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Protein

Basic leucine zipper and W2 domain-containing protein 2

Gene

BZW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 2
Gene namesi
Name:BZW2
ORF Names:HSPC028, MSTP017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136261.14
HGNCiHGNC:18808 BZW2
neXtProtiNX_Q9Y6E2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi28969
OpenTargetsiENSG00000136261
PharmGKBiPA38690

Polymorphism and mutation databases

BioMutaiBZW2
DMDMi74762077

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546181 – 419Basic leucine zipper and W2 domain-containing protein 2Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117N6-acetyllysineCombined sources1
Modified residuei412PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6E2
PaxDbiQ9Y6E2
PeptideAtlasiQ9Y6E2
PRIDEiQ9Y6E2
ProteomicsDBi86659

PTM databases

iPTMnetiQ9Y6E2
PhosphoSitePlusiQ9Y6E2
SwissPalmiQ9Y6E2

Expressioni

Gene expression databases

BgeeiENSG00000136261 Expressed in 238 organ(s), highest expression level in chorionic villus
CleanExiHS_BZW2
ExpressionAtlasiQ9Y6E2 baseline and differential
GenevisibleiQ9Y6E2 HS

Organism-specific databases

HPAiHPA022813
HPA026709

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2S2P200422EBI-1051021,EBI-711977

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118793, 72 interactors
IntActiQ9Y6E2, 10 interactors
MINTiQ9Y6E2
STRINGi9606.ENSP00000258761

Structurei

3D structure databases

ProteinModelPortaliQ9Y6E2
SMRiQ9Y6E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 415W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated

Phylogenomic databases

eggNOGiKOG2297 Eukaryota
ENOG410XR08 LUCA
GeneTreeiENSGT00390000012561
HOGENOMiHOG000252932
HOVERGENiHBG080940
InParanoidiQ9Y6E2
OMAiFMNKHQK
OrthoDBiEOG091G090E
PhylomeDBiQ9Y6E2
TreeFamiTF324313

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSETEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEEN
Length:419
Mass (Da):48,162
Last modified:November 1, 1999 - v1
Checksum:i7ABFE7A51501E721
GO
Isoform 2 (identifier: Q9Y6E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-201: IAASFAVKLFKAWMAEKDAN → NEAPVFSPVRQQKKNKVTDS
     202-419: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,819
Checksum:i894B75B91E22764F
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCE7B5MCE7_HUMAN
Basic leucine zipper and W2 domain-...
BZW2 hCG_19293
225Annotation score:
B5MCH7B5MCH7_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
343Annotation score:
E7ETZ4E7ETZ4_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
408Annotation score:
E9PFD4E9PFD4_HUMAN
BZW2 protein
BZW2
189Annotation score:
Q75MG1Q75MG1_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
274Annotation score:
C9JF98C9JF98_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
162Annotation score:
F8WDX8F8WDX8_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
170Annotation score:
E7EMS9E7EMS9_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
208Annotation score:
E9PFE3E9PFE3_HUMAN
Basic leucine zipper and W2 domain-...
BZW2
161Annotation score:

Sequence cautioni

The sequence AAI07758 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203V → G in AAG39278 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03364244D → A. Corresponds to variant dbSNP:rs35233079Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055568182 – 201IAASF…EKDAN → NEAPVFSPVRQQKKNKVTDS in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_055569202 – 419Missing in isoform 2. 1 PublicationAdd BLAST218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110323 mRNA Translation: AAG39278.1
AF083246 mRNA Translation: AAD39844.1
AK001218 mRNA Translation: BAA91562.1
AK027837 mRNA Translation: BAB55401.1
CH236948 Genomic DNA Translation: EAL24285.1
CH471073 Genomic DNA Translation: EAW93675.1
CH471073 Genomic DNA Translation: EAW93678.1
BC003056 mRNA Translation: AAH03056.1
BC008453 mRNA Translation: AAH08453.1
BC009597 mRNA Translation: AAH09597.1
BC107757 mRNA Translation: AAI07758.1 Sequence problems.
CCDSiCCDS5362.1 [Q9Y6E2-1]
RefSeqiNP_001153239.1, NM_001159767.1 [Q9Y6E2-1]
NP_054757.1, NM_014038.2 [Q9Y6E2-1]
XP_006715769.1, XM_006715706.1
XP_006715770.1, XM_006715707.1 [Q9Y6E2-1]
XP_006715771.1, XM_006715708.1 [Q9Y6E2-1]
UniGeneiHs.487635

Genome annotation databases

EnsembliENST00000258761; ENSP00000258761; ENSG00000136261 [Q9Y6E2-1]
ENST00000433922; ENSP00000397249; ENSG00000136261 [Q9Y6E2-1]
GeneIDi28969
KEGGihsa:28969
UCSCiuc003stj.3 human [Q9Y6E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110323 mRNA Translation: AAG39278.1
AF083246 mRNA Translation: AAD39844.1
AK001218 mRNA Translation: BAA91562.1
AK027837 mRNA Translation: BAB55401.1
CH236948 Genomic DNA Translation: EAL24285.1
CH471073 Genomic DNA Translation: EAW93675.1
CH471073 Genomic DNA Translation: EAW93678.1
BC003056 mRNA Translation: AAH03056.1
BC008453 mRNA Translation: AAH08453.1
BC009597 mRNA Translation: AAH09597.1
BC107757 mRNA Translation: AAI07758.1 Sequence problems.
CCDSiCCDS5362.1 [Q9Y6E2-1]
RefSeqiNP_001153239.1, NM_001159767.1 [Q9Y6E2-1]
NP_054757.1, NM_014038.2 [Q9Y6E2-1]
XP_006715769.1, XM_006715706.1
XP_006715770.1, XM_006715707.1 [Q9Y6E2-1]
XP_006715771.1, XM_006715708.1 [Q9Y6E2-1]
UniGeneiHs.487635

3D structure databases

ProteinModelPortaliQ9Y6E2
SMRiQ9Y6E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118793, 72 interactors
IntActiQ9Y6E2, 10 interactors
MINTiQ9Y6E2
STRINGi9606.ENSP00000258761

PTM databases

iPTMnetiQ9Y6E2
PhosphoSitePlusiQ9Y6E2
SwissPalmiQ9Y6E2

Polymorphism and mutation databases

BioMutaiBZW2
DMDMi74762077

Proteomic databases

EPDiQ9Y6E2
PaxDbiQ9Y6E2
PeptideAtlasiQ9Y6E2
PRIDEiQ9Y6E2
ProteomicsDBi86659

Protocols and materials databases

DNASUi28969
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258761; ENSP00000258761; ENSG00000136261 [Q9Y6E2-1]
ENST00000433922; ENSP00000397249; ENSG00000136261 [Q9Y6E2-1]
GeneIDi28969
KEGGihsa:28969
UCSCiuc003stj.3 human [Q9Y6E2-1]

Organism-specific databases

CTDi28969
DisGeNETi28969
EuPathDBiHostDB:ENSG00000136261.14
GeneCardsiBZW2
HGNCiHGNC:18808 BZW2
HPAiHPA022813
HPA026709
neXtProtiNX_Q9Y6E2
OpenTargetsiENSG00000136261
PharmGKBiPA38690
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2297 Eukaryota
ENOG410XR08 LUCA
GeneTreeiENSGT00390000012561
HOGENOMiHOG000252932
HOVERGENiHBG080940
InParanoidiQ9Y6E2
OMAiFMNKHQK
OrthoDBiEOG091G090E
PhylomeDBiQ9Y6E2
TreeFamiTF324313

Miscellaneous databases

ChiTaRSiBZW2 human
GeneWikiiBZW2
GenomeRNAii28969
PROiPR:Q9Y6E2

Gene expression databases

BgeeiENSG00000136261 Expressed in 238 organ(s), highest expression level in chorionic villus
CleanExiHS_BZW2
ExpressionAtlasiQ9Y6E2 baseline and differential
GenevisibleiQ9Y6E2 HS

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBZW2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6E2
Secondary accession number(s): A4D123
, Q3B779, Q96JW5, Q9H3F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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