UniProtKB - Q9Y6E2 (BZW2_HUMAN)
Protein
Basic leucine zipper and W2 domain-containing protein 2
Gene
BZW2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in neuronal differentiation.By similarity
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6E2 |
SIGNORi | Q9Y6E2 |
Names & Taxonomyi
Protein namesi | Recommended name: Basic leucine zipper and W2 domain-containing protein 2 |
Gene namesi | Name:BZW2 ORF Names:HSPC028, MSTP017 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18808, BZW2 |
neXtProti | NX_Q9Y6E2 |
VEuPathDBi | HostDB:ENSG00000136261.14 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 28969 |
OpenTargetsi | ENSG00000136261 |
PharmGKBi | PA38690 |
Miscellaneous databases
Pharosi | Q9Y6E2, Tbio |
Genetic variation databases
BioMutai | BZW2 |
DMDMi | 74762077 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254618 | 1 – 419 | Basic leucine zipper and W2 domain-containing protein 2Add BLAST | 419 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Modified residuei | 414 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y6E2 |
jPOSTi | Q9Y6E2 |
MassIVEi | Q9Y6E2 |
PaxDbi | Q9Y6E2 |
PeptideAtlasi | Q9Y6E2 |
PRIDEi | Q9Y6E2 |
ProteomicsDBi | 86659 [Q9Y6E2-1] |
PTM databases
iPTMneti | Q9Y6E2 |
MetOSitei | Q9Y6E2 |
PhosphoSitePlusi | Q9Y6E2 |
SwissPalmi | Q9Y6E2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136261, Expressed in chorionic villus and 250 other tissues |
ExpressionAtlasi | Q9Y6E2, baseline and differential |
Genevisiblei | Q9Y6E2, HS |
Organism-specific databases
HPAi | ENSG00000136261, Tissue enhanced (placenta, skeletal muscle) |
Interactioni
Binary interactionsi
Q9Y6E2
With | #Exp. | IntAct |
---|---|---|
EIF2S2 [P20042] | 2 | EBI-1051021,EBI-711977 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 118793, 90 interactors |
IntActi | Q9Y6E2, 39 interactors |
MINTi | Q9Y6E2 |
STRINGi | 9606.ENSP00000397249 |
Miscellaneous databases
RNActi | Q9Y6E2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 248 – 415 | W2PROSITE-ProRule annotationAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the BZW family.Curated
Phylogenomic databases
eggNOGi | KOG2297, Eukaryota |
GeneTreei | ENSGT00390000012561 |
HOGENOMi | CLU_032849_0_1_1 |
InParanoidi | Q9Y6E2 |
OMAi | EPFCNGP |
PhylomeDBi | Q9Y6E2 |
TreeFami | TF324313 |
Family and domain databases
CDDi | cd11560, W2_eIF5C_like, 1 hit |
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR016021, MIF4-like_sf IPR043510, W2_BZW1/2 IPR003307, W2_domain |
Pfami | View protein in Pfam PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y6E2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSETEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEEN
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ETZ4 | E7ETZ4_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 408 | Annotation score: | ||
B5MCE7 | B5MCE7_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 hCG_19293 | 225 | Annotation score: | ||
B5MCH7 | B5MCH7_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 343 | Annotation score: | ||
E7EMS9 | E7EMS9_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 208 | Annotation score: | ||
Q75MG1 | Q75MG1_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 274 | Annotation score: | ||
C9JF98 | C9JF98_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 162 | Annotation score: | ||
F8WDX8 | F8WDX8_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 170 | Annotation score: | ||
E9PFE3 | E9PFE3_HUMAN | Basic leucine zipper and W2 domain-... | BZW2 | 161 | Annotation score: | ||
E9PFD4 | E9PFD4_HUMAN | BZW2 protein | BZW2 | 189 | Annotation score: |
Sequence cautioni
The sequence AAI07758 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 203 | V → G in AAG39278 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033642 | 44 | D → A. Corresponds to variant dbSNP:rs35233079Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055568 | 182 – 201 | IAASF…EKDAN → NEAPVFSPVRQQKKNKVTDS in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_055569 | 202 – 419 | Missing in isoform 2. 1 PublicationAdd BLAST | 218 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110323 mRNA Translation: AAG39278.1 AF083246 mRNA Translation: AAD39844.1 AK001218 mRNA Translation: BAA91562.1 AK027837 mRNA Translation: BAB55401.1 CH236948 Genomic DNA Translation: EAL24285.1 CH471073 Genomic DNA Translation: EAW93675.1 CH471073 Genomic DNA Translation: EAW93678.1 BC003056 mRNA Translation: AAH03056.1 BC008453 mRNA Translation: AAH08453.1 BC009597 mRNA Translation: AAH09597.1 BC107757 mRNA Translation: AAI07758.1 Sequence problems. |
CCDSi | CCDS5362.1 [Q9Y6E2-1] |
RefSeqi | NP_001153239.1, NM_001159767.1 [Q9Y6E2-1] NP_054757.1, NM_014038.2 [Q9Y6E2-1] XP_006715769.1, XM_006715706.1 XP_006715770.1, XM_006715707.1 [Q9Y6E2-1] XP_006715771.1, XM_006715708.1 [Q9Y6E2-1] |
Genome annotation databases
Ensembli | ENST00000258761; ENSP00000258761; ENSG00000136261 [Q9Y6E2-1] ENST00000433922; ENSP00000397249; ENSG00000136261 [Q9Y6E2-1] |
GeneIDi | 28969 |
KEGGi | hsa:28969 |
UCSCi | uc003stj.3, human [Q9Y6E2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110323 mRNA Translation: AAG39278.1 AF083246 mRNA Translation: AAD39844.1 AK001218 mRNA Translation: BAA91562.1 AK027837 mRNA Translation: BAB55401.1 CH236948 Genomic DNA Translation: EAL24285.1 CH471073 Genomic DNA Translation: EAW93675.1 CH471073 Genomic DNA Translation: EAW93678.1 BC003056 mRNA Translation: AAH03056.1 BC008453 mRNA Translation: AAH08453.1 BC009597 mRNA Translation: AAH09597.1 BC107757 mRNA Translation: AAI07758.1 Sequence problems. |
CCDSi | CCDS5362.1 [Q9Y6E2-1] |
RefSeqi | NP_001153239.1, NM_001159767.1 [Q9Y6E2-1] NP_054757.1, NM_014038.2 [Q9Y6E2-1] XP_006715769.1, XM_006715706.1 XP_006715770.1, XM_006715707.1 [Q9Y6E2-1] XP_006715771.1, XM_006715708.1 [Q9Y6E2-1] |
3D structure databases
SMRi | Q9Y6E2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118793, 90 interactors |
IntActi | Q9Y6E2, 39 interactors |
MINTi | Q9Y6E2 |
STRINGi | 9606.ENSP00000397249 |
PTM databases
iPTMneti | Q9Y6E2 |
MetOSitei | Q9Y6E2 |
PhosphoSitePlusi | Q9Y6E2 |
SwissPalmi | Q9Y6E2 |
Genetic variation databases
BioMutai | BZW2 |
DMDMi | 74762077 |
Proteomic databases
EPDi | Q9Y6E2 |
jPOSTi | Q9Y6E2 |
MassIVEi | Q9Y6E2 |
PaxDbi | Q9Y6E2 |
PeptideAtlasi | Q9Y6E2 |
PRIDEi | Q9Y6E2 |
ProteomicsDBi | 86659 [Q9Y6E2-1] |
Protocols and materials databases
Antibodypediai | 11817, 99 antibodies |
DNASUi | 28969 |
Genome annotation databases
Ensembli | ENST00000258761; ENSP00000258761; ENSG00000136261 [Q9Y6E2-1] ENST00000433922; ENSP00000397249; ENSG00000136261 [Q9Y6E2-1] |
GeneIDi | 28969 |
KEGGi | hsa:28969 |
UCSCi | uc003stj.3, human [Q9Y6E2-1] |
Organism-specific databases
CTDi | 28969 |
DisGeNETi | 28969 |
GeneCardsi | BZW2 |
HGNCi | HGNC:18808, BZW2 |
HPAi | ENSG00000136261, Tissue enhanced (placenta, skeletal muscle) |
neXtProti | NX_Q9Y6E2 |
OpenTargetsi | ENSG00000136261 |
PharmGKBi | PA38690 |
VEuPathDBi | HostDB:ENSG00000136261.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2297, Eukaryota |
GeneTreei | ENSGT00390000012561 |
HOGENOMi | CLU_032849_0_1_1 |
InParanoidi | Q9Y6E2 |
OMAi | EPFCNGP |
PhylomeDBi | Q9Y6E2 |
TreeFami | TF324313 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6E2 |
SIGNORi | Q9Y6E2 |
Miscellaneous databases
BioGRID-ORCSi | 28969, 8 hits in 998 CRISPR screens |
ChiTaRSi | BZW2, human |
GeneWikii | BZW2 |
GenomeRNAii | 28969 |
Pharosi | Q9Y6E2, Tbio |
PROi | PR:Q9Y6E2 |
RNActi | Q9Y6E2, protein |
Gene expression databases
Bgeei | ENSG00000136261, Expressed in chorionic villus and 250 other tissues |
ExpressionAtlasi | Q9Y6E2, baseline and differential |
Genevisiblei | Q9Y6E2, HS |
Family and domain databases
CDDi | cd11560, W2_eIF5C_like, 1 hit |
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR016021, MIF4-like_sf IPR043510, W2_BZW1/2 IPR003307, W2_domain |
Pfami | View protein in Pfam PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BZW2_HUMAN | |
Accessioni | Q9Y6E2Primary (citable) accession number: Q9Y6E2 Secondary accession number(s): A4D123 Q9H3F7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families