UniProtKB - Q9Y691 (KCMB2_HUMAN)
Calcium-activated potassium channel subunit beta-2
KCNMB2
Functioni
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
2 PublicationsGO - Molecular functioni
- calcium-activated potassium channel activity Source: UniProtKB
- ion channel inhibitor activity Source: ProtInc
- potassium channel regulator activity Source: GO_Central
GO - Biological processi
- action potential Source: UniProtKB
- detection of calcium ion Source: UniProtKB
- neuronal action potential Source: UniProtKB
- potassium ion transport Source: UniProtKB
- regulation of vasoconstriction Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y691 |
Reactomei | R-HSA-1296052, Ca2+ activated K+ channels R-HSA-418457, cGMP effects |
SignaLinki | Q9Y691 |
Protein family/group databases
TCDBi | 8.A.14.1.3, the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-activated potassium channel subunit beta-2Alternative name(s): BK channel subunit beta-2 Short name: BKbeta2 Short name: Hbeta2 Calcium-activated potassium channel, subfamily M subunit beta-2 Charybdotoxin receptor subunit beta-2 Hbeta3 K(VCA)beta-2 Maxi K channel subunit beta-2 Slo-beta-2 |
Gene namesi | Name:KCNMB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6286, KCNMB2 |
MIMi | 605214, gene |
neXtProti | NX_Q9Y691 |
VEuPathDBi | HostDB:ENSG00000197584 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- voltage-gated potassium channel complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 46 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 47 – 67 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 68 – 194 | ExtracellularSequence analysisAdd BLAST | 127 | |
Transmembranei | 195 – 215 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 235 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 – 4 | FIW → GGG: Abolishes inactivation of KCNMA1 channel. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 10242 |
OpenTargetsi | ENSG00000197584 ENSG00000275163 |
PharmGKBi | PA30066 |
Miscellaneous databases
Pharosi | Q9Y691, Tbio |
Chemistry databases
DrugBanki | DB03861, (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine DB01110, Miconazole DB00721, Procaine DB09089, Trimebutine |
Genetic variation databases
BioMutai | KCNMB2 |
DMDMi | 46396054 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187051 | 1 – 235 | Calcium-activated potassium channel subunit beta-2Add BLAST | 235 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9Y691 |
MassIVEi | Q9Y691 |
PaxDbi | Q9Y691 |
PeptideAtlasi | Q9Y691 |
PRIDEi | Q9Y691 |
ProteomicsDBi | 86624 |
PTM databases
GlyGeni | Q9Y691, 3 sites |
iPTMneti | Q9Y691 |
PhosphoSitePlusi | Q9Y691 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000197584, Expressed in islet of Langerhans and 135 other tissues |
ExpressionAtlasi | Q9Y691, baseline and differential |
Genevisiblei | Q9Y691, HS |
Organism-specific databases
HPAi | ENSG00000197584, Tissue enhanced (epididymis, fallopian tube, ovary) |
Interactioni
Subunit structurei
Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 115536, 11 interactors |
IntActi | Q9Y691, 3 interactors |
MINTi | Q9Y691 |
STRINGi | 9606.ENSP00000407592 |
Miscellaneous databases
RNActi | Q9Y691, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9Y691 |
BMRBi | Q9Y691 |
SMRi | Q9Y691 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y691 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | Ball and chainAdd BLAST | 45 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSCP, Eukaryota |
GeneTreei | ENSGT00950000183039 |
HOGENOMi | CLU_085739_1_1_1 |
InParanoidi | Q9Y691 |
OMAi | FACYSDP |
OrthoDBi | 1178937at2759 |
PhylomeDBi | Q9Y691 |
TreeFami | TF328589 |
Family and domain databases
Gene3Di | 4.10.81.20, 1 hit |
InterProi | View protein in InterPro IPR003930, K_chnl_Ca-activ_BK_bsu IPR037096, KCNMB2_ball/chain_dom_sf IPR015382, KCNMB2_ball_chain_dom |
PANTHERi | PTHR10258, PTHR10258, 1 hit |
Pfami | View protein in Pfam PF03185, CaKB, 1 hit PF09303, KcnmB2_inactiv, 1 hit |
PRINTSi | PR01450, BKCHANNELB |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL
60 70 80 90 100
GLAMMVCSIM MYFLLGITLL RSYMQSVWTE ESQCTLLNAS ITETFNCSFS
110 120 130 140 150
CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETIKINQ KCSYIPKCGK
160 170 180 190 200
NFEESMSLVN VVMENFRKYQ HFSCYSDPEG NQKSVILTKL YSSNVLFHSL
210 220 230
FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ETM2 | E7ETM2_HUMAN | Calcium-activated potassium channel... | KCNMB2 | 137 | Annotation score: | ||
E7EM81 | E7EM81_HUMAN | Calcium-activated potassium channel... | KCNMB2 | 100 | Annotation score: | ||
F8WE19 | F8WE19_HUMAN | Calcium-activated potassium channel... | KCNMB2 | 26 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF099137 mRNA Translation: AAD23380.1 AF209747 mRNA Translation: AAF36562.1 BC017825 mRNA Translation: AAH17825.1 |
CCDSi | CCDS3223.1 |
RefSeqi | NP_001265840.1, NM_001278911.1 NP_005823.1, NM_005832.4 NP_852006.1, NM_181361.2 XP_011510627.1, XM_011512325.2 |
Genome annotation databases
Ensembli | ENST00000358316.7; ENSP00000351068.3; ENSG00000197584.13 ENST00000420517.6; ENSP00000408252.2; ENSG00000197584.13 ENST00000432997.5; ENSP00000407592.1; ENSG00000197584.13 ENST00000452583.6; ENSP00000397483.1; ENSG00000197584.13 |
GeneIDi | 10242 |
KEGGi | hsa:10242 |
MANE-Selecti | ENST00000452583.6; ENSP00000397483.1; NM_181361.3; NP_852006.1 |
UCSCi | uc003fjd.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF099137 mRNA Translation: AAD23380.1 AF209747 mRNA Translation: AAF36562.1 BC017825 mRNA Translation: AAH17825.1 |
CCDSi | CCDS3223.1 |
RefSeqi | NP_001265840.1, NM_001278911.1 NP_005823.1, NM_005832.4 NP_852006.1, NM_181361.2 XP_011510627.1, XM_011512325.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JO6 | NMR | - | A | 1-45 | [»] | |
AlphaFoldDBi | Q9Y691 | |||||
BMRBi | Q9Y691 | |||||
SMRi | Q9Y691 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115536, 11 interactors |
IntActi | Q9Y691, 3 interactors |
MINTi | Q9Y691 |
STRINGi | 9606.ENSP00000407592 |
Chemistry databases
DrugBanki | DB03861, (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine DB01110, Miconazole DB00721, Procaine DB09089, Trimebutine |
Protein family/group databases
TCDBi | 8.A.14.1.3, the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family |
PTM databases
GlyGeni | Q9Y691, 3 sites |
iPTMneti | Q9Y691 |
PhosphoSitePlusi | Q9Y691 |
Genetic variation databases
BioMutai | KCNMB2 |
DMDMi | 46396054 |
Proteomic databases
jPOSTi | Q9Y691 |
MassIVEi | Q9Y691 |
PaxDbi | Q9Y691 |
PeptideAtlasi | Q9Y691 |
PRIDEi | Q9Y691 |
ProteomicsDBi | 86624 |
Protocols and materials databases
ABCDi | Q9Y691, 1 sequenced antibody |
Antibodypediai | 33738, 252 antibodies from 29 providers |
DNASUi | 10242 |
Genome annotation databases
Ensembli | ENST00000358316.7; ENSP00000351068.3; ENSG00000197584.13 ENST00000420517.6; ENSP00000408252.2; ENSG00000197584.13 ENST00000432997.5; ENSP00000407592.1; ENSG00000197584.13 ENST00000452583.6; ENSP00000397483.1; ENSG00000197584.13 |
GeneIDi | 10242 |
KEGGi | hsa:10242 |
MANE-Selecti | ENST00000452583.6; ENSP00000397483.1; NM_181361.3; NP_852006.1 |
UCSCi | uc003fjd.5, human |
Organism-specific databases
CTDi | 10242 |
DisGeNETi | 10242 |
GeneCardsi | KCNMB2 |
HGNCi | HGNC:6286, KCNMB2 |
HPAi | ENSG00000197584, Tissue enhanced (epididymis, fallopian tube, ovary) |
MIMi | 605214, gene |
neXtProti | NX_Q9Y691 |
OpenTargetsi | ENSG00000197584 ENSG00000275163 |
PharmGKBi | PA30066 |
VEuPathDBi | HostDB:ENSG00000197584 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSCP, Eukaryota |
GeneTreei | ENSGT00950000183039 |
HOGENOMi | CLU_085739_1_1_1 |
InParanoidi | Q9Y691 |
OMAi | FACYSDP |
OrthoDBi | 1178937at2759 |
PhylomeDBi | Q9Y691 |
TreeFami | TF328589 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y691 |
Reactomei | R-HSA-1296052, Ca2+ activated K+ channels R-HSA-418457, cGMP effects |
SignaLinki | Q9Y691 |
Miscellaneous databases
BioGRID-ORCSi | 10242, 12 hits in 1070 CRISPR screens |
ChiTaRSi | KCNMB2, human |
EvolutionaryTracei | Q9Y691 |
GeneWikii | KCNMB2 |
GenomeRNAii | 10242 |
Pharosi | Q9Y691, Tbio |
PROi | PR:Q9Y691 |
RNActi | Q9Y691, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197584, Expressed in islet of Langerhans and 135 other tissues |
ExpressionAtlasi | Q9Y691, baseline and differential |
Genevisiblei | Q9Y691, HS |
Family and domain databases
Gene3Di | 4.10.81.20, 1 hit |
InterProi | View protein in InterPro IPR003930, K_chnl_Ca-activ_BK_bsu IPR037096, KCNMB2_ball/chain_dom_sf IPR015382, KCNMB2_ball_chain_dom |
PANTHERi | PTHR10258, PTHR10258, 1 hit |
Pfami | View protein in Pfam PF03185, CaKB, 1 hit PF09303, KcnmB2_inactiv, 1 hit |
PRINTSi | PR01450, BKCHANNELB |
MobiDBi | Search... |
Entry informationi
Entry namei | KCMB2_HUMAN | |
Accessioni | Q9Y691Primary (citable) accession number: Q9Y691 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families