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Entry version 176 (13 Feb 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Calcineurin-binding protein cabin-1

Gene

CABIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase inhibitor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y6J0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcineurin-binding protein cabin-1
Alternative name(s):
Calcineurin inhibitor
Short name:
CAIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CABIN1
Synonyms:KIAA0330
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099991.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24187 CABIN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604251 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6J0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2172L → A, K or W: Abrogates binding to MEF2B. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23523

Open Targets

More...
OpenTargetsi
ENSG00000099991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164717549

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CABIN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6685261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062751 – 2220Calcineurin-binding protein cabin-1Add BLAST2220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei12PhosphothreonineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1924PhosphothreonineCombined sources1
Modified residuei2094PhosphoserineCombined sources1
Modified residuei2151PhosphothreonineCombined sources1
Modified residuei2154PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.2 Publications
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6J0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6J0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6J0

PeptideAtlas

More...
PeptideAtlasi
Q9Y6J0

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6J0

ProteomicsDB human proteome resource

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ProteomicsDBi
86699

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6J0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in different tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000099991 Expressed in 234 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y6J0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y6J0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043296

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117070, 31 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y6J0

Protein interaction database and analysis system

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IntActi
Q9Y6J0, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6J0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263119

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20G2156-2190[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y6J0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y6J0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y6J0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 69TPR 1Add BLAST34
Repeati90 – 123TPR 2Add BLAST34
Repeati125 – 157TPR 3Add BLAST33
Repeati615 – 648TPR 4Add BLAST34
Repeati1055 – 1088TPR 5Add BLAST34
Repeati1106 – 1139TPR 6Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2116 – 2153Required for interaction with calcineurinBy similarityAdd BLAST38

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFFG Eukaryota
ENOG410XY91 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111281

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050758

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y6J0

KEGG Orthology (KO)

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KOi
K17613

Identification of Orthologs from Complete Genome Data

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OMAi
HRQCFEC

Database of Orthologous Groups

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OrthoDBi
56555at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y6J0

TreeFam database of animal gene trees

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TreeFami
TF323227

Family and domain databases

Conserved Domains Database

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CDDi
cd13839 MEF2_binding, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033053 Hir3/CABIN1
IPR015134 MEF2-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

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PANTHERi
PTHR15502 PTHR15502, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09047 MEF2_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00028 TPR, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIRIAALNAS STIEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD
60 70 80 90 100
RFEESAKAYH ELLEASLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA
110 120 130 140 150
AQREDLETAM EFYLEAVMLD STDVNLWYKI GHVALRLIRI PLARHAFEEG
160 170 180 190 200
LRCNPDHWPC LDNLITVLYT LSDYTTCLYF ICKALEKDCR YSKGLVLKEK
210 220 230 240 250
IFEEQPCLRK DSLRMFLKCD MSIHDVSVSA AETQAIVDEA LGLRKKRQAL
260 270 280 290 300
IVREKEPDLK LVQPIPFFTW KCLGESLLAM YNHLTTCEPP RPSLGKRIDL
310 320 330 340 350
SDYQDPSQPL ESSMVVTPVN VIQPSTVSTN PAVAVAEPVV SYTSVATTSF
360 370 380 390 400
PLHSPGLLET GAPVGDISGG DKSKKGVKRK KISEESGETA KRRSARVRNT
410 420 430 440 450
KCKKEEKVDF QELLMKFLPS RLRKLDPEEE DDSFNNYEVQ SEAKLESFPS
460 470 480 490 500
IGPQRLSFDS ATFMESEKQD VHEFLLENLT NGGILELMMR YLKAMGHKFL
510 520 530 540 550
VRWPPGLAEV VLSVYHSWRR HSTSLPNPLL RDCSNKHIKD MMLMSLSCME
560 570 580 590 600
LQLDQWLLTK GRSSAVSPRN CPAGMVNGRF GPDFPGTHCL GDLLQLSFAS
610 620 630 640 650
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEMLQSSTA
660 670 680 690 700
IQVEAGAERR DIVIRLPNLH NDSVVSLEEI DKNLKSLERC QSLEEIQRLY
710 720 730 740 750
EAGDYKAVVH LLRPTLCTSG FDRAKHLEFM TSIPERPAQL LLLQDSLLRL
760 770 780 790 800
KDYRQCFECS DVALNEAVQQ MVNSGEAAAK EEWVATVTQL LMGIEQALSA
810 820 830 840 850
DSSGSILKVS SSTTGLVRLT NNLIQVIDCS MAVQEEAKEP HVSSVLPWII
860 870 880 890 900
LHRIIWQEED TFHSLCHQQQ LQNPAEEGMS ETPMLPSSLM LLNTAHEYLG
910 920 930 940 950
RRSWCCNSDG ALLRFYVRVL QKELAASTSE DTHPYKEELE TALEQCFYCL
960 970 980 990 1000
YSFPSKKSKA RYLEEHSAQQ VDLIWEDALF MFEYFKPKTL PEFDSYKTST
1010 1020 1030 1040 1050
VSADLANLLK RIATIVPRTE RPALSLDKVS AYIEGTSTEV PCLPEGADPS
1060 1070 1080 1090 1100
PPVVNELYYL LADYHFKNKE QSKAIKFYMH DICICPNRFD SWAGMALARA
1110 1120 1130 1140 1150
SRIQDKLNSN ELKSDGPIWK HATPVLNCFR RALEIDSSNL SLWIEYGTMS
1160 1170 1180 1190 1200
YALHSFASRQ LKQWRGELPP ELVQQMEGRR DSMLETAKHC FTSAARCEGD
1210 1220 1230 1240 1250
GDEEEWLIHY MLGKVAEKQQ QPPTVYLLHY RQAGHYLHEE AARYPKKIHY
1260 1270 1280 1290 1300
HNPPELAMEA LEVYFRLHAS ILKLLGKPDS GVGAEVLVNF MKEAAEGPFA
1310 1320 1330 1340 1350
RGEEKNTPKA SEKEKACLVD EDSHSSAGTL PGPGASLPSS SGPGLTSPPY
1360 1370 1380 1390 1400
TATPIDHDYV KCKKPHQQAT PDDRSQDSTA VALSDSSSTQ DFFNEPTSLL
1410 1420 1430 1440 1450
EGSRKSYTEK RLPILSSQAG ATGKDLQGAT EERGKNEESL ESTEGFRAAE
1460 1470 1480 1490 1500
QGVQKPAAET PASACIPGKP SASTPTLWDG KKRGDLPGEP VAFPQGLPAG
1510 1520 1530 1540 1550
AEEQRQFLTE QCIASFRLCL SRFPQHYKSL YRLAFLYTYS KTHRNLQWAR
1560 1570 1580 1590 1600
DVLLGSSIPW QQLQHMPAQG LFCERNKTNF FNGIWRIPVD EIDRPGSFAW
1610 1620 1630 1640 1650
HMNRSIVLLL KVLAQLRDHS TLLKVSSMLQ RTPDQGKKYL RDADRQVLAQ
1660 1670 1680 1690 1700
RAFILTVKVL EDTLSELAEG SERPGPKVCG LPGARMTTDV SHKASPEDGQ
1710 1720 1730 1740 1750
EGLPQPKKPP LADGSGPGPE PGGKVGLLNH RPVAMDAGDS ADQSGERKDK
1760 1770 1780 1790 1800
ESPRAGPTEP MDTSEATVCH SDLERTPPLL PGRPARDRGP ESRPTELSLE
1810 1820 1830 1840 1850
ELSISARQQP TPLTPAQPAP APAPATTTGT RAGGHPEEPL SRLSRKRKLL
1860 1870 1880 1890 1900
EDTESGKTLL LDAYRVWQQG QKGVAYDLGR VERIMSETYM LIKQVDEEAA
1910 1920 1930 1940 1950
LEQAVKFCQV HLGAAAQRQA SGDTPTTPKH PKDSRENFFP VTVVPTAPDP
1960 1970 1980 1990 2000
VPADSVQRPS DAHTKPRPAL AAATTIITCP PSASASTLDQ SKDPGPPRPH
2010 2020 2030 2040 2050
RPEATPSMAS LGPEGEELAR VAEGTSFPPQ EPRHSPQVKM APTSSPAEPH
2060 2070 2080 2090 2100
CWPAEAALGT GAEPTCSQEG KLRPEPRRDG EAQEAASETQ PLSSPPTAAS
2110 2120 2130 2140 2150
SKAPSSGSAQ PPEGHPGKPE PSRAKSRPLP NMPKLVIPSA ATKFPPEITV
2160 2170 2180 2190 2200
TPPTPTLLSP KGSISEETKQ KLKSAILSAQ SAANVRKESL CQPALEVLET
2210 2220
SSQESSLESE TDEDDDYMDI
Length:2,220
Mass (Da):246,352
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA4AD1741056C233
GO
Isoform 2 (identifier: Q9Y6J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-269: Missing.
     1344-1372: Missing.

Note: No experimental confirmation available.
Show »
Length:2,141
Mass (Da):237,574
Checksum:i3F14AC67988BE2E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWW8A0A087WWW8_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
2,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MEB3B5MEB3_HUMAN
Calcineurin binding protein 1, isof...
CABIN1 hCG_41092
590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JT60C9JT60_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J068C9J068_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20788 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05260756A → T. Corresponds to variant dbSNP:rs5760185Ensembl.1
Natural variantiVAR_052608225D → N. Corresponds to variant dbSNP:rs17004823Ensembl.1
Natural variantiVAR_052609517S → R. Corresponds to variant dbSNP:rs9624393Ensembl.1
Natural variantiVAR_052610660R → S. Corresponds to variant dbSNP:rs9624395Ensembl.1
Natural variantiVAR_052611853R → Q1 PublicationCorresponds to variant dbSNP:rs17854874Ensembl.1
Natural variantiVAR_052612921Q → E. Corresponds to variant dbSNP:rs12166151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054161220 – 269Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_0541621344 – 1372Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072441 mRNA Translation: AAD40846.1
AP000351 Genomic DNA No translation available.
AP000352 Genomic DNA No translation available.
AP000353 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59639.1
BC054497 mRNA Translation: AAH54497.1
Z92546 Genomic DNA Translation: CAB62954.1
AB002328 mRNA Translation: BAA20788.2 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13823.1 [Q9Y6J0-1]

NCBI Reference Sequences

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RefSeqi
NP_001186210.1, NM_001199281.1 [Q9Y6J0-1]
NP_001188358.1, NM_001201429.1
NP_036427.1, NM_012295.3 [Q9Y6J0-1]
XP_016884172.1, XM_017028683.1 [Q9Y6J0-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.517478

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263119; ENSP00000263119; ENSG00000099991 [Q9Y6J0-1]
ENST00000398319; ENSP00000381364; ENSG00000099991 [Q9Y6J0-1]
ENST00000405822; ENSP00000384694; ENSG00000099991 [Q9Y6J0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23523

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23523

UCSC genome browser

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UCSCi
uc002zzi.1 human [Q9Y6J0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072441 mRNA Translation: AAD40846.1
AP000351 Genomic DNA No translation available.
AP000352 Genomic DNA No translation available.
AP000353 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59639.1
BC054497 mRNA Translation: AAH54497.1
Z92546 Genomic DNA Translation: CAB62954.1
AB002328 mRNA Translation: BAA20788.2 Different initiation.
CCDSiCCDS13823.1 [Q9Y6J0-1]
RefSeqiNP_001186210.1, NM_001199281.1 [Q9Y6J0-1]
NP_001188358.1, NM_001201429.1
NP_036427.1, NM_012295.3 [Q9Y6J0-1]
XP_016884172.1, XM_017028683.1 [Q9Y6J0-2]
UniGeneiHs.517478

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20G2156-2190[»]
ProteinModelPortaliQ9Y6J0
SMRiQ9Y6J0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117070, 31 interactors
CORUMiQ9Y6J0
IntActiQ9Y6J0, 7 interactors
MINTiQ9Y6J0
STRINGi9606.ENSP00000263119

PTM databases

iPTMnetiQ9Y6J0
PhosphoSitePlusiQ9Y6J0

Polymorphism and mutation databases

BioMutaiCABIN1
DMDMi6685261

Proteomic databases

EPDiQ9Y6J0
jPOSTiQ9Y6J0
PaxDbiQ9Y6J0
PeptideAtlasiQ9Y6J0
PRIDEiQ9Y6J0
ProteomicsDBi86699

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263119; ENSP00000263119; ENSG00000099991 [Q9Y6J0-1]
ENST00000398319; ENSP00000381364; ENSG00000099991 [Q9Y6J0-1]
ENST00000405822; ENSP00000384694; ENSG00000099991 [Q9Y6J0-2]
GeneIDi23523
KEGGihsa:23523
UCSCiuc002zzi.1 human [Q9Y6J0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23523
DisGeNETi23523
EuPathDBiHostDB:ENSG00000099991.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CABIN1
HGNCiHGNC:24187 CABIN1
HPAiHPA043296
MIMi604251 gene
neXtProtiNX_Q9Y6J0
OpenTargetsiENSG00000099991
PharmGKBiPA164717549

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFFG Eukaryota
ENOG410XY91 LUCA
GeneTreeiENSGT00390000008529
HOGENOMiHOG000111281
HOVERGENiHBG050758
InParanoidiQ9Y6J0
KOiK17613
OMAiHRQCFEC
OrthoDBi56555at2759
PhylomeDBiQ9Y6J0
TreeFamiTF323227

Enzyme and pathway databases

ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORiQ9Y6J0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CABIN1 human
EvolutionaryTraceiQ9Y6J0

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CABIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23523

Protein Ontology

More...
PROi
PR:Q9Y6J0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099991 Expressed in 234 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9Y6J0 baseline and differential
GenevisibleiQ9Y6J0 HS

Family and domain databases

CDDicd13839 MEF2_binding, 1 hit
Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR033053 Hir3/CABIN1
IPR015134 MEF2-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15502 PTHR15502, 1 hit
PfamiView protein in Pfam
PF09047 MEF2_binding, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCABIN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6J0
Secondary accession number(s): G5E9F3, Q6PHY0, Q9Y460
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 13, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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