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Entry version 173 (29 Sep 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.

5 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=713 nM for prostaglandin E22 Publications
  2. KM=440 µM for tetracycline2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y694

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-561048, Organic anion transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.25, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 7
Alternative name(s):
Novel liver transporter
Organic anion transporter 2
Short name:
hOAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A7
Synonyms:NLT, OAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10971, SLC22A7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604995, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y694

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137204

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei376 – 397HelicalSequence analysisAdd BLAST22
Transmembranei404 – 423HelicalSequence analysisAdd BLAST20
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10864

Open Targets

More...
OpenTargetsi
ENSG00000137204

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35848

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y694, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1955711

Drug and drug target database

More...
DrugBanki
DB00437, Allopurinol
DB00345, Aminohippuric acid
DB00887, Bumetanide
DB00456, Cefalotin
DB01326, Cefamandole
DB01329, Cefoperazone
DB00493, Cefotaxime
DB02659, Cholic Acid
DB00501, Cimetidine
DB01211, Clarithromycin
DB02527, Cyclic adenosine monophosphate
DB01160, Dinoprost tromethamine
DB00917, Dinoprostone
DB01248, Docetaxel
DB00584, Enalapril
DB00544, Fluorouracil
DB01004, Ganciclovir
DB03553, Glutaric Acid
DB01016, Glyburide
DB00328, Indomethacin
DB01009, Ketoprofen
DB00563, Methotrexate
DB01017, Minocycline
DB01303, Oxtriphylline
DB00595, Oxytetracycline
DB00175, Pravastatin
DB01032, Probenecid
DB01045, Rifampicin
DB00936, Salicylic acid
DB09327, Tegafur-uracil
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB00759, Tetracycline
DB00277, Theophylline
DB00313, Valproic acid
DB00943, Zalcitabine
DB00495, Zidovudine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174811 – 548Solute carrier family 22 member 7Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y694

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y694

PeptideAtlas

More...
PeptideAtlasi
Q9Y694

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y694

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86628 [Q9Y694-1]
86629 [Q9Y694-2]
86630 [Q9Y694-3]
86631 [Q9Y694-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9Y694, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y694

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y694

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver and kidney.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137204, Expressed in liver and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y694, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y694, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137204, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9Y694, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361666

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y694

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y694, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni522 – 548DisorderedSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0255, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154922

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_33_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y694

Identification of Orthologs from Complete Genome Data

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OMAi
QAFFYNA

Database of Orthologous Groups

More...
OrthoDBi
435631at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y694

TreeFam database of animal gene trees

More...
TreeFami
TF315847

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004749, Orgcat_transp/SVOP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00898, 2A0119, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA
60 70 80 90 100
LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS
110 120 130 140 150
RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF
160 170 180 190 200
FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI
210 220 230 240 250
TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV
260 270 280 290 300
GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH
310 320 330 340 350
CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC
360 370 380 390 400
VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA
410 420 430 440 450
GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY
460 470 480 490 500
LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG
510 520 530 540
IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
Length:548
Mass (Da):60,026
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BA4C3FCC3C57533
GO
Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: Missing.

Show »
Length:546
Mass (Da):59,810
Checksum:i6A87AA1BD6FEA15C
GO
Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: Missing.
     531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

Show »
Length:539
Mass (Da):59,082
Checksum:iF3D6F799778EFE63
GO
Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-317: PVCEDSFSQE → MLQPHLLPYQ

Show »
Length:241
Mass (Da):26,213
Checksum:i8AF6769F5CAC8439
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T051Q5T051_HUMAN
Solute carrier family 22 member 7
SLC22A7
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T047Q5T047_HUMAN
Solute carrier family 22 member 7
SLC22A7
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RDF7X6RDF7_HUMAN
Solute carrier family 22 member 7
SLC22A7
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304L → P in AAG43523 (Ref. 2) Curated1
Sequence conflicti413T → A in AAG43523 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047875303R → K1 PublicationCorresponds to variant dbSNP:rs70953684Ensembl.1
Natural variantiVAR_047876327R → W1 PublicationCorresponds to variant dbSNP:rs36040909Ensembl.1
Natural variantiVAR_047877507G → V1 PublicationCorresponds to variant dbSNP:rs70953693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0309911 – 307Missing in isoform 4. CuratedAdd BLAST307
Alternative sequenceiVSP_030992132 – 133Missing in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_030993308 – 317PVCEDSFSQE → MLQPHLLPYQ in isoform 4. Curated10
Alternative sequenceiVSP_030994531 – 548SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF097518 mRNA Translation: AAD37091.1
AF210455 mRNA Translation: AAG43523.1
AY050498 mRNA Translation: AAL12496.1
AK290796 mRNA Translation: BAF83485.1
AK290806 mRNA Translation: BAF83495.1
EU562669 Genomic DNA Translation: ACB21045.1
AL583834 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04172.1
CH471081 Genomic DNA Translation: EAX04175.1
BC033805 mRNA Translation: AAH33805.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4892.1 [Q9Y694-2]
CCDS4893.2 [Q9Y694-1]

NCBI Reference Sequences

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RefSeqi
NP_006663.2, NM_006672.3 [Q9Y694-2]
NP_696961.2, NM_153320.2 [Q9Y694-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372574; ENSP00000361655; ENSG00000137204 [Q9Y694-3]
ENST00000372585; ENSP00000361666; ENSG00000137204 [Q9Y694-1]
ENST00000372589; ENSP00000361670; ENSG00000137204 [Q9Y694-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10864

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10864

UCSC genome browser

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UCSCi
uc003ous.4, human [Q9Y694-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097518 mRNA Translation: AAD37091.1
AF210455 mRNA Translation: AAG43523.1
AY050498 mRNA Translation: AAL12496.1
AK290796 mRNA Translation: BAF83485.1
AK290806 mRNA Translation: BAF83495.1
EU562669 Genomic DNA Translation: ACB21045.1
AL583834 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04172.1
CH471081 Genomic DNA Translation: EAX04175.1
BC033805 mRNA Translation: AAH33805.1
CCDSiCCDS4892.1 [Q9Y694-2]
CCDS4893.2 [Q9Y694-1]
RefSeqiNP_006663.2, NM_006672.3 [Q9Y694-2]
NP_696961.2, NM_153320.2 [Q9Y694-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9Y694, 2 interactors
STRINGi9606.ENSP00000361666

Chemistry databases

BindingDBiQ9Y694
ChEMBLiCHEMBL1955711
DrugBankiDB00437, Allopurinol
DB00345, Aminohippuric acid
DB00887, Bumetanide
DB00456, Cefalotin
DB01326, Cefamandole
DB01329, Cefoperazone
DB00493, Cefotaxime
DB02659, Cholic Acid
DB00501, Cimetidine
DB01211, Clarithromycin
DB02527, Cyclic adenosine monophosphate
DB01160, Dinoprost tromethamine
DB00917, Dinoprostone
DB01248, Docetaxel
DB00584, Enalapril
DB00544, Fluorouracil
DB01004, Ganciclovir
DB03553, Glutaric Acid
DB01016, Glyburide
DB00328, Indomethacin
DB01009, Ketoprofen
DB00563, Methotrexate
DB01017, Minocycline
DB01303, Oxtriphylline
DB00595, Oxytetracycline
DB00175, Pravastatin
DB01032, Probenecid
DB01045, Rifampicin
DB00936, Salicylic acid
DB09327, Tegafur-uracil
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB00759, Tetracycline
DB00277, Theophylline
DB00313, Valproic acid
DB00943, Zalcitabine
DB00495, Zidovudine

Protein family/group databases

TCDBi2.A.1.19.25, the major facilitator superfamily (mfs)

PTM databases

GlyGeniQ9Y694, 1 site
iPTMnetiQ9Y694
PhosphoSitePlusiQ9Y694

Genetic variation databases

BioMutaiSLC22A7
DMDMi74753520

Proteomic databases

MassIVEiQ9Y694
PaxDbiQ9Y694
PeptideAtlasiQ9Y694
PRIDEiQ9Y694
ProteomicsDBi86628 [Q9Y694-1]
86629 [Q9Y694-2]
86630 [Q9Y694-3]
86631 [Q9Y694-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30365, 108 antibodies

The DNASU plasmid repository

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DNASUi
10864

Genome annotation databases

EnsembliENST00000372574; ENSP00000361655; ENSG00000137204 [Q9Y694-3]
ENST00000372585; ENSP00000361666; ENSG00000137204 [Q9Y694-1]
ENST00000372589; ENSP00000361670; ENSG00000137204 [Q9Y694-2]
GeneIDi10864
KEGGihsa:10864
UCSCiuc003ous.4, human [Q9Y694-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10864
DisGeNETi10864

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC22A7
HGNCiHGNC:10971, SLC22A7
HPAiENSG00000137204, Tissue enriched (liver)
MIMi604995, gene
neXtProtiNX_Q9Y694
OpenTargetsiENSG00000137204
PharmGKBiPA35848
VEuPathDBiHostDB:ENSG00000137204

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0255, Eukaryota
GeneTreeiENSGT00940000154922
HOGENOMiCLU_001265_33_3_1
InParanoidiQ9Y694
OMAiQAFFYNA
OrthoDBi435631at2759
PhylomeDBiQ9Y694
TreeFamiTF315847

Enzyme and pathway databases

PathwayCommonsiQ9Y694
ReactomeiR-HSA-561048, Organic anion transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10864, 4 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC22A7, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC22A7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10864
PharosiQ9Y694, Tbio

Protein Ontology

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PROi
PR:Q9Y694
RNActiQ9Y694, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137204, Expressed in liver and 188 other tissues
ExpressionAtlasiQ9Y694, baseline and differential
GenevisibleiQ9Y694, HS

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004749, Orgcat_transp/SVOP
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00898, 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22A7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y694
Secondary accession number(s): B2CZX6
, Q5T046, Q5T048, Q5T050, Q9H2W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1999
Last modified: September 29, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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