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Entry version 181 (13 Feb 2019)
Sequence version 3 (12 Apr 2005)
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Protein

Cysteine desulfurase, mitochondrial

Gene

NFS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateBy similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kinetic parameter was determined for the protein lacking the 55 N-terminal amino acids and in a complex with LYRM4.
  1. KM=434.75 µM for L-cysteine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei207Pyridoxal phosphateBy similarity1
    Binding sitei235Pyridoxal phosphateBy similarity1
    Binding sitei295Pyridoxal phosphateBy similarity1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei381Cysteine persulfide intermediateBy similarity1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi381Iron-sulfur (2Fe-2S); via persulfide group; shared with ISCUBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processMolybdenum cofactor biosynthesis
    LigandIron, Iron-sulfur, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS01304-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis
    R-HSA-947581 Molybdenum cofactor biosynthesis

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cysteine desulfurase, mitochondrial (EC:2.8.1.7)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NFS1
    Synonyms:NIFS
    ORF Names:HUSSY-08
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000244005.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:15910 NFS1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    603485 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9Y697

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    MalaCards human disease database

    More...
    MalaCardsi
    NFS1

    Open Targets

    More...
    OpenTargetsi
    ENSG00000244005

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    397593 Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA31607

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00160 L-Alanine
    DB00151 L-Cysteine
    DB00114 Pyridoxal Phosphate

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NFS1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    62512153

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000001292? – 457Cysteine desulfurase, mitochondrial
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258N6-(pyridoxal phosphate)lysineBy similarity1

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9Y697

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9Y697

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9Y697

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9Y697

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9Y697

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    86633
    86634 [Q9Y697-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9Y697

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9Y697

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9Y697

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000244005 Expressed in 206 organ(s), highest expression level in right adrenal gland

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9Y697 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9Y697 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB034314
    HPA051801
    HPA054755

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Binds ISCU/NIFUN (PubMed:11060020). Forms a complex with LYRM4 (PubMed:18650437, PubMed:19454487). Interacts with HSPA9 (PubMed:26702583).4 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114516, 38 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9Y697, 21 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000363205

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1457
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5KZ5electron microscopy14.301/2/3/4/M/N/O/P/Q/R/S/T67-457[»]
    5USRX-ray3.09A/C/E/G56-457[»]
    5WGBX-ray2.75A56-457[»]
    5WKPX-ray3.15A/E56-457[»]
    5WLWX-ray3.32A/E56-457[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9Y697

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9Y697

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 128Pyridoxal phosphate bindingBy similarity2
    Regioni255 – 257Pyridoxal phosphate bindingBy similarity3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1549 Eukaryota
    COG1104 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155740

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000017510

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG003708

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9Y697

    KEGG Orthology (KO)

    More...
    KOi
    K04487

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EPIQSGG

    Database of Orthologous Groups

    More...
    OrthoDBi
    664730at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9Y697

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105658

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.640.10, 1 hit
    3.90.1150.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00331 Cys_desulf_IscS, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000192 Aminotrans_V_dom
    IPR020578 Aminotrans_V_PyrdxlP_BS
    IPR010240 Cys_deSase_IscS
    IPR016454 Cysteine_dSase
    IPR015424 PyrdxlP-dep_Trfase
    IPR015422 PyrdxlP-dep_Trfase_dom1
    IPR015421 PyrdxlP-dep_Trfase_major

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11601:SF34 PTHR11601:SF34, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00266 Aminotran_5, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005572 NifS, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53383 SSF53383, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02006 IscS, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00595 AA_TRANSFER_CLASS_5, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket
    Note: Individual cells may vary AUG utilization in accordance with changes in metabolic status, the cytosolic pH being a strong determinant of this modulation.

    This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform Mitochondrial (identifier: Q9Y697-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MLLRAAWRRA AVAVTAAPGP KPAAPTRGLR LRVGDRAPQS AVPADTAAAP
    60 70 80 90 100
    EVGPVLRPLY MDVQATTPLD PRVLDAMLPY LINYYGNPHS RTHAYGWESE
    110 120 130 140 150
    AAMERARQQV ASLIGADPRE IIFTSGATES NNIAIKGVAR FYRSRKKHLI
    160 170 180 190 200
    TTQTEHKCVL DSCRSLEAEG FQVTYLPVQK SGIIDLKELE AAIQPDTSLV
    210 220 230 240 250
    SVMTVNNEIG VKQPIAEIGR ICSSRKVYFH TDAAQAVGKI PLDVNDMKID
    260 270 280 290 300
    LMSISGHKIY GPKGVGAIYI RRRPRVRVEA LQSGGGQERG MRSGTVPTPL
    310 320 330 340 350
    VVGLGAACEV AQQEMEYDHK RISKLSERLI QNIMKSLPDV VMNGDPKHHY
    360 370 380 390 400
    PGCINLSFAY VEGESLLMAL KDVALSSGSA CTSASLEPSY VLRAIGTDED
    410 420 430 440 450
    LAHSSIRFGI GRFTTEEEVD YTVEKCIQHV KRLREMSPLW EMVQDGIDLK

    SIKWTQH
    Length:457
    Mass (Da):50,196
    Last modified:April 12, 2005 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDE76177DB6E751B
    GO
    Isoform Cytoplasmic (identifier: Q9Y697-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Show »
    Length:397
    Mass (Da):44,017
    Checksum:i61DF3AD65D5CDD3C
    GO
    Isoform 3 (identifier: Q9Y697-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         136-186: Missing.

    Show »
    Length:406
    Mass (Da):44,362
    Checksum:i422B10BDBCD0FAB2
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q8WV90Q8WV90_HUMAN
    Cysteine desulfurase, mitochondrial
    NFS1
    189Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A2A2M1A2A2M1_HUMAN
    Cysteine desulfurase, mitochondrial
    NFS1
    107Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F2Z2E7F2Z2E7_HUMAN
    Cysteine desulfurase, mitochondrial
    NFS1
    204Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WB23F8WB23_HUMAN
    Cysteine desulfurase, mitochondrial
    NFS1
    147Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WER8F8WER8_HUMAN
    Cysteine desulfurase, mitochondrial
    NFS1
    87Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → V in AAD09187 (PubMed:9885568).Curated1
    Sequence conflicti47A → T in AAD09187 (PubMed:9885568).Curated1
    Sequence conflicti197T → A in BAG63421 (PubMed:14702039).Curated1
    Sequence conflicti412R → A in AAD09187 (PubMed:9885568).Curated1
    Sequence conflicti431K → N in AAD09187 (PubMed:9885568).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0186461 – 60Missing in isoform Cytoplasmic. 4 PublicationsAdd BLAST60
    Alternative sequenceiVSP_045860136 – 186Missing in isoform 3. 1 PublicationAdd BLAST51

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF097025 mRNA Translation: AAD09187.2
    AK001470 mRNA Translation: BAG50917.1
    AK302023 mRNA Translation: BAG63421.1
    AL109827 Genomic DNA No translation available.
    AL357374 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW76170.1
    CH471077 Genomic DNA Translation: EAW76172.1
    BC065560 mRNA Translation: AAH65560.1
    AJ010952 mRNA Translation: CAA09424.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13262.1 [Q9Y697-1]
    CCDS56185.1 [Q9Y697-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001185918.1, NM_001198989.1 [Q9Y697-3]
    NP_066923.3, NM_021100.4 [Q9Y697-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.194692

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000374085; ENSP00000363198; ENSG00000244005 [Q9Y697-2]
    ENST00000374092; ENSP00000363205; ENSG00000244005 [Q9Y697-1]
    ENST00000397425; ENSP00000380570; ENSG00000244005 [Q9Y697-2]
    ENST00000541387; ENSP00000440897; ENSG00000244005 [Q9Y697-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9054

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:9054

    UCSC genome browser

    More...
    UCSCi
    uc002xdt.3 human [Q9Y697-1]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF097025 mRNA Translation: AAD09187.2
    AK001470 mRNA Translation: BAG50917.1
    AK302023 mRNA Translation: BAG63421.1
    AL109827 Genomic DNA No translation available.
    AL357374 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW76170.1
    CH471077 Genomic DNA Translation: EAW76172.1
    BC065560 mRNA Translation: AAH65560.1
    AJ010952 mRNA Translation: CAA09424.1
    CCDSiCCDS13262.1 [Q9Y697-1]
    CCDS56185.1 [Q9Y697-3]
    RefSeqiNP_001185918.1, NM_001198989.1 [Q9Y697-3]
    NP_066923.3, NM_021100.4 [Q9Y697-1]
    UniGeneiHs.194692

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5KZ5electron microscopy14.301/2/3/4/M/N/O/P/Q/R/S/T67-457[»]
    5USRX-ray3.09A/C/E/G56-457[»]
    5WGBX-ray2.75A56-457[»]
    5WKPX-ray3.15A/E56-457[»]
    5WLWX-ray3.32A/E56-457[»]
    ProteinModelPortaliQ9Y697
    SMRiQ9Y697
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi114516, 38 interactors
    IntActiQ9Y697, 21 interactors
    STRINGi9606.ENSP00000363205

    Chemistry databases

    DrugBankiDB00160 L-Alanine
    DB00151 L-Cysteine
    DB00114 Pyridoxal Phosphate

    PTM databases

    iPTMnetiQ9Y697
    PhosphoSitePlusiQ9Y697
    SwissPalmiQ9Y697

    Polymorphism and mutation databases

    BioMutaiNFS1
    DMDMi62512153

    Proteomic databases

    EPDiQ9Y697
    jPOSTiQ9Y697
    PaxDbiQ9Y697
    PeptideAtlasiQ9Y697
    PRIDEiQ9Y697
    ProteomicsDBi86633
    86634 [Q9Y697-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    9054
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000374085; ENSP00000363198; ENSG00000244005 [Q9Y697-2]
    ENST00000374092; ENSP00000363205; ENSG00000244005 [Q9Y697-1]
    ENST00000397425; ENSP00000380570; ENSG00000244005 [Q9Y697-2]
    ENST00000541387; ENSP00000440897; ENSG00000244005 [Q9Y697-3]
    GeneIDi9054
    KEGGihsa:9054
    UCSCiuc002xdt.3 human [Q9Y697-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9054
    EuPathDBiHostDB:ENSG00000244005.12

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NFS1
    HGNCiHGNC:15910 NFS1
    HPAiCAB034314
    HPA051801
    HPA054755
    MalaCardsiNFS1
    MIMi603485 gene
    neXtProtiNX_Q9Y697
    OpenTargetsiENSG00000244005
    Orphaneti397593 Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency
    PharmGKBiPA31607

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1549 Eukaryota
    COG1104 LUCA
    GeneTreeiENSGT00940000155740
    HOGENOMiHOG000017510
    HOVERGENiHBG003708
    InParanoidiQ9Y697
    KOiK04487
    OMAiEPIQSGG
    OrthoDBi664730at2759
    PhylomeDBiQ9Y697
    TreeFamiTF105658

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01304-MONOMER
    ReactomeiR-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis
    R-HSA-947581 Molybdenum cofactor biosynthesis

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NFS1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    NFS1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9054

    Protein Ontology

    More...
    PROi
    PR:Q9Y697

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000244005 Expressed in 206 organ(s), highest expression level in right adrenal gland
    ExpressionAtlasiQ9Y697 baseline and differential
    GenevisibleiQ9Y697 HS

    Family and domain databases

    Gene3Di3.40.640.10, 1 hit
    3.90.1150.10, 1 hit
    HAMAPiMF_00331 Cys_desulf_IscS, 1 hit
    InterProiView protein in InterPro
    IPR000192 Aminotrans_V_dom
    IPR020578 Aminotrans_V_PyrdxlP_BS
    IPR010240 Cys_deSase_IscS
    IPR016454 Cysteine_dSase
    IPR015424 PyrdxlP-dep_Trfase
    IPR015422 PyrdxlP-dep_Trfase_dom1
    IPR015421 PyrdxlP-dep_Trfase_major
    PANTHERiPTHR11601:SF34 PTHR11601:SF34, 1 hit
    PfamiView protein in Pfam
    PF00266 Aminotran_5, 1 hit
    PIRSFiPIRSF005572 NifS, 1 hit
    SUPFAMiSSF53383 SSF53383, 1 hit
    TIGRFAMsiTIGR02006 IscS, 1 hit
    PROSITEiView protein in PROSITE
    PS00595 AA_TRANSFER_CLASS_5, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFS1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y697
    Secondary accession number(s): B3KMA5
    , B4DXK9, E1P5R8, F5GYK5, Q6P0L8, Q9NTZ5, Q9Y481
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 12, 2005
    Last modified: February 13, 2019
    This is version 181 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
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