UniProtKB - Q9Y6I7 (WSB1_HUMAN)
WD repeat and SOCS box-containing protein 1
WSB1
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- intracellular signal transduction Source: InterPro
- post-translational protein modification Source: Reactome
- protein polyubiquitination Source: Reactome
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6I7 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9Y6I7 |
SIGNORi | Q9Y6I7 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat and SOCS box-containing protein 1Short name: WSB-1 Alternative name(s): SOCS box-containing WD protein SWiP-1 |
Gene namesi | Name:WSB1 Synonyms:SWIP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19221, WSB1 |
MIMi | 610091, gene |
neXtProti | NX_Q9Y6I7 |
VEuPathDBi | HostDB:ENSG00000109046.14 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 26118 |
OpenTargetsi | ENSG00000109046 |
PharmGKBi | PA134867554 |
Miscellaneous databases
Pharosi | Q9Y6I7, Tbio |
Genetic variation databases
BioMutai | WSB1 |
DMDMi | 20532298 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051457 | 1 – 421 | WD repeat and SOCS box-containing protein 1Add BLAST | 421 |
Proteomic databases
EPDi | Q9Y6I7 |
MassIVEi | Q9Y6I7 |
PaxDbi | Q9Y6I7 |
PeptideAtlasi | Q9Y6I7 |
PRIDEi | Q9Y6I7 |
ProteomicsDBi | 86693 [Q9Y6I7-1] 86694 [Q9Y6I7-2] 86695 [Q9Y6I7-3] |
PTM databases
iPTMneti | Q9Y6I7 |
PhosphoSitePlusi | Q9Y6I7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109046, Expressed in upper lobe of lung and 245 other tissues |
ExpressionAtlasi | Q9Y6I7, baseline and differential |
Genevisiblei | Q9Y6I7, HS |
Organism-specific databases
HPAi | ENSG00000109046, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DIO2.
Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1.
Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1.
Interacts with CUL5, RNF7, ELOB and ELOC. Binds to HIPK2 through WD40 repeats.
3 PublicationsBinary interactionsi
Hide detailsQ9Y6I7
With | #Exp. | IntAct |
---|---|---|
LRRK2 [Q5S007] | 5 | EBI-1171494,EBI-5323863 |
VHL - isoform 2 [P40337-2] | 3 | EBI-1171494,EBI-12157263 |
Hipk2 [Q9QZR5] from Mus musculus. | 5 | EBI-1171494,EBI-366905 |
Protein-protein interaction databases
BioGRIDi | 117560, 19 interactors |
CORUMi | Q9Y6I7 |
IntActi | Q9Y6I7, 9 interactors |
MINTi | Q9Y6I7 |
STRINGi | 9606.ENSP00000262394 |
Miscellaneous databases
RNActi | Q9Y6I7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 32 – 71 | WD 1Add BLAST | 40 | |
Repeati | 124 – 165 | WD 2Add BLAST | 42 | |
Repeati | 168 – 208 | WD 3Add BLAST | 41 | |
Repeati | 212 – 251 | WD 4Add BLAST | 40 | |
Repeati | 254 – 293 | WD 5Add BLAST | 40 | |
Repeati | 309 – 346 | WD 6Add BLAST | 38 | |
Domaini | 372 – 421 | SOCS boxPROSITE-ProRule annotationAdd BLAST | 50 |
Domaini
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0266, Eukaryota |
GeneTreei | ENSGT00890000139406 |
HOGENOMi | CLU_056876_0_0_1 |
InParanoidi | Q9Y6I7 |
OMAi | VAPFDQK |
PhylomeDBi | Q9Y6I7 |
TreeFami | TF329216 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF07525, SOCS_box, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit SM00320, WD40, 6 hits |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50225, SOCS, 1 hit PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA
60 70 80 90 100
WSQGHRTVKL VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR
110 120 130 140 150
EHIIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG
160 170 180 190 200
RIKIWDVYTG KLLLNLVDHT EVVRDLTFAP DGSLILVSAS RDKTLRVWDL
210 220 230 240 250
KDDGNMMKVL RGHQNWVYSC AFSPDSSMLC SVGASKAVFL WNMDKYTMIR
260 270 280 290 300
KLEGHHHDVV ACDFSPDGAL LATASYDTRV YIWDPHNGDI LMEFGHLFPP
310 320 330 340 350
PTPIFAGGAN DRWVRSVSFS HDGLHVASLA DDKMVRFWRI DEDYPVQVAP
360 370 380 390 400
LSNGLCCAFS TDGSVLAAGT HDGSVYFWAT PRQVPSLQHL CRMSIRRVMP
410 420
TQEVQELPIP SKLLEFLSYR I
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KT03 | J3KT03_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 207 | Annotation score: | ||
B4DGB8 | B4DGB8_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 213 | Annotation score: | ||
J3KTB3 | J3KTB3_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 143 | Annotation score: | ||
B4DTL1 | B4DTL1_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 247 | Annotation score: | ||
J3KRG6 | J3KRG6_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 98 | Annotation score: | ||
J3KSQ3 | J3KSQ3_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 54 | Annotation score: | ||
J3KS88 | J3KS88_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 78 | Annotation score: | ||
J3QLM8 | J3QLM8_HUMAN | WD repeat and SOCS box-containing p... | WSB1 | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 | N → S in CAB53708 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 171 | E → G in CAB53708 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 178 | F → L in AAD43036 (Ref. 6) Curated | 1 | |
Sequence conflicti | 201 | K → R in CAB53708 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 231 | S → P in AAD43036 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024701 | 16 | L → S2 PublicationsCorresponds to variant dbSNP:rs6561Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053402 | 1 – 35 | MASFP…KKCGR → MLNIILIKFSSFSIRCAILS SVCLNEAITFAFLLQ in isoform 4. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_006792 | 14 – 159 | Missing in isoform 2. 1 PublicationAdd BLAST | 146 | |
Alternative sequenceiVSP_053403 | 36 – 237 | Missing in isoform 4. 1 PublicationAdd BLAST | 202 | |
Alternative sequenceiVSP_039111 | 239 – 244 | FLWNMD → VAAILV in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_039112 | 245 – 421 | Missing in isoform 3. 1 PublicationAdd BLAST | 177 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF072880 mRNA Translation: AAD28808.1 AF106684 mRNA Translation: AAD43037.1 AF069313 mRNA Translation: AAD20954.2 AF240696 mRNA Translation: AAF82746.1 AL110243 mRNA Translation: CAB53693.1 AF112205 mRNA Translation: AAF17193.1 AF106683 mRNA Translation: AAD43036.1 AL110269 mRNA Translation: CAB53708.2 BC021110 mRNA Translation: AAH21110.1 |
CCDSi | CCDS11220.1 [Q9Y6I7-1] CCDS11221.1 [Q9Y6I7-2] |
PIRi | T14773 T14788 |
RefSeqi | NP_056441.6, NM_015626.9 [Q9Y6I7-1] NP_599027.1, NM_134265.3 [Q9Y6I7-2] XP_016879924.1, XM_017024435.1 [Q9Y6I7-4] XP_016879925.1, XM_017024436.1 [Q9Y6I7-4] |
Genome annotation databases
Ensembli | ENST00000262394; ENSP00000262394; ENSG00000109046 [Q9Y6I7-1] ENST00000348811; ENSP00000327055; ENSG00000109046 [Q9Y6I7-2] |
GeneIDi | 26118 |
KEGGi | hsa:26118 |
UCSCi | uc002gzd.2, human [Q9Y6I7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF072880 mRNA Translation: AAD28808.1 AF106684 mRNA Translation: AAD43037.1 AF069313 mRNA Translation: AAD20954.2 AF240696 mRNA Translation: AAF82746.1 AL110243 mRNA Translation: CAB53693.1 AF112205 mRNA Translation: AAF17193.1 AF106683 mRNA Translation: AAD43036.1 AL110269 mRNA Translation: CAB53708.2 BC021110 mRNA Translation: AAH21110.1 |
CCDSi | CCDS11220.1 [Q9Y6I7-1] CCDS11221.1 [Q9Y6I7-2] |
PIRi | T14773 T14788 |
RefSeqi | NP_056441.6, NM_015626.9 [Q9Y6I7-1] NP_599027.1, NM_134265.3 [Q9Y6I7-2] XP_016879924.1, XM_017024435.1 [Q9Y6I7-4] XP_016879925.1, XM_017024436.1 [Q9Y6I7-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117560, 19 interactors |
CORUMi | Q9Y6I7 |
IntActi | Q9Y6I7, 9 interactors |
MINTi | Q9Y6I7 |
STRINGi | 9606.ENSP00000262394 |
PTM databases
iPTMneti | Q9Y6I7 |
PhosphoSitePlusi | Q9Y6I7 |
Genetic variation databases
BioMutai | WSB1 |
DMDMi | 20532298 |
Proteomic databases
EPDi | Q9Y6I7 |
MassIVEi | Q9Y6I7 |
PaxDbi | Q9Y6I7 |
PeptideAtlasi | Q9Y6I7 |
PRIDEi | Q9Y6I7 |
ProteomicsDBi | 86693 [Q9Y6I7-1] 86694 [Q9Y6I7-2] 86695 [Q9Y6I7-3] |
Protocols and materials databases
Antibodypediai | 1139, 142 antibodies |
DNASUi | 26118 |
Genome annotation databases
Ensembli | ENST00000262394; ENSP00000262394; ENSG00000109046 [Q9Y6I7-1] ENST00000348811; ENSP00000327055; ENSG00000109046 [Q9Y6I7-2] |
GeneIDi | 26118 |
KEGGi | hsa:26118 |
UCSCi | uc002gzd.2, human [Q9Y6I7-1] |
Organism-specific databases
CTDi | 26118 |
DisGeNETi | 26118 |
GeneCardsi | WSB1 |
HGNCi | HGNC:19221, WSB1 |
HPAi | ENSG00000109046, Low tissue specificity |
MIMi | 610091, gene |
neXtProti | NX_Q9Y6I7 |
OpenTargetsi | ENSG00000109046 |
PharmGKBi | PA134867554 |
VEuPathDBi | HostDB:ENSG00000109046.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0266, Eukaryota |
GeneTreei | ENSGT00890000139406 |
HOGENOMi | CLU_056876_0_0_1 |
InParanoidi | Q9Y6I7 |
OMAi | VAPFDQK |
PhylomeDBi | Q9Y6I7 |
TreeFami | TF329216 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9Y6I7 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9Y6I7 |
SIGNORi | Q9Y6I7 |
Miscellaneous databases
BioGRID-ORCSi | 26118, 19 hits in 874 CRISPR screens |
ChiTaRSi | WSB1, human |
GeneWikii | WSB1 |
GenomeRNAii | 26118 |
Pharosi | Q9Y6I7, Tbio |
PROi | PR:Q9Y6I7 |
RNActi | Q9Y6I7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109046, Expressed in upper lobe of lung and 245 other tissues |
ExpressionAtlasi | Q9Y6I7, baseline and differential |
Genevisiblei | Q9Y6I7, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF07525, SOCS_box, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit SM00320, WD40, 6 hits |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50225, SOCS, 1 hit PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WSB1_HUMAN | |
Accessioni | Q9Y6I7Primary (citable) accession number: Q9Y6I7 Secondary accession number(s): Q9NRB1 Q9Y656 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways