UniProtKB - Q9Y6H3 (ATP23_HUMAN)
Protein
Mitochondrial inner membrane protease ATP23 homolog
Gene
ATP23
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 125 | Divalent metal cation; catalyticBy similarity | 1 | |
Active sitei | 126 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 129 | Divalent metal cation; catalyticBy similarity | 1 |
GO - Molecular functioni
- DNA-dependent protein kinase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
GO - Biological processi
- double-strand break repair via nonhomologous end joining Source: UniProtKB
- mitochondrial protein processing Source: GO_Central
- mitochondrial proton-transporting ATP synthase complex assembly Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6H3 |
Protein family/group databases
MEROPSi | M76.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial inner membrane protease ATP23 homolog (EC:3.4.24.-)Alternative name(s): Ku70-binding protein 3 XRCC6-binding protein 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166896.7 |
HGNCi | HGNC:29452, ATP23 |
neXtProti | NX_Q9Y6H3 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Mitochondrion
- extrinsic component of mitochondrial inner membrane Source: GO_Central
Nucleus
- DNA-dependent protein kinase-DNA ligase 4 complex Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell junction Source: HPA
- intracellular membrane-bounded organelle Source: HPA
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 91419 |
OpenTargetsi | ENSG00000166896 |
PharmGKBi | PA142670557 |
Miscellaneous databases
Pharosi | Q9Y6H3, Tdark |
Polymorphism and mutation databases
BioMutai | ATP23 |
DMDMi | 224471894 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000330344 | 1 – 246 | Mitochondrial inner membrane protease ATP23 homologAdd BLAST | 246 |
Proteomic databases
EPDi | Q9Y6H3 |
jPOSTi | Q9Y6H3 |
MassIVEi | Q9Y6H3 |
MaxQBi | Q9Y6H3 |
PaxDbi | Q9Y6H3 |
PeptideAtlasi | Q9Y6H3 |
PRIDEi | Q9Y6H3 |
ProteomicsDBi | 86679 |
PTM databases
iPTMneti | Q9Y6H3 |
PhosphoSitePlusi | Q9Y6H3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166896, Expressed in right testis and 185 other tissues |
ExpressionAtlasi | Q9Y6H3, baseline and differential |
Genevisiblei | Q9Y6H3, HS |
Organism-specific databases
HPAi | ENSG00000166896, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with XRCC6.
1 PublicationBinary interactionsi
Hide detailsQ9Y6H3
Protein-protein interaction databases
BioGRIDi | 124830, 48 interactors |
IntActi | Q9Y6H3, 36 interactors |
STRINGi | 9606.ENSP00000300145 |
Miscellaneous databases
RNActi | Q9Y6H3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase M76 family.Curated
Phylogenomic databases
eggNOGi | KOG3314, Eukaryota |
GeneTreei | ENSGT00390000010948 |
HOGENOMi | CLU_079125_1_0_1 |
InParanoidi | Q9Y6H3 |
OMAi | VDHLACT |
OrthoDBi | 1288109at2759 |
PhylomeDBi | Q9Y6H3 |
TreeFami | TF327014 |
Family and domain databases
InterProi | View protein in InterPro IPR019165, Peptidase_M76_ATP23 |
PANTHERi | PTHR21711, PTHR21711, 1 hit |
Pfami | View protein in Pfam PF09768, Peptidase_M76, 1 hit |
PROSITEi | View protein in PROSITE PS00142, ZINC_PROTEASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y6H3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGAPDERRR GPAAGEQLQQ QHVSCQVFPE RLAQGNPQQG FFSSFFTSNQ
60 70 80 90 100
KCQLRLLKTL ETNPYVKLLL DAMKHSGCAV NKDRHFSCED CNGNVSGGFD
110 120 130 140 150
ASTSQIVLCQ NNIHNQAHMN RVVTHELIHA FDHCRAHVDW FTNIRHLACS
160 170 180 190 200
EVRAANLSGD CSLVNEIFRL HFGLKQHHQT CVRDRATLSI LAVRNISKEV
210 220 230 240
AKKAVDEVFE SCFNDHEPFG RIPHNKTYAR YAHRDFENRD RYYSNI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YIJ9 | H0YIJ9_HUMAN | Mitochondrial inner membrane protea... | ATP23 | 37 | Annotation score: |
Sequence cautioni
The sequence AAD31085 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054489 | 48 | S → C1 PublicationCorresponds to variant dbSNP:rs3751325Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF078164 mRNA Translation: AAD31085.1 Different initiation. AC084033 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97091.1 BC012776 mRNA Translation: AAH12776.3 BC115381 mRNA Translation: AAI15382.1 BC115382 mRNA Translation: AAI15383.1 |
CCDSi | CCDS41802.1 |
RefSeqi | NP_001307337.1, NM_001320408.1 NP_001307338.1, NM_001320409.1 NP_001307339.1, NM_001320410.1 NP_150592.1, NM_033276.3 |
Genome annotation databases
Ensembli | ENST00000300145; ENSP00000300145; ENSG00000166896 ENST00000571490; ENSP00000460944; ENSG00000262145 |
GeneIDi | 91419 |
KEGGi | hsa:91419 |
UCSCi | uc001sqp.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF078164 mRNA Translation: AAD31085.1 Different initiation. AC084033 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97091.1 BC012776 mRNA Translation: AAH12776.3 BC115381 mRNA Translation: AAI15382.1 BC115382 mRNA Translation: AAI15383.1 |
CCDSi | CCDS41802.1 |
RefSeqi | NP_001307337.1, NM_001320408.1 NP_001307338.1, NM_001320409.1 NP_001307339.1, NM_001320410.1 NP_150592.1, NM_033276.3 |
3D structure databases
SMRi | Q9Y6H3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124830, 48 interactors |
IntActi | Q9Y6H3, 36 interactors |
STRINGi | 9606.ENSP00000300145 |
Protein family/group databases
MEROPSi | M76.001 |
PTM databases
iPTMneti | Q9Y6H3 |
PhosphoSitePlusi | Q9Y6H3 |
Polymorphism and mutation databases
BioMutai | ATP23 |
DMDMi | 224471894 |
Proteomic databases
EPDi | Q9Y6H3 |
jPOSTi | Q9Y6H3 |
MassIVEi | Q9Y6H3 |
MaxQBi | Q9Y6H3 |
PaxDbi | Q9Y6H3 |
PeptideAtlasi | Q9Y6H3 |
PRIDEi | Q9Y6H3 |
ProteomicsDBi | 86679 |
Protocols and materials databases
Antibodypediai | 28994, 90 antibodies |
DNASUi | 91419 |
Genome annotation databases
Ensembli | ENST00000300145; ENSP00000300145; ENSG00000166896 ENST00000571490; ENSP00000460944; ENSG00000262145 |
GeneIDi | 91419 |
KEGGi | hsa:91419 |
UCSCi | uc001sqp.4, human |
Organism-specific databases
CTDi | 91419 |
DisGeNETi | 91419 |
EuPathDBi | HostDB:ENSG00000166896.7 |
GeneCardsi | ATP23 |
HGNCi | HGNC:29452, ATP23 |
HPAi | ENSG00000166896, Tissue enhanced (testis) |
neXtProti | NX_Q9Y6H3 |
OpenTargetsi | ENSG00000166896 |
PharmGKBi | PA142670557 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3314, Eukaryota |
GeneTreei | ENSGT00390000010948 |
HOGENOMi | CLU_079125_1_0_1 |
InParanoidi | Q9Y6H3 |
OMAi | VDHLACT |
OrthoDBi | 1288109at2759 |
PhylomeDBi | Q9Y6H3 |
TreeFami | TF327014 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6H3 |
Miscellaneous databases
BioGRID-ORCSi | 91419, 51 hits in 846 CRISPR screens |
ChiTaRSi | ATP23, human |
GenomeRNAii | 91419 |
Pharosi | Q9Y6H3, Tdark |
PROi | PR:Q9Y6H3 |
RNActi | Q9Y6H3, protein |
Gene expression databases
Bgeei | ENSG00000166896, Expressed in right testis and 185 other tissues |
ExpressionAtlasi | Q9Y6H3, baseline and differential |
Genevisiblei | Q9Y6H3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019165, Peptidase_M76_ATP23 |
PANTHERi | PTHR21711, PTHR21711, 1 hit |
Pfami | View protein in Pfam PF09768, Peptidase_M76, 1 hit |
PROSITEi | View protein in PROSITE PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATP23_HUMAN | |
Accessioni | Q9Y6H3Primary (citable) accession number: Q9Y6H3 Secondary accession number(s): Q1RLM4, Q96E81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries