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Protein

39S ribosomal protein L42, mitochondrial

Gene

MRPL42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Has also been found in a preparation of mitochondrial small ribosomal subunits. Was erroneously (PubMed:11279123, PubMed:11551941) assigned to be MRP-S32.2 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L42, mitochondrial1 Publication
Short name:
L42mt
Short name:
MRP-L42
Alternative name(s):
39S ribosomal protein L31, mitochondrialBy similarity
Short name:
L31mt
Short name:
MRP-L31
Mitochondrial large ribosomal subunit protein mL421 Publication
Gene namesi
Name:MRPL42
Synonyms:MRPL31, MRPS32, RPML31
ORF Names:HSPC204, PTD007
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198015.12
HGNCiHGNC:14493 MRPL42
MIMi611847 gene
neXtProtiNX_Q9Y6G3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198015
PharmGKBiPA30974

Polymorphism and mutation databases

BioMutaiMRPL42
DMDMi24212391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionBy similarityAdd BLAST32
ChainiPRO_000008772433 – 14239S ribosomal protein L42, mitochondrialAdd BLAST110

Proteomic databases

EPDiQ9Y6G3
MaxQBiQ9Y6G3
PaxDbiQ9Y6G3
PeptideAtlasiQ9Y6G3
PRIDEiQ9Y6G3
ProteomicsDBi86675
TopDownProteomicsiQ9Y6G3

PTM databases

iPTMnetiQ9Y6G3
PhosphoSitePlusiQ9Y6G3

Expressioni

Gene expression databases

BgeeiENSG00000198015 Expressed in 222 organ(s), highest expression level in adrenal tissue
CleanExiHS_MRPL42
ExpressionAtlasiQ9Y6G3 baseline and differential
GenevisibleiQ9Y6G3 HS

Organism-specific databases

HPAiHPA039398

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi118800, 84 interactors
CORUMiQ9Y6G3
IntActiQ9Y6G3, 8 interactors
STRINGi9606.ENSP00000447547

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y6G3
SMRiQ9Y6G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4106 Eukaryota
ENOG4111TTH LUCA
GeneTreeiENSGT00390000010491
HOGENOMiHOG000293154
HOVERGENiHBG023706
InParanoidiQ9Y6G3
KOiK17423
OMAiMQLTHTT
PhylomeDBiQ9Y6G3
TreeFamiTF324368

Family and domain databases

InterProiView protein in InterPro
IPR019346 Ribosomal-S32_mit
PANTHERiPTHR13450 PTHR13450, 1 hit
PfamiView protein in Pfam
PF10210 MRP-S32, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9Y6G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA
60 70 80 90 100
LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHDQ VLKTRLEEKV
110 120 130 140
EHLEEGPMIE QLSKMFFTTK HRWYPHGRYH RCRKNLNPPK DR
Length:142
Mass (Da):16,661
Last modified:November 1, 1999 - v1
Checksum:iAED9ECFA653F870A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2Z7S4R2Z7_HUMAN
39S ribosomal protein L42, mitochon...
MRPL42
155Annotation score:
S4R360S4R360_HUMAN
39S ribosomal protein L42, mitochon...
MRPL42
128Annotation score:
J3KPP0J3KPP0_HUMAN
39S ribosomal protein L42, mitochon...
MRPL42
139Annotation score:
F8VVR0F8VVR0_HUMAN
39S ribosomal protein L42, mitochon...
MRPL42
53Annotation score:
J3KP21J3KP21_HUMAN
39S ribosomal protein L42, mitochon...
MRPL42
51Annotation score:

Sequence cautioni

The sequence AAF36124 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078860 mRNA Translation: AAD44492.1
AF135160 mRNA Translation: AAF43784.1
AF151038 mRNA Translation: AAF36124.1 Frameshift.
AL136659 mRNA Translation: CAB66594.1
AK000285 mRNA Translation: BAA91054.1
CR533495 mRNA Translation: CAG38526.1
CH471054 Genomic DNA Translation: EAW97484.1
BC040240 mRNA Translation: AAH40240.1
AB051626 Genomic DNA Translation: BAB54953.1
CCDSiCCDS9045.1
RefSeqiNP_054769.1, NM_014050.3
NP_751917.1, NM_172177.3
UniGeneiHs.199579

Genome annotation databases

EnsembliENST00000549561; ENSP00000449392; ENSG00000198015
ENST00000549982; ENSP00000449884; ENSG00000198015
ENST00000552217; ENSP00000447547; ENSG00000198015
GeneIDi28977
KEGGihsa:28977
UCSCiuc001tcr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078860 mRNA Translation: AAD44492.1
AF135160 mRNA Translation: AAF43784.1
AF151038 mRNA Translation: AAF36124.1 Frameshift.
AL136659 mRNA Translation: CAB66594.1
AK000285 mRNA Translation: BAA91054.1
CR533495 mRNA Translation: CAG38526.1
CH471054 Genomic DNA Translation: EAW97484.1
BC040240 mRNA Translation: AAH40240.1
AB051626 Genomic DNA Translation: BAB54953.1
CCDSiCCDS9045.1
RefSeqiNP_054769.1, NM_014050.3
NP_751917.1, NM_172177.3
UniGeneiHs.199579

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40a1-142[»]
3J9Melectron microscopy3.50a1-142[»]
5OOLelectron microscopy3.06a1-142[»]
5OOMelectron microscopy3.03a1-142[»]
ProteinModelPortaliQ9Y6G3
SMRiQ9Y6G3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118800, 84 interactors
CORUMiQ9Y6G3
IntActiQ9Y6G3, 8 interactors
STRINGi9606.ENSP00000447547

PTM databases

iPTMnetiQ9Y6G3
PhosphoSitePlusiQ9Y6G3

Polymorphism and mutation databases

BioMutaiMRPL42
DMDMi24212391

Proteomic databases

EPDiQ9Y6G3
MaxQBiQ9Y6G3
PaxDbiQ9Y6G3
PeptideAtlasiQ9Y6G3
PRIDEiQ9Y6G3
ProteomicsDBi86675
TopDownProteomicsiQ9Y6G3

Protocols and materials databases

DNASUi28977
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000549561; ENSP00000449392; ENSG00000198015
ENST00000549982; ENSP00000449884; ENSG00000198015
ENST00000552217; ENSP00000447547; ENSG00000198015
GeneIDi28977
KEGGihsa:28977
UCSCiuc001tcr.4 human

Organism-specific databases

CTDi28977
EuPathDBiHostDB:ENSG00000198015.12
GeneCardsiMRPL42
HGNCiHGNC:14493 MRPL42
HPAiHPA039398
MIMi611847 gene
neXtProtiNX_Q9Y6G3
OpenTargetsiENSG00000198015
PharmGKBiPA30974
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4106 Eukaryota
ENOG4111TTH LUCA
GeneTreeiENSGT00390000010491
HOGENOMiHOG000293154
HOVERGENiHBG023706
InParanoidiQ9Y6G3
KOiK17423
OMAiMQLTHTT
PhylomeDBiQ9Y6G3
TreeFamiTF324368

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL42 human
GeneWikiiMitochondrial_ribosomal_protein_L42
GenomeRNAii28977
PROiPR:Q9Y6G3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198015 Expressed in 222 organ(s), highest expression level in adrenal tissue
CleanExiHS_MRPL42
ExpressionAtlasiQ9Y6G3 baseline and differential
GenevisibleiQ9Y6G3 HS

Family and domain databases

InterProiView protein in InterPro
IPR019346 Ribosomal-S32_mit
PANTHERiPTHR13450 PTHR13450, 1 hit
PfamiView protein in Pfam
PF10210 MRP-S32, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM42_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G3
Secondary accession number(s): Q6FID1, Q96Q48, Q9P0S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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