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UniProtKB - Q9Y6J0 (CABIN_HUMAN)

Entry version 185 (17 Jun 2020)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
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Protein

Calcineurin-binding protein cabin-1

Gene

CABIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase inhibitor activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y6J0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcineurin-binding protein cabin-1
Alternative name(s):
Calcineurin inhibitor
Short name:
CAIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CABIN1
Synonyms:KIAA0330
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000099991.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:24187 CABIN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604251 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y6J0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2172L → A, K or W: Abrogates binding to MEF2B. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		23523

Open Targets

More...OpenTargetsi		ENSG00000099991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164717549

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y6J0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CABIN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		6685261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062751 – 2220Calcineurin-binding protein cabin-1Add BLAST2220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei12PhosphothreonineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1924PhosphothreonineCombined sources1
Modified residuei2094PhosphoserineCombined sources1
Modified residuei2151PhosphothreonineCombined sources1
Modified residuei2154PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.2 Publications
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y6J0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y6J0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y6J0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y6J0

PeptideAtlas

More...PeptideAtlasi		Q9Y6J0

PRoteomics IDEntifications database

More...PRIDEi		Q9Y6J0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33920
86699 [Q9Y6J0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y6J0

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y6J0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y6J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in different tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000099991 Expressed in right hemisphere of cerebellum and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y6J0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y6J0 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000099991 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1.

Interacts with calcineurin.

Interacts with MEF2B.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117070, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y6J0

Protein interaction database and analysis system

More...IntActi		Q9Y6J0, 15 interactors

Molecular INTeraction database

More...MINTi		Q9Y6J0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381364

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y6J0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y6J0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y6J0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 69TPR 1Add BLAST34
Repeati90 – 123TPR 2Add BLAST34
Repeati125 – 157TPR 3Add BLAST33
Repeati615 – 648TPR 4Add BLAST34
Repeati1055 – 1088TPR 5Add BLAST34
Repeati1106 – 1139TPR 6Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2116 – 2153Required for interaction with calcineurinBy similarityAdd BLAST38

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFFG Eukaryota
ENOG410XY91 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008529

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y6J0

KEGG Orthology (KO)

More...KOi		K17613

Identification of Orthologs from Complete Genome Data

More...OMAi		VCPDRFD

Database of Orthologous Groups

More...OrthoDBi		56555at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y6J0

TreeFam database of animal gene trees

More...TreeFami		TF323227

Family and domain databases

Conserved Domains Database

More...CDDi		cd13839 MEF2_binding, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00183

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033053 Hir3/CABIN1
IPR015134 MEF2-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...PANTHERi		PTHR15502 PTHR15502, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09047 MEF2_binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028 TPR, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIRIAALNAS STIEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD 
        60         70         80         90        100
RFEESAKAYH ELLEASLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA 
       110        120        130        140        150
AQREDLETAM EFYLEAVMLD STDVNLWYKI GHVALRLIRI PLARHAFEEG 
       160        170        180        190        200
LRCNPDHWPC LDNLITVLYT LSDYTTCLYF ICKALEKDCR YSKGLVLKEK 
       210        220        230        240        250
IFEEQPCLRK DSLRMFLKCD MSIHDVSVSA AETQAIVDEA LGLRKKRQAL 
       260        270        280        290        300
IVREKEPDLK LVQPIPFFTW KCLGESLLAM YNHLTTCEPP RPSLGKRIDL 
       310        320        330        340        350
SDYQDPSQPL ESSMVVTPVN VIQPSTVSTN PAVAVAEPVV SYTSVATTSF 
       360        370        380        390        400
PLHSPGLLET GAPVGDISGG DKSKKGVKRK KISEESGETA KRRSARVRNT 
       410        420        430        440        450
KCKKEEKVDF QELLMKFLPS RLRKLDPEEE DDSFNNYEVQ SEAKLESFPS 
       460        470        480        490        500
IGPQRLSFDS ATFMESEKQD VHEFLLENLT NGGILELMMR YLKAMGHKFL 
       510        520        530        540        550
VRWPPGLAEV VLSVYHSWRR HSTSLPNPLL RDCSNKHIKD MMLMSLSCME 
       560        570        580        590        600
LQLDQWLLTK GRSSAVSPRN CPAGMVNGRF GPDFPGTHCL GDLLQLSFAS 
       610        620        630        640        650
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEMLQSSTA 
       660        670        680        690        700
IQVEAGAERR DIVIRLPNLH NDSVVSLEEI DKNLKSLERC QSLEEIQRLY 
       710        720        730        740        750
EAGDYKAVVH LLRPTLCTSG FDRAKHLEFM TSIPERPAQL LLLQDSLLRL 
       760        770        780        790        800
KDYRQCFECS DVALNEAVQQ MVNSGEAAAK EEWVATVTQL LMGIEQALSA 
       810        820        830        840        850
DSSGSILKVS SSTTGLVRLT NNLIQVIDCS MAVQEEAKEP HVSSVLPWII 
       860        870        880        890        900
LHRIIWQEED TFHSLCHQQQ LQNPAEEGMS ETPMLPSSLM LLNTAHEYLG 
       910        920        930        940        950
RRSWCCNSDG ALLRFYVRVL QKELAASTSE DTHPYKEELE TALEQCFYCL 
       960        970        980        990       1000
YSFPSKKSKA RYLEEHSAQQ VDLIWEDALF MFEYFKPKTL PEFDSYKTST 
      1010       1020       1030       1040       1050
VSADLANLLK RIATIVPRTE RPALSLDKVS AYIEGTSTEV PCLPEGADPS 
      1060       1070       1080       1090       1100
PPVVNELYYL LADYHFKNKE QSKAIKFYMH DICICPNRFD SWAGMALARA 
      1110       1120       1130       1140       1150
SRIQDKLNSN ELKSDGPIWK HATPVLNCFR RALEIDSSNL SLWIEYGTMS 
      1160       1170       1180       1190       1200
YALHSFASRQ LKQWRGELPP ELVQQMEGRR DSMLETAKHC FTSAARCEGD 
      1210       1220       1230       1240       1250
GDEEEWLIHY MLGKVAEKQQ QPPTVYLLHY RQAGHYLHEE AARYPKKIHY 
      1260       1270       1280       1290       1300
HNPPELAMEA LEVYFRLHAS ILKLLGKPDS GVGAEVLVNF MKEAAEGPFA 
      1310       1320       1330       1340       1350
RGEEKNTPKA SEKEKACLVD EDSHSSAGTL PGPGASLPSS SGPGLTSPPY 
      1360       1370       1380       1390       1400
TATPIDHDYV KCKKPHQQAT PDDRSQDSTA VALSDSSSTQ DFFNEPTSLL 
      1410       1420       1430       1440       1450
EGSRKSYTEK RLPILSSQAG ATGKDLQGAT EERGKNEESL ESTEGFRAAE 
      1460       1470       1480       1490       1500
QGVQKPAAET PASACIPGKP SASTPTLWDG KKRGDLPGEP VAFPQGLPAG 
      1510       1520       1530       1540       1550
AEEQRQFLTE QCIASFRLCL SRFPQHYKSL YRLAFLYTYS KTHRNLQWAR 
      1560       1570       1580       1590       1600
DVLLGSSIPW QQLQHMPAQG LFCERNKTNF FNGIWRIPVD EIDRPGSFAW 
      1610       1620       1630       1640       1650
HMNRSIVLLL KVLAQLRDHS TLLKVSSMLQ RTPDQGKKYL RDADRQVLAQ 
      1660       1670       1680       1690       1700
RAFILTVKVL EDTLSELAEG SERPGPKVCG LPGARMTTDV SHKASPEDGQ 
      1710       1720       1730       1740       1750
EGLPQPKKPP LADGSGPGPE PGGKVGLLNH RPVAMDAGDS ADQSGERKDK 
      1760       1770       1780       1790       1800
ESPRAGPTEP MDTSEATVCH SDLERTPPLL PGRPARDRGP ESRPTELSLE 
      1810       1820       1830       1840       1850
ELSISARQQP TPLTPAQPAP APAPATTTGT RAGGHPEEPL SRLSRKRKLL 
      1860       1870       1880       1890       1900
EDTESGKTLL LDAYRVWQQG QKGVAYDLGR VERIMSETYM LIKQVDEEAA 
      1910       1920       1930       1940       1950
LEQAVKFCQV HLGAAAQRQA SGDTPTTPKH PKDSRENFFP VTVVPTAPDP 
      1960       1970       1980       1990       2000
VPADSVQRPS DAHTKPRPAL AAATTIITCP PSASASTLDQ SKDPGPPRPH 
      2010       2020       2030       2040       2050
RPEATPSMAS LGPEGEELAR VAEGTSFPPQ EPRHSPQVKM APTSSPAEPH 
      2060       2070       2080       2090       2100
CWPAEAALGT GAEPTCSQEG KLRPEPRRDG EAQEAASETQ PLSSPPTAAS 
      2110       2120       2130       2140       2150
SKAPSSGSAQ PPEGHPGKPE PSRAKSRPLP NMPKLVIPSA ATKFPPEITV 
      2160       2170       2180       2190       2200
TPPTPTLLSP KGSISEETKQ KLKSAILSAQ SAANVRKESL CQPALEVLET 
      2210       2220
SSQESSLESE TDEDDDYMDI
Length:2,220
Mass (Da):246,352
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA4AD1741056C233
GO
Isoform 2 (identifier: Q9Y6J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-269: Missing.
     1344-1372: Missing.

Show »
Length:2,141
Mass (Da):237,574
Checksum:i3F14AC67988BE2E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWW8A0A087WWW8_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
2,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MEB3B5MEB3_HUMAN
Calcineurin binding protein 1, isof...
CABIN1 hCG_41092
590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J068C9J068_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JT60C9JT60_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20788 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05260756A → T. Corresponds to variant dbSNP:rs5760185Ensembl.1
Natural variantiVAR_052608225D → N. Corresponds to variant dbSNP:rs17004823Ensembl.1
Natural variantiVAR_052609517S → R. Corresponds to variant dbSNP:rs9624393Ensembl.1
Natural variantiVAR_052610660R → S. Corresponds to variant dbSNP:rs9624395Ensembl.1
Natural variantiVAR_052611853R → Q1 PublicationCorresponds to variant dbSNP:rs17854874Ensembl.1
Natural variantiVAR_052612921Q → E. Corresponds to variant dbSNP:rs12166151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054161220 – 269Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_0541621344 – 1372Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF072441 mRNA Translation: AAD40846.1
AP000351 Genomic DNA No translation available.
AP000352 Genomic DNA No translation available.
AP000353 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59639.1
BC054497 mRNA Translation: AAH54497.1
Z92546 Genomic DNA Translation: CAB62954.1
AB002328 mRNA Translation: BAA20788.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13823.1 [Q9Y6J0-1]

NCBI Reference Sequences

More...RefSeqi		NP_001186210.1, NM_001199281.1 [Q9Y6J0-1]
NP_001188358.1, NM_001201429.1
NP_036427.1, NM_012295.3 [Q9Y6J0-1]
XP_016884172.1, XM_017028683.1 [Q9Y6J0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263119; ENSP00000263119; ENSG00000099991 [Q9Y6J0-1]
ENST00000398319; ENSP00000381364; ENSG00000099991 [Q9Y6J0-1]
ENST00000405822; ENSP00000384694; ENSG00000099991 [Q9Y6J0-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23523

UCSC genome browser

More...UCSCi		uc002zzi.1 human [Q9Y6J0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072441 mRNA Translation: AAD40846.1
AP000351 Genomic DNA No translation available.
AP000352 Genomic DNA No translation available.
AP000353 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59639.1
BC054497 mRNA Translation: AAH54497.1
Z92546 Genomic DNA Translation: CAB62954.1
AB002328 mRNA Translation: BAA20788.2 Different initiation.
CCDSiCCDS13823.1 [Q9Y6J0-1]
RefSeqiNP_001186210.1, NM_001199281.1 [Q9Y6J0-1]
NP_001188358.1, NM_001201429.1
NP_036427.1, NM_012295.3 [Q9Y6J0-1]
XP_016884172.1, XM_017028683.1 [Q9Y6J0-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20G2156-2190[»]
SMRiQ9Y6J0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117070, 37 interactors
CORUMiQ9Y6J0
IntActiQ9Y6J0, 15 interactors
MINTiQ9Y6J0
STRINGi9606.ENSP00000381364

PTM databases

iPTMnetiQ9Y6J0
MetOSiteiQ9Y6J0
PhosphoSitePlusiQ9Y6J0

Polymorphism and mutation databases

BioMutaiCABIN1
DMDMi6685261

Proteomic databases

EPDiQ9Y6J0
jPOSTiQ9Y6J0
MassIVEiQ9Y6J0
PaxDbiQ9Y6J0
PeptideAtlasiQ9Y6J0
PRIDEiQ9Y6J0
ProteomicsDBi33920
86699 [Q9Y6J0-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23901 87 antibodies

Genome annotation databases

EnsembliENST00000263119; ENSP00000263119; ENSG00000099991 [Q9Y6J0-1]
ENST00000398319; ENSP00000381364; ENSG00000099991 [Q9Y6J0-1]
ENST00000405822; ENSP00000384694; ENSG00000099991 [Q9Y6J0-2]
GeneIDi23523
KEGGihsa:23523
UCSCiuc002zzi.1 human [Q9Y6J0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23523
DisGeNETi23523
EuPathDBiHostDB:ENSG00000099991.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		CABIN1
HGNCiHGNC:24187 CABIN1
HPAiENSG00000099991 Low tissue specificity
MIMi604251 gene
neXtProtiNX_Q9Y6J0
OpenTargetsiENSG00000099991
PharmGKBiPA164717549

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFFG Eukaryota
ENOG410XY91 LUCA
GeneTreeiENSGT00390000008529
InParanoidiQ9Y6J0
KOiK17613
OMAiVCPDRFD
OrthoDBi56555at2759
PhylomeDBiQ9Y6J0
TreeFamiTF323227

Enzyme and pathway databases

ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORiQ9Y6J0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23523 77 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CABIN1 human
EvolutionaryTraceiQ9Y6J0

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CABIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23523
PharosiQ9Y6J0 Tbio

Protein Ontology

More...PROi		PR:Q9Y6J0
RNActiQ9Y6J0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000099991 Expressed in right hemisphere of cerebellum and 233 other tissues
ExpressionAtlasiQ9Y6J0 baseline and differential
GenevisibleiQ9Y6J0 HS

Family and domain databases

CDDicd13839 MEF2_binding, 1 hit
Gene3Di1.25.40.10, 2 hits
IDEALiIID00183
InterProiView protein in InterPro
IPR033053 Hir3/CABIN1
IPR015134 MEF2-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15502 PTHR15502, 1 hit
PfamiView protein in Pfam
PF09047 MEF2_binding, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCABIN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6J0
Secondary accession number(s): G5E9F3, Q6PHY0, Q9Y460
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 17, 2020
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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