WSB1

Functionⁱ

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.3 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

ubiquitin-protein transferase activity
Source: Reactome
Inferred from experimentⁱ
- 19028597

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular signal transduction Source: InterPro
post-translational protein modification Source: Reactome
protein polyubiquitination Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q9Y6I7
SIGNORⁱ	Q9Y6I7
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat and SOCS box-containing protein 1 Short name: WSB-1 Alternative name(s): SOCS box-containing WD protein SWiP-1
Gene namesⁱ	Name:WSB1 Synonyms:SWIP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109046.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19221 WSB1
MIMⁱ	610091 gene
neXtProtⁱ	NX_Q9Y6I7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26118
Open Targets More...OpenTargetsⁱ	ENSG00000109046
PharmGKBⁱ	PA134867554

Polymorphism and mutation databases

BioMutaⁱ	WSB1
DMDMⁱ	20532298

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051457	1 – 421	WD repeat and SOCS box-containing protein 1Add BLAST		421

Proteomic databases

EPDⁱ	Q9Y6I7
PaxDbⁱ	Q9Y6I7
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6I7
PRIDEⁱ	Q9Y6I7
ProteomicsDBⁱ	86693 86694 [Q9Y6I7-2] 86695 [Q9Y6I7-3]

PTM databases

iPTMnetⁱ	Q9Y6I7
PhosphoSitePlusⁱ	Q9Y6I7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000109046 Expressed in 235 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_WSB1
ExpressionAtlasⁱ	Q9Y6I7 baseline and differential
Genevisibleⁱ	Q9Y6I7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003293

HPAⁱ

HPA003293

Interactionⁱ

Subunit structureⁱ

Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, ELOB and ELOC. Binds to HIPK2 through WD40 repeats.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Hipk2	Q9QZR5	5	EBI-1171494,EBI-366905	From Mus musculus.
LRRK2	Q5S007	5	EBI-1171494,EBI-5323863

Protein-protein interaction databases

BioGridⁱ	117560, 16 interactors
CORUMⁱ	Q9Y6I7
IntActⁱ	Q9Y6I7, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y6I7
STRINGⁱ	9606.ENSP00000262394

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y6I7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	32 – 71	WD 1Add BLAST	40
Repeatⁱ	124 – 165	WD 2Add BLAST	42
Repeatⁱ	168 – 208	WD 3Add BLAST	41
Repeatⁱ	212 – 251	WD 4Add BLAST	40
Repeatⁱ	254 – 293	WD 5Add BLAST	40
Repeatⁱ	309 – 346	WD 6Add BLAST	38
Domainⁱ	372 – 421	SOCS boxPROSITE-ProRule annotationAdd BLAST	50

Domainⁱ

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IQ0Y Eukaryota ENOG411010D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139406
HOGENOMⁱ	HOG000063727
HOVERGENⁱ	HBG070207
InParanoidⁱ	Q9Y6I7
KEGG Orthology (KO) More...KOⁱ	K10341
OMAⁱ	GHHNDVV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06GY
PhylomeDBⁱ	Q9Y6I7
TreeFamⁱ	TF329216

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07525 SOCS_box, 1 hit PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit SM00320 WD40, 6 hits
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50225 SOCS, 1 hit PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 6 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y6I7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA 
        60         70         80         90        100
WSQGHRTVKL VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR 
       110        120        130        140        150
EHIIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG 
       160        170        180        190        200
RIKIWDVYTG KLLLNLVDHT EVVRDLTFAP DGSLILVSAS RDKTLRVWDL 
       210        220        230        240        250
KDDGNMMKVL RGHQNWVYSC AFSPDSSMLC SVGASKAVFL WNMDKYTMIR 
       260        270        280        290        300
KLEGHHHDVV ACDFSPDGAL LATASYDTRV YIWDPHNGDI LMEFGHLFPP 
       310        320        330        340        350
PTPIFAGGAN DRWVRSVSFS HDGLHVASLA DDKMVRFWRI DEDYPVQVAP 
       360        370        380        390        400
LSNGLCCAFS TDGSVLAAGT HDGSVYFWAT PRQVPSLQHL CRMSIRRVMP 
       410        420 
TQEVQELPIP SKLLEFLSYR I

Length:421

Mass (Da):47,432

Last modified:November 1, 1999 - v1

Checksum:ⁱ650D4942E97D4BED

GO

Isoform 2 (identifier: Q9Y6I7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
14-159: Missing.

« Hide

        10         20         30         40         50
MASFPPRVNE KEIGKLLLNL VDHTEVVRDL TFAPDGSLIL VSASRDKTLR 
        60         70         80         90        100
VWDLKDDGNM MKVLRGHQNW VYSCAFSPDS SMLCSVGASK AVFLWNMDKY 
       110        120        130        140        150
TMIRKLEGHH HDVVACDFSP DGALLATASY DTRVYIWDPH NGDILMEFGH 
       160        170        180        190        200
LFPPPTPIFA GGANDRWVRS VSFSHDGLHV ASLADDKMVR FWRIDEDYPV 
       210        220        230        240        250
QVAPLSNGLC CAFSTDGSVL AAGTHDGSVY FWATPRQVPS LQHLCRMSIR 
       260        270 
RVMPTQEVQE LPIPSKLLEF LSYRI

Show »

Length:275

Mass (Da):30,883

Checksum:ⁱ8F3B7D4C581CBD3D

GO

Isoform 3 (identifier: Q9Y6I7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
239-244: FLWNMD → VAAILV
245-421: Missing.

« Hide

        10         20         30         40         50
MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA 
        60         70         80         90        100
WSQGHRTVKL VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR 
       110        120        130        140        150
EHIIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG 
       160        170        180        190        200
RIKIWDVYTG KLLLNLVDHT EVVRDLTFAP DGSLILVSAS RDKTLRVWDL 
       210        220        230        240 
KDDGNMMKVL RGHQNWVYSC AFSPDSSMLC SVGASKAVVA AILV

Show »

Length:244

Mass (Da):27,295

Checksum:ⁱE3D403F3CEB81109

GO

Isoform 4 (identifier: Q9Y6I7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-35: MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGR → MLNIILIKFSSFSIRCAILSSVCLNEAITFAFLLQ
36-237: Missing.

« Hide

        10         20         30         40         50
MLNIILIKFS SFSIRCAILS SVCLNEAITF AFLLQVFLWN MDKYTMIRKL 
        60         70         80         90        100
EGHHHDVVAC DFSPDGALLA TASYDTRVYI WDPHNGDILM EFGHLFPPPT 
       110        120        130        140        150
PIFAGGANDR WVRSVSFSHD GLHVASLADD KMVRFWRIDE DYPVQVAPLS 
       160        170        180        190        200
NGLCCAFSTD GSVLAAGTHD GSVYFWATPR QVPSLQHLCR MSIRRVMPTQ 
       210 
EVQELPIPSK LLEFLSYRI

Show »

Length:219

Mass (Da):24,724

Checksum:ⁱ832E6744DD6F23DC

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KT03	J3KT03_HUMAN	WD repeat and SOCS box-containing p... WD repeat and SOCS box-containing protein 1	WSB1	207	Annotation score:
B4DGB8	B4DGB8_HUMAN	cDNA FLJ58059, highly similar to WD... cDNA FLJ58059, highly similar to WD repeat and SOCS box-containing protein 1	WSB1	213	Annotation score:
B4DTL1	B4DTL1_HUMAN	cDNA FLJ59301, highly similar to WD... cDNA FLJ59301, highly similar to WD repeat and SOCS box-containing protein 1	WSB1	247	Annotation score:
J3KTB3	J3KTB3_HUMAN	WD repeat and SOCS box-containing p... WD repeat and SOCS box-containing protein 1	WSB1	143	Annotation score:
J3KRG6	J3KRG6_HUMAN	WD repeat and SOCS box-containing p... WD repeat and SOCS box-containing protein 1	WSB1	98	Annotation score:
J3KSQ3	J3KSQ3_HUMAN	WD repeat and SOCS box-containing p... WD repeat and SOCS box-containing protein 1	WSB1	54	Annotation score:
J3QLM8	J3QLM8_HUMAN	WD repeat and SOCS box-containing p... WD repeat and SOCS box-containing protein 1	WSB1	74	Annotation score:
J3KS88	J3KS88_HUMAN	WD repeat and SOCS box-containing p... WD repeat and SOCS box-containing protein 1	WSB1	78	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	149	N → S in CAB53708 (PubMed:17974005).Curated	1
Sequence conflictⁱ	171	E → G in CAB53708 (PubMed:17974005).Curated	1
Sequence conflictⁱ	178	F → L in AAD43036 (Ref. 6) Curated	1
Sequence conflictⁱ	201	K → R in CAB53708 (PubMed:17974005).Curated	1
Sequence conflictⁱ	231	S → P in AAD43036 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024701	16	L → S2 PublicationsCorresponds to variant dbSNP:rs6561Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053402	1 – 35	MASFP…KKCGR → MLNIILIKFSSFSIRCAILS SVCLNEAITFAFLLQ in isoform 4. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_006792	14 – 159	Missing in isoform 2. 1 PublicationAdd BLAST	146
Alternative sequenceⁱVSP_053403	36 – 237	Missing in isoform 4. 1 PublicationAdd BLAST	202
Alternative sequenceⁱVSP_039111	239 – 244	FLWNMD → VAAILV in isoform 3. 1 Publication	6
Alternative sequenceⁱVSP_039112	245 – 421	Missing in isoform 3. 1 PublicationAdd BLAST	177

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF072880 mRNA Translation: AAD28808.1 AF106684 mRNA Translation: AAD43037.1 AF069313 mRNA Translation: AAD20954.2 AF240696 mRNA Translation: AAF82746.1 AL110243 mRNA Translation: CAB53693.1 AF112205 mRNA Translation: AAF17193.1 AF106683 mRNA Translation: AAD43036.1 AL110269 mRNA Translation: CAB53708.2 BC021110 mRNA Translation: AAH21110.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11220.1 [Q9Y6I7-1] CCDS11221.1 [Q9Y6I7-2]
PIRⁱ	T14773 T14788
NCBI Reference Sequences More...RefSeqⁱ	NP_056441.6, NM_015626.9 [Q9Y6I7-1] NP_599027.1, NM_134265.3 [Q9Y6I7-2] XP_016879924.1, XM_017024435.1 [Q9Y6I7-4] XP_016879925.1, XM_017024436.1 [Q9Y6I7-4]
UniGeneⁱ	Hs.446017 Hs.655024

Genome annotation databases

Ensemblⁱ	ENST00000262394; ENSP00000262394; ENSG00000109046 [Q9Y6I7-1] ENST00000348811; ENSP00000327055; ENSG00000109046 [Q9Y6I7-2]
GeneIDⁱ	26118
KEGGⁱ	hsa:26118
UCSC genome browser More...UCSCⁱ	uc002gzd.2 human [Q9Y6I7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6I7	WD repeat and SOCS box-containing 1, isoform CRA_b		HUMAN		421	UniRef100_Q9Y6I7
UPI000387D291		HUMAN		216
Q9Y6I7-2	WD repeat and SOCS box-containing 1, isoform CRA_c		HUMAN		275	UniRef100_A0A024QZ36
WSB1 isoform 13		PONAB		275
WD repeat and SOCS box-containing protein 1 (Fragment)		HUMAN		143
WSB1 isoform 15 (Fragment)		PONAB		143
Q9Y6I7-4	WSB1 protein (Fragment)		HUMAN		193	UniRef100_Q9Y6I7-4

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6I7	WD repeat and SOCS box-containing 1, isoform CRA_b		HUMAN		421	UniRef90_Q9Y6I7
WD repeat and SOCS box-containing protein 1		MYOBR		478
WD repeat and SOCS box-containing protein 1		MYODS		459
Uncharacterized protein		Cebus capucinus imitator		428
WD repeat and SOCS box containing 1		SAIBB		422
+127
Q9Y6I7-2	Uncharacterized protein		MACMU		275	UniRef90_F6V1X6
Uncharacterized protein		PAPAN		275
Uncharacterized protein		MACFA		275
WD repeat and SOCS box-containing 1, isoform CRA_c		HUMAN		275
WSB1 isoform 13		PONAB		275
+28
Q9Y6I7-3	cDNA FLJ59301, highly similar to WD repeat and SOCS box-containing protein 1		HUMAN		247	UniRef90_Q9Y6I7-3
WSB1 isoform 10		PONAB		247
WSB1 isoform 10		PANTR		247
Uncharacterized protein		PIG		247
Putative wd repeat and socs box-containing protein 1		DESRO		247
+48
Q9Y6I7-4	WSB1 protein (Fragment)		HUMAN		193	UniRef90_Q9Y6I7-4
WD repeat and SOCS box-containing 1		MOUSE		179
UPI00072EC57D		ACIJB		215
UPI00076638F0		PANTA		215
UPI000B4E8963		MERUN		186

Protein	Similar proteins		Species	Score	Length	Source
Q9Y6I7	WD repeat and SOCS box-containing protein 1		MOUSE		421	UniRef50_Q9Y6I7
WD repeat and SOCS box-containing protein 1		XENTR		422
WD repeat and SOCS box-containing 1, isoform CRA_b		HUMAN		421
WD repeat and SOCS box-containing protein 1		MYOBR		478
WD repeat and SOCS box-containing protein 1		MYODS		459
+282
Q9Y6I7-2	Uncharacterized protein		MACMU		275	UniRef50_F6V1X6
Uncharacterized protein		PAPAN		275
Uncharacterized protein		MACFA		275
WD repeat and SOCS box-containing protein 1 isoform X2		LIPVE		275
Uncharacterized protein		MACNE		275
+31
Q9Y6I7-3	Uncharacterized protein		PIG		247	UniRef50_Q9Y6I7-3
cDNA FLJ59301, highly similar to WD repeat and SOCS box-containing protein 1		HUMAN		247
WSB1 isoform 10		PANTR		247
WSB1 isoform 10		PONAB		247
Putative wd repeat and socs box-containing protein 1		DESRO		247
+64
Q9Y6I7-4	WSB1 protein (Fragment)		HUMAN		193	UniRef50_Q9Y6I7-4
WD repeat and SOCS box-containing 1		MOUSE		179
UPI00076638F0		PANTA		215
UPI00072EC57D		ACIJB		215
UPI000B4E8963		MERUN		186
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF072880 mRNA Translation: AAD28808.1 AF106684 mRNA Translation: AAD43037.1 AF069313 mRNA Translation: AAD20954.2 AF240696 mRNA Translation: AAF82746.1 AL110243 mRNA Translation: CAB53693.1 AF112205 mRNA Translation: AAF17193.1 AF106683 mRNA Translation: AAD43036.1 AL110269 mRNA Translation: CAB53708.2 BC021110 mRNA Translation: AAH21110.1
CCDSⁱ	CCDS11220.1 [Q9Y6I7-1] CCDS11221.1 [Q9Y6I7-2]
PIRⁱ	T14773 T14788
RefSeqⁱ	NP_056441.6, NM_015626.9 [Q9Y6I7-1] NP_599027.1, NM_134265.3 [Q9Y6I7-2] XP_016879924.1, XM_017024435.1 [Q9Y6I7-4] XP_016879925.1, XM_017024436.1 [Q9Y6I7-4]
UniGeneⁱ	Hs.446017 Hs.655024

3D structure databases

ProteinModelPortalⁱ	Q9Y6I7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117560, 16 interactors
CORUMⁱ	Q9Y6I7
IntActⁱ	Q9Y6I7, 6 interactors
MINTⁱ	Q9Y6I7
STRINGⁱ	9606.ENSP00000262394

PTM databases

iPTMnetⁱ	Q9Y6I7
PhosphoSitePlusⁱ	Q9Y6I7

Polymorphism and mutation databases

BioMutaⁱ	WSB1
DMDMⁱ	20532298

Proteomic databases

EPDⁱ	Q9Y6I7
PaxDbⁱ	Q9Y6I7
PeptideAtlasⁱ	Q9Y6I7
PRIDEⁱ	Q9Y6I7
ProteomicsDBⁱ	86693 86694 [Q9Y6I7-2] 86695 [Q9Y6I7-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26118
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262394; ENSP00000262394; ENSG00000109046 [Q9Y6I7-1] ENST00000348811; ENSP00000327055; ENSG00000109046 [Q9Y6I7-2]
GeneIDⁱ	26118
KEGGⁱ	hsa:26118
UCSCⁱ	uc002gzd.2 human [Q9Y6I7-1]

Organism-specific databases

CTDⁱ	26118
DisGeNETⁱ	26118
EuPathDBⁱ	HostDB:ENSG00000109046.14
GeneCardsⁱ	WSB1
HGNCⁱ	HGNC:19221 WSB1
HPAⁱ	HPA003293
MIMⁱ	610091 gene
neXtProtⁱ	NX_Q9Y6I7
OpenTargetsⁱ	ENSG00000109046
PharmGKBⁱ	PA134867554
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ0Y Eukaryota ENOG411010D LUCA
GeneTreeⁱ	ENSGT00890000139406
HOGENOMⁱ	HOG000063727
HOVERGENⁱ	HBG070207
InParanoidⁱ	Q9Y6I7
KOⁱ	K10341
OMAⁱ	GHHNDVV
OrthoDBⁱ	EOG091G06GY
PhylomeDBⁱ	Q9Y6I7
TreeFamⁱ	TF329216

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q9Y6I7
SIGNORⁱ	Q9Y6I7

Miscellaneous databases

ChiTaRSⁱ	WSB1 human
GeneWikiⁱ	WSB1
GenomeRNAiⁱ	26118
Protein Ontology More...PROⁱ	PR:Q9Y6I7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109046 Expressed in 235 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_WSB1
ExpressionAtlasⁱ	Q9Y6I7 baseline and differential
Genevisibleⁱ	Q9Y6I7 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF07525 SOCS_box, 1 hit PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit SM00320 WD40, 6 hits
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50225 SOCS, 1 hit PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 6 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WSB1_HUMAN
Accessionⁱ	Q9Y6I7Primary (citable) accession number: Q9Y6I7 Secondary accession number(s): Q9NRB1 , Q9UBH9, Q9UG25, Q9UNN6, Q9Y656
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q9Y6I7 (WSB1_HUMAN)

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WD repeat and SOCS box-containing protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ