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Protein

Cilia- and flagella-associated protein 20

Gene

CFAP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).1 Publication

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • positive regulation of cell motility Source: UniProtKB
  • positive regulation of feeding behavior Source: UniProtKB
  • protein polyglutamylation Source: UniProtKB
  • regulation of cilium beat frequency involved in ciliary motility Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 20
Alternative name(s):
Basal body up-regulated protein 22
Transcription factor IIB
Gene namesi
Name:CFAP20
Synonyms:BUG22, C16orf80, GTL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000070761.7
HGNCiHGNC:29523 CFAP20
MIMi617906 gene
neXtProtiNX_Q9Y6A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29105
OpenTargetsiENSG00000070761
PharmGKBiPA162378384

Polymorphism and mutation databases

BioMutaiC16orf80
DMDMi74753521

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963981 – 193Cilia- and flagella-associated protein 20Add BLAST193

Proteomic databases

EPDiQ9Y6A4
MaxQBiQ9Y6A4
PaxDbiQ9Y6A4
PeptideAtlasiQ9Y6A4
PRIDEiQ9Y6A4
ProteomicsDBi86641

PTM databases

CarbonylDBiQ9Y6A4
iPTMnetiQ9Y6A4
PhosphoSitePlusiQ9Y6A4

Expressioni

Gene expression databases

BgeeiENSG00000070761 Expressed in 221 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_C16orf80
ExpressionAtlasiQ9Y6A4 baseline and differential
GenevisibleiQ9Y6A4 HS

Organism-specific databases

HPAiHPA018195

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi118873, 39 interactors
CORUMiQ9Y6A4
IntActiQ9Y6A4, 26 interactors
MINTiQ9Y6A4
STRINGi9606.ENSP00000262498

Structurei

3D structure databases

ProteinModelPortaliQ9Y6A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CFAP20 family.Curated

Phylogenomic databases

eggNOGiKOG3213 Eukaryota
ENOG410XS39 LUCA
GeneTreeiENSGT00390000004554
HOGENOMiHOG000257095
HOVERGENiHBG102938
InParanoidiQ9Y6A4
OMAiHNTFQSG
OrthoDBiEOG091G0NXL
PhylomeDBiQ9Y6A4
TreeFamiTF313405

Family and domain databases

InterProiView protein in InterPro
IPR007714 CFA20/WDR90/C3orf67
PANTHERiPTHR12458 PTHR12458, 1 hit
PfamiView protein in Pfam
PF05018 DUF667, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9Y6A4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE
60 70 80 90 100
GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR
110 120 130 140 150
RRFRASNYQS TTRVKPFICT MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE
160 170 180 190
TLRVQIHANC RIRRVYFSDR LYSEDELPAE FKLYLPVQNK AKQ
Length:193
Mass (Da):22,774
Last modified:November 1, 1999 - v1
Checksum:i82ECDB0D2515BF77
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPA3H3BPA3_HUMAN
Cilia- and flagella-associated prot...
CFAP20
108Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087845 mRNA Translation: AAP97158.1
AF093680 mRNA Translation: AAD40382.1
AC009107 Genomic DNA No translation available.
AC026771 Genomic DNA No translation available.
BC005152 mRNA Translation: AAH05152.1
CCDSiCCDS10793.1
RefSeqiNP_037374.1, NM_013242.2
UniGeneiHs.532755

Genome annotation databases

EnsembliENST00000262498; ENSP00000262498; ENSG00000070761
GeneIDi29105
KEGGihsa:29105
UCSCiuc002enb.2 human

Similar proteinsi

Entry informationi

Entry nameiCFA20_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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