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UniProtKB - Q9Y6F9 (WNT6_HUMAN)
Protein
Protein Wnt-6
Gene
WNT6
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
1 PublicationGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
GO - Biological processi
- axis specification Source: Ensembl
- branching involved in ureteric bud morphogenesis Source: Ensembl
- canonical Wnt signaling pathway Source: GO_Central
- cell fate commitment Source: GO_Central
- cellular response to retinoic acid Source: UniProtKB
- cornea development in camera-type eye Source: BHF-UCL
- epithelial-mesenchymal cell signaling Source: Ensembl
- nephron tubule formation Source: Ensembl
- neuron differentiation Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: BHF-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of tooth mineralization Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6F9 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | Q9Y6F9 |
SIGNORi | Q9Y6F9 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-6 |
Gene namesi | Name:WNT6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12785, WNT6 |
MIMi | 604663, gene |
neXtProti | NX_Q9Y6F9 |
VEuPathDBi | HostDB:ENSG00000115596 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: Reactome
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: Ensembl
- endocytic vesicle membrane Source: Reactome
- extracellular matrix Source: Ensembl
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 7475 |
OpenTargetsi | ENSG00000115596 |
PharmGKBi | PA37386 |
Miscellaneous databases
Pharosi | Q9Y6F9, Tbio |
Genetic variation databases
BioMutai | WNT6 |
DMDMi | 14424016 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000041440 | 25 – 365 | Protein Wnt-6Add BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 76 ↔ 87 | By similarity | ||
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 124 ↔ 132 | By similarity | ||
Disulfide bondi | 134 ↔ 172 | By similarity | ||
Disulfide bondi | 222 ↔ 236 | By similarity | ||
Disulfide bondi | 224 ↔ 231 | By similarity | ||
Lipidationi | 228 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Disulfide bondi | 294 ↔ 325 | By similarity | ||
Disulfide bondi | 310 ↔ 320 | By similarity | ||
Glycosylationi | 311 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 324 ↔ 364 | By similarity | ||
Disulfide bondi | 340 ↔ 355 | By similarity | ||
Disulfide bondi | 342 ↔ 352 | By similarity | ||
Disulfide bondi | 347 ↔ 348 | By similarity |
Post-translational modificationi
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
MassIVEi | Q9Y6F9 |
PaxDbi | Q9Y6F9 |
PeptideAtlasi | Q9Y6F9 |
PRIDEi | Q9Y6F9 |
ProteomicsDBi | 86672 |
PTM databases
GlyGeni | Q9Y6F9, 2 sites |
iPTMneti | Q9Y6F9 |
PhosphoSitePlusi | Q9Y6F9 |
Expressioni
Tissue specificityi
Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000115596, Expressed in zone of skin and 115 other tissues |
Genevisiblei | Q9Y6F9, HS |
Organism-specific databases
HPAi | ENSG00000115596, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PORCN.
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113312, 12 interactors |
STRINGi | 9606.ENSP00000233948 |
Miscellaneous databases
RNActi | Q9Y6F9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 140 – 164 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 142 – 159 | Pro residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the Wnt family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000159281 |
HOGENOMi | CLU_033039_1_3_1 |
InParanoidi | Q9Y6F9 |
OMAi | EQTNCKC |
OrthoDBi | 624528at2759 |
PhylomeDBi | Q9Y6F9 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009143, Wnt6 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01845, WNT6PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9Y6F9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR
60 70 80 90 100
QAELCQAEPE VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ
110 120 130 140 150
DIRETAFVFA ITAAGASHAV TQACSMGELL QCGCQAPRGR APPRPSGLPG
160 170 180 190 200
TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD EKSRLFMDAR HKRGRGDIRA
210 220 230 240 250
LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL PPFREVGARL
260 270 280 290 300
LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT
310 320 330 340 350
GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV
360
QCHRCRVRKE LSLCL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY009401 mRNA Translation: AAG38661.1 AB059570 mRNA Translation: BAB55603.1 BT007456 mRNA Translation: AAP36124.1 BC004329 mRNA Translation: AAH04329.1 AF315943 Genomic DNA Translation: AAG45154.1 AF079522 Genomic DNA Translation: AAD41674.1 |
CCDSi | CCDS2425.1 |
PIRi | JC7694 |
RefSeqi | NP_006513.1, NM_006522.3 |
Genome annotation databases
Ensembli | ENST00000233948.4; ENSP00000233948.3; ENSG00000115596.4 |
GeneIDi | 7475 |
KEGGi | hsa:7475 |
MANE-Selecti | ENST00000233948.4; ENSP00000233948.3; NM_006522.4; NP_006513.1 |
UCSCi | uc002vjc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY009401 mRNA Translation: AAG38661.1 AB059570 mRNA Translation: BAB55603.1 BT007456 mRNA Translation: AAP36124.1 BC004329 mRNA Translation: AAH04329.1 AF315943 Genomic DNA Translation: AAG45154.1 AF079522 Genomic DNA Translation: AAD41674.1 |
CCDSi | CCDS2425.1 |
PIRi | JC7694 |
RefSeqi | NP_006513.1, NM_006522.3 |
3D structure databases
AlphaFoldDBi | Q9Y6F9 |
SMRi | Q9Y6F9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113312, 12 interactors |
STRINGi | 9606.ENSP00000233948 |
PTM databases
GlyGeni | Q9Y6F9, 2 sites |
iPTMneti | Q9Y6F9 |
PhosphoSitePlusi | Q9Y6F9 |
Genetic variation databases
BioMutai | WNT6 |
DMDMi | 14424016 |
Proteomic databases
MassIVEi | Q9Y6F9 |
PaxDbi | Q9Y6F9 |
PeptideAtlasi | Q9Y6F9 |
PRIDEi | Q9Y6F9 |
ProteomicsDBi | 86672 |
Protocols and materials databases
Antibodypediai | 34291, 248 antibodies from 34 providers |
DNASUi | 7475 |
Genome annotation databases
Ensembli | ENST00000233948.4; ENSP00000233948.3; ENSG00000115596.4 |
GeneIDi | 7475 |
KEGGi | hsa:7475 |
MANE-Selecti | ENST00000233948.4; ENSP00000233948.3; NM_006522.4; NP_006513.1 |
UCSCi | uc002vjc.2, human |
Organism-specific databases
CTDi | 7475 |
DisGeNETi | 7475 |
GeneCardsi | WNT6 |
HGNCi | HGNC:12785, WNT6 |
HPAi | ENSG00000115596, Low tissue specificity |
MIMi | 604663, gene |
neXtProti | NX_Q9Y6F9 |
OpenTargetsi | ENSG00000115596 |
PharmGKBi | PA37386 |
VEuPathDBi | HostDB:ENSG00000115596 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000159281 |
HOGENOMi | CLU_033039_1_3_1 |
InParanoidi | Q9Y6F9 |
OMAi | EQTNCKC |
OrthoDBi | 624528at2759 |
PhylomeDBi | Q9Y6F9 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6F9 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | Q9Y6F9 |
SIGNORi | Q9Y6F9 |
Miscellaneous databases
BioGRID-ORCSi | 7475, 48 hits in 1067 CRISPR screens |
ChiTaRSi | WNT6, human |
GenomeRNAii | 7475 |
Pharosi | Q9Y6F9, Tbio |
PROi | PR:Q9Y6F9 |
RNActi | Q9Y6F9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115596, Expressed in zone of skin and 115 other tissues |
Genevisiblei | Q9Y6F9, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009143, Wnt6 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01845, WNT6PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT6_HUMAN | |
Accessioni | Q9Y6F9Primary (citable) accession number: Q9Y6F9 Secondary accession number(s): Q9H1J6, Q9H238 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 20, 2001 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families