UniProtKB - Q9Y676 (RT18B_HUMAN)
28S ribosomal protein S18b, mitochondrial
MRPS18B
Functioni
Miscellaneous
GO - Molecular functioni
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- mitochondrial translation Source: UniProtKB
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
- translation Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q9Y676 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q9Y676 |
Names & Taxonomyi
Protein namesi | Recommended name: 28S ribosomal protein S18b, mitochondrialShort name: MRP-S18-b Short name: Mrps18-b Short name: S18mt-b Alternative name(s): 28S ribosomal protein S18-2, mitochondrial Short name: MRP-S18-2 Mitochondrial small ribosomal subunit protein bS18b1 Publication Mitochondrial small ribosomal subunit protein mS401 Publication |
Gene namesi | Name:MRPS18B Synonyms:C6orf14 ORF Names:HSPC183, PTD017 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14516, MRPS18B |
MIMi | 611982, gene |
neXtProti | NX_Q9Y676 |
VEuPathDBi | HostDB:ENSG00000204568.11 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial small ribosomal subunit Source: UniProtKB
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cell junction Source: HPA
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 28973 |
OpenTargetsi | ENSG00000204568 |
PharmGKBi | PA31004 |
Miscellaneous databases
Pharosi | Q9Y676, Tdark |
Genetic variation databases
BioMutai | MRPS18B |
DMDMi | 24212203 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | MitochondrionBy similarityAdd BLAST | 35 | |
ChainiPRO_0000030627 | 36 – 258 | 28S ribosomal protein S18b, mitochondrialAdd BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | PhosphoserineCombined sources | 1 | |
Modified residuei | 49 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y676 |
jPOSTi | Q9Y676 |
MassIVEi | Q9Y676 |
MaxQBi | Q9Y676 |
PaxDbi | Q9Y676 |
PeptideAtlasi | Q9Y676 |
PRIDEi | Q9Y676 |
ProteomicsDBi | 86614 |
PTM databases
iPTMneti | Q9Y676 |
PhosphoSitePlusi | Q9Y676 |
SwissPalmi | Q9Y676 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204568, Expressed in liver and 254 other tissues |
ExpressionAtlasi | Q9Y676, baseline and differential |
Genevisiblei | Q9Y676, HS |
Organism-specific databases
HPAi | ENSG00000204568, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.
1 PublicationBinary interactionsi
Hide detailsQ9Y676
Protein-protein interaction databases
BioGRIDi | 118797, 148 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q9Y676 |
DIPi | DIP-29894N |
IntActi | Q9Y676, 66 interactors |
MINTi | Q9Y676 |
STRINGi | 9606.ENSP00000259873 |
Miscellaneous databases
RNActi | Q9Y676, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG4021, Eukaryota |
GeneTreei | ENSGT00390000010554 |
HOGENOMi | CLU_089746_0_0_1 |
InParanoidi | Q9Y676 |
OMAi | PWEYLET |
OrthoDBi | 1023024at2759 |
PhylomeDBi | Q9Y676 |
TreeFami | TF315059 |
Family and domain databases
Gene3Di | 4.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR040054, MRPS18B IPR001648, Ribosomal_S18 IPR036870, Ribosomal_S18_sf |
PANTHERi | PTHR13329, PTHR13329, 1 hit |
Pfami | View protein in Pfam PF01084, Ribosomal_S18, 1 hit |
SUPFAMi | SSF46911, SSF46911, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP
60 70 80 90 100
YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV
110 120 130 140 150
VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL
160 170 180 190 200
TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY
210 220 230 240 250
PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG
QTGPQSAL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JIC6 | A0A0G2JIC6_HUMAN | 28S ribosomal protein S18b, mitocho... | MRPS18B | 215 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | G → S in AAH05373 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052056 | 230 | P → A. Corresponds to variant dbSNP:rs34315095Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF100761 mRNA Translation: AAD43025.1 AF151017 mRNA Translation: AAF36103.1 AL050361 mRNA Translation: CAH56415.1 AB110933 Genomic DNA Translation: BAD13699.1 AB110934 Genomic DNA Translation: BAD13700.1 AB202094 Genomic DNA Translation: BAE78614.1 AL662800 Genomic DNA No translation available. AL662825 Genomic DNA No translation available. AL732442 Genomic DNA No translation available. BX119957 Genomic DNA No translation available. AL845353 Genomic DNA No translation available. BX248507 Genomic DNA No translation available. CR753328 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03304.1 BC005373 mRNA Translation: AAH05373.1 |
CCDSi | CCDS4682.1 |
RefSeqi | NP_054765.1, NM_014046.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF100761 mRNA Translation: AAD43025.1 AF151017 mRNA Translation: AAF36103.1 AL050361 mRNA Translation: CAH56415.1 AB110933 Genomic DNA Translation: BAD13699.1 AB110934 Genomic DNA Translation: BAD13700.1 AB202094 Genomic DNA Translation: BAE78614.1 AL662800 Genomic DNA No translation available. AL662825 Genomic DNA No translation available. AL732442 Genomic DNA No translation available. BX119957 Genomic DNA No translation available. AL845353 Genomic DNA No translation available. BX248507 Genomic DNA No translation available. CR753328 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03304.1 BC005373 mRNA Translation: AAH05373.1 |
CCDSi | CCDS4682.1 |
RefSeqi | NP_054765.1, NM_014046.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J9M | electron microscopy | 3.50 | AO | 1-258 | [»] | |
6NU2 | electron microscopy | 3.90 | AO | 52-236 | [»] | |
6NU3 | electron microscopy | 4.40 | AO | 52-236 | [»] | |
6RW4 | electron microscopy | 2.97 | O | 1-258 | [»] | |
6RW5 | electron microscopy | 3.14 | O | 1-258 | [»] | |
6VLZ | electron microscopy | 2.97 | AO | 1-258 | [»] | |
6VMI | electron microscopy | 2.96 | AO | 1-258 | [»] | |
6ZS9 | electron microscopy | 4.00 | AO | 1-258 | [»] | |
6ZSA | electron microscopy | 4.00 | AO | 1-258 | [»] | |
6ZSB | electron microscopy | 4.50 | AO | 1-258 | [»] | |
6ZSC | electron microscopy | 3.50 | AO | 1-258 | [»] | |
6ZSD | electron microscopy | 3.70 | AO | 1-258 | [»] | |
6ZSE | electron microscopy | 5.00 | AO | 1-236 | [»] | |
6ZSG | electron microscopy | 4.00 | AO | 1-258 | [»] | |
SMRi | Q9Y676 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118797, 148 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q9Y676 |
DIPi | DIP-29894N |
IntActi | Q9Y676, 66 interactors |
MINTi | Q9Y676 |
STRINGi | 9606.ENSP00000259873 |
PTM databases
iPTMneti | Q9Y676 |
PhosphoSitePlusi | Q9Y676 |
SwissPalmi | Q9Y676 |
Genetic variation databases
BioMutai | MRPS18B |
DMDMi | 24212203 |
Proteomic databases
EPDi | Q9Y676 |
jPOSTi | Q9Y676 |
MassIVEi | Q9Y676 |
MaxQBi | Q9Y676 |
PaxDbi | Q9Y676 |
PeptideAtlasi | Q9Y676 |
PRIDEi | Q9Y676 |
ProteomicsDBi | 86614 |
Protocols and materials databases
Antibodypediai | 26399, 78 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 28973 |
DisGeNETi | 28973 |
GeneCardsi | MRPS18B |
HGNCi | HGNC:14516, MRPS18B |
HPAi | ENSG00000204568, Low tissue specificity |
MIMi | 611982, gene |
neXtProti | NX_Q9Y676 |
OpenTargetsi | ENSG00000204568 |
PharmGKBi | PA31004 |
VEuPathDBi | HostDB:ENSG00000204568.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4021, Eukaryota |
GeneTreei | ENSGT00390000010554 |
HOGENOMi | CLU_089746_0_0_1 |
InParanoidi | Q9Y676 |
OMAi | PWEYLET |
OrthoDBi | 1023024at2759 |
PhylomeDBi | Q9Y676 |
TreeFami | TF315059 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y676 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q9Y676 |
Miscellaneous databases
BioGRID-ORCSi | 28973, 296 hits in 885 CRISPR screens |
ChiTaRSi | MRPS18B, human |
GeneWikii | MRPS18B |
GenomeRNAii | 28973 |
Pharosi | Q9Y676, Tdark |
PROi | PR:Q9Y676 |
RNActi | Q9Y676, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204568, Expressed in liver and 254 other tissues |
ExpressionAtlasi | Q9Y676, baseline and differential |
Genevisiblei | Q9Y676, HS |
Family and domain databases
Gene3Di | 4.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR040054, MRPS18B IPR001648, Ribosomal_S18 IPR036870, Ribosomal_S18_sf |
PANTHERi | PTHR13329, PTHR13329, 1 hit |
Pfami | View protein in Pfam PF01084, Ribosomal_S18, 1 hit |
SUPFAMi | SSF46911, SSF46911, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RT18B_HUMAN | |
Accessioni | Q9Y676Primary (citable) accession number: Q9Y676 Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families