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Protein

Calcium-activated potassium channel subunit beta-2

Gene

KCNMB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-activated potassium channel activity Source: UniProtKB
  • ion channel inhibitor activity Source: ProtInc
  • potassium channel regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.14.1.3 the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-2
Alternative name(s):
BK channel subunit beta-2
Short name:
BKbeta2
Short name:
Hbeta2
Calcium-activated potassium channel, subfamily M subunit beta-2
Charybdotoxin receptor subunit beta-2
Hbeta3
K(VCA)beta-2
Maxi K channel subunit beta-2
Slo-beta-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNMB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197584.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6286 KCNMB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605214 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y691

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 194ExtracellularSequence analysisAdd BLAST127
Transmembranei195 – 215Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 4FIW → GGG: Abolishes inactivation of KCNMA1 channel. 1 Publication3

Organism-specific databases

DisGeNET

More...
DisGeNETi
10242

Open Targets

More...
OpenTargetsi
ENSG00000197584
ENSG00000275163

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30066

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01110 Miconazole
DB00721 Procaine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNMB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46396054

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870511 – 235Calcium-activated potassium channel subunit beta-2Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y691

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y691

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86624

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y691

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y691

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197584 Expressed in 109 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_KCNMB2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y691 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y691 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022649

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115536, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y691, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9Y691

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351068

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JO6NMR-A1-45[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y691

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y691

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y691

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45Ball and chainAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEU4 Eukaryota
ENOG4111FIG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154116

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052223

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y691

KEGG Orthology (KO)

More...
KOi
K04938

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECSYIPK

Database of Orthologous Groups

More...
OrthoDBi
1178937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y691

TreeFam database of animal gene trees

More...
TreeFami
TF328589

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.81.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
IPR037096 KCNMB2_ball/chain_dom_sf
IPR015382 KCNMB2_ball_chain_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10258 PTHR10258, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03185 CaKB, 1 hit
PF09303 KcnmB2_inactiv, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01450 BKCHANNELB

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y691-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL
60 70 80 90 100
GLAMMVCSIM MYFLLGITLL RSYMQSVWTE ESQCTLLNAS ITETFNCSFS
110 120 130 140 150
CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETIKINQ KCSYIPKCGK
160 170 180 190 200
NFEESMSLVN VVMENFRKYQ HFSCYSDPEG NQKSVILTKL YSSNVLFHSL
210 220 230
FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
Length:235
Mass (Da):27,130
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5752021DF27D8CF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5BNW5B5BNW5_HUMAN
Calcium-activated potassium channel...
KCNMB2
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EM81E7EM81_HUMAN
Calcium-activated potassium channel...
KCNMB2
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETM2E7ETM2_HUMAN
Calcium-activated potassium channel...
KCNMB2
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE19F8WE19_HUMAN
Calcium-activated potassium channel...
KCNMB2
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF099137 mRNA Translation: AAD23380.1
AF209747 mRNA Translation: AAF36562.1
BC017825 mRNA Translation: AAH17825.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3223.1

NCBI Reference Sequences

More...
RefSeqi
NP_001265840.1, NM_001278911.1
NP_005823.1, NM_005832.4
NP_852006.1, NM_181361.2
XP_011510627.1, XM_011512325.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.478368

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358316; ENSP00000351068; ENSG00000197584
ENST00000420517; ENSP00000408252; ENSG00000197584
ENST00000432997; ENSP00000407592; ENSG00000197584
ENST00000452583; ENSP00000397483; ENSG00000197584

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10242

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10242

UCSC genome browser

More...
UCSCi
uc003fjd.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099137 mRNA Translation: AAD23380.1
AF209747 mRNA Translation: AAF36562.1
BC017825 mRNA Translation: AAH17825.1
CCDSiCCDS3223.1
RefSeqiNP_001265840.1, NM_001278911.1
NP_005823.1, NM_005832.4
NP_852006.1, NM_181361.2
XP_011510627.1, XM_011512325.2
UniGeneiHs.478368

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JO6NMR-A1-45[»]
ProteinModelPortaliQ9Y691
SMRiQ9Y691
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115536, 4 interactors
IntActiQ9Y691, 1 interactor
MINTiQ9Y691
STRINGi9606.ENSP00000351068

Chemistry databases

DrugBankiDB01110 Miconazole
DB00721 Procaine

Protein family/group databases

TCDBi8.A.14.1.3 the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family

PTM databases

iPTMnetiQ9Y691
PhosphoSitePlusiQ9Y691

Polymorphism and mutation databases

BioMutaiKCNMB2
DMDMi46396054

Proteomic databases

PaxDbiQ9Y691
PRIDEiQ9Y691
ProteomicsDBi86624

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10242
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358316; ENSP00000351068; ENSG00000197584
ENST00000420517; ENSP00000408252; ENSG00000197584
ENST00000432997; ENSP00000407592; ENSG00000197584
ENST00000452583; ENSP00000397483; ENSG00000197584
GeneIDi10242
KEGGihsa:10242
UCSCiuc003fjd.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10242
DisGeNETi10242
EuPathDBiHostDB:ENSG00000197584.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNMB2
HGNCiHGNC:6286 KCNMB2
HPAiCAB022649
MIMi605214 gene
neXtProtiNX_Q9Y691
OpenTargetsiENSG00000197584
ENSG00000275163
PharmGKBiPA30066

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEU4 Eukaryota
ENOG4111FIG LUCA
GeneTreeiENSGT00940000154116
HOVERGENiHBG052223
InParanoidiQ9Y691
KOiK04938
OMAiECSYIPK
OrthoDBi1178937at2759
PhylomeDBiQ9Y691
TreeFamiTF328589

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Miscellaneous databases

EvolutionaryTraceiQ9Y691

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNMB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10242

Protein Ontology

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PROi
PR:Q9Y691

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197584 Expressed in 109 organ(s), highest expression level in kidney
CleanExiHS_KCNMB2
ExpressionAtlasiQ9Y691 baseline and differential
GenevisibleiQ9Y691 HS

Family and domain databases

Gene3Di4.10.81.20, 1 hit
InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
IPR037096 KCNMB2_ball/chain_dom_sf
IPR015382 KCNMB2_ball_chain_dom
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit
PF09303 KcnmB2_inactiv, 1 hit
PRINTSiPR01450 BKCHANNELB

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCMB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y691
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1999
Last modified: January 16, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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