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UniProtKB - Q9Y6J0 (CABIN_HUMAN)

Protein

Calcineurin-binding protein cabin-1

Gene

CABIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.2 Publications

GO - Molecular functioni

  • protein phosphatase inhibitor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChromatin regulator

Enzyme and pathway databases

ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORiQ9Y6J0

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin-binding protein cabin-1
Alternative name(s):
Calcineurin inhibitor
Short name:
CAIN
Gene namesi
Name:CABIN1
Synonyms:KIAA0330
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099991.16
HGNCiHGNC:24187 CABIN1
MIMi604251 gene
neXtProtiNX_Q9Y6J0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2172L → A, K or W: Abrogates binding to MEF2B. 1 Publication1

Organism-specific databases

DisGeNETi23523
OpenTargetsiENSG00000099991
PharmGKBiPA164717549

Polymorphism and mutation databases

BioMutaiCABIN1
DMDMi6685261

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001062751 – 2220Calcineurin-binding protein cabin-1Add BLAST2220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei12PhosphothreonineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1924PhosphothreonineCombined sources1
Modified residuei2094PhosphoserineCombined sources1
Modified residuei2151PhosphothreonineCombined sources1
Modified residuei2154PhosphothreonineCombined sources1

Post-translational modificationi

Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.2 Publications
Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y6J0
PaxDbiQ9Y6J0
PeptideAtlasiQ9Y6J0
PRIDEiQ9Y6J0
ProteomicsDBi86699

PTM databases

iPTMnetiQ9Y6J0
PhosphoSitePlusiQ9Y6J0

Expressioni

Tissue specificityi

Widely expressed in different tissues.1 Publication

Gene expression databases

BgeeiENSG00000099991 Expressed in 234 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CABIN1
ExpressionAtlasiQ9Y6J0 baseline and differential
GenevisibleiQ9Y6J0 HS

Organism-specific databases

HPAiHPA043296

Interactioni

Subunit structurei

Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.3 Publications

Protein-protein interaction databases

BioGridi117070, 29 interactors
CORUMiQ9Y6J0
IntActiQ9Y6J0, 6 interactors
MINTiQ9Y6J0
STRINGi9606.ENSP00000263119

Structurei

Secondary structure

12220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6J0
SMRiQ9Y6J0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6J0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 69TPR 1Add BLAST34
Repeati90 – 123TPR 2Add BLAST34
Repeati125 – 157TPR 3Add BLAST33
Repeati615 – 648TPR 4Add BLAST34
Repeati1055 – 1088TPR 5Add BLAST34
Repeati1106 – 1139TPR 6Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2116 – 2153Required for interaction with calcineurinBy similarityAdd BLAST38

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFFG Eukaryota
ENOG410XY91 LUCA
GeneTreeiENSGT00390000008529
HOGENOMiHOG000111281
HOVERGENiHBG050758
InParanoidiQ9Y6J0
KOiK17613
OMAiHRQCFEC
OrthoDBiEOG091G008Y
PhylomeDBiQ9Y6J0
TreeFamiTF323227

Family and domain databases

CDDicd13839 MEF2_binding, 1 hit
Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR033053 Hir3/CABIN1
IPR015134 MEF2-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15502 PTHR15502, 1 hit
PfamiView protein in Pfam
PF09047 MEF2_binding, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIRIAALNAS STIEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD 
        60         70         80         90        100
RFEESAKAYH ELLEASLLRE AVSSGDEKEG LKHPGLILKY STYKNLAQLA 
       110        120        130        140        150
AQREDLETAM EFYLEAVMLD STDVNLWYKI GHVALRLIRI PLARHAFEEG 
       160        170        180        190        200
LRCNPDHWPC LDNLITVLYT LSDYTTCLYF ICKALEKDCR YSKGLVLKEK 
       210        220        230        240        250
IFEEQPCLRK DSLRMFLKCD MSIHDVSVSA AETQAIVDEA LGLRKKRQAL 
       260        270        280        290        300
IVREKEPDLK LVQPIPFFTW KCLGESLLAM YNHLTTCEPP RPSLGKRIDL 
       310        320        330        340        350
SDYQDPSQPL ESSMVVTPVN VIQPSTVSTN PAVAVAEPVV SYTSVATTSF 
       360        370        380        390        400
PLHSPGLLET GAPVGDISGG DKSKKGVKRK KISEESGETA KRRSARVRNT 
       410        420        430        440        450
KCKKEEKVDF QELLMKFLPS RLRKLDPEEE DDSFNNYEVQ SEAKLESFPS 
       460        470        480        490        500
IGPQRLSFDS ATFMESEKQD VHEFLLENLT NGGILELMMR YLKAMGHKFL 
       510        520        530        540        550
VRWPPGLAEV VLSVYHSWRR HSTSLPNPLL RDCSNKHIKD MMLMSLSCME 
       560        570        580        590        600
LQLDQWLLTK GRSSAVSPRN CPAGMVNGRF GPDFPGTHCL GDLLQLSFAS 
       610        620        630        640        650
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEMLQSSTA 
       660        670        680        690        700
IQVEAGAERR DIVIRLPNLH NDSVVSLEEI DKNLKSLERC QSLEEIQRLY 
       710        720        730        740        750
EAGDYKAVVH LLRPTLCTSG FDRAKHLEFM TSIPERPAQL LLLQDSLLRL 
       760        770        780        790        800
KDYRQCFECS DVALNEAVQQ MVNSGEAAAK EEWVATVTQL LMGIEQALSA 
       810        820        830        840        850
DSSGSILKVS SSTTGLVRLT NNLIQVIDCS MAVQEEAKEP HVSSVLPWII 
       860        870        880        890        900
LHRIIWQEED TFHSLCHQQQ LQNPAEEGMS ETPMLPSSLM LLNTAHEYLG 
       910        920        930        940        950
RRSWCCNSDG ALLRFYVRVL QKELAASTSE DTHPYKEELE TALEQCFYCL 
       960        970        980        990       1000
YSFPSKKSKA RYLEEHSAQQ VDLIWEDALF MFEYFKPKTL PEFDSYKTST 
      1010       1020       1030       1040       1050
VSADLANLLK RIATIVPRTE RPALSLDKVS AYIEGTSTEV PCLPEGADPS 
      1060       1070       1080       1090       1100
PPVVNELYYL LADYHFKNKE QSKAIKFYMH DICICPNRFD SWAGMALARA 
      1110       1120       1130       1140       1150
SRIQDKLNSN ELKSDGPIWK HATPVLNCFR RALEIDSSNL SLWIEYGTMS 
      1160       1170       1180       1190       1200
YALHSFASRQ LKQWRGELPP ELVQQMEGRR DSMLETAKHC FTSAARCEGD 
      1210       1220       1230       1240       1250
GDEEEWLIHY MLGKVAEKQQ QPPTVYLLHY RQAGHYLHEE AARYPKKIHY 
      1260       1270       1280       1290       1300
HNPPELAMEA LEVYFRLHAS ILKLLGKPDS GVGAEVLVNF MKEAAEGPFA 
      1310       1320       1330       1340       1350
RGEEKNTPKA SEKEKACLVD EDSHSSAGTL PGPGASLPSS SGPGLTSPPY 
      1360       1370       1380       1390       1400
TATPIDHDYV KCKKPHQQAT PDDRSQDSTA VALSDSSSTQ DFFNEPTSLL 
      1410       1420       1430       1440       1450
EGSRKSYTEK RLPILSSQAG ATGKDLQGAT EERGKNEESL ESTEGFRAAE 
      1460       1470       1480       1490       1500
QGVQKPAAET PASACIPGKP SASTPTLWDG KKRGDLPGEP VAFPQGLPAG 
      1510       1520       1530       1540       1550
AEEQRQFLTE QCIASFRLCL SRFPQHYKSL YRLAFLYTYS KTHRNLQWAR 
      1560       1570       1580       1590       1600
DVLLGSSIPW QQLQHMPAQG LFCERNKTNF FNGIWRIPVD EIDRPGSFAW 
      1610       1620       1630       1640       1650
HMNRSIVLLL KVLAQLRDHS TLLKVSSMLQ RTPDQGKKYL RDADRQVLAQ 
      1660       1670       1680       1690       1700
RAFILTVKVL EDTLSELAEG SERPGPKVCG LPGARMTTDV SHKASPEDGQ 
      1710       1720       1730       1740       1750
EGLPQPKKPP LADGSGPGPE PGGKVGLLNH RPVAMDAGDS ADQSGERKDK 
      1760       1770       1780       1790       1800
ESPRAGPTEP MDTSEATVCH SDLERTPPLL PGRPARDRGP ESRPTELSLE 
      1810       1820       1830       1840       1850
ELSISARQQP TPLTPAQPAP APAPATTTGT RAGGHPEEPL SRLSRKRKLL 
      1860       1870       1880       1890       1900
EDTESGKTLL LDAYRVWQQG QKGVAYDLGR VERIMSETYM LIKQVDEEAA 
      1910       1920       1930       1940       1950
LEQAVKFCQV HLGAAAQRQA SGDTPTTPKH PKDSRENFFP VTVVPTAPDP 
      1960       1970       1980       1990       2000
VPADSVQRPS DAHTKPRPAL AAATTIITCP PSASASTLDQ SKDPGPPRPH 
      2010       2020       2030       2040       2050
RPEATPSMAS LGPEGEELAR VAEGTSFPPQ EPRHSPQVKM APTSSPAEPH 
      2060       2070       2080       2090       2100
CWPAEAALGT GAEPTCSQEG KLRPEPRRDG EAQEAASETQ PLSSPPTAAS 
      2110       2120       2130       2140       2150
SKAPSSGSAQ PPEGHPGKPE PSRAKSRPLP NMPKLVIPSA ATKFPPEITV 
      2160       2170       2180       2190       2200
TPPTPTLLSP KGSISEETKQ KLKSAILSAQ SAANVRKESL CQPALEVLET 
      2210       2220
SSQESSLESE TDEDDDYMDI
Length:2,220
Mass (Da):246,352
Last modified:November 1, 1999 - v1
Checksum:iBA4AD1741056C233
GO
Isoform 2 (identifier: Q9Y6J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-269: Missing.
     1344-1372: Missing.

Note: No experimental confirmation available.
Show »
Length:2,141
Mass (Da):237,574
Checksum:i3F14AC67988BE2E5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWW8A0A087WWW8_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
2,170Annotation score:
B5MEB3B5MEB3_HUMAN
Calcineurin binding protein 1, isof...
CABIN1 hCG_41092
590Annotation score:
C9J068C9J068_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
361Annotation score:
C9JT60C9JT60_HUMAN
Calcineurin-binding protein cabin-1
CABIN1
357Annotation score:

Sequence cautioni

The sequence BAA20788 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05260756A → T. Corresponds to variant dbSNP:rs5760185Ensembl.1
Natural variantiVAR_052608225D → N. Corresponds to variant dbSNP:rs17004823Ensembl.1
Natural variantiVAR_052609517S → R. Corresponds to variant dbSNP:rs9624393Ensembl.1
Natural variantiVAR_052610660R → S. Corresponds to variant dbSNP:rs9624395Ensembl.1
Natural variantiVAR_052611853R → Q1 PublicationCorresponds to variant dbSNP:rs17854874Ensembl.1
Natural variantiVAR_052612921Q → E. Corresponds to variant dbSNP:rs12166151Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054161220 – 269Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_0541621344 – 1372Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072441 mRNA Translation: AAD40846.1
AP000351 Genomic DNA No translation available.
AP000352 Genomic DNA No translation available.
AP000353 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59639.1
BC054497 mRNA Translation: AAH54497.1
Z92546 Genomic DNA Translation: CAB62954.1
AB002328 mRNA Translation: BAA20788.2 Different initiation.
CCDSiCCDS13823.1 [Q9Y6J0-1]
RefSeqiNP_001186210.1, NM_001199281.1 [Q9Y6J0-1]
NP_001188358.1, NM_001201429.1
NP_036427.1, NM_012295.3 [Q9Y6J0-1]
XP_016884172.1, XM_017028683.1 [Q9Y6J0-2]
UniGeneiHs.517478

Genome annotation databases

EnsembliENST00000263119; ENSP00000263119; ENSG00000099991 [Q9Y6J0-1]
ENST00000398319; ENSP00000381364; ENSG00000099991 [Q9Y6J0-1]
ENST00000405822; ENSP00000384694; ENSG00000099991 [Q9Y6J0-2]
GeneIDi23523
KEGGihsa:23523
UCSCiuc002zzi.1 human [Q9Y6J0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072441 mRNA Translation: AAD40846.1
AP000351 Genomic DNA No translation available.
AP000352 Genomic DNA No translation available.
AP000353 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59639.1
BC054497 mRNA Translation: AAH54497.1
Z92546 Genomic DNA Translation: CAB62954.1
AB002328 mRNA Translation: BAA20788.2 Different initiation.
CCDSiCCDS13823.1 [Q9Y6J0-1]
RefSeqiNP_001186210.1, NM_001199281.1 [Q9Y6J0-1]
NP_001188358.1, NM_001201429.1
NP_036427.1, NM_012295.3 [Q9Y6J0-1]
XP_016884172.1, XM_017028683.1 [Q9Y6J0-2]
UniGeneiHs.517478

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20G2156-2190[»]
ProteinModelPortaliQ9Y6J0
SMRiQ9Y6J0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117070, 29 interactors
CORUMiQ9Y6J0
IntActiQ9Y6J0, 6 interactors
MINTiQ9Y6J0
STRINGi9606.ENSP00000263119

PTM databases

iPTMnetiQ9Y6J0
PhosphoSitePlusiQ9Y6J0

Polymorphism and mutation databases

BioMutaiCABIN1
DMDMi6685261

Proteomic databases

EPDiQ9Y6J0
PaxDbiQ9Y6J0
PeptideAtlasiQ9Y6J0
PRIDEiQ9Y6J0
ProteomicsDBi86699

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263119; ENSP00000263119; ENSG00000099991 [Q9Y6J0-1]
ENST00000398319; ENSP00000381364; ENSG00000099991 [Q9Y6J0-1]
ENST00000405822; ENSP00000384694; ENSG00000099991 [Q9Y6J0-2]
GeneIDi23523
KEGGihsa:23523
UCSCiuc002zzi.1 human [Q9Y6J0-1]

Organism-specific databases

CTDi23523
DisGeNETi23523
EuPathDBiHostDB:ENSG00000099991.16
GeneCardsiCABIN1
HGNCiHGNC:24187 CABIN1
HPAiHPA043296
MIMi604251 gene
neXtProtiNX_Q9Y6J0
OpenTargetsiENSG00000099991
PharmGKBiPA164717549
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFG Eukaryota
ENOG410XY91 LUCA
GeneTreeiENSGT00390000008529
HOGENOMiHOG000111281
HOVERGENiHBG050758
InParanoidiQ9Y6J0
KOiK17613
OMAiHRQCFEC
OrthoDBiEOG091G008Y
PhylomeDBiQ9Y6J0
TreeFamiTF323227

Enzyme and pathway databases

ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORiQ9Y6J0

Miscellaneous databases

ChiTaRSiCABIN1 human
EvolutionaryTraceiQ9Y6J0
GeneWikiiCABIN1
GenomeRNAii23523
PROiPR:Q9Y6J0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099991 Expressed in 234 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CABIN1
ExpressionAtlasiQ9Y6J0 baseline and differential
GenevisibleiQ9Y6J0 HS

Family and domain databases

CDDicd13839 MEF2_binding, 1 hit
Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR033053 Hir3/CABIN1
IPR015134 MEF2-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15502 PTHR15502, 1 hit
PfamiView protein in Pfam
PF09047 MEF2_binding, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCABIN_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6J0
Secondary accession number(s): G5E9F3, Q6PHY0, Q9Y460
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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