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Entry version 162 (16 Oct 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=713 nM for prostaglandin E22 Publications
  2. KM=440 µM for tetracycline2 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processIon transport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-561048 Organic anion transport

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.1.19.25 the major facilitator superfamily (mfs)

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 22 member 7
    Alternative name(s):
    Novel liver transporter
    Organic anion transporter 2
    Short name:
    hOAT2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC22A7
    Synonyms:NLT, OAT2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10971 SLC22A7

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604995 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9Y694

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
    Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
    Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
    Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
    Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
    Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
    Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
    Transmembranei376 – 397HelicalSequence analysisAdd BLAST22
    Transmembranei404 – 423HelicalSequence analysisAdd BLAST20
    Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
    Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
    Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    10864

    Open Targets

    More...
    OpenTargetsi
    ENSG00000137204

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35848

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9Y694

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1955711

    Drug and drug target database

    More...
    DrugBanki
    DB00437 Allopurinol
    DB00345 Aminohippuric acid
    DB00887 Bumetanide
    DB00456 Cefalotin
    DB01326 Cefamandole
    DB01329 Cefoperazone
    DB00493 Cefotaxime
    DB02659 Cholic Acid
    DB00501 Cimetidine
    DB01211 Clarithromycin
    DB02527 Cyclic adenosine monophosphate
    DB01160 Dinoprost tromethamine
    DB00917 Dinoprostone
    DB01248 Docetaxel
    DB00584 Enalapril
    DB00544 Fluorouracil
    DB01004 Ganciclovir
    DB03553 Glutaric Acid
    DB01016 Glyburide
    DB00328 Indometacin
    DB01009 Ketoprofen
    DB00563 Methotrexate
    DB01017 Minocycline
    DB01303 Oxtriphylline
    DB00595 Oxytetracycline
    DB00175 Pravastatin
    DB01032 Probenecid
    DB01045 Rifampicin
    DB00936 Salicylic acid
    DB09327 Tegafur-uracil
    DB00624 Testosterone
    DB13943 Testosterone cypionate
    DB13944 Testosterone enanthate
    DB13946 Testosterone undecanoate
    DB00759 Tetracycline
    DB00277 Theophylline
    DB00313 Valproic Acid
    DB00943 Zalcitabine
    DB00495 Zidovudine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC22A7

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74753520

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174811 – 548Solute carrier family 22 member 7Add BLAST548

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9Y694

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9Y694

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9Y694

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9Y694

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    86628 [Q9Y694-1]
    86629 [Q9Y694-2]
    86630 [Q9Y694-3]
    86631 [Q9Y694-4]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9Y694

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9Y694

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in liver and kidney.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000137204 Expressed in 178 organ(s), highest expression level in liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9Y694 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9Y694 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA030220

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q9Y694, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000361666

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9Y694

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0255 Eukaryota
    COG0477 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154922

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000234569

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9Y694

    KEGG Orthology (KO)

    More...
    KOi
    K08204

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YIMFVIT

    Database of Orthologous Groups

    More...
    OrthoDBi
    435631at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9Y694

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315847

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011701 MFS
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004749 Orgcat_transp/SVOP

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07690 MFS_1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF103473 SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00898 2A0119, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50850 MFS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA
    60 70 80 90 100
    LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS
    110 120 130 140 150
    RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF
    160 170 180 190 200
    FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI
    210 220 230 240 250
    TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV
    260 270 280 290 300
    GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH
    310 320 330 340 350
    CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC
    360 370 380 390 400
    VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA
    410 420 430 440 450
    GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY
    460 470 480 490 500
    LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG
    510 520 530 540
    IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
    Length:548
    Mass (Da):60,026
    Last modified:November 1, 1999 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BA4C3FCC3C57533
    GO
    Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.

    Show »
    Length:546
    Mass (Da):59,810
    Checksum:i6A87AA1BD6FEA15C
    GO
    Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.
         531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

    Show »
    Length:539
    Mass (Da):59,082
    Checksum:iF3D6F799778EFE63
    GO
    Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-317: PVCEDSFSQE → MLQPHLLPYQ

    Show »
    Length:241
    Mass (Da):26,213
    Checksum:i8AF6769F5CAC8439
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q5T047Q5T047_HUMAN
    Solute carrier family 22 member 7
    SLC22A7
    147Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q5T051Q5T051_HUMAN
    Solute carrier family 22 member 7
    SLC22A7
    278Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    X6RDF7X6RDF7_HUMAN
    Solute carrier family 22 member 7
    SLC22A7
    211Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304L → P in AAG43523 (Ref. 2) Curated1
    Sequence conflicti413T → A in AAG43523 (Ref. 2) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047875303R → K1 PublicationCorresponds to variant dbSNP:rs70953684Ensembl.1
    Natural variantiVAR_047876327R → W1 PublicationCorresponds to variant dbSNP:rs36040909Ensembl.1
    Natural variantiVAR_047877507G → V1 PublicationCorresponds to variant dbSNP:rs70953693Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0309911 – 307Missing in isoform 4. CuratedAdd BLAST307
    Alternative sequenceiVSP_030992132 – 133Missing in isoform 2 and isoform 3. 2 Publications2
    Alternative sequenceiVSP_030993308 – 317PVCEDSFSQE → MLQPHLLPYQ in isoform 4. Curated10
    Alternative sequenceiVSP_030994531 – 548SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsAdd BLAST18

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF097518 mRNA Translation: AAD37091.1
    AF210455 mRNA Translation: AAG43523.1
    AY050498 mRNA Translation: AAL12496.1
    AK290796 mRNA Translation: BAF83485.1
    AK290806 mRNA Translation: BAF83495.1
    EU562669 Genomic DNA Translation: ACB21045.1
    AL583834 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04172.1
    CH471081 Genomic DNA Translation: EAX04175.1
    BC033805 mRNA Translation: AAH33805.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4892.1 [Q9Y694-2]
    CCDS4893.2 [Q9Y694-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_006663.2, NM_006672.3 [Q9Y694-2]
    NP_696961.2, NM_153320.2 [Q9Y694-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000372574; ENSP00000361655; ENSG00000137204 [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204 [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204 [Q9Y694-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10864

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:10864

    UCSC genome browser

    More...
    UCSCi
    uc003ous.4 human [Q9Y694-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF097518 mRNA Translation: AAD37091.1
    AF210455 mRNA Translation: AAG43523.1
    AY050498 mRNA Translation: AAL12496.1
    AK290796 mRNA Translation: BAF83485.1
    AK290806 mRNA Translation: BAF83495.1
    EU562669 Genomic DNA Translation: ACB21045.1
    AL583834 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04172.1
    CH471081 Genomic DNA Translation: EAX04175.1
    BC033805 mRNA Translation: AAH33805.1
    CCDSiCCDS4892.1 [Q9Y694-2]
    CCDS4893.2 [Q9Y694-1]
    RefSeqiNP_006663.2, NM_006672.3 [Q9Y694-2]
    NP_696961.2, NM_153320.2 [Q9Y694-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    IntActiQ9Y694, 2 interactors
    STRINGi9606.ENSP00000361666

    Chemistry databases

    BindingDBiQ9Y694
    ChEMBLiCHEMBL1955711
    DrugBankiDB00437 Allopurinol
    DB00345 Aminohippuric acid
    DB00887 Bumetanide
    DB00456 Cefalotin
    DB01326 Cefamandole
    DB01329 Cefoperazone
    DB00493 Cefotaxime
    DB02659 Cholic Acid
    DB00501 Cimetidine
    DB01211 Clarithromycin
    DB02527 Cyclic adenosine monophosphate
    DB01160 Dinoprost tromethamine
    DB00917 Dinoprostone
    DB01248 Docetaxel
    DB00584 Enalapril
    DB00544 Fluorouracil
    DB01004 Ganciclovir
    DB03553 Glutaric Acid
    DB01016 Glyburide
    DB00328 Indometacin
    DB01009 Ketoprofen
    DB00563 Methotrexate
    DB01017 Minocycline
    DB01303 Oxtriphylline
    DB00595 Oxytetracycline
    DB00175 Pravastatin
    DB01032 Probenecid
    DB01045 Rifampicin
    DB00936 Salicylic acid
    DB09327 Tegafur-uracil
    DB00624 Testosterone
    DB13943 Testosterone cypionate
    DB13944 Testosterone enanthate
    DB13946 Testosterone undecanoate
    DB00759 Tetracycline
    DB00277 Theophylline
    DB00313 Valproic Acid
    DB00943 Zalcitabine
    DB00495 Zidovudine

    Protein family/group databases

    TCDBi2.A.1.19.25 the major facilitator superfamily (mfs)

    PTM databases

    iPTMnetiQ9Y694
    PhosphoSitePlusiQ9Y694

    Polymorphism and mutation databases

    BioMutaiSLC22A7
    DMDMi74753520

    Proteomic databases

    MassIVEiQ9Y694
    PaxDbiQ9Y694
    PeptideAtlasiQ9Y694
    PRIDEiQ9Y694
    ProteomicsDBi86628 [Q9Y694-1]
    86629 [Q9Y694-2]
    86630 [Q9Y694-3]
    86631 [Q9Y694-4]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    10864

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204 [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204 [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204 [Q9Y694-2]
    GeneIDi10864
    KEGGihsa:10864
    UCSCiuc003ous.4 human [Q9Y694-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10864
    DisGeNETi10864

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC22A7
    HGNCiHGNC:10971 SLC22A7
    HPAiHPA030220
    MIMi604995 gene
    neXtProtiNX_Q9Y694
    OpenTargetsiENSG00000137204
    PharmGKBiPA35848

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0255 Eukaryota
    COG0477 LUCA
    GeneTreeiENSGT00940000154922
    HOGENOMiHOG000234569
    InParanoidiQ9Y694
    KOiK08204
    OMAiYIMFVIT
    OrthoDBi435631at2759
    PhylomeDBiQ9Y694
    TreeFamiTF315847

    Enzyme and pathway databases

    ReactomeiR-HSA-561048 Organic anion transport

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC22A7 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC22A7

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    10864
    PharosiQ9Y694

    Protein Ontology

    More...
    PROi
    PR:Q9Y694

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000137204 Expressed in 178 organ(s), highest expression level in liver
    ExpressionAtlasiQ9Y694 baseline and differential
    GenevisibleiQ9Y694 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR011701 MFS
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004749 Orgcat_transp/SVOP
    PfamiView protein in Pfam
    PF07690 MFS_1, 1 hit
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00898 2A0119, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22A7_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y694
    Secondary accession number(s): B2CZX6
    , Q5T046, Q5T048, Q5T050, Q9H2W5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1999
    Last modified: October 16, 2019
    This is version 162 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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