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Protein

Coatomer subunit gamma-1

Gene

COPG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-1
Alternative name(s):
Gamma-1-coat protein
Short name:
Gamma-1-COP
Gene namesi
Name:COPG1
Synonyms:COPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000181789.14
HGNCiHGNC:2236 COPG1
MIMi615525 gene
neXtProtiNX_Q9Y678

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi776W → S: Loss of interaction with ZNF289/ARFGAP2. 1 Publication1

Organism-specific databases

DisGeNETi22820
OpenTargetsiENSG00000181789
PharmGKBiPA26752

Chemistry databases

DrugBankiDB03963 S-(Dimethylarsenic)Cysteine

Polymorphism and mutation databases

BioMutaiCOPG1
DMDMi12229771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938581 – 874Coatomer subunit gamma-1Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y678
MaxQBiQ9Y678
PaxDbiQ9Y678
PeptideAtlasiQ9Y678
PRIDEiQ9Y678
ProteomicsDBi86615

PTM databases

iPTMnetiQ9Y678
PhosphoSitePlusiQ9Y678
SwissPalmiQ9Y678

Expressioni

Gene expression databases

BgeeiENSG00000181789 Expressed in 224 organ(s), highest expression level in adenohypophysis
CleanExiHS_COPG
ExpressionAtlasiQ9Y678 baseline and differential
GenevisibleiQ9Y678 HS

Organism-specific databases

HPAiHPA037866
HPA037867
HPA045712

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with COPB1. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116496, 82 interactors
DIPiDIP-29872N
IntActiQ9Y678, 44 interactors
MINTiQ9Y678
STRINGi9606.ENSP00000325002

Structurei

Secondary structure

1874
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y678
SMRiQ9Y678
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y678

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 101HEAT 1Add BLAST38
Repeati283 – 320HEAT 2Add BLAST38
Repeati322 – 355HEAT 3Add BLAST34
Repeati356 – 392HEAT 4Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 874Interaction with ZNF289/ARFGAP21 PublicationAdd BLAST266

Sequence similaritiesi

Belongs to the COPG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1078 Eukaryota
COG5240 LUCA
GeneTreeiENSGT00390000016313
HOGENOMiHOG000184434
HOVERGENiHBG004368
InParanoidiQ9Y678
KOiK17267
OMAiPVNARKC
OrthoDBiEOG091G0HWQ
PhylomeDBiQ9Y678
TreeFamiTF300324

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y678-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKKFDKKDE ESGGGSNPFQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK
60 70 80 90 100
ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAI ERYMKQAIVD
160 170 180 190 200
KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL
210 220 230 240 250
YHVRKNDRLA VNKMISKVTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP
260 270 280 290 300
LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK
310 320 330 340 350
AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF
410 420 430 440 450
LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV
460 470 480 490 500
LATRILHLLG QEGPKTTNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA
510 520 530 540 550
QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG
560 570 580 590 600
LTVSIPGLER ALQQYTLEPS EKPFDLKSVP LATAPMAEQR TESTPITAVK
610 620 630 640 650
QPEKVAATRQ EIFQEQLAAV PEFRGLGPLF KSSPEPVALT ESETEYVIRC
660 670 680 690 700
TKHTFTNHMV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL CYVPARSLPY
710 720 730 740 750
NQPGTCYTLV ALPKEDPTAV ACTFSCMMKF TVKDCDPTTG ETDDEGYEDE
760 770 780 790 800
YVLEDLEVTV ADHIQKVMKL NFEAAWDEVG DEFEKEETFT LSTIKTLEEA
810 820 830 840 850
VGNIVKFLGM HPCERSDKVP DNKNTHTLLL AGVFRGGHDI LVRSRLLLLD
860 870
TVTMQVTARS LEELPVDIIL ASVG
Length:874
Mass (Da):97,718
Last modified:November 1, 1999 - v1
Checksum:iA2FAB492C598EC98
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8G2H0Y8G2_HUMAN
Coatomer subunit gamma-1
COPG1
76Annotation score:
H0Y8X7H0Y8X7_HUMAN
Coatomer subunit gamma-1
COPG1
188Annotation score:
D6RG17D6RG17_HUMAN
Coatomer subunit gamma-1
COPG1
49Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti622E → V in BAG50968 (PubMed:14702039).Curated1
Sequence conflicti786E → G in BAG50968 (PubMed:14702039).Curated1
Sequence conflicti842V → M in BAG50968 (PubMed:14702039).Curated1
Sequence conflicti854M → T in BAF84382 (PubMed:14702039).Curated1
Sequence conflicti854M → T in BAG50968 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054039681M → T. Corresponds to variant dbSNP:rs15648Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047846 mRNA Translation: BAB17657.1
AF100756 mRNA Translation: AAD43020.1
AK001724 mRNA Translation: BAG50968.1
AK291693 mRNA Translation: BAF84382.1
CH471052 Genomic DNA Translation: EAW79267.1
BC066650 mRNA Translation: AAH66650.1
CCDSiCCDS33851.1
RefSeqiNP_057212.1, NM_016128.3
UniGeneiHs.518250

Genome annotation databases

EnsembliENST00000314797; ENSP00000325002; ENSG00000181789
GeneIDi22820
KEGGihsa:22820
UCSCiuc003els.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047846 mRNA Translation: BAB17657.1
AF100756 mRNA Translation: AAD43020.1
AK001724 mRNA Translation: BAG50968.1
AK291693 mRNA Translation: BAF84382.1
CH471052 Genomic DNA Translation: EAW79267.1
BC066650 mRNA Translation: AAH66650.1
CCDSiCCDS33851.1
RefSeqiNP_057212.1, NM_016128.3
UniGeneiHs.518250

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R4XX-ray1.90A608-874[»]
ProteinModelPortaliQ9Y678
SMRiQ9Y678
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116496, 82 interactors
DIPiDIP-29872N
IntActiQ9Y678, 44 interactors
MINTiQ9Y678
STRINGi9606.ENSP00000325002

Chemistry databases

DrugBankiDB03963 S-(Dimethylarsenic)Cysteine

PTM databases

iPTMnetiQ9Y678
PhosphoSitePlusiQ9Y678
SwissPalmiQ9Y678

Polymorphism and mutation databases

BioMutaiCOPG1
DMDMi12229771

Proteomic databases

EPDiQ9Y678
MaxQBiQ9Y678
PaxDbiQ9Y678
PeptideAtlasiQ9Y678
PRIDEiQ9Y678
ProteomicsDBi86615

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314797; ENSP00000325002; ENSG00000181789
GeneIDi22820
KEGGihsa:22820
UCSCiuc003els.4 human

Organism-specific databases

CTDi22820
DisGeNETi22820
EuPathDBiHostDB:ENSG00000181789.14
GeneCardsiCOPG1
HGNCiHGNC:2236 COPG1
HPAiHPA037866
HPA037867
HPA045712
MIMi615525 gene
neXtProtiNX_Q9Y678
OpenTargetsiENSG00000181789
PharmGKBiPA26752
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1078 Eukaryota
COG5240 LUCA
GeneTreeiENSGT00390000016313
HOGENOMiHOG000184434
HOVERGENiHBG004368
InParanoidiQ9Y678
KOiK17267
OMAiPVNARKC
OrthoDBiEOG091G0HWQ
PhylomeDBiQ9Y678
TreeFamiTF300324

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiCOPG1 human
EvolutionaryTraceiQ9Y678
GeneWikiiCOPG
GenomeRNAii22820
PROiPR:Q9Y678
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181789 Expressed in 224 organ(s), highest expression level in adenohypophysis
CleanExiHS_COPG
ExpressionAtlasiQ9Y678 baseline and differential
GenevisibleiQ9Y678 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
2.60.40.1480, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR032154 Coatomer_g_Cpla
IPR017106 Coatomer_gsu
IPR013040 Coatomer_gsu_app_Ig-like_dom
IPR037067 Coatomer_gsu_app_sf
IPR012295 TBP_dom_sf
PANTHERiPTHR10261 PTHR10261, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF16381 Coatomer_g_Cpla, 1 hit
PF08752 COP-gamma_platf, 1 hit
PIRSFiPIRSF037093 Coatomer_gamma_subunit, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y678
Secondary accession number(s): A8K6M8, B3KMF6, Q54AC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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