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Protein

LHFPL tetraspan subfamily member 6 protein

Gene

LHFPL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi1.A.82.1.6 the lhfpl tetraspan protein (ltsp) family

Names & Taxonomyi

Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 6 proteinImported
Alternative name(s):
Lipoma HMGIC fusion partnerImported
Gene namesi
Name:LHFPL6Imported
Synonyms:LHFPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000183722.7
HGNCiHGNC:6586 LHFPL6
MIMi606710 gene
neXtProtiNX_Q9Y693

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LHFP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in lipomas.1 Publication

Organism-specific databases

DisGeNETi10186
OpenTargetsiENSG00000183722
PharmGKBiPA30358

Polymorphism and mutation databases

BioMutaiLHFP
DMDMi74753519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000024475622 – 200LHFPL tetraspan subfamily member 6 proteinAdd BLAST179

Proteomic databases

MaxQBiQ9Y693
PaxDbiQ9Y693
PeptideAtlasiQ9Y693
PRIDEiQ9Y693
ProteomicsDBi86627

PTM databases

iPTMnetiQ9Y693
PhosphoSitePlusiQ9Y693
SwissPalmiQ9Y693

Expressioni

Tissue specificityi

Pancreas, kidney, skeletal muscle, liver, lung brain, heart, colon, small intestine, uterus, testis, prostate, thymus, spleen and placenta.1 Publication

Gene expression databases

BgeeiENSG00000183722 Expressed in 231 organ(s), highest expression level in female reproductive system
CleanExiHS_LHFP
ExpressionAtlasiQ9Y693 baseline and differential
GenevisibleiQ9Y693 HS

Organism-specific databases

HPAiHPA058975

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368908

Structurei

3D structure databases

ProteinModelPortaliQ9Y693
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00550000074479
HOGENOMiHOG000007007
HOVERGENiHBG080585
InParanoidiQ9Y693
OMAiSTEWRIC
OrthoDBiEOG091G10EV
PhylomeDBiQ9Y693
TreeFamiTF321143

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y693-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSLTCTGV IWALLSFLCA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC
60 70 80 90 100
SYPVHDESRQ MMVMVEECGR YASFQGIPSA EWRICTIVTG LGCGLLLLVA
110 120 130 140 150
LTALMGCCVS DLISRTVGRV AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ
160 170 180 190 200
TCGYTSGQFD LGKCEIGWAY YCTGAGATAA MLLCTWLACF SGKKQKHYPY
Length:200
Mass (Da):21,598
Last modified:November 1, 1999 - v1
Checksum:i49D1161602966423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098807 mRNA Translation: AAD31386.1
AL138685 Genomic DNA No translation available.
AL136358 Genomic DNA No translation available.
AL158194 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08616.1
BC017824 mRNA Translation: AAH17824.1
AK223369 mRNA Translation: BAD97089.1
AK313036 mRNA Translation: BAG35869.1
CCDSiCCDS9369.1
RefSeqiNP_005771.1, NM_005780.2
XP_011533163.1, XM_011534861.1
UniGeneiHs.507798

Genome annotation databases

EnsembliENST00000379589; ENSP00000368908; ENSG00000183722
GeneIDi10186
KEGGihsa:10186
UCSCiuc001uxf.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098807 mRNA Translation: AAD31386.1
AL138685 Genomic DNA No translation available.
AL136358 Genomic DNA No translation available.
AL158194 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08616.1
BC017824 mRNA Translation: AAH17824.1
AK223369 mRNA Translation: BAD97089.1
AK313036 mRNA Translation: BAG35869.1
CCDSiCCDS9369.1
RefSeqiNP_005771.1, NM_005780.2
XP_011533163.1, XM_011534861.1
UniGeneiHs.507798

3D structure databases

ProteinModelPortaliQ9Y693
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368908

Protein family/group databases

TCDBi1.A.82.1.6 the lhfpl tetraspan protein (ltsp) family

PTM databases

iPTMnetiQ9Y693
PhosphoSitePlusiQ9Y693
SwissPalmiQ9Y693

Polymorphism and mutation databases

BioMutaiLHFP
DMDMi74753519

Proteomic databases

MaxQBiQ9Y693
PaxDbiQ9Y693
PeptideAtlasiQ9Y693
PRIDEiQ9Y693
ProteomicsDBi86627

Protocols and materials databases

DNASUi10186
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379589; ENSP00000368908; ENSG00000183722
GeneIDi10186
KEGGihsa:10186
UCSCiuc001uxf.4 human

Organism-specific databases

CTDi10186
DisGeNETi10186
EuPathDBiHostDB:ENSG00000183722.7
GeneCardsiLHFPL6
HGNCiHGNC:6586 LHFPL6
HPAiHPA058975
MIMi606710 gene
neXtProtiNX_Q9Y693
OpenTargetsiENSG00000183722
PharmGKBiPA30358
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4026 Eukaryota
ENOG410XSUB LUCA
GeneTreeiENSGT00550000074479
HOGENOMiHOG000007007
HOVERGENiHBG080585
InParanoidiQ9Y693
OMAiSTEWRIC
OrthoDBiEOG091G10EV
PhylomeDBiQ9Y693
TreeFamiTF321143

Miscellaneous databases

ChiTaRSiLHFP human
GeneWikiiLHFP
GenomeRNAii10186
PROiPR:Q9Y693
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183722 Expressed in 231 organ(s), highest expression level in female reproductive system
CleanExiHS_LHFP
ExpressionAtlasiQ9Y693 baseline and differential
GenevisibleiQ9Y693 HS

Family and domain databases

InterProiView protein in InterPro
IPR019372 LHFPL
PANTHERiPTHR12489 PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242 L_HMGIC_fpl, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y693
Secondary accession number(s): B2R7M2, Q53FC0, Q96SH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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