UniProtKB - Q9Y680 (FKBP7_HUMAN)
Protein
Peptidyl-prolyl cis-trans isomerase FKBP7
Gene
FKBP7
Organism
Homo sapiens (Human)
Status
Functioni
PPIases accelerate the folding of proteins during protein synthesis.
Miscellaneous
Binds calcium.By similarity
Catalytic activityi
- EC:5.2.1.8
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 158 – 169 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 202 – 213 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: Ensembl
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase, Rotamase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y680 |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)Short name: PPIase FKBP7 Alternative name(s): 23 kDa FK506-binding protein Short name: 23 kDa FKBP Short name: FKBP-23 FK506-binding protein 7 Short name: FKBP-7 Rotamase |
Gene namesi | Name:FKBP7 Synonyms:FKBP23 ORF Names:UNQ670/PRO1304 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3723, FKBP7 |
MIMi | 607062, gene |
neXtProti | NX_Q9Y680 |
VEuPathDBi | HostDB:ENSG00000079150.17 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen PROSITE-ProRule annotation
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulumPathology & Biotechi
Organism-specific databases
DisGeNETi | 51661 |
OpenTargetsi | ENSG00000079150 |
PharmGKBi | PA28164 |
Miscellaneous databases
Pharosi | Q9Y680, Tbio |
Genetic variation databases
BioMutai | FKBP7 |
DMDMi | 23396602 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000025513 | 24 – 222 | Peptidyl-prolyl cis-trans isomerase FKBP7Add BLAST | 199 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9Y680 |
jPOSTi | Q9Y680 |
MassIVEi | Q9Y680 |
PeptideAtlasi | Q9Y680 |
PRIDEi | Q9Y680 |
ProteomicsDBi | 86619 [Q9Y680-1] 86620 [Q9Y680-2] 86621 [Q9Y680-3] |
PTM databases
GlyGeni | Q9Y680, 1 site |
iPTMneti | Q9Y680 |
MetOSitei | Q9Y680 |
PhosphoSitePlusi | Q9Y680 |
Expressioni
Gene expression databases
Bgeei | ENSG00000079150, Expressed in female gonad and 206 other tissues |
ExpressionAtlasi | Q9Y680, baseline and differential |
Genevisiblei | Q9Y680, HS |
Organism-specific databases
HPAi | ENSG00000079150, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y680
Protein-protein interaction databases
BioGRIDi | 119666, 104 interactors |
IntActi | Q9Y680, 85 interactors |
MINTi | Q9Y680 |
Miscellaneous databases
RNActi | Q9Y680, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 145 | PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 145 – 180 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 189 – 222 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 34 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 219 – 222 | Retention in the endoplasmic reticulumPROSITE-ProRule annotation | 4 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
GeneTreei | ENSGT00940000159964 |
HOGENOMi | CLU_013615_5_0_1 |
InParanoidi | Q9Y680 |
OMAi | PRSMEAF |
OrthoDBi | 1507309at2759 |
PhylomeDBi | Q9Y680 |
TreeFami | TF105296 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001179, PPIase_FKBP_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00254, FKBP_C, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS00014, ER_TARGET, 1 hit PS50059, FKBP_PPIASE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: Q9Y680-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS
60 70 80 90 100
KKGDLLNAHY DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM
110 120 130 140 150
TDMCPGEKRK VVIPPSFAYG KEGYAEGKIP PDATLIFEIE LYAVTKGPRS
160 170 180 190 200
IETFKQIDMD NDRQLSKAEI NLYLQREFEK DEKPRDKSYQ DAVLEDIFKK
210 220
NDHDGDGFIS PKEYNVYQHD EL
Isoform 1 (identifier: Q9Y680-1) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
125-127: AEG → GST
128-222: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZJ4 | H7BZJ4_HUMAN | Peptidylprolyl isomerase | FKBP7 | 67 | Annotation score: | ||
F8WBF2 | F8WBF2_HUMAN | Peptidyl-prolyl cis-trans isomerase... | FKBP7 | 86 | Annotation score: | ||
F8WCU2 | F8WCU2_HUMAN | Peptidyl-prolyl cis-trans isomerase... | FKBP7 | 74 | Annotation score: |
Sequence cautioni
The sequence AAD43015 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 124 | Y → H in AAD40379 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 200 | K → M in AAQ57208 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059387 | 125 – 127 | AEG → GST in isoform 1. 1 Publication | 3 | |
Alternative sequenceiVSP_041018 | 125 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_059388 | 128 – 222 | Missing in isoform 1. 1 PublicationAdd BLAST | 95 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF092137 mRNA Translation: AAD40379.1 AF100751 mRNA Translation: AAD43015.1 Frameshift. AY359015 mRNA Translation: AAQ89374.1 AK292145 mRNA Translation: BAF84834.1 BT007122 mRNA Translation: AAP35786.1 AY353086 mRNA Translation: AAQ57208.1 AC009948 Genomic DNA Translation: AAX88883.1 BC009711 mRNA Translation: AAH09711.1 |
CCDSi | CCDS2280.1 [Q9Y680-2] CCDS46462.1 [Q9Y680-3] |
RefSeqi | NP_001128684.1, NM_001135212.1 [Q9Y680-3] NP_851939.1, NM_181342.2 [Q9Y680-2] |
Genome annotation databases
Ensembli | ENST00000233092; ENSP00000233092; ENSG00000079150 [Q9Y680-1] ENST00000424785; ENSP00000413152; ENSG00000079150 [Q9Y680-2] ENST00000434643; ENSP00000415486; ENSG00000079150 [Q9Y680-3] |
GeneIDi | 51661 |
KEGGi | hsa:51661 |
UCSCi | uc002umk.4, human [Q9Y680-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF092137 mRNA Translation: AAD40379.1 AF100751 mRNA Translation: AAD43015.1 Frameshift. AY359015 mRNA Translation: AAQ89374.1 AK292145 mRNA Translation: BAF84834.1 BT007122 mRNA Translation: AAP35786.1 AY353086 mRNA Translation: AAQ57208.1 AC009948 Genomic DNA Translation: AAX88883.1 BC009711 mRNA Translation: AAH09711.1 |
CCDSi | CCDS2280.1 [Q9Y680-2] CCDS46462.1 [Q9Y680-3] |
RefSeqi | NP_001128684.1, NM_001135212.1 [Q9Y680-3] NP_851939.1, NM_181342.2 [Q9Y680-2] |
3D structure databases
SMRi | Q9Y680 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119666, 104 interactors |
IntActi | Q9Y680, 85 interactors |
MINTi | Q9Y680 |
PTM databases
GlyGeni | Q9Y680, 1 site |
iPTMneti | Q9Y680 |
MetOSitei | Q9Y680 |
PhosphoSitePlusi | Q9Y680 |
Genetic variation databases
BioMutai | FKBP7 |
DMDMi | 23396602 |
Proteomic databases
EPDi | Q9Y680 |
jPOSTi | Q9Y680 |
MassIVEi | Q9Y680 |
PeptideAtlasi | Q9Y680 |
PRIDEi | Q9Y680 |
ProteomicsDBi | 86619 [Q9Y680-1] 86620 [Q9Y680-2] 86621 [Q9Y680-3] |
Protocols and materials databases
Antibodypediai | 2249, 166 antibodies |
DNASUi | 51661 |
Genome annotation databases
Ensembli | ENST00000233092; ENSP00000233092; ENSG00000079150 [Q9Y680-1] ENST00000424785; ENSP00000413152; ENSG00000079150 [Q9Y680-2] ENST00000434643; ENSP00000415486; ENSG00000079150 [Q9Y680-3] |
GeneIDi | 51661 |
KEGGi | hsa:51661 |
UCSCi | uc002umk.4, human [Q9Y680-2] |
Organism-specific databases
CTDi | 51661 |
DisGeNETi | 51661 |
GeneCardsi | FKBP7 |
HGNCi | HGNC:3723, FKBP7 |
HPAi | ENSG00000079150, Low tissue specificity |
MIMi | 607062, gene |
neXtProti | NX_Q9Y680 |
OpenTargetsi | ENSG00000079150 |
PharmGKBi | PA28164 |
VEuPathDBi | HostDB:ENSG00000079150.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159964 |
HOGENOMi | CLU_013615_5_0_1 |
InParanoidi | Q9Y680 |
OMAi | PRSMEAF |
OrthoDBi | 1507309at2759 |
PhylomeDBi | Q9Y680 |
TreeFami | TF105296 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y680 |
Miscellaneous databases
BioGRID-ORCSi | 51661, 1 hit in 875 CRISPR screens |
ChiTaRSi | FKBP7, human |
GenomeRNAii | 51661 |
Pharosi | Q9Y680, Tbio |
PROi | PR:Q9Y680 |
RNActi | Q9Y680, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079150, Expressed in female gonad and 206 other tissues |
ExpressionAtlasi | Q9Y680, baseline and differential |
Genevisiblei | Q9Y680, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001179, PPIase_FKBP_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00254, FKBP_C, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS00014, ER_TARGET, 1 hit PS50059, FKBP_PPIASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FKBP7_HUMAN | |
Accessioni | Q9Y680Primary (citable) accession number: Q9Y680 Secondary accession number(s): Q4ZG70 Q9Y6B0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot