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Entry version 144 (29 Sep 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Cilia- and flagella-associated protein 20

Gene

CFAP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207).

Required for axonemal microtubules polyglutamylation (PubMed:24414207).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y6A4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 20
Alternative name(s):
Basal body up-regulated protein 22
Transcription factor IIB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP20
Synonyms:BUG22, C16orf80, GTL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29523, CFAP20

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617906, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6A4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000070761

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29105

Open Targets

More...
OpenTargetsi
ENSG00000070761

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162378384

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6A4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CFAP20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753521

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002963981 – 193Cilia- and flagella-associated protein 20Add BLAST193

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6A4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6A4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y6A4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y6A4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6A4

PeptideAtlas

More...
PeptideAtlasi
Q9Y6A4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6A4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86641

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9Y6A4

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6A4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6A4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000070761, Expressed in bronchial epithelial cell and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6A4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6A4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000070761, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118873, 71 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y6A4

Protein interaction database and analysis system

More...
IntActi
Q9Y6A4, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6A4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262498

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y6A4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6A4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFAP20 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3213, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004554

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_060610_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6A4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTYISCP

Database of Orthologous Groups

More...
OrthoDBi
1213295at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6A4

TreeFam database of animal gene trees

More...
TreeFami
TF313405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040441, CFA20/CFAP20DC
IPR007714, CFA20_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12458, PTHR12458, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05018, DUF667, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y6A4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE
60 70 80 90 100
GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR
110 120 130 140 150
RRFRASNYQS TTRVKPFICT MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE
160 170 180 190
TLRVQIHANC RIRRVYFSDR LYSEDELPAE FKLYLPVQNK AKQ
Length:193
Mass (Da):22,774
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82ECDB0D2515BF77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPA3H3BPA3_HUMAN
Cilia- and flagella-associated prot...
CFAP20
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF087845 mRNA Translation: AAP97158.1
AF093680 mRNA Translation: AAD40382.1
AC009107 Genomic DNA No translation available.
AC026771 Genomic DNA No translation available.
BC005152 mRNA Translation: AAH05152.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10793.1

NCBI Reference Sequences

More...
RefSeqi
NP_037374.1, NM_013242.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262498; ENSP00000262498; ENSG00000070761

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29105

UCSC genome browser

More...
UCSCi
uc002enb.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087845 mRNA Translation: AAP97158.1
AF093680 mRNA Translation: AAD40382.1
AC009107 Genomic DNA No translation available.
AC026771 Genomic DNA No translation available.
BC005152 mRNA Translation: AAH05152.1
CCDSiCCDS10793.1
RefSeqiNP_037374.1, NM_013242.2

3D structure databases

SMRiQ9Y6A4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118873, 71 interactors
CORUMiQ9Y6A4
IntActiQ9Y6A4, 37 interactors
MINTiQ9Y6A4
STRINGi9606.ENSP00000262498

PTM databases

CarbonylDBiQ9Y6A4
iPTMnetiQ9Y6A4
PhosphoSitePlusiQ9Y6A4

Genetic variation databases

BioMutaiCFAP20
DMDMi74753521

Proteomic databases

EPDiQ9Y6A4
jPOSTiQ9Y6A4
MassIVEiQ9Y6A4
MaxQBiQ9Y6A4
PaxDbiQ9Y6A4
PeptideAtlasiQ9Y6A4
PRIDEiQ9Y6A4
ProteomicsDBi86641

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15216, 119 antibodies

The DNASU plasmid repository

More...
DNASUi
29105

Genome annotation databases

EnsembliENST00000262498; ENSP00000262498; ENSG00000070761
GeneIDi29105
KEGGihsa:29105
UCSCiuc002enb.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29105
DisGeNETi29105

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CFAP20
HGNCiHGNC:29523, CFAP20
HPAiENSG00000070761, Low tissue specificity
MIMi617906, gene
neXtProtiNX_Q9Y6A4
OpenTargetsiENSG00000070761
PharmGKBiPA162378384
VEuPathDBiHostDB:ENSG00000070761

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3213, Eukaryota
GeneTreeiENSGT00390000004554
HOGENOMiCLU_060610_1_1_1
InParanoidiQ9Y6A4
OMAiTTYISCP
OrthoDBi1213295at2759
PhylomeDBiQ9Y6A4
TreeFamiTF313405

Enzyme and pathway databases

PathwayCommonsiQ9Y6A4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
29105, 454 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CFAP20, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29105
PharosiQ9Y6A4, Tbio

Protein Ontology

More...
PROi
PR:Q9Y6A4
RNActiQ9Y6A4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000070761, Expressed in bronchial epithelial cell and 233 other tissues
ExpressionAtlasiQ9Y6A4, baseline and differential
GenevisibleiQ9Y6A4, HS

Family and domain databases

InterProiView protein in InterPro
IPR040441, CFA20/CFAP20DC
IPR007714, CFA20_dom
PANTHERiPTHR12458, PTHR12458, 1 hit
PfamiView protein in Pfam
PF05018, DUF667, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFA20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6A4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 1, 1999
Last modified: September 29, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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