MRPS18B

Functionⁱ

Miscellaneous

There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b, this protein) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.1 Publication

GO - Molecular functionⁱ

structural constituent of ribosome
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11402041

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translation
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11402041
mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome
translation
Source: UniProtKB
Non-traceable author statementⁱ
- 11279123

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 28S ribosomal protein S18b, mitochondrial Short name: MRP-S18-b Short name: Mrps18-b Short name: S18mt-b Alternative name(s): 28S ribosomal protein S18-2, mitochondrial Short name: MRP-S18-2 Mitochondrial small ribosomal subunit protein bS18b1 Publication Mitochondrial small ribosomal subunit protein mS401 Publication
Gene namesⁱ	Name:MRPS18B Synonyms:C6orf14 ORF Names:HSPC183, PTD017
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204568.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14516 MRPS18B
MIMⁱ	611982 gene
neXtProtⁱ	NX_Q9Y676

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28973
Open Targets More...OpenTargetsⁱ	ENSG00000204568
PharmGKBⁱ	PA31004

Polymorphism and mutation databases

BioMutaⁱ	MRPS18B
DMDMⁱ	24212203

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 35	MitochondrionBy similarityAdd BLAST		35
ChainⁱPRO_0000030627	36 – 258	28S ribosomal protein S18b, mitochondrialAdd BLAST		223

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	38	PhosphoserineCombined sources		1
Modified residueⁱ	49	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y676
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y676
PaxDbⁱ	Q9Y676
PeptideAtlas More...PeptideAtlasⁱ	Q9Y676
PRIDEⁱ	Q9Y676
ProteomicsDBⁱ	86614

PTM databases

iPTMnetⁱ	Q9Y676
PhosphoSitePlusⁱ	Q9Y676
SwissPalmⁱ	Q9Y676

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204568 Expressed in 242 organ(s), highest expression level in liver
CleanExⁱ	HS_MRPS18B
ExpressionAtlasⁱ	Q9Y676 baseline and differential
Genevisibleⁱ	Q9Y676 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043485 HPA050334

HPAⁱ

HPA043485
HPA050334

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EBNA6	P03204	6	EBI-750085,EBI-9255985	From Epstein-Barr virus (strain B95-8).
MRPS27	Q92552	2	EBI-750085,EBI-2211879
RB1	P06400	2	EBI-750085,EBI-491274

Protein-protein interaction databases

BioGridⁱ	118797, 102 interactors
CORUMⁱ	Q9Y676
Database of interacting proteins More...DIPⁱ	DIP-29894N
IntActⁱ	Q9Y676, 47 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y676
STRINGⁱ	9606.ENSP00000259873

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y676
SMRⁱ	Q9Y676
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG4021 Eukaryota ENOG4111KH6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010554
HOGENOMⁱ	HOG000039992
HOVERGENⁱ	HBG054347
InParanoidⁱ	Q9Y676
KEGG Orthology (KO) More...KOⁱ	K16174
OMAⁱ	VIFHAPY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U9G
PhylomeDBⁱ	Q9Y676
TreeFamⁱ	TF315059

Family and domain databases

Gene3Dⁱ	4.10.640.10, 1 hit
InterProⁱ	View protein in InterPro IPR040054 MRPS18B IPR001648 Ribosomal_S18 IPR036870 Ribosomal_S18_sf
PANTHERⁱ	PTHR13329 PTHR13329, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01084 Ribosomal_S18, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002239 Ribosomal_S18, 1 hit
SUPFAMⁱ	SSF46911 SSF46911, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y676-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP 
        60         70         80         90        100
YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV 
       110        120        130        140        150
VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL 
       160        170        180        190        200
TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY 
       210        220        230        240        250
PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG 

QTGPQSAL

Length:258

Mass (Da):29,396

Last modified:November 1, 1999 - v1

Checksum:ⁱB4C83E5593796C5D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JIC6	A0A0G2JIC6_HUMAN		28S ribosomal protein S18b, mitocho... 28S ribosomal protein S18b, mitochondrial	MRPS18B	215	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	196	G → S in AAH05373 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052056	230	P → A. Corresponds to variant dbSNP:rs34315095Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF100761 mRNA Translation: AAD43025.1 AF151017 mRNA Translation: AAF36103.1 AL050361 mRNA Translation: CAH56415.1 AB110933 Genomic DNA Translation: BAD13699.1 AB110934 Genomic DNA Translation: BAD13700.1 AB202094 Genomic DNA Translation: BAE78614.1 AL662800 Genomic DNA No translation available. AL662825 Genomic DNA No translation available. AL732442 Genomic DNA No translation available. BX119957 Genomic DNA No translation available. AL845353 Genomic DNA No translation available. BX248507 Genomic DNA No translation available. CR753328 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03304.1 BC005373 mRNA Translation: AAH05373.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4682.1
NCBI Reference Sequences More...RefSeqⁱ	NP_054765.1, NM_014046.3
UniGeneⁱ	Hs.655329

Genome annotation databases

Ensemblⁱ	ENST00000259873; ENSP00000259873; ENSG00000204568 ENST00000327800; ENSP00000383438; ENSG00000203624 ENST00000412451; ENSP00000402718; ENSG00000223775 ENST00000426945; ENSP00000397790; ENSG00000229861 ENST00000430402; ENSP00000398494; ENSG00000233813 ENST00000451032; ENSP00000415703; ENSG00000226111 ENST00000454427; ENSP00000414972; ENSG00000227420
GeneIDⁱ	28973
KEGGⁱ	hsa:28973
UCSC genome browser More...UCSCⁱ	uc003nqo.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y676	MRPS18B		HUMAN		258	UniRef100_Q9Y676

Protein	Similar proteins		Species	Score	Length	Source
Q9Y676	28S ribosomal protein S18b, mitochondrial		PANTR		258	UniRef90_Q9Y676
MRPS18B		HUMAN		258
Uncharacterized protein		PANPA		258
MRPS18B isoform 1		PONAB		258
Uncharacterized protein		NOMLE		258
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9Y676	28S ribosomal protein S18b, mitochondrial		PANTR		258	UniRef50_Q9Y676
28S ribosomal protein S18b, mitochondrial	)	BOVIN		258
28S ribosomal protein S18b, mitochondrial	)	PIG		258
MRPS18B		HUMAN		258
MRPS18B isoform 1		PONAB		258
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF100761 mRNA Translation: AAD43025.1 AF151017 mRNA Translation: AAF36103.1 AL050361 mRNA Translation: CAH56415.1 AB110933 Genomic DNA Translation: BAD13699.1 AB110934 Genomic DNA Translation: BAD13700.1 AB202094 Genomic DNA Translation: BAE78614.1 AL662800 Genomic DNA No translation available. AL662825 Genomic DNA No translation available. AL732442 Genomic DNA No translation available. BX119957 Genomic DNA No translation available. AL845353 Genomic DNA No translation available. BX248507 Genomic DNA No translation available. CR753328 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03304.1 BC005373 mRNA Translation: AAH05373.1
CCDSⁱ	CCDS4682.1
RefSeqⁱ	NP_054765.1, NM_014046.3
UniGeneⁱ	Hs.655329

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J9M	electron microscopy	3.50	AO	1-258	[»]
ProteinModelPortalⁱ	Q9Y676
SMRⁱ	Q9Y676
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118797, 102 interactors
CORUMⁱ	Q9Y676
DIPⁱ	DIP-29894N
IntActⁱ	Q9Y676, 47 interactors
MINTⁱ	Q9Y676
STRINGⁱ	9606.ENSP00000259873

PTM databases

iPTMnetⁱ	Q9Y676
PhosphoSitePlusⁱ	Q9Y676
SwissPalmⁱ	Q9Y676

Polymorphism and mutation databases

BioMutaⁱ	MRPS18B
DMDMⁱ	24212203

Proteomic databases

EPDⁱ	Q9Y676
MaxQBⁱ	Q9Y676
PaxDbⁱ	Q9Y676
PeptideAtlasⁱ	Q9Y676
PRIDEⁱ	Q9Y676
ProteomicsDBⁱ	86614

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000259873; ENSP00000259873; ENSG00000204568 ENST00000327800; ENSP00000383438; ENSG00000203624 ENST00000412451; ENSP00000402718; ENSG00000223775 ENST00000426945; ENSP00000397790; ENSG00000229861 ENST00000430402; ENSP00000398494; ENSG00000233813 ENST00000451032; ENSP00000415703; ENSG00000226111 ENST00000454427; ENSP00000414972; ENSG00000227420
GeneIDⁱ	28973
KEGGⁱ	hsa:28973
UCSCⁱ	uc003nqo.3 human

Organism-specific databases

CTDⁱ	28973
DisGeNETⁱ	28973
EuPathDBⁱ	HostDB:ENSG00000204568.11
GeneCardsⁱ	MRPS18B
HGNCⁱ	HGNC:14516 MRPS18B
HPAⁱ	HPA043485 HPA050334
MIMⁱ	611982 gene
neXtProtⁱ	NX_Q9Y676
OpenTargetsⁱ	ENSG00000204568
PharmGKBⁱ	PA31004
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4021 Eukaryota ENOG4111KH6 LUCA
GeneTreeⁱ	ENSGT00390000010554
HOGENOMⁱ	HOG000039992
HOVERGENⁱ	HBG054347
InParanoidⁱ	Q9Y676
KOⁱ	K16174
OMAⁱ	VIFHAPY
OrthoDBⁱ	EOG091G0U9G
PhylomeDBⁱ	Q9Y676
TreeFamⁱ	TF315059

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPS18B human
GeneWikiⁱ	MRPS18B
GenomeRNAiⁱ	28973
Protein Ontology More...PROⁱ	PR:Q9Y676
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204568 Expressed in 242 organ(s), highest expression level in liver
CleanExⁱ	HS_MRPS18B
ExpressionAtlasⁱ	Q9Y676 baseline and differential
Genevisibleⁱ	Q9Y676 HS

Family and domain databases

Gene3Dⁱ	4.10.640.10, 1 hit
InterProⁱ	View protein in InterPro IPR040054 MRPS18B IPR001648 Ribosomal_S18 IPR036870 Ribosomal_S18_sf
PANTHERⁱ	PTHR13329 PTHR13329, 1 hit
Pfamⁱ	View protein in Pfam PF01084 Ribosomal_S18, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002239 Ribosomal_S18, 1 hit
SUPFAMⁱ	SSF46911 SSF46911, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RT18B_HUMAN
Accessionⁱ	Q9Y676Primary (citable) accession number: Q9Y676 Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Ribosomal proteins
Ribosomal proteins families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y676 (RT18B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

28S ribosomal protein S18b, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ