UniProtKB - Q9Y6D5 (BIG2_HUMAN)
Protein
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Gene
ARFGEF2
Organism
Homo sapiens (Human)
Status
Functioni
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.7 Publications
Activity regulationi
Inhibited by brefeldin A.
GO - Molecular functioni
- ARF guanyl-nucleotide exchange factor activity Source: UniProtKB
- GABA receptor binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: MGI
- myosin binding Source: Ensembl
- protein kinase A regulatory subunit binding Source: UniProtKB
GO - Biological processi
- endomembrane system organization Source: UniProtKB
- endosome organization Source: UniProtKB
- exocytosis Source: ProtInc
- Golgi to plasma membrane transport Source: UniProtKB
- intracellular signal transduction Source: MGI
- positive regulation of tumor necrosis factor production Source: UniProtKB
- protein transport Source: UniProtKB-KW
- receptor recycling Source: UniProtKB
- regulation of ARF protein signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6D5 |
Reactomei | R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Brefeldin A-inhibited guanine nucleotide-exchange protein 2Short name: Brefeldin A-inhibited GEP 2 Alternative name(s): ADP-ribosylation factor guanine nucleotide-exchange factor 2 |
Gene namesi | Name:ARFGEF2 Synonyms:ARFGEP2, BIG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15853, ARFGEF2 |
MIMi | 605371, gene |
neXtProti | NX_Q9Y6D5 |
VEuPathDBi | HostDB:ENSG00000124198.8 |
Subcellular locationi
Cytoskeleton
- centrosome
- cytoskeleton By similarity
Golgi apparatus
- Golgi apparatus
- trans-Golgi network By similarity
Endosome
- Endosome By similarity
Other locations
- Cytoplasm
- Membrane
- perinuclear region
- dendrite By similarity
- Cytoplasmic vesicle By similarity
- synapse By similarity
Note: Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes.
Cytoskeleton
- axonemal microtubule Source: UniProtKB
- microtubule organizing center Source: UniProtKB
Cytosol
- cytosol Source: MGI
Endosome
- recycling endosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB
- trans-Golgi network Source: UniProtKB
Other locations
- asymmetric synapse Source: UniProtKB
- cytoplasmic vesicle Source: UniProtKB
- dendritic spine Source: UniProtKB
- membrane Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- symmetric synapse Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, SynapsePathology & Biotechi
Involvement in diseasei
Periventricular nodular heterotopia 2 (PVNH2)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH2 is an autosomal recessive form characterized by microcephaly (small brain), severe developmental delay and recurrent infections. No anomalies extrinsic to the central nervous system, such as dysmorphic features or grossly abnormal endocrine or other conditions, are associated with PVNH2.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037438 | 209 | E → K in PVNH2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs28937880EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 289 | V → W: Abolishes interaction with PRKAR2B and impairs TNFRSF1A release. 1 Publication | 1 | |
Mutagenesisi | 534 | V → W: Abolishes interaction with PRKAR2B and impairs TNFRSF1A release. 1 Publication | 1 | |
Mutagenesisi | 738 | E → K: Disturbs membrane organization at the TGN, impairs association of the AP-1 complex and GGA1 with the TGN membranes. 2 Publications | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 10564 |
MalaCardsi | ARFGEF2 |
MIMi | 608097, phenotype |
OpenTargetsi | ENSG00000124198 |
Orphaneti | 98892, Periventricular nodular heterotopia |
PharmGKBi | PA24945 |
Miscellaneous databases
Pharosi | Q9Y6D5, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105732 |
Genetic variation databases
BioMutai | ARFGEF2 |
DMDMi | 146329988 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120208 | 1 – 1785 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2Add BLAST | 1785 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 214 | PhosphoserineCombined sources | 1 | |
Modified residuei | 218 | PhosphoserineCombined sources | 1 | |
Modified residuei | 227 | PhosphoserineCombined sources | 1 | |
Modified residuei | 244 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 277 | PhosphoserineCombined sources | 1 | |
Modified residuei | 348 | PhosphoserineBy similarity | 1 | |
Modified residuei | 349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 616 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 617 | PhosphoserineBy similarity | 1 | |
Modified residuei | 626 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 700 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1511 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1513 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1514 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1525 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1528 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1534 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1782 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y6D5 |
jPOSTi | Q9Y6D5 |
MassIVEi | Q9Y6D5 |
MaxQBi | Q9Y6D5 |
PaxDbi | Q9Y6D5 |
PeptideAtlasi | Q9Y6D5 |
PRIDEi | Q9Y6D5 |
ProteomicsDBi | 86654 |
PTM databases
iPTMneti | Q9Y6D5 |
PhosphoSitePlusi | Q9Y6D5 |
Expressioni
Tissue specificityi
Expressed in placenta, lung, heart, brain, kidney and pancreas.
Gene expression databases
Bgeei | ENSG00000124198, Expressed in caput epididymis and 247 other tissues |
Genevisiblei | Q9Y6D5, HS |
Organism-specific databases
HPAi | ENSG00000124198, Tissue enhanced (parathyroid) |
Interactioni
Subunit structurei
Homodimer (Probable).
Interacts with ARFGEF1/BIG1; both proteins are probably part of the same or very similar macromolecular complexes.
Interacts with PRKAR1A, PRKAR2A, PRKAR1B, PRKAR2B, PPP1CC, PDE3A, TNFRSF1A, MYCBP and EXOC7.
Interacts with GABRB1, GABRB2 and GABRB3 (By similarity).
By similarityCuratedBinary interactionsi
Hide detailsQ9Y6D5
With | #Exp. | IntAct |
---|---|---|
ARFGEF1 [Q9Y6D6] | 12 | EBI-2837511,EBI-1044254 |
EXOC7 - isoform 1 [Q9UPT5-1] | 4 | EBI-2837511,EBI-6251402 |
MYCBP [Q99417] | 5 | EBI-2837511,EBI-716185 |
PDE3A [Q14432] | 5 | EBI-2837511,EBI-7192066 |
GO - Molecular functioni
- ARF guanyl-nucleotide exchange factor activity Source: UniProtKB
- GABA receptor binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: MGI
- myosin binding Source: Ensembl
- protein kinase A regulatory subunit binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115815, 70 interactors |
DIPi | DIP-48794N |
IntActi | Q9Y6D5, 34 interactors |
MINTi | Q9Y6D5 |
STRINGi | 9606.ENSP00000360985 |
Miscellaneous databases
RNActi | Q9Y6D5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y6D5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 654 – 785 | SEC7PROSITE-ProRule annotationAdd BLAST | 132 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 224 | DCB; DCB:DCB domain and DCB:HUS domain interactionAdd BLAST | 223 | |
Regioni | 508 – 528 | HUS; DCB:HUS domain interactionAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG0929, Eukaryota |
GeneTreei | ENSGT00940000158950 |
HOGENOMi | CLU_000691_1_2_1 |
InParanoidi | Q9Y6D5 |
OMAi | FRMYSDP |
OrthoDBi | 815698at2759 |
PhylomeDBi | Q9Y6D5 |
TreeFami | TF300714 |
Family and domain databases
CDDi | cd00171, Sec7, 1 hit |
Gene3Di | 1.10.1000.11, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR032629, DCB_dom IPR015403, Sec7_C IPR023394, Sec7_C_sf IPR000904, Sec7_dom IPR035999, Sec7_dom_sf IPR032691, Sec7_N |
Pfami | View protein in Pfam PF16213, DCB, 1 hit PF09324, DUF1981, 1 hit PF01369, Sec7, 1 hit PF12783, Sec7_N, 1 hit |
SMARTi | View protein in SMART SM00222, Sec7, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48425, SSF48425, 1 hit |
PROSITEi | View protein in PROSITE PS50190, SEC7, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y6D5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQESQTKSMF VSRALEKILA DKEVKRPQHS QLRRACQVAL DEIKAEIEKQ
60 70 80 90 100
RLGTAAPPKA NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI
110 120 130 140 150
TGNAPDSGAP GKRLIDRIVE TICSCFQGPQ TDEGVQLQII KALLTAVTSP
160 170 180 190 200
HIEIHEGTIL QTVRTCYNIY LASKNLINQT TAKATLTQML NVIFTRMENQ
210 220 230 240 250
VLQEARELEK PIQSKPQSPV IQAAAVSPKF VRLKHSQAQS KPTTPEKTDL
260 270 280 290 300
TNGEHARSDS GKVSTENGDA PRERGSSLSG TDDGAQEVVK DILEDVVTSA
310 320 330 340 350
IKEAAEKHGL TEPERVLGEL ECQECAIPPG VDENSQTNGI ADDRQSLSSA
360 370 380 390 400
DNLESDAQGH QVAARFSHVL QKDAFLVFRS LCKLSMKPLG EGPPDPKSHE
410 420 430 440 450
LRSKVVSLQL LLSVLQNAGP VFRTHEMFIN AIKQYLCVAL SKNGVSSVPD
460 470 480 490 500
VFELSLAIFL TLLSNFKMHL KMQIEVFFKE IFLNILETST SSFEHRWMVI
510 520 530 540 550
QTLTRICADA QCVVDIYVNY DCDLNAANIF ERLVNDLSKI AQGRSGHELG
560 570 580 590 600
MTPLQELSLR KKGLECLVSI LKCMVEWSKD LYVNPNHQTS LGQERLTDQE
610 620 630 640 650
IGDGKGLDMA RRCSVTSMES TVSSGTQTTV QDDPEQFEVI KQQKEIIEHG
660 670 680 690 700
IELFNKKPKR GIQFLQEQGM LGTSVEDIAQ FLHQEERLDS TQVGDFLGDS
710 720 730 740 750
ARFNKEVMYA YVDQLDFCEK EFVSALRTFL EGFRLPGEAQ KIDRLMEKFA
760 770 780 790 800
ARYIECNQGQ TLFASADTAY VLAYSIIMLT TDLHSPQVKN KMTKEQYIKM
810 820 830 840 850
NRGINDSKDL PEEYLSSIYE EIEGKKIAMK ETKELTIATK STKQNVASEK
860 870 880 890 900
QRRLLYNLEM EQMAKTAKAL MEAVSHAKAP FTSATHLDHV RPMFKLVWTP
910 920 930 940 950
LLAAYSIGLQ NCDDTEVASL CLEGIRCAIR IACIFGMQLE RDAYVQALAR
960 970 980 990 1000
FSLLTASSSI TEMKQKNIDT IKTLITVAHT DGNYLGNSWH EILKCISQLE
1010 1020 1030 1040 1050
LAQLIGTGVK TRYLSGSGRE REGSLKGHTL AGEEFMGLGL GNLVSGGVDK
1060 1070 1080 1090 1100
RQMASFQESV GETSSQSVVV AVDRIFTGST RLDGNAIVDF VRWLCAVSMD
1110 1120 1130 1140 1150
ELASPHHPRM FSLQKIVEIS YYNMNRIRLQ WSRIWHVIGD HFNKVGCNPN
1160 1170 1180 1190 1200
EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKKNRSPTIR
1210 1220 1230 1240 1250
DMAIRCIAQM VNSQAANIRS GWKNIFAVFH QAASDHDGNI VELAFQTTCH
1260 1270 1280 1290 1300
IVTTIFQHHF PAAIDSFQDA VKCLSEFACN AAFPDTSMEA IRLIRFCGKY
1310 1320 1330 1340 1350
VSERPRVLQE YTSDDMNVAP GDRVWVRGWF PILFELSCII NRCKLDVRTR
1360 1370 1380 1390 1400
GLTVMFEIMK SYGHTFEKHW WQDLFRIVFR IFDNMKLPEQ LSEKSEWMTT
1410 1420 1430 1440 1450
TCNHALYAIC DVFTQFYEAL NEVLLSDVFA QLQWCVKQDN EQLARSGTNC
1460 1470 1480 1490 1500
LENLVISNGE KFSPEVWDET CNCMLDIFKT TIPHVLLTWR PVGMEEDSSE
1510 1520 1530 1540 1550
KHLDVDLDRQ SLSSIDKNPS ERGQSQLSNP TDDSWKGRPY ANQKLFASLL
1560 1570 1580 1590 1600
IKCVVQLELI QTIDNIVFYP ATSKKEDAEH MVAAQQDTLD ADIHIETEDQ
1610 1620 1630 1640 1650
GMYKYMSSQH LFKLLDCLQE SHSFSKAFNS NYEQRTVLWR AGFKGKSKPN
1660 1670 1680 1690 1700
LLKQETSSLA CCLRILFRMY VDENRRDSWE EIQQRLLTVC SEALAYFITV
1710 1720 1730 1740 1750
NSESHREAWT SLLLLLLTKT LKINDEKFKA HASMYYPYLC EIMQFDLIPE
1760 1770 1780
LRAVLRKFFL RIGVVYKIWI PEEPSQVPAA LSPVW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 | E → R in AAD38428 (PubMed:10212200).Curated | 1 | |
Sequence conflicti | 962 | E → K in AAD38428 (PubMed:10212200).Curated | 1 | |
Sequence conflicti | 1049 | D → N in AAD38428 (PubMed:10212200).Curated | 1 | |
Sequence conflicti | 1763 | G → S in AAD38428 (PubMed:10212200).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037438 | 209 | E → K in PVNH2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs28937880EnsemblClinVar. | 1 | |
Natural variantiVAR_028750 | 527 | A → V. Corresponds to variant dbSNP:rs6063343Ensembl. | 1 | |
Natural variantiVAR_036156 | 794 | K → E in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_069404 | 802 | R → Q1 PublicationCorresponds to variant dbSNP:rs748482139Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF084521 mRNA Translation: AAD38428.1 AL049537 Genomic DNA No translation available. AL121903 Genomic DNA No translation available. |
CCDSi | CCDS13411.1 |
RefSeqi | NP_006411.2, NM_006420.2 |
Genome annotation databases
Ensembli | ENST00000371917; ENSP00000360985; ENSG00000124198 |
GeneIDi | 10564 |
KEGGi | hsa:10564 |
UCSCi | uc002xtx.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF084521 mRNA Translation: AAD38428.1 AL049537 Genomic DNA No translation available. AL121903 Genomic DNA No translation available. |
CCDSi | CCDS13411.1 |
RefSeqi | NP_006411.2, NM_006420.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3L8N | X-ray | 2.86 | A | 635-836 | [»] | |
3SWV | X-ray | 3.00 | A | 635-836 | [»] | |
SMRi | Q9Y6D5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115815, 70 interactors |
DIPi | DIP-48794N |
IntActi | Q9Y6D5, 34 interactors |
MINTi | Q9Y6D5 |
STRINGi | 9606.ENSP00000360985 |
Chemistry databases
ChEMBLi | CHEMBL4105732 |
PTM databases
iPTMneti | Q9Y6D5 |
PhosphoSitePlusi | Q9Y6D5 |
Genetic variation databases
BioMutai | ARFGEF2 |
DMDMi | 146329988 |
Proteomic databases
EPDi | Q9Y6D5 |
jPOSTi | Q9Y6D5 |
MassIVEi | Q9Y6D5 |
MaxQBi | Q9Y6D5 |
PaxDbi | Q9Y6D5 |
PeptideAtlasi | Q9Y6D5 |
PRIDEi | Q9Y6D5 |
ProteomicsDBi | 86654 |
Protocols and materials databases
Antibodypediai | 13512, 134 antibodies |
Genome annotation databases
Ensembli | ENST00000371917; ENSP00000360985; ENSG00000124198 |
GeneIDi | 10564 |
KEGGi | hsa:10564 |
UCSCi | uc002xtx.5, human |
Organism-specific databases
CTDi | 10564 |
DisGeNETi | 10564 |
GeneCardsi | ARFGEF2 |
HGNCi | HGNC:15853, ARFGEF2 |
HPAi | ENSG00000124198, Tissue enhanced (parathyroid) |
MalaCardsi | ARFGEF2 |
MIMi | 605371, gene 608097, phenotype |
neXtProti | NX_Q9Y6D5 |
OpenTargetsi | ENSG00000124198 |
Orphaneti | 98892, Periventricular nodular heterotopia |
PharmGKBi | PA24945 |
VEuPathDBi | HostDB:ENSG00000124198.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0929, Eukaryota |
GeneTreei | ENSGT00940000158950 |
HOGENOMi | CLU_000691_1_2_1 |
InParanoidi | Q9Y6D5 |
OMAi | FRMYSDP |
OrthoDBi | 815698at2759 |
PhylomeDBi | Q9Y6D5 |
TreeFami | TF300714 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y6D5 |
Reactomei | R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 10564, 5 hits in 875 CRISPR screens |
ChiTaRSi | ARFGEF2, human |
GeneWikii | ARFGEF2 |
GenomeRNAii | 10564 |
Pharosi | Q9Y6D5, Tbio |
PROi | PR:Q9Y6D5 |
RNActi | Q9Y6D5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124198, Expressed in caput epididymis and 247 other tissues |
Genevisiblei | Q9Y6D5, HS |
Family and domain databases
CDDi | cd00171, Sec7, 1 hit |
Gene3Di | 1.10.1000.11, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR032629, DCB_dom IPR015403, Sec7_C IPR023394, Sec7_C_sf IPR000904, Sec7_dom IPR035999, Sec7_dom_sf IPR032691, Sec7_N |
Pfami | View protein in Pfam PF16213, DCB, 1 hit PF09324, DUF1981, 1 hit PF01369, Sec7, 1 hit PF12783, Sec7_N, 1 hit |
SMARTi | View protein in SMART SM00222, Sec7, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48425, SSF48425, 1 hit |
PROSITEi | View protein in PROSITE PS50190, SEC7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIG2_HUMAN | |
Accessioni | Q9Y6D5Primary (citable) accession number: Q9Y6D5 Secondary accession number(s): Q5TFT9, Q9NTS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | March 6, 2007 | |
Last modified: | February 10, 2021 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references