UniProtKB - Q9Y6E0 (STK24_HUMAN)
Serine/threonine-protein kinase 24
STK24
Functioni
Catalytic activityi
Cofactori
Kineticsi
- KM=12.8 µM for manganese ions1 Publication
- KM=34.9 µM for cobalt ions1 Publication
- KM=22.7 µM for magnesium ions1 Publication
- KM=4.1 µM for zinc ions1 Publication
- Vmax=2623.1 pmol/min/mg enzyme for manganese ions1 Publication
- Vmax=1746.1 pmol/min/mg enzyme for cobalt ions1 Publication
- Vmax=129.1 pmol/min/mg enzyme for magnesium ions1 Publication
- Vmax=22.3 pmol/min/mg enzyme for zinc ions1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 65 | ATP | 1 | |
Active sitei | 156 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 161 | Magnesium | 1 | |
Metal bindingi | 174 | Magnesium | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 42 – 50 | ATP | 9 | |
Nucleotide bindingi | 112 – 114 | ATP | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: ProtInc
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- cellular response to starvation Source: UniProtKB
- execution phase of apoptosis Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of axon regeneration Source: UniProtKB
- response to hydrogen peroxide Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6E0 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-75153, Apoptotic execution phase |
SABIO-RKi | Q9Y6E0 |
SignaLinki | Q9Y6E0 |
SIGNORi | Q9Y6E0 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase 24 (EC:2.7.11.1)Alternative name(s): Mammalian STE20-like protein kinase 3 Short name: MST-3 STE20-like kinase MST3 Cleaved into the following 2 chains: Alternative name(s): Mammalian STE20-like protein kinase 3 N-terminal Short name: MST3/N Alternative name(s): Mammalian STE20-like protein kinase 3 C-terminal Short name: MST3/C |
Gene namesi | Name:STK24 Synonyms:MST3, STK3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11403, STK24 |
MIMi | 604984, gene |
neXtProti | NX_Q9Y6E0 |
VEuPathDBi | HostDB:ENSG00000102572.14 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 18 | T → A: Loss of phosphorylation by PKA. 1 Publication | 1 | |
Mutagenesisi | 65 | K → A: Loss of activity and autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 190 | T → A: Loss of activity and autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 321 | D → N: Loss of proteolytic cleavage by caspases. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8428 |
OpenTargetsi | ENSG00000102572 |
PharmGKBi | PA36210 |
Miscellaneous databases
Pharosi | Q9Y6E0, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5082 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y6E0 |
GuidetoPHARMACOLOGYi | 2217 |
Genetic variation databases
BioMutai | STK24 |
DMDMi | 13626607 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
ChainiPRO_0000086711 | 1 – 443 | Serine/threonine-protein kinase 24Add BLAST | 443 | ||
ChainiPRO_0000413618 | 1 – 325 | Serine/threonine-protein kinase 24 36 kDa subunitAdd BLAST | 325 | ||
ChainiPRO_0000413619 | 326 – 443 | Serine/threonine-protein kinase 24 12 kDa subunitAdd BLAST | 118 | ||
Isoform A (identifier: Q9Y6E0-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 18 | Phosphothreonine; by PKA1 Publication | 1 | ||
Modified residuei | 190 | Phosphothreonine; by autocatalysisCombined sources3 Publications | 1 | ||
Modified residuei | 320 | PhosphoserineCombined sources | 1 | ||
Isoform A (identifier: Q9Y6E0-2) | |||||
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 4 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 325 – 326 | Cleavage; by caspase-3, caspase-7 and caspase-8 | 2 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y6E0 |
jPOSTi | Q9Y6E0 |
MassIVEi | Q9Y6E0 |
PaxDbi | Q9Y6E0 |
PeptideAtlasi | Q9Y6E0 |
PRIDEi | Q9Y6E0 |
ProteomicsDBi | 86657 [Q9Y6E0-1] 86658 [Q9Y6E0-2] |
PTM databases
iPTMneti | Q9Y6E0 |
MetOSitei | Q9Y6E0 |
PhosphoSitePlusi | Q9Y6E0 |
SwissPalmi | Q9Y6E0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000102572, Expressed in secondary oocyte and 248 other tissues |
ExpressionAtlasi | Q9Y6E0, baseline and differential |
Genevisiblei | Q9Y6E0, HS |
Organism-specific databases
HPAi | ENSG00000102572, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:20124694).
Interacts with CTTNBP2NL (PubMed:18782753).
Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006).
Interacts with PDCD10; this interaction is required for the association of STK24 with RIPOR1 (PubMed:27807006).
3 PublicationsBinary interactionsi
Hide detailsQ9Y6E0
Isoform A [Q9Y6E0-2]
With | #Exp. | IntAct |
---|---|---|
CAB39 [Q9Y376] | 3 | EBI-10299018,EBI-306905 |
PDCD10 [Q9BUL8] | 9 | EBI-10299018,EBI-740195 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 114011, 82 interactors |
DIPi | DIP-40608N |
IntActi | Q9Y6E0, 46 interactors |
MINTi | Q9Y6E0 |
STRINGi | 9606.ENSP00000365730 |
Chemistry databases
BindingDBi | Q9Y6E0 |
Miscellaneous databases
RNActi | Q9Y6E0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y6E0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y6E0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 286 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 251 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 278 – 292 | Bipartite nuclear localization signalAdd BLAST | 15 | |
Motifi | 335 – 386 | Nuclear export signal (NES)Add BLAST | 52 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0201, Eukaryota |
GeneTreei | ENSGT00940000153476 |
InParanoidi | Q9Y6E0 |
OMAi | YCDGGSC |
OrthoDBi | 967913at2759 |
PhylomeDBi | Q9Y6E0 |
TreeFami | TF354217 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV
60 70 80 90 100
FKGIDNRTQK VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS
110 120 130 140 150
YLKDTKLWII MEYLGGGSAL DLLEPGPLDE TQIATILREI LKGLDYLHSE
160 170 180 190 200
KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ LTDTQIKRNT FVGTPFWMAP
210 220 230 240 250
EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL FLIPKNNPPT
260 270 280 290 300
LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI
310 320 330 340 350
DRYKRWKAEQ SHDDSSSEDS DAETDGQASG GSDSGDWIFT IREKDPKNLE
360 370 380 390 400
NGALQPSDLD RNKMKDIPKR PFSQCLSTII SPLFAELKEK SQACGGNLGS
410 420 430 440
IEELRGAIYL AEEACPGISD TMVAQLVQRL QRYSLSGGGT SSH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DR80 | B4DR80_HUMAN | Serine/threonine-protein kinase 24 | STK24 | 412 | Annotation score: | ||
H0Y630 | H0Y630_HUMAN | Serine/threonine-protein kinase 24 | STK24 | 369 | Annotation score: | ||
Q5JV98 | Q5JV98_HUMAN | Serine/threonine-protein kinase 24 | STK24 | 209 | Annotation score: | ||
Q5JV99 | Q5JV99_HUMAN | Serine/threonine-protein kinase 24 | STK24 | 142 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041148 | 414 | A → V2 PublicationsCorresponds to variant dbSNP:rs55953606Ensembl. | 1 | |
Natural variantiVAR_041149 | 426 | L → I1 PublicationCorresponds to variant dbSNP:rs55897869Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004874 | 1 – 26 | MDSRA…PGGST → MAHSPVQSGLPGMQ in isoform A. 2 PublicationsAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024636 mRNA Translation: AAB82560.1 AF083420 mRNA Translation: AAD42039.1 AL356423 Genomic DNA No translation available. AL137249 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX08986.1 BC035578 mRNA Translation: AAH35578.1 |
CCDSi | CCDS32001.1 [Q9Y6E0-2] CCDS9488.1 [Q9Y6E0-1] |
RefSeqi | NP_001027467.2, NM_001032296.3 [Q9Y6E0-2] NP_003567.2, NM_003576.4 [Q9Y6E0-1] |
Genome annotation databases
Ensembli | ENST00000376547; ENSP00000365730; ENSG00000102572 [Q9Y6E0-1] ENST00000539966; ENSP00000442539; ENSG00000102572 [Q9Y6E0-2] |
GeneIDi | 8428 |
KEGGi | hsa:8428 |
UCSCi | uc001vnm.3, human [Q9Y6E0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024636 mRNA Translation: AAB82560.1 AF083420 mRNA Translation: AAD42039.1 AL356423 Genomic DNA No translation available. AL137249 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX08986.1 BC035578 mRNA Translation: AAH35578.1 |
CCDSi | CCDS32001.1 [Q9Y6E0-2] CCDS9488.1 [Q9Y6E0-1] |
RefSeqi | NP_001027467.2, NM_001032296.3 [Q9Y6E0-2] NP_003567.2, NM_003576.4 [Q9Y6E0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3A7F | X-ray | 1.55 | A | 27-315 | [»] | |
3A7G | X-ray | 2.00 | A/B | 27-315 | [»] | |
3A7H | X-ray | 1.96 | A/B | 27-315 | [»] | |
3A7I | X-ray | 1.45 | A | 27-315 | [»] | |
3A7J | X-ray | 1.50 | A | 27-315 | [»] | |
3CKW | X-ray | 1.96 | A | 31-323 | [»] | |
3CKX | X-ray | 2.70 | A | 31-323 | [»] | |
3ZHP | X-ray | 2.90 | C/D | 31-301 | [»] | |
4O27 | X-ray | 3.19 | B | 30-309 | [»] | |
4QML | X-ray | 1.88 | A | 24-315 | [»] | |
4QMM | X-ray | 1.85 | A | 24-315 | [»] | |
4QMN | X-ray | 2.09 | A | 27-315 | [»] | |
4QMO | X-ray | 1.90 | A | 24-315 | [»] | |
4QMP | X-ray | 2.00 | A | 24-315 | [»] | |
4QMQ | X-ray | 1.77 | A | 24-315 | [»] | |
4QMS | X-ray | 1.88 | A | 24-315 | [»] | |
4QMT | X-ray | 1.50 | A | 24-315 | [»] | |
4QMU | X-ray | 1.55 | A | 24-315 | [»] | |
4QMV | X-ray | 2.40 | A | 24-315 | [»] | |
4QMW | X-ray | 1.60 | A | 24-315 | [»] | |
4QMX | X-ray | 1.88 | A | 24-315 | [»] | |
4QMY | X-ray | 1.88 | A | 24-315 | [»] | |
4QMZ | X-ray | 1.88 | A | 24-315 | [»] | |
4QNA | X-ray | 1.85 | A | 27-315 | [»] | |
4QO9 | X-ray | 2.20 | A/B | 24-315 | [»] | |
4U8Z | X-ray | 1.63 | A | 24-310 | [»] | |
4W8D | X-ray | 1.77 | A | 24-310 | [»] | |
4W8E | X-ray | 1.79 | A | 24-311 | [»] | |
SMRi | Q9Y6E0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114011, 82 interactors |
DIPi | DIP-40608N |
IntActi | Q9Y6E0, 46 interactors |
MINTi | Q9Y6E0 |
STRINGi | 9606.ENSP00000365730 |
Chemistry databases
BindingDBi | Q9Y6E0 |
ChEMBLi | CHEMBL5082 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y6E0 |
GuidetoPHARMACOLOGYi | 2217 |
PTM databases
iPTMneti | Q9Y6E0 |
MetOSitei | Q9Y6E0 |
PhosphoSitePlusi | Q9Y6E0 |
SwissPalmi | Q9Y6E0 |
Genetic variation databases
BioMutai | STK24 |
DMDMi | 13626607 |
Proteomic databases
EPDi | Q9Y6E0 |
jPOSTi | Q9Y6E0 |
MassIVEi | Q9Y6E0 |
PaxDbi | Q9Y6E0 |
PeptideAtlasi | Q9Y6E0 |
PRIDEi | Q9Y6E0 |
ProteomicsDBi | 86657 [Q9Y6E0-1] 86658 [Q9Y6E0-2] |
Protocols and materials databases
Antibodypediai | 10785, 332 antibodies |
DNASUi | 8428 |
Genome annotation databases
Ensembli | ENST00000376547; ENSP00000365730; ENSG00000102572 [Q9Y6E0-1] ENST00000539966; ENSP00000442539; ENSG00000102572 [Q9Y6E0-2] |
GeneIDi | 8428 |
KEGGi | hsa:8428 |
UCSCi | uc001vnm.3, human [Q9Y6E0-1] |
Organism-specific databases
CTDi | 8428 |
DisGeNETi | 8428 |
GeneCardsi | STK24 |
HGNCi | HGNC:11403, STK24 |
HPAi | ENSG00000102572, Low tissue specificity |
MIMi | 604984, gene |
neXtProti | NX_Q9Y6E0 |
OpenTargetsi | ENSG00000102572 |
PharmGKBi | PA36210 |
VEuPathDBi | HostDB:ENSG00000102572.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0201, Eukaryota |
GeneTreei | ENSGT00940000153476 |
InParanoidi | Q9Y6E0 |
OMAi | YCDGGSC |
OrthoDBi | 967913at2759 |
PhylomeDBi | Q9Y6E0 |
TreeFami | TF354217 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6E0 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-75153, Apoptotic execution phase |
SABIO-RKi | Q9Y6E0 |
SignaLinki | Q9Y6E0 |
SIGNORi | Q9Y6E0 |
Miscellaneous databases
BioGRID-ORCSi | 8428, 7 hits in 906 CRISPR screens |
ChiTaRSi | STK24, human |
EvolutionaryTracei | Q9Y6E0 |
GeneWikii | STK24 |
GenomeRNAii | 8428 |
Pharosi | Q9Y6E0, Tchem |
PROi | PR:Q9Y6E0 |
RNActi | Q9Y6E0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102572, Expressed in secondary oocyte and 248 other tissues |
ExpressionAtlasi | Q9Y6E0, baseline and differential |
Genevisiblei | Q9Y6E0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STK24_HUMAN | |
Accessioni | Q9Y6E0Primary (citable) accession number: Q9Y6E0 Secondary accession number(s): O14840, Q5JV92 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families