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Protein

Transmembrane protein 14A

Gene

TMEM14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14A
Gene namesi
Name:TMEM14A
Synonyms:C6orf73
ORF Names:PTD011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000096092.5
HGNCiHGNC:21076 TMEM14A
neXtProtiNX_Q9Y6G1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000096092
PharmGKBiPA134974524

Polymorphism and mutation databases

BioMutaiTMEM14A
DMDMi9910842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211691 – 99Transmembrane protein 14AAdd BLAST99

Proteomic databases

PaxDbiQ9Y6G1
PeptideAtlasiQ9Y6G1
PRIDEiQ9Y6G1
ProteomicsDBi86673
TopDownProteomicsiQ9Y6G1

PTM databases

iPTMnetiQ9Y6G1
PhosphoSitePlusiQ9Y6G1

Expressioni

Tissue specificityi

Expressed at significantly higher levels in ovarian cancer tissues than in normal tissues (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000096092
CleanExiHS_TMEM14A
GenevisibleiQ9Y6G1 HS

Organism-specific databases

HPAiHPA072536

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LXNQ9BS403EBI-2800360,EBI-1044504

Protein-protein interaction databases

BioGridi118801, 8 interactors
IntActiQ9Y6G1, 30 interactors
MINTiQ9Y6G1

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 19Combined sources14
Helixi29 – 46Combined sources18
Beta strandi47 – 49Combined sources3
Helixi54 – 67Combined sources14
Beta strandi73 – 80Combined sources8
Helixi81 – 94Combined sources14

3D structure databases

ProteinModelPortaliQ9Y6G1
SMRiQ9Y6G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267 Eukaryota
ENOG4112205 LUCA
GeneTreeiENSGT00390000013475
HOGENOMiHOG000211932
HOVERGENiHBG054211
InParanoidiQ9Y6G1
OMAiMGMRFKR
OrthoDBiEOG091G0XXJ
PhylomeDBiQ9Y6G1
TreeFamiTF323345

Family and domain databases

InterProiView protein in InterPro
IPR005349 TMEM14
PANTHERiPTHR12668 PTHR12668, 1 hit
PfamiView protein in Pfam
PF03647 Tmemb_14, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK
60 70 80 90
RDVKVSLFTA FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLL
Length:99
Mass (Da):10,712
Last modified:November 1, 1999 - v1
Checksum:iD41CBB95241969B3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05249737C → R. Corresponds to variant dbSNP:rs11543266Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078864 mRNA Translation: AAD44496.1
AF239771 mRNA Translation: AAF59948.1
AK312063 mRNA Translation: BAG34999.1
AL109918 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04380.1
BC015097 mRNA Translation: AAH15097.1
BC019328 mRNA Translation: AAH19328.1
CCDSiCCDS4943.1
RefSeqiNP_054770.1, NM_014051.3
UniGeneiHs.94896

Genome annotation databases

EnsembliENST00000211314; ENSP00000211314; ENSG00000096092
GeneIDi28978
KEGGihsa:28978
UCSCiuc003pax.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM14A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G1
Secondary accession number(s): B2R552
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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