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Protein

Mitochondrial carrier homolog 2

Gene

MTCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The substrate transported is not yet known. Induces mitochondrial depolarization.

GO - Biological processi

  • positive regulation of apoptotic process Source: GO_Central
  • protein localization to mitochondrion Source: MGI

Keywordsi

Biological processTransport

Enzyme and pathway databases

SIGNORiQ9Y6C9

Protein family/group databases

TCDBi2.A.29.25.2 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 2
Alternative name(s):
Met-induced mitochondrial protein
Gene namesi
Name:MTCH2
Synonyms:MIMP
ORF Names:HSPC032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000109919.9
HGNCiHGNC:17587 MTCH2
MIMi613221 gene
neXtProtiNX_Q9Y6C9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23788
OpenTargetsiENSG00000109919
PharmGKBiPA134951260

Polymorphism and mutation databases

BioMutaiMTCH2
DMDMi67461088

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000906372 – 303Mitochondrial carrier homolog 2Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y6C9
MaxQBiQ9Y6C9
PaxDbiQ9Y6C9
PeptideAtlasiQ9Y6C9
PRIDEiQ9Y6C9
ProteomicsDBi86652
TopDownProteomicsiQ9Y6C9

PTM databases

iPTMnetiQ9Y6C9
PhosphoSitePlusiQ9Y6C9
SwissPalmiQ9Y6C9

Expressioni

Gene expression databases

BgeeiENSG00000109919 Expressed in 227 organ(s), highest expression level in testis
CleanExiHS_MTCH2
ExpressionAtlasiQ9Y6C9 baseline and differential
GenevisibleiQ9Y6C9 HS

Organism-specific databases

HPAiHPA038390

Interactioni

Protein-protein interaction databases

BioGridi117287, 96 interactors
IntActiQ9Y6C9, 30 interactors
MINTiQ9Y6C9
STRINGi9606.ENSP00000303222

Structurei

3D structure databases

ProteinModelPortaliQ9Y6C9
SMRiQ9Y6C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 98Solcar 1Add BLAST97
Repeati118 – 206Solcar 2Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2745 Eukaryota
ENOG410XSXF LUCA
GeneTreeiENSGT00390000000020
HOGENOMiHOG000231394
HOVERGENiHBG058632
InParanoidiQ9Y6C9
KOiK17885
OMAiHYQECDK
OrthoDBiEOG091G0DU5
PhylomeDBiQ9Y6C9
TreeFamiTF313721

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 1 hit
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y6C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ
60 70 80 90 100
LPGLFSYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK
110 120 130 140 150
GEELGPGNVQ KEVSSSFDHV IKETTREMIA RSAATLITHP FHVITLRSMV
160 170 180 190 200
QFIGRESKYC GLCDSIITIY REEGILGFFA GLVPRLLGDI LSLWLCNSLA
210 220 230 240 250
YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG
260 270 280 290 300
LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK

MLI
Length:303
Mass (Da):33,331
Last modified:November 1, 1999 - v1
Checksum:i339087A8AF4A4508
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIE4E9PIE4_HUMAN
Mitochondrial carrier homolog 2
MTCH2
262Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05012868R → S. Corresponds to variant dbSNP:rs34072236Ensembl.1
Natural variantiVAR_050129290P → A. Corresponds to variant dbSNP:rs1064608Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380792 mRNA Translation: AAQ88168.1
AF176008 mRNA Translation: AAD52646.1
AF085361 mRNA Translation: AAD40196.1
AK313032 mRNA Translation: BAG35865.1
CH471064 Genomic DNA Translation: EAW67892.1
BC000875 mRNA Translation: AAH00875.1
CCDSiCCDS7943.1
RefSeqiNP_001304160.1, NM_001317231.1
NP_001304161.1, NM_001317232.1
NP_001304162.1, NM_001317233.1
NP_055157.1, NM_014342.3
UniGeneiHs.269944

Genome annotation databases

EnsembliENST00000302503; ENSP00000303222; ENSG00000109919
ENST00000643223; ENSP00000495027; ENSG00000285121
GeneIDi23788
KEGGihsa:23788
UCSCiuc010rho.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380792 mRNA Translation: AAQ88168.1
AF176008 mRNA Translation: AAD52646.1
AF085361 mRNA Translation: AAD40196.1
AK313032 mRNA Translation: BAG35865.1
CH471064 Genomic DNA Translation: EAW67892.1
BC000875 mRNA Translation: AAH00875.1
CCDSiCCDS7943.1
RefSeqiNP_001304160.1, NM_001317231.1
NP_001304161.1, NM_001317232.1
NP_001304162.1, NM_001317233.1
NP_055157.1, NM_014342.3
UniGeneiHs.269944

3D structure databases

ProteinModelPortaliQ9Y6C9
SMRiQ9Y6C9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117287, 96 interactors
IntActiQ9Y6C9, 30 interactors
MINTiQ9Y6C9
STRINGi9606.ENSP00000303222

Protein family/group databases

TCDBi2.A.29.25.2 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ9Y6C9
PhosphoSitePlusiQ9Y6C9
SwissPalmiQ9Y6C9

Polymorphism and mutation databases

BioMutaiMTCH2
DMDMi67461088

Proteomic databases

EPDiQ9Y6C9
MaxQBiQ9Y6C9
PaxDbiQ9Y6C9
PeptideAtlasiQ9Y6C9
PRIDEiQ9Y6C9
ProteomicsDBi86652
TopDownProteomicsiQ9Y6C9

Protocols and materials databases

DNASUi23788
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302503; ENSP00000303222; ENSG00000109919
ENST00000643223; ENSP00000495027; ENSG00000285121
GeneIDi23788
KEGGihsa:23788
UCSCiuc010rho.3 human

Organism-specific databases

CTDi23788
DisGeNETi23788
EuPathDBiHostDB:ENSG00000109919.9
GeneCardsiMTCH2
HGNCiHGNC:17587 MTCH2
HPAiHPA038390
MIMi613221 gene
neXtProtiNX_Q9Y6C9
OpenTargetsiENSG00000109919
PharmGKBiPA134951260
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2745 Eukaryota
ENOG410XSXF LUCA
GeneTreeiENSGT00390000000020
HOGENOMiHOG000231394
HOVERGENiHBG058632
InParanoidiQ9Y6C9
KOiK17885
OMAiHYQECDK
OrthoDBiEOG091G0DU5
PhylomeDBiQ9Y6C9
TreeFamiTF313721

Enzyme and pathway databases

SIGNORiQ9Y6C9

Miscellaneous databases

ChiTaRSiMTCH2 human
GeneWikiiMTCH2
GenomeRNAii23788
PROiPR:Q9Y6C9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109919 Expressed in 227 organ(s), highest expression level in testis
CleanExiHS_MTCH2
ExpressionAtlasiQ9Y6C9 baseline and differential
GenevisibleiQ9Y6C9 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 1 hit
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTCH2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6C9
Secondary accession number(s): B2R7L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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