Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ancient ubiquitous protein 1

Gene

AUP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.1 Publication

GO - Molecular functioni

GO - Biological processi

  • retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
  • ubiquitin-dependent ERAD pathway Source: GO_Central

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ancient ubiquitous protein 1
Gene namesi
Name:AUP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115307.16
HGNCiHGNC:891 AUP1
MIMi602434 gene
neXtProtiNX_Q9Y679

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20LumenalSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini42 – 476CytoplasmicSequence analysisAdd BLAST435

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115307
PharmGKBiPA25182

Polymorphism and mutation databases

BioMutaiAUP1
DMDMi12643958

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000207651 – 476Ancient ubiquitous protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei433PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y679
PaxDbiQ9Y679
PeptideAtlasiQ9Y679
PRIDEiQ9Y679
ProteomicsDBi86616
86617 [Q9Y679-2]
86618 [Q9Y679-3]

PTM databases

iPTMnetiQ9Y679
PhosphoSitePlusiQ9Y679
SwissPalmiQ9Y679

Expressioni

Tissue specificityi

Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.1 Publication

Gene expression databases

BgeeiENSG00000115307
CleanExiHS_AUP1
GenevisibleiQ9Y679 HS

Organism-specific databases

HPAiHPA007674

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OPRM1P353724EBI-1058701,EBI-2624570

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107031, 60 interactors
CORUMiQ9Y679
IntActiQ9Y679, 34 interactors
MINTiQ9Y679
STRINGi9606.ENSP00000366748

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi363 – 373Combined sources11
Beta strandi375 – 377Combined sources3
Helixi379 – 387Combined sources9
Helixi392 – 400Combined sources9

3D structure databases

ProteinModelPortaliQ9Y679
SMRiQ9Y679
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y679

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini362 – 404CUEPROSITE-ProRule annotationAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 165Poly-Phe6

Sequence similaritiesi

Belongs to the AUP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2898 Eukaryota
ENOG410Y6KF LUCA
GeneTreeiENSGT00390000016110
HOGENOMiHOG000034232
HOVERGENiHBG004321
InParanoidiQ9Y679
KOiK19716
OMAiLGIHVFL
OrthoDBiEOG091G0CVF
PhylomeDBiQ9Y679
TreeFamiTF313372

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q9Y679-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF
60 70 80 90 100
LVSCALPDSV LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF
110 120 130 140 150
DHNIVNLLTT CSTVSESEAE SATGRFPGAQ LKAPLSPLAF RMEDTEALPL
160 170 180 190 200
TPILYPTCQF FFFIFLNIFL LAFSSPGSQP LLNSPPSFVC WSRGFMEMNG
210 220 230 240 250
RGELVESLKR FCASTRLPPT PLLLFPEEEA TNGREGLLRF SSWPFSIQDV
260 270 280 290 300
VQPLTLQVQR PLVSVTVSDA SWVSELLWSL FVPFTVYQVR WLRPVHRQLG
310 320 330 340 350
EANEEFALRV QQLVAKELGQ TGTRLTPADK AEHMKRQRHP RLRPQSAQSS
360 370 380 390 400
FPPSPGPSPD VQLATLAQRV KEVLPHVPLG VIQRDLAKTG CVDLTITNLL
410 420 430 440 450
EGAVAFMPED ITKGTQSLPT ASASKFPSSG PVTPQPTALT FAKSSWARQE
460 470
SLQERKQALY EYARRRFTER RAQEAD
Length:476
Mass (Da):53,028
Last modified:November 1, 1999 - v1
Checksum:iA6AF3AAD84AE86CB
GO
Isoform Short (identifier: Q9Y679-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-179: Missing.

Show »
Length:410
Mass (Da):45,787
Checksum:i1A06476225C5DFDC
GO
Isoform 3 (identifier: Q9Y679-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-179: Missing.
     426-439: FPSSGPVTPQPTAL → AFDACLMMMTPQAL
     440-476: Missing.

Show »
Length:373
Mass (Da):41,385
Checksum:iAAB256D01055538E
GO

Sequence cautioni

The sequence AAH33646 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354S → P in AAD43010 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004133114 – 179Missing in isoform Short and isoform 3. 5 PublicationsAdd BLAST66
Alternative sequenceiVSP_036228426 – 439FPSSG…QPTAL → AFDACLMMMTPQAL in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_036229440 – 476Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100754 mRNA Translation: AAD43018.1
AF100753 mRNA Translation: AAD43017.1
AF100746 mRNA Translation: AAD43010.1
AF165515 mRNA Translation: AAF86645.1
AK023983 mRNA Translation: BAB14753.1
CH471053 Genomic DNA Translation: EAW99623.1
BC001658 mRNA Translation: AAH01658.1
BC033646 mRNA Translation: AAH33646.2 Different initiation.
CCDSiCCDS42702.1 [Q9Y679-2]
RefSeqiNP_853553.1, NM_181575.4 [Q9Y679-2]
UniGeneiHs.411480

Genome annotation databases

EnsembliENST00000377526; ENSP00000366748; ENSG00000115307 [Q9Y679-2]
ENST00000425118; ENSP00000403430; ENSG00000115307 [Q9Y679-3]
GeneIDi550
KEGGihsa:550
UCSCiuc002smf.4 human [Q9Y679-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAUP1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y679
Secondary accession number(s): C0H5W8
, Q9H866, Q9UNQ6, Q9Y685
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health