UniProtKB - Q9Y6D9 (MD1L1_HUMAN)
Mitotic spindle assembly checkpoint protein MAD1
MAD1L1
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
- kinetochore binding Source: UniProtKB
GO - Biological processi
- attachment of mitotic spindle microtubules to kinetochore Source: GO_Central
- cell division Source: UniProtKB-KW
- mitotic spindle assembly checkpoint Source: UniProtKB
- mitotic spindle organization Source: Reactome
- negative regulation of T cell proliferation Source: Ensembl
- regulation of metaphase plate congression Source: UniProtKB
- thymus development Source: Ensembl
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6D9 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | Q9Y6D9 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitotic spindle assembly checkpoint protein MAD1Alternative name(s): Mitotic arrest deficient 1-like protein 1 Short name: MAD1-like protein 1 Mitotic checkpoint MAD1 protein homolog Short name: HsMAD1 Short name: hMAD1 Tax-binding protein 181 |
Gene namesi | Name:MAD1L1 Synonyms:MAD1, TXBP181 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6762, MAD1L1 |
MIMi | 602686, gene |
neXtProti | NX_Q9Y6D9 |
VEuPathDBi | HostDB:ENSG00000002822.15 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Nucleus envelope 2 Publications
Cytoskeleton
- centrosome 2 Publications
- spindle 1 Publication
- spindle pole 1 Publication
Other locations
- kinetochore 4 Publications
Note: Co-localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:22351768, PubMed:18981471). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768).5 Publications
Cytoskeleton
- centrosome Source: UniProtKB
- mitotic spindle Source: UniProtKB
- spindle Source: UniProtKB
- spindle pole Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear pore nuclear basket Source: UniProtKB
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- kinetochore Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1 – 485 | Missing : Defective dimerization. Abolishes binding to the closed and open conformations of MAD2L1. Impairs mitotic checkpoint signaling abolishing mitotic arrest, and shortens the duration of mitosis. 1 PublicationAdd BLAST | 485 | |
Mutagenesisi | 541 | K → A: Abolishes binding to closed and open conformations of MAD2L1 and impairs mitotic checkpint signaling abolishing mitotic arrest, and shortens the duration of mitosis; in association with A-543. 1 Publication | 1 | |
Mutagenesisi | 543 | L → A: Abolishes binding to closed and open conformations of MAD2L1 and impairs mitotic checkpoint signaling abolishing mitotic arrest, and shortens the duration of mitosis; in association with A-541. 1 Publication | 1 | |
Mutagenesisi | 597 – 718 | Missing : Defective dimerization. Reduces binding to the closed and open conformations of MAD2L1. Impairs mitotic checkpoint signaling abolishing mitotic arrest, and shortens the duration of mitosis. 1 PublicationAdd BLAST | 122 | |
Mutagenesisi | 598 | S → A or E: Does not impact the duration of mitosis. 1 Publication | 1 | |
Mutagenesisi | 610 | S → A or E: Impairs mitotic checkpoint signaling and shortens the duration of mitosis. 1 Publication | 1 | |
Mutagenesisi | 634 | Y → E: Reduces binding to closed and open conformations of MAD2L1. Impairs mitotic checkpoint signaling abolishing mitotic arrest, and shortens the duration of mitosis. 1 Publication | 1 | |
Mutagenesisi | 634 | Y → F: Reduces binding to closed and open conformations of MAD2L1. Does not impact the duration of mitosis. 1 Publication | 1 | |
Mutagenesisi | 716 | T → A or E: Reduces binding to closed and open conformations of MAD2L1. Impairs mitotic checkpoint signaling and shortens the duration of mitosis. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 8379 |
MalaCardsi | MAD1L1 |
OpenTargetsi | ENSG00000002822 |
PharmGKBi | PA372 |
Miscellaneous databases
Pharosi | Q9Y6D9, Tbio |
Genetic variation databases
BioMutai | MAD1L1 |
DMDMi | 52783153 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213800 | 1 – 718 | Mitotic spindle assembly checkpoint protein MAD1Add BLAST | 718 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 61 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 61 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 214 | PhosphoserineCombined sources | 1 | |
Modified residuei | 428 | PhosphoserineCombined sources | 1 | |
Modified residuei | 598 | Phosphoserine1 Publication | 1 | |
Modified residuei | 610 | Phosphoserine1 Publication | 1 | |
Modified residuei | 634 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 716 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y6D9 |
jPOSTi | Q9Y6D9 |
MassIVEi | Q9Y6D9 |
PaxDbi | Q9Y6D9 |
PeptideAtlasi | Q9Y6D9 |
PRIDEi | Q9Y6D9 |
ProteomicsDBi | 3578 86656 [Q9Y6D9-1] |
PTM databases
iPTMneti | Q9Y6D9 |
MetOSitei | Q9Y6D9 |
PhosphoSitePlusi | Q9Y6D9 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000002822, Expressed in sural nerve and 213 other tissues |
ExpressionAtlasi | Q9Y6D9, baseline and differential |
Genevisiblei | Q9Y6D9, HS |
Organism-specific databases
HPAi | ENSG00000002822, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:9546394, PubMed:29162720). Dimerizes via its N- and C- terminal regions (PubMed:29162720). Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex (PubMed:22351768, PubMed:9546394, PubMed:18981471, PubMed:12006501).
Interacts with the closed conformation form of MAD2L1 (C-MAD2) and open conformation form of MAD2L1 (O-MAD2) (PubMed:29162720). It is unclear whether MAD1L1 dimerization promotes the conversion of closed to open conformation of MAD2L1 (PubMed:29162720). Formation of a heterotetrameric core complex containing two molecules each of MAD1L1 and of MAD2L1 promotes binding of another molecule of MAD2L1 to each MAD2L1, resulting in a heterohexamer (PubMed:12006501). Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1 (PubMed:12006501). CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20 (PubMed:12006501). Also able to interact with the BUB1/BUB3 complex (PubMed:10198256).
Interacts with NEK2 (PubMed:14978040).
Interacts with TTK (PubMed:29162720).
Interacts with TPR; the interactions occurs in a microtubule-independent manner (PubMed:18981471, PubMed:19273613, PubMed:20133940).
Interacts with IK (PubMed:22351768).
Interacts with the viral Tax protein (PubMed:9546394).
9 PublicationsBinary interactionsi
Hide detailsQ9Y6D9
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 113971, 109 interactors |
ComplexPortali | CPX-82, Mitotic spindle assembly checkpoint Mad1 complex CPX-85, Mitotic spindle assembly checkpoint MAD1-MAD2 complex |
CORUMi | Q9Y6D9 |
DIPi | DIP-29654N |
ELMi | Q9Y6D9 |
IntActi | Q9Y6D9, 81 interactors |
MINTi | Q9Y6D9 |
STRINGi | 9606.ENSP00000385334 |
Miscellaneous databases
RNActi | Q9Y6D9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y6D9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y6D9 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 301 – 340 | Important for interaction with IK1 PublicationAdd BLAST | 40 | |
Regioni | 380 – 532 | Necessary for interaction with NEK21 PublicationAdd BLAST | 153 | |
Regioni | 439 – 480 | Important for interaction with IK1 PublicationAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 46 – 632 | Sequence analysisAdd BLAST | 587 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4593, Eukaryota |
GeneTreei | ENSGT00390000001316 |
HOGENOMi | CLU_023576_1_0_1 |
InParanoidi | Q9Y6D9 |
OMAi | YMLLGYR |
OrthoDBi | 602490at2759 |
PhylomeDBi | Q9Y6D9 |
TreeFami | TF101083 |
Family and domain databases
InterProi | View protein in InterPro IPR008672, Mad1 |
PANTHERi | PTHR23168, PTHR23168, 1 hit |
Pfami | View protein in Pfam PF05557, MAD, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDLGENTMV LSTLRSLNNF ISQRVEGGSG LDISTSAPGS LQMQYQQSMQ
60 70 80 90 100
LEERAEQIRS KSHLIQVERE KMQMELSHKR ARVELERAAS TSARNYEREV
110 120 130 140 150
DRNQELLTRI RQLQEREAGA EEKMQEQLER NRQCQQNLDA ASKRLREKED
160 170 180 190 200
SLAQAGETIN ALKGRISELQ WSVMDQEMRV KRLESEKQEL QEQLDLQHKK
210 220 230 240 250
CQEANQKIQE LQASQEARAD HEQQIKDLEQ KLSLQEQDAA IVKNMKSELV
260 270 280 290 300
RLPRLERELK QLREESAHLR EMRETNGLLQ EELEGLQRKL GRQEKMQETL
310 320 330 340 350
VGLELENERL LAKLQSWERL DQTMGLSIRT PEDLSRFVVE LQQRELALKD
360 370 380 390 400
KNSAVTSSAR GLEKARQQLQ EELRQVSGQL LEERKKRETH EALARRLQKR
410 420 430 440 450
VLLLTKERDG MRAILGSYDS ELTPAEYSPQ LTRRMREAED MVQKVHSHSA
460 470 480 490 500
EMEAQLSQAL EELGGQKQRA DMLEMELKML KSQSSSAEQS FLFSREEADT
510 520 530 540 550
LRLKVEELEG ERSRLEEEKR MLEAQLERRA LQGDYDQSRT KVLHMSLNPT
560 570 580 590 600
SVARQRLRED HSQLQAECER LRGLLRAMER GGTVPADLEA AAASLPSSKE
610 620 630 640 650
VAELKKQVES AELKNQRLKE VFQTKIQEFR KACYTLTGYQ IDITTENQYR
660 670 680 690 700
LTSLYAEHPG DCLIFKATSP SGSKMQLLET EFSHTVGELI EVHLRRQDSI
710
PAFLSSLTLE LFSRQTVA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JJ38 | C9JJ38_HUMAN | Mitotic spindle assembly checkpoint... | MAD1L1 | 157 | Annotation score: | ||
C9JKI7 | C9JKI7_HUMAN | Mitotic spindle assembly checkpoint... | MAD1L1 | 122 | Annotation score: | ||
C9JX80 | C9JX80_HUMAN | Mitotic spindle assembly checkpoint... | MAD1L1 | 80 | Annotation score: | ||
C9JIR0 | C9JIR0_HUMAN | Mitotic spindle assembly checkpoint... | MAD1L1 | 144 | Annotation score: | ||
C9J9H5 | C9J9H5_HUMAN | Mitotic spindle assembly checkpoint... | MAD1L1 | 41 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 – 190 | EL → DV in AAC52059 (PubMed:9546394).Curated | 2 | |
Sequence conflicti | 189 – 190 | EL → DV in AAD24498 (PubMed:10049595).Curated | 2 | |
Sequence conflicti | 260 | K → E in AAC52059 (PubMed:9546394).Curated | 1 | |
Sequence conflicti | 260 | K → E in AAD24498 (PubMed:10049595).Curated | 1 | |
Sequence conflicti | 268 | Missing in AAC52059 (PubMed:9546394).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019707 | 29 | S → L in a lymphoid cancer cell line; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_019708 | 59 | R → C in a prostate cancer cell line; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121908982EnsemblClinVar. | 1 | |
Natural variantiVAR_019709 | 160 | N → S1 PublicationCorresponds to variant dbSNP:rs550573452Ensembl. | 1 | |
Natural variantiVAR_019710 | 299 | T → A in lung cancer cell line; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_019711 | 360 | R → Q in a prostate cancer cell line; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs769418574Ensembl. | 1 | |
Natural variantiVAR_019712 | 500 | T → M2 PublicationsCorresponds to variant dbSNP:rs193231481Ensembl. | 1 | |
Natural variantiVAR_019713 | 511 | E → K1 PublicationCorresponds to variant dbSNP:rs377555260Ensembl. | 1 | |
Natural variantiVAR_019714 | 516 | E → K in a breast cancer cell line; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_019715 | 556 | R → C in a prostate cancer cell line; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371561369Ensembl. | 1 | |
Natural variantiVAR_019716 | 556 | R → H in one individual with lung cancer. 1 PublicationCorresponds to variant dbSNP:rs755012008Ensembl. | 1 | |
Natural variantiVAR_019717 | 558 | R → H in a cancer cell line. 3 PublicationsCorresponds to variant dbSNP:rs1801368Ensembl. | 1 | |
Natural variantiVAR_019718 | 569 | E → K in a breast cancer cell line; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs201951163Ensembl. | 1 | |
Natural variantiVAR_019719 | 572 | R → H in a cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs1801500Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056160 | 1 – 65 | MEDLG…KSHLI → MLPARGCVRKRTVWPRLARV LIVTLLTLELSYAPLPCQLS GVPYNTGDPVGRWARPCIWP CPWHT in isoform 2. 1 PublicationAdd BLAST | 65 | |
Alternative sequenceiVSP_056161 | 66 – 157 | Missing in isoform 2. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33822 mRNA Translation: AAC52059.1 Frameshift. AF123318 mRNA Translation: AAD20359.1 AF083811 mRNA Translation: AAD24498.1 AK090959 mRNA Translation: BAG52253.1 AC005282 Genomic DNA No translation available. AC006433 Genomic DNA No translation available. AC069288 Genomic DNA Translation: AAS07503.1 AC104129 Genomic DNA Translation: AAP21876.1 AC110781 Genomic DNA No translation available. BC009964 mRNA Translation: AAH09964.1 |
CCDSi | CCDS43539.1 [Q9Y6D9-1] CCDS78201.1 [Q9Y6D9-3] |
RefSeqi | NP_001013858.1, NM_001013836.1 [Q9Y6D9-1] NP_001013859.1, NM_001013837.1 [Q9Y6D9-1] NP_001291452.1, NM_001304523.1 [Q9Y6D9-1] NP_001291453.1, NM_001304524.1 [Q9Y6D9-3] NP_003541.2, NM_003550.2 [Q9Y6D9-1] |
Genome annotation databases
Ensembli | ENST00000265854; ENSP00000265854; ENSG00000002822 [Q9Y6D9-1] ENST00000399654; ENSP00000382562; ENSG00000002822 [Q9Y6D9-1] ENST00000402746; ENSP00000384155; ENSG00000002822 [Q9Y6D9-3] ENST00000406869; ENSP00000385334; ENSG00000002822 [Q9Y6D9-1] |
GeneIDi | 8379 |
KEGGi | hsa:8379 |
UCSCi | uc003slf.2, human [Q9Y6D9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33822 mRNA Translation: AAC52059.1 Frameshift. AF123318 mRNA Translation: AAD20359.1 AF083811 mRNA Translation: AAD24498.1 AK090959 mRNA Translation: BAG52253.1 AC005282 Genomic DNA No translation available. AC006433 Genomic DNA No translation available. AC069288 Genomic DNA Translation: AAS07503.1 AC104129 Genomic DNA Translation: AAP21876.1 AC110781 Genomic DNA No translation available. BC009964 mRNA Translation: AAH09964.1 |
CCDSi | CCDS43539.1 [Q9Y6D9-1] CCDS78201.1 [Q9Y6D9-3] |
RefSeqi | NP_001013858.1, NM_001013836.1 [Q9Y6D9-1] NP_001013859.1, NM_001013837.1 [Q9Y6D9-1] NP_001291452.1, NM_001304523.1 [Q9Y6D9-1] NP_001291453.1, NM_001304524.1 [Q9Y6D9-3] NP_003541.2, NM_003550.2 [Q9Y6D9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GO4 | X-ray | 2.05 | E/F/G/H | 485-584 | [»] | |
4DZO | X-ray | 1.76 | A/B | 597-718 | [»] | |
SMRi | Q9Y6D9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113971, 109 interactors |
ComplexPortali | CPX-82, Mitotic spindle assembly checkpoint Mad1 complex CPX-85, Mitotic spindle assembly checkpoint MAD1-MAD2 complex |
CORUMi | Q9Y6D9 |
DIPi | DIP-29654N |
ELMi | Q9Y6D9 |
IntActi | Q9Y6D9, 81 interactors |
MINTi | Q9Y6D9 |
STRINGi | 9606.ENSP00000385334 |
PTM databases
iPTMneti | Q9Y6D9 |
MetOSitei | Q9Y6D9 |
PhosphoSitePlusi | Q9Y6D9 |
Genetic variation databases
BioMutai | MAD1L1 |
DMDMi | 52783153 |
Proteomic databases
EPDi | Q9Y6D9 |
jPOSTi | Q9Y6D9 |
MassIVEi | Q9Y6D9 |
PaxDbi | Q9Y6D9 |
PeptideAtlasi | Q9Y6D9 |
PRIDEi | Q9Y6D9 |
ProteomicsDBi | 3578 86656 [Q9Y6D9-1] |
Protocols and materials databases
Antibodypediai | 1135, 399 antibodies |
DNASUi | 8379 |
Genome annotation databases
Ensembli | ENST00000265854; ENSP00000265854; ENSG00000002822 [Q9Y6D9-1] ENST00000399654; ENSP00000382562; ENSG00000002822 [Q9Y6D9-1] ENST00000402746; ENSP00000384155; ENSG00000002822 [Q9Y6D9-3] ENST00000406869; ENSP00000385334; ENSG00000002822 [Q9Y6D9-1] |
GeneIDi | 8379 |
KEGGi | hsa:8379 |
UCSCi | uc003slf.2, human [Q9Y6D9-1] |
Organism-specific databases
CTDi | 8379 |
DisGeNETi | 8379 |
GeneCardsi | MAD1L1 |
HGNCi | HGNC:6762, MAD1L1 |
HPAi | ENSG00000002822, Low tissue specificity |
MalaCardsi | MAD1L1 |
MIMi | 602686, gene |
neXtProti | NX_Q9Y6D9 |
OpenTargetsi | ENSG00000002822 |
PharmGKBi | PA372 |
VEuPathDBi | HostDB:ENSG00000002822.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4593, Eukaryota |
GeneTreei | ENSGT00390000001316 |
HOGENOMi | CLU_023576_1_0_1 |
InParanoidi | Q9Y6D9 |
OMAi | YMLLGYR |
OrthoDBi | 602490at2759 |
PhylomeDBi | Q9Y6D9 |
TreeFami | TF101083 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6D9 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | Q9Y6D9 |
Miscellaneous databases
BioGRID-ORCSi | 8379, 32 hits in 1000 CRISPR screens |
ChiTaRSi | MAD1L1, human |
EvolutionaryTracei | Q9Y6D9 |
GeneWikii | Mad1 |
GenomeRNAii | 8379 |
Pharosi | Q9Y6D9, Tbio |
PROi | PR:Q9Y6D9 |
RNActi | Q9Y6D9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000002822, Expressed in sural nerve and 213 other tissues |
ExpressionAtlasi | Q9Y6D9, baseline and differential |
Genevisiblei | Q9Y6D9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008672, Mad1 |
PANTHERi | PTHR23168, PTHR23168, 1 hit |
Pfami | View protein in Pfam PF05557, MAD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MD1L1_HUMAN | |
Accessioni | Q9Y6D9Primary (citable) accession number: Q9Y6D9 Secondary accession number(s): B3KR41 Q9UNH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | September 27, 2004 | |
Last modified: | April 7, 2021 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families