases tail current in KCNH2/KCNE2 channel. 1 Publication		1

Keywords - Diseaseⁱ

Atrial fibrillation, Disease mutation, Long QT syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9992
GeneReviewsⁱ	KCNE2
MalaCards human disease database More...MalaCardsⁱ	KCNE2
MIMⁱ	611493 phenotype 613693 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000159197
Orphanetⁱ	334 Familial atrial fibrillation 101016 Romano-Ward syndrome
PharmGKBⁱ	PA392

Polymorphism and mutation databases

BioMutaⁱ	KCNE2
DMDMⁱ	6685661

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144285	1 – 123	Potassium voltage-gated channel subfamily E member 2Add BLAST		123

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9Y6J6
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6J6
PRIDEⁱ	Q9Y6J6
ProteomicsDBⁱ	86701

PTM databases

iPTMnetⁱ	Q9Y6J6
PhosphoSitePlusⁱ	Q9Y6J6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000159197 Expressed in 90 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_KCNE2
Genevisibleⁱ	Q9Y6J6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029706 HPA051553

HPAⁱ

HPA029706
HPA051553

Interactionⁱ

Subunit structureⁱ

Interacts with KCNB1 (By similarity). Associates with KCNH2/ERG1 (PubMed:10219239). May associate with KCNQ2 and KCNQ3 (PubMed:11034315,). Associates with HCN1 and probably HCN2. Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity). Interacts with KCNQ1; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505, PubMed:20533308).By similarity4 Publications

GO - Molecular functionⁱ

ion channel binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10219239
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115313, 3 interactors
ComplexPortalⁱ	CPX-3073 Voltage-gated potassium channel complex variant 2
CORUMⁱ	Q9Y6J6
STRINGⁱ	9606.ENSP00000290310

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 38	Combined sources	36
Helixⁱ	46 – 74	Combined sources	29
Helixⁱ	88 – 114	Combined sources	27

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y6J6
SMRⁱ	Q9Y6J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the potassium channel KCNE family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IX4Y Eukaryota ENOG411297Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048894
HOGENOMⁱ	HOG000113208
HOVERGENⁱ	HBG052227
InParanoidⁱ	Q9Y6J6
KEGG Orthology (KO) More...KOⁱ	K04896
OMAⁱ	NWRRNTT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UDJ
PhylomeDBⁱ	Q9Y6J6
TreeFamⁱ	TF336058

Family and domain databases

InterProⁱ	View protein in InterPro IPR000369 K_chnl_KCNE IPR005425 K_chnl_volt-dep_bsu_KCNE2
PANTHERⁱ	PTHR15282 PTHR15282, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02060 ISK_Channel, 1 hit
PRINTSⁱ	PR01605 KCNE2CHANNEL

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Y6J6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTLSNFTQT LEDVFRRIFI TYMDNWRQNT TAEQEALQAK VDAENFYYVI 
        60         70         80         90        100
LYLMVMIGMF SFIIVAILVS TVKSKRREHS NDPYHQYIVE DWQEKYKSQI 
       110        120 
LNLEESKATI HENIGAAGFK MSP

Length:123

Mass (Da):14,472

Last modified:November 1, 1999 - v1

Checksum:ⁱC3016415E1B44890

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_008375	8	T → A2 PublicationsCorresponds to variant dbSNP:rs2234916EnsemblClinVar.	1
Natural variantⁱVAR_037794	8	T → I. Corresponds to variant dbSNP:rs35759083Ensembl.	1
Natural variantⁱVAR_008376	9	Q → E Polymorphism; risk factor for drug-induced arrhythmia; impedes activation and increases sensitivity to macrolide antibiotics; may lower current in KCNQ1/KCNE2 channel. 1 PublicationCorresponds to variant dbSNP:rs16991652EnsemblClinVar.	1
Natural variantⁱVAR_074921	14	V → I in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs142153692EnsemblClinVar.	1
Natural variantⁱVAR_074922	20	I → N in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199473363EnsemblClinVar.	1
Natural variantⁱVAR_037795	27	R → C in ATFB4; gain-of-function mutation associated with the initiation and/or maintenance of AF. 1 PublicationCorresponds to variant dbSNP:rs74315449EnsemblClinVar.	1
Natural variantⁱVAR_074923	27	R → H in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148968498EnsemblClinVar.	1
Natural variantⁱVAR_008377	54	M → T in LQT6; forms I(KR) channels that deactivate twice as fast as wild type. 2 PublicationsCorresponds to variant dbSNP:rs74315447EnsemblClinVar.	1
Natural variantⁱVAR_008378	57	I → T in LQT6; may affect KCNQ1/KCNE2 channel. 3 PublicationsCorresponds to variant dbSNP:rs74315448EnsemblClinVar.	1
Natural variantⁱVAR_029334	60	F → L in LQT6; may be a rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs16991654EnsemblClinVar.	1
Natural variantⁱVAR_074924	65	V → L in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199473364EnsemblClinVar.	1
Natural variantⁱVAR_015063	65	V → M in LQT6. 1 PublicationCorresponds to variant dbSNP:rs199473364EnsemblClinVar.	1
Natural variantⁱVAR_022052	66	A → V. Corresponds to variant dbSNP:rs16991656EnsemblClinVar.	1
Natural variantⁱVAR_074925	77	R → Q in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199473365EnsemblClinVar.	1
Natural variantⁱVAR_035386	77	R → W in LQT6. 1 PublicationCorresponds to variant dbSNP:rs141423405EnsemblClinVar.	1
Natural variantⁱVAR_074926	94	E → G in LQT6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs74424227EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071002 mRNA Translation: AAD28086.1 AF302095 mRNA Translation: AAG13416.1 DQ784804 Genomic DNA Translation: ABQ01239.1 CH471079 Genomic DNA Translation: EAX09791.1 BC093892 mRNA Translation: AAH93892.1 BC112087 mRNA Translation: AAI12088.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13635.1
NCBI Reference Sequences More...RefSeqⁱ	NP_751951.1, NM_172201.1
UniGeneⁱ	Hs.551521 Hs.736062

Genome annotation databases

Ensemblⁱ	ENST00000290310; ENSP00000290310; ENSG00000159197
GeneIDⁱ	9992
KEGGⁱ	hsa:9992
UCSC genome browser More...UCSCⁱ	uc002ytt.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6J6	KCNE2 isoform 1		PONAB		123	UniRef100_Q9Y6J6
Cardiac voltage-gated potassium channel accessory subunit 2 (Fragment)		HUMAN		102
MinK-related peptide 1 (Fragment)		CANLF		72

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6J6	KCNE2 isoform 1		PONAB		123	UniRef90_Q9Y6J6
Cardiac voltage-gated potassium channel accessory subunit 2 (Fragment)		HUMAN		102
MinK-related peptide 1 (Fragment)		CANLF		72
Uncharacterized protein (Fragment)		AILME		123
Potassium voltage-gated channel subfamily E member 2		TUPCH		123
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6J6	KCNE2 isoform 1		PONAB		123	UniRef50_Q9Y6J6
Cardiac voltage-gated potassium channel accessory subunit 2 (Fragment)		HUMAN		102
MinK-related peptide 1 (Fragment)		CANLF		72
Uncharacterized protein (Fragment)		AILME		123
potassium voltage-gated channel subfamily E member 2		NEOSC		123
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071002 mRNA Translation: AAD28086.1 AF302095 mRNA Translation: AAG13416.1 DQ784804 Genomic DNA Translation: ABQ01239.1 CH471079 Genomic DNA Translation: EAX09791.1 BC093892 mRNA Translation: AAH93892.1 BC112087 mRNA Translation: AAI12088.1
CCDSⁱ	CCDS13635.1
RefSeqⁱ	NP_751951.1, NM_172201.1
UniGeneⁱ	Hs.551521 Hs.736062

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2M0Q	NMR	-	A	1-123	[»]
ProteinModelPortalⁱ	Q9Y6J6
SMRⁱ	Q9Y6J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115313, 3 interactors
ComplexPortalⁱ	CPX-3073 Voltage-gated potassium channel complex variant 2
CORUMⁱ	Q9Y6J6
STRINGⁱ	9606.ENSP00000290310

PTM databases

iPTMnetⁱ	Q9Y6J6
PhosphoSitePlusⁱ	Q9Y6J6

Polymorphism and mutation databases

BioMutaⁱ	KCNE2
DMDMⁱ	6685661

Proteomic databases

PaxDbⁱ	Q9Y6J6
PeptideAtlasⁱ	Q9Y6J6
PRIDEⁱ	Q9Y6J6
ProteomicsDBⁱ	86701

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9992
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000290310; ENSP00000290310; ENSG00000159197
GeneIDⁱ	9992
KEGGⁱ	hsa:9992
UCSCⁱ	uc002ytt.2 human

Organism-specific databases

CTDⁱ	9992
DisGeNETⁱ	9992
EuPathDBⁱ	HostDB:ENSG00000159197.3
GeneCardsⁱ	KCNE2
GeneReviewsⁱ	KCNE2
HGNCⁱ	HGNC:6242 KCNE2
HPAⁱ	HPA029706 HPA051553
MalaCardsⁱ	KCNE2
MIMⁱ	603796 gene 611493 phenotype 613693 phenotype
neXtProtⁱ	NX_Q9Y6J6
OpenTargetsⁱ	ENSG00000159197
Orphanetⁱ	334 Familial atrial fibrillation 101016 Romano-Ward syndrome
PharmGKBⁱ	PA392
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IX4Y Eukaryota ENOG411297Y LUCA
GeneTreeⁱ	ENSGT00510000048894
HOGENOMⁱ	HOG000113208
HOVERGENⁱ	HBG052227
InParanoidⁱ	Q9Y6J6
KOⁱ	K04896
OMAⁱ	NWRRNTT
OrthoDBⁱ	EOG091G0UDJ
PhylomeDBⁱ	Q9Y6J6
TreeFamⁱ	TF336058

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5576890 Phase 3 - rapid repolarisation R-HSA-5576893 Phase 2 - plateau phase

Reactomeⁱ

R-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase

Miscellaneous databases

GeneWikiⁱ	KCNE2
GenomeRNAiⁱ	9992
Protein Ontology More...PROⁱ	PR:Q9Y6J6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159197 Expressed in 90 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_KCNE2
Genevisibleⁱ	Q9Y6J6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000369 K_chnl_KCNE IPR005425 K_chnl_volt-dep_bsu_KCNE2
PANTHERⁱ	PTHR15282 PTHR15282, 1 hit
Pfamⁱ	View protein in Pfam PF02060 ISK_Channel, 1 hit
PRINTSⁱ	PR01605 KCNE2CHANNEL
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNE2_HUMAN
Accessionⁱ	Q9Y6J6Primary (citable) accession number: Q9Y6J6 Secondary accession number(s): A5H1P3, D3DSF8, Q52LJ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y6J6 (KCNE2_HUMAN)

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Potassium voltage-gated channel subfamily E member 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ