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Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications

Kineticsi

  1. KM=713 nM for prostaglandin E22 Publications
  2. KM=440 µM for tetracycline2 Publications

    GO - Molecular functioni

    GO - Biological processi

    • organic anion transport Source: ProtInc
    • sodium-independent organic anion transport Source: GO_Central

    Keywordsi

    Biological processIon transport, Transport

    Enzyme and pathway databases

    ReactomeiR-HSA-561048 Organic anion transport

    Protein family/group databases

    TCDBi2.A.1.19.25 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 7
    Alternative name(s):
    Novel liver transporter
    Organic anion transporter 2
    Short name:
    hOAT2
    Gene namesi
    Name:SLC22A7
    Synonyms:NLT, OAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000137204.14
    HGNCiHGNC:10971 SLC22A7
    MIMi604995 gene
    neXtProtiNX_Q9Y694

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
    Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
    Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
    Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
    Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
    Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
    Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
    Transmembranei376 – 397HelicalSequence analysisAdd BLAST22
    Transmembranei404 – 423HelicalSequence analysisAdd BLAST20
    Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
    Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
    Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi10864
    OpenTargetsiENSG00000137204
    PharmGKBiPA35848

    Chemistry databases

    ChEMBLiCHEMBL1955711
    DrugBankiDB00945 Acetylsalicylic acid
    DB00437 Allopurinol
    DB00345 Aminohippuric acid
    DB00887 Bumetanide
    DB00456 Cefalotin
    DB01326 Cefamandole
    DB01329 Cefoperazone
    DB00493 Cefotaxime
    DB02659 Cholic Acid
    DB00501 Cimetidine
    DB01211 Clarithromycin
    DB02527 Cyclic Adenosine Monophosphate
    DB01160 Dinoprost Tromethamine
    DB00917 Dinoprostone
    DB01248 Docetaxel
    DB00584 Enalapril
    DB00544 Fluorouracil
    DB01004 Ganciclovir
    DB03553 Glutaric Acid
    DB01016 Glyburide
    DB00328 Indomethacin
    DB01009 Ketoprofen
    DB00563 Methotrexate
    DB01017 Minocycline
    DB01303 Oxtriphylline
    DB00595 Oxytetracycline
    DB00175 Pravastatin
    DB01032 Probenecid
    DB01045 Rifampicin
    DB00936 Salicylic acid
    DB00624 Testosterone
    DB00759 Tetracycline
    DB00277 Theophylline
    DB00313 Valproic Acid
    DB00943 Zalcitabine
    DB00495 Zidovudine

    Polymorphism and mutation databases

    BioMutaiSLC22A7
    DMDMi74753520

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003174811 – 548Solute carrier family 22 member 7Add BLAST548

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y694
    PeptideAtlasiQ9Y694
    PRIDEiQ9Y694
    ProteomicsDBi86628
    86629 [Q9Y694-2]
    86630 [Q9Y694-3]
    86631 [Q9Y694-4]

    PTM databases

    iPTMnetiQ9Y694
    PhosphoSitePlusiQ9Y694

    Expressioni

    Tissue specificityi

    Expressed in liver and kidney.3 Publications

    Gene expression databases

    BgeeiENSG00000137204 Expressed in 178 organ(s), highest expression level in liver
    CleanExiHS_SLC22A7
    ExpressionAtlasiQ9Y694 baseline and differential
    GenevisibleiQ9Y694 HS

    Organism-specific databases

    HPAiHPA030220

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Y694, 2 interactors
    STRINGi9606.ENSP00000361666

    Chemistry databases

    BindingDBiQ9Y694

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y694
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0255 Eukaryota
    COG0477 LUCA
    GeneTreeiENSGT00760000118852
    HOGENOMiHOG000234569
    HOVERGENiHBG108433
    InParanoidiQ9Y694
    KOiK08204
    OMAiLLPMHFL
    OrthoDBiEOG091G07GO
    PhylomeDBiQ9Y694
    TreeFamiTF315847

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR011701 MFS
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004749 Orgcat_transp/SVOP
    PfamiView protein in Pfam
    PF07690 MFS_1, 1 hit
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00898 2A0119, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit

    Sequences (4+)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA
    60 70 80 90 100
    LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS
    110 120 130 140 150
    RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF
    160 170 180 190 200
    FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI
    210 220 230 240 250
    TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV
    260 270 280 290 300
    GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH
    310 320 330 340 350
    CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC
    360 370 380 390 400
    VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA
    410 420 430 440 450
    GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY
    460 470 480 490 500
    LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG
    510 520 530 540
    IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
    Length:548
    Mass (Da):60,026
    Last modified:November 1, 1999 - v1
    Checksum:i5BA4C3FCC3C57533
    GO
    Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.

    Show »
    Length:546
    Mass (Da):59,810
    Checksum:i6A87AA1BD6FEA15C
    GO
    Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.
         531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

    Show »
    Length:539
    Mass (Da):59,082
    Checksum:iF3D6F799778EFE63
    GO
    Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-317: PVCEDSFSQE → MLQPHLLPYQ

    Show »
    Length:241
    Mass (Da):26,213
    Checksum:i8AF6769F5CAC8439
    GO

    Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q5T051Q5T051_HUMAN
    Solute carrier family 22 member 7
    SLC22A7
    278Annotation score:
    Q5T047Q5T047_HUMAN
    Solute carrier family 22 member 7
    SLC22A7
    147Annotation score:
    X6RDF7X6RDF7_HUMAN
    Solute carrier family 22 member 7
    SLC22A7
    211Annotation score:
    Q8WWC3Q8WWC3_HUMAN
    SLC22A7 protein
    SLC22A7 hCG_19011
    235Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti304L → P in AAG43523 (Ref. 2) Curated1
    Sequence conflicti413T → A in AAG43523 (Ref. 2) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_047875303R → K1 PublicationCorresponds to variant dbSNP:rs70953684Ensembl.1
    Natural variantiVAR_047876327R → W1 PublicationCorresponds to variant dbSNP:rs36040909Ensembl.1
    Natural variantiVAR_047877507G → V1 PublicationCorresponds to variant dbSNP:rs70953693Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0309911 – 307Missing in isoform 4. CuratedAdd BLAST307
    Alternative sequenceiVSP_030992132 – 133Missing in isoform 2 and isoform 3. 2 Publications2
    Alternative sequenceiVSP_030993308 – 317PVCEDSFSQE → MLQPHLLPYQ in isoform 4. Curated10
    Alternative sequenceiVSP_030994531 – 548SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsAdd BLAST18

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF097518 mRNA Translation: AAD37091.1
    AF210455 mRNA Translation: AAG43523.1
    AY050498 mRNA Translation: AAL12496.1
    AK290796 mRNA Translation: BAF83485.1
    AK290806 mRNA Translation: BAF83495.1
    EU562669 Genomic DNA Translation: ACB21045.1
    AL583834 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04172.1
    CH471081 Genomic DNA Translation: EAX04175.1
    BC033805 mRNA Translation: AAH33805.1
    CCDSiCCDS4892.1 [Q9Y694-2]
    CCDS4893.2 [Q9Y694-1]
    RefSeqiNP_006663.2, NM_006672.3 [Q9Y694-2]
    NP_696961.2, NM_153320.2 [Q9Y694-1]
    UniGeneiHs.485438

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204 [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204 [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204 [Q9Y694-2]
    GeneIDi10864
    KEGGihsa:10864
    UCSCiuc003ous.4 human [Q9Y694-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF097518 mRNA Translation: AAD37091.1
    AF210455 mRNA Translation: AAG43523.1
    AY050498 mRNA Translation: AAL12496.1
    AK290796 mRNA Translation: BAF83485.1
    AK290806 mRNA Translation: BAF83495.1
    EU562669 Genomic DNA Translation: ACB21045.1
    AL583834 Genomic DNA No translation available.
    CH471081 Genomic DNA Translation: EAX04172.1
    CH471081 Genomic DNA Translation: EAX04175.1
    BC033805 mRNA Translation: AAH33805.1
    CCDSiCCDS4892.1 [Q9Y694-2]
    CCDS4893.2 [Q9Y694-1]
    RefSeqiNP_006663.2, NM_006672.3 [Q9Y694-2]
    NP_696961.2, NM_153320.2 [Q9Y694-1]
    UniGeneiHs.485438

    3D structure databases

    ProteinModelPortaliQ9Y694
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9Y694, 2 interactors
    STRINGi9606.ENSP00000361666

    Chemistry databases

    BindingDBiQ9Y694
    ChEMBLiCHEMBL1955711
    DrugBankiDB00945 Acetylsalicylic acid
    DB00437 Allopurinol
    DB00345 Aminohippuric acid
    DB00887 Bumetanide
    DB00456 Cefalotin
    DB01326 Cefamandole
    DB01329 Cefoperazone
    DB00493 Cefotaxime
    DB02659 Cholic Acid
    DB00501 Cimetidine
    DB01211 Clarithromycin
    DB02527 Cyclic Adenosine Monophosphate
    DB01160 Dinoprost Tromethamine
    DB00917 Dinoprostone
    DB01248 Docetaxel
    DB00584 Enalapril
    DB00544 Fluorouracil
    DB01004 Ganciclovir
    DB03553 Glutaric Acid
    DB01016 Glyburide
    DB00328 Indomethacin
    DB01009 Ketoprofen
    DB00563 Methotrexate
    DB01017 Minocycline
    DB01303 Oxtriphylline
    DB00595 Oxytetracycline
    DB00175 Pravastatin
    DB01032 Probenecid
    DB01045 Rifampicin
    DB00936 Salicylic acid
    DB00624 Testosterone
    DB00759 Tetracycline
    DB00277 Theophylline
    DB00313 Valproic Acid
    DB00943 Zalcitabine
    DB00495 Zidovudine

    Protein family/group databases

    TCDBi2.A.1.19.25 the major facilitator superfamily (mfs)

    PTM databases

    iPTMnetiQ9Y694
    PhosphoSitePlusiQ9Y694

    Polymorphism and mutation databases

    BioMutaiSLC22A7
    DMDMi74753520

    Proteomic databases

    PaxDbiQ9Y694
    PeptideAtlasiQ9Y694
    PRIDEiQ9Y694
    ProteomicsDBi86628
    86629 [Q9Y694-2]
    86630 [Q9Y694-3]
    86631 [Q9Y694-4]

    Protocols and materials databases

    DNASUi10864
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204 [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204 [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204 [Q9Y694-2]
    GeneIDi10864
    KEGGihsa:10864
    UCSCiuc003ous.4 human [Q9Y694-1]

    Organism-specific databases

    CTDi10864
    DisGeNETi10864
    EuPathDBiHostDB:ENSG00000137204.14
    GeneCardsiSLC22A7
    HGNCiHGNC:10971 SLC22A7
    HPAiHPA030220
    MIMi604995 gene
    neXtProtiNX_Q9Y694
    OpenTargetsiENSG00000137204
    PharmGKBiPA35848
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0255 Eukaryota
    COG0477 LUCA
    GeneTreeiENSGT00760000118852
    HOGENOMiHOG000234569
    HOVERGENiHBG108433
    InParanoidiQ9Y694
    KOiK08204
    OMAiLLPMHFL
    OrthoDBiEOG091G07GO
    PhylomeDBiQ9Y694
    TreeFamiTF315847

    Enzyme and pathway databases

    ReactomeiR-HSA-561048 Organic anion transport

    Miscellaneous databases

    ChiTaRSiSLC22A7 human
    GeneWikiiSLC22A7
    GenomeRNAii10864
    PROiPR:Q9Y694
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000137204 Expressed in 178 organ(s), highest expression level in liver
    CleanExiHS_SLC22A7
    ExpressionAtlasiQ9Y694 baseline and differential
    GenevisibleiQ9Y694 HS

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR011701 MFS
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004749 Orgcat_transp/SVOP
    PfamiView protein in Pfam
    PF07690 MFS_1, 1 hit
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00898 2A0119, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiS22A7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y694
    Secondary accession number(s): B2CZX6
    , Q5T046, Q5T048, Q5T050, Q9H2W5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1999
    Last modified: September 12, 2018
    This is version 153 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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