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Protein

Adhesion G-protein coupled receptor G1

Gene

ADGRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).By similarity6 Publications
ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA (PubMed:21724588).1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ADGRG1 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands and /or homophilic ADGRG1NT interactions may relieve the inhibition (PubMed:21708946, PubMed:24949629, PubMed:25918380). Following ligand binding to the N-terminal fragment, the N-terminal fragment is released from the seven-transmembrane C-terminal fragment to unveil a new N-terminal stalk, which then stimulates G-protein-dependent signaling activity (PubMed:25918380). The N-terminal stalk has also been shown to be dispensable for at least some G-protein-dependent signaling (PubMed:26710850).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Heparin-binding, Receptor, Transducer
Biological processCell adhesion, Differentiation, Neurogenesis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y653

Protein family/group databases

MEROPS protease database

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MEROPSi
P02.008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G1
Alternative name(s):
G-protein coupled receptor 56
Protein TM7XN1
Cleaved into the following 2 chains:
ADGRG1 N-terminal fragment
Short name:
ADGRG1 NT
Alternative name(s):
GPR56 N-terminal fragment
Short name:
GPR56 NT
Short name:
GPR56(N)
GPR56 extracellular subunit
GPR56 subunit alpha
ADGRG1 C-terminal fragment
Short name:
ADGRG1 CT
Alternative name(s):
GPR56 C-terminal fragment
Short name:
GPR56 CT
Short name:
GPR56(C)
GPR56 seven-transmembrane subunit
Short name:
GPR56 7TM
GPR56 subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRG1Imported
Synonyms:GPR56, TM7LN4, TM7XN1
ORF Names:UNQ540/PRO1083
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000205336.11

Human Gene Nomenclature Database

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HGNCi
HGNC:4512 ADGRG1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604110 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y653

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 402ExtracellularSequence analysisAdd BLAST377
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei403 – 423Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini424 – 448CytoplasmicSequence analysisAdd BLAST25
Transmembranei449 – 469Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini470 – 476ExtracellularSequence analysis7
Transmembranei477 – 497Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini498 – 518CytoplasmicSequence analysisAdd BLAST21
Transmembranei519 – 539Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini540 – 576ExtracellularSequence analysisAdd BLAST37
Transmembranei577 – 597Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini598 – 609CytoplasmicSequence analysisAdd BLAST12
Transmembranei610 – 630Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini631 – 636ExtracellularSequence analysis6
Transmembranei637 – 657Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini658 – 693CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polymicrogyria, bilateral frontoparietal (BFPP)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination, most severe in the frontoparietal regions. BFPP clinical manifestations include developmental and psychomotor delay, cerebellar and pyramidal signs, truncal ataxia, seizures, hyperreflexia. Polymicrogyria is a heterogeneous disorder, considered to be the result of postmigratory abnormal cortical organization.
See also OMIM:606854
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06958138R → Q in BFPP; abolishes interaction with COL3A1. 2 PublicationsCorresponds to variant dbSNP:rs764367185Ensembl.1
Natural variantiVAR_02624238R → W in BFPP; abolishes interaction with COL3A1; reduces cell surface localization. 4 PublicationsCorresponds to variant dbSNP:rs121908462EnsemblClinVar.1
Natural variantiVAR_02624388Y → C in BFPP; abolishes interaction with COL3A1; reduces cell surface localization. 3 PublicationsCorresponds to variant dbSNP:rs121908466EnsemblClinVar.1
Natural variantiVAR_02624491C → S in BFPP; abolishes interaction with COL3A1; reduces cell surface localization. 3 PublicationsCorresponds to variant dbSNP:rs121908465EnsemblClinVar.1
Natural variantiVAR_026245346C → S in BFPP; abolishes autoproteolytic cleavage; reduces cell surface localization. 2 PublicationsCorresponds to variant dbSNP:rs121908463EnsemblClinVar.1
Natural variantiVAR_069582349W → S in BFPP; abolishes autoproteolytic cleavage; reduces cell surface localization. 2 Publications1
Natural variantiVAR_069583496E → K in BFPP; reduces cell surface localization. 1 PublicationCorresponds to variant dbSNP:rs556518689Ensembl.1
Natural variantiVAR_026246565R → W in BFPP; reduces cell surface localization. 3 PublicationsCorresponds to variant dbSNP:rs121908464EnsemblClinVar.1
Natural variantiVAR_069584640L → R in BFPP; unclear effects on cell surface localization; blocks downstream RhoA activation. 3 Publications1
Polymicrogyria, bilateral perisylvian, autosomal recessive (BPPR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Homozygous deletion of 1 of 2 tandem 15-bp repeats located 144 bp upstream of the ADGRG1 non-coding exon 1m transcription start site, results in impaired perisylvian ADGRG1 expression and disruption of perisylvian gyri (PubMed:24531968).1 Publication
Disease descriptionA form of polymicrogyria, a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. BPPR is characterized by strikingly restricted polymicrogyria limited to the cortex surrounding the Sylvian fissure. Affected individuals have intellectual and language difficulty and seizures, but no motor disability. Polymicrogyria is a heterogeneous disorder, considered to be the result of post-migratory abnormal cortical organization.
See also OMIM:615752

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28H → A: Abolishes heparin-binding; when associated with A-29 and A-33. 1 Publication1
Mutagenesisi29R → A: Abolishes heparin-binding; when associated with A-28 and A-33. 1 Publication1
Mutagenesisi33R → A: Reduces heparin-binding. Abolishes heparin-binding; when associated with A-28 and A-29. 1 Publication1
Mutagenesisi381H → S: Abolishes cleavage. 1 Publication1
Mutagenesisi383T → G: Abolishes cleavage but does not affect cell membrane localization or signaling activity. 3 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9289

MalaCards human disease database

More...
MalaCardsi
ADGRG1
MIMi606854 phenotype
615752 phenotype

Open Targets

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OpenTargetsi
ENSG00000205336

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
101070 Bilateral frontoparietal polymicrogyria
98889 Bilateral perisylvian polymicrogyria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28901

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GPR56

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45476992

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001288026 – 693Adhesion G-protein coupled receptor G1Add BLAST668
ChainiPRO_000042308626 – ?382ADGRG1 N-terminal fragment1 PublicationAdd BLAST357
ChainiPRO_0000423087?383 – 693ADGRG1 C-terminal fragment1 PublicationAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s) (PubMed:22333914).1 Publication
N-glycosylated. Contains sialic acid residues.1 Publication
Ubiquitinated. Undergoes polyubiquitination upon activation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei382 – 383Cleavage; by autolysis1 Publication2

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y653

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y653

PeptideAtlas

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PeptideAtlasi
Q9Y653

PRoteomics IDEntifications database

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PRIDEi
Q9Y653

ProteomicsDB human proteome resource

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ProteomicsDBi
86601
86602 [Q9Y653-2]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1288

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y653

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y653

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205336 Expressed in 227 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

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CleanExi
HS_GPR56

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y653 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y653 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA046065

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1-CT) predominantly remain associated and non-covalently linked. ADGRG1 NT self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. ADGRG1-CT interacts with ARRB2; the interaction is impaired by ADGRG1 NT. Interacts with TGM2; TGM2 probably is not a ADGRG1 ligand and the interaction is reported controversial (PubMed:16757564, PubMed:21349848). Part of a GPCR-tetraspanin complex at least consisting of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11. Interacts with heparin; leading to the reduction of ADGRG1 shedding (PubMed:27068534).6 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114704, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y653

Protein interaction database and analysis system

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IntActi
Q9Y653, 3 interactors

Molecular INTeraction database

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MINTi
Q9Y653

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369018

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y653

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y653

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini343 – 394GPSPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 33Heparin-binding1 Publication8
Regioni190 – 200Heparin-binding1 PublicationAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015136

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051814

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y653

KEGG Orthology (KO)

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KOi
K08450

Identification of Orthologs from Complete Genome Data

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OMAi
VWKLQPT

Database of Orthologous Groups

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OrthoDBi
EOG091G02U6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y653

TreeFam database of animal gene trees

More...
TreeFami
TF321769

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR003910 GPR1/GPR3/GPR5
IPR000203 GPS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN
PR01422 GPR56ORPHANR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00303 GPS, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 47 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y653-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPQSLLQTT LFLLSLLFLV QGAHGRGHRE DFRFCSQRNQ THRSSLHYKP
60 70 80 90 100
TPDLRISIEN SEEALTVHAP FPAAHPASRS FPDPRGLYHF CLYWNRHAGR
110 120 130 140 150
LHLLYGKRDF LLSDKASSLL CFQHQEESLA QGPPLLATSV TSWWSPQNIS
160 170 180 190 200
LPSAASFTFS FHSPPHTAAH NASVDMCELK RDLQLLSQFL KHPQKASRRP
210 220 230 240 250
SAAPASQQLQ SLESKLTSVR FMGDMVSFEE DRINATVWKL QPTAGLQDLH
260 270 280 290 300
IHSRQEEEQS EIMEYSVLLP RTLFQRTKGR SGEAEKRLLL VDFSSQALFQ
310 320 330 340 350
DKNSSQVLGE KVLGIVVQNT KVANLTEPVV LTFQHQLQPK NVTLQCVFWV
360 370 380 390 400
EDPTLSSPGH WSSAGCETVR RETQTSCFCN HLTYFAVLMV SSVEVDAVHK
410 420 430 440 450
HYLSLLSYVG CVVSALACLV TIAAYLCSRV PLPCRRKPRD YTIKVHMNLL
460 470 480 490 500
LAVFLLDTSF LLSEPVALTG SEAGCRASAI FLHFSLLTCL SWMGLEGYNL
510 520 530 540 550
YRLVVEVFGT YVPGYLLKLS AMGWGFPIFL VTLVALVDVD NYGPIILAVH
560 570 580 590 600
RTPEGVIYPS MCWIRDSLVS YITNLGLFSL VFLFNMAMLA TMVVQILRLR
610 620 630 640 650
PHTQKWSHVL TLLGLSLVLG LPWALIFFSF ASGTFQLVVL YLFSIITSFQ
660 670 680 690
GFLIFIWYWS MRLQARGGPS PLKSNSDSAR LPISSGSTSS SRI
Length:693
Mass (Da):77,738
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i801C8E62666A5155
GO
Isoform 2 (identifier: Q9Y653-2) [UniParc]FASTAAdd to basket
Also known as: S1

The sequence of this isoform differs from the canonical sequence as follows:
     429-434: Missing.

Show »
Length:687
Mass (Da):77,072
Checksum:iBB8712796ED1B99B
GO
Isoform 3 (identifier: Q9Y653-3) [UniParc]FASTAAdd to basket
Also known as: S2

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: Q → QASASS
     429-434: Missing.

Show »
Length:692
Mass (Da):77,476
Checksum:i62A00681FE932B65
GO
Isoform 4 (identifier: Q9Y653-4) [UniParc]FASTAAdd to basket
Also known as: S3

The sequence of this isoform differs from the canonical sequence as follows:
     38-207: Missing.

Show »
Length:523
Mass (Da):58,655
Checksum:iC4CB64E369DDC33C
GO
Isoform 5 (identifier: Q9Y653-5) [UniParc]FASTAAdd to basket
Also known as: S4

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: Has no predictable signal peptide.
Show »
Length:518
Mass (Da):58,042
Checksum:i7CFB3855CAED164C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 47 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSJ6H3BSJ6_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRH0H3BRH0_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMF8H3BMF8_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSR1H3BSR1_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT88H3BT88_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTH7H3BTH7_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQJ9H3BQJ9_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSP5H3BSP5_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTK9H3BTK9_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRB4H3BRB4_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti329V → A (PubMed:17974005).Curated1
Sequence conflicti561M → R in BAD18684 (PubMed:14702039).Curated1
Sequence conflicti678S → C in AAD30545 (PubMed:10049584).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06958138R → Q in BFPP; abolishes interaction with COL3A1. 2 PublicationsCorresponds to variant dbSNP:rs764367185Ensembl.1
Natural variantiVAR_02624238R → W in BFPP; abolishes interaction with COL3A1; reduces cell surface localization. 4 PublicationsCorresponds to variant dbSNP:rs121908462EnsemblClinVar.1
Natural variantiVAR_02624388Y → C in BFPP; abolishes interaction with COL3A1; reduces cell surface localization. 3 PublicationsCorresponds to variant dbSNP:rs121908466EnsemblClinVar.1
Natural variantiVAR_02624491C → S in BFPP; abolishes interaction with COL3A1; reduces cell surface localization. 3 PublicationsCorresponds to variant dbSNP:rs121908465EnsemblClinVar.1
Natural variantiVAR_017910281S → R3 PublicationsCorresponds to variant dbSNP:rs1801257EnsemblClinVar.1
Natural variantiVAR_017911306Q → H6 PublicationsCorresponds to variant dbSNP:rs1801255EnsemblClinVar.1
Natural variantiVAR_026245346C → S in BFPP; abolishes autoproteolytic cleavage; reduces cell surface localization. 2 PublicationsCorresponds to variant dbSNP:rs121908463EnsemblClinVar.1
Natural variantiVAR_069582349W → S in BFPP; abolishes autoproteolytic cleavage; reduces cell surface localization. 2 Publications1
Natural variantiVAR_049457493M → T. Corresponds to variant dbSNP:rs17379472EnsemblClinVar.1
Natural variantiVAR_069583496E → K in BFPP; reduces cell surface localization. 1 PublicationCorresponds to variant dbSNP:rs556518689Ensembl.1
Natural variantiVAR_049458527P → L. Corresponds to variant dbSNP:rs16958679Ensembl.1
Natural variantiVAR_026246565R → W in BFPP; reduces cell surface localization. 3 PublicationsCorresponds to variant dbSNP:rs121908464EnsemblClinVar.1
Natural variantiVAR_069584640L → R in BFPP; unclear effects on cell surface localization; blocks downstream RhoA activation. 3 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475541 – 175Missing in isoform 5. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_04755521Q → QASASS in isoform 3. 1 Publication1
Alternative sequenceiVSP_04755638 – 207Missing in isoform 4. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_035068429 – 434Missing in isoform 2 and isoform 3. 2 Publications6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF106858 mRNA Translation: AAD30545.1
AJ011001 mRNA Translation: CAB37294.1
EU432119 mRNA Translation: ABY87918.1
AY358400 mRNA Translation: AAQ88766.1
AK131550 mRNA Translation: BAD18684.1
AK299110 mRNA Translation: BAG61166.1
AB065909 Genomic DNA Translation: BAC06124.1
BT007311 mRNA Translation: AAP35975.1
CR936747 mRNA No translation available.
AC018552 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82939.1
CH471092 Genomic DNA Translation: EAW82940.1
BC008770 mRNA Translation: AAH08770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32460.1 [Q9Y653-1]
CCDS32461.1 [Q9Y653-2]
CCDS73893.1 [Q9Y653-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001139242.1, NM_001145770.2 [Q9Y653-2]
NP_001139243.1, NM_001145771.2 [Q9Y653-1]
NP_001139244.1, NM_001145772.2 [Q9Y653-2]
NP_001139245.1, NM_001145773.2 [Q9Y653-3]
NP_001139246.1, NM_001145774.2 [Q9Y653-2]
NP_001277071.1, NM_001290142.1 [Q9Y653-4]
NP_001277072.1, NM_001290143.1 [Q9Y653-5]
NP_005673.3, NM_005682.6 [Q9Y653-1]
NP_958932.1, NM_201524.3 [Q9Y653-2]
NP_958933.1, NM_201525.3 [Q9Y653-2]
XP_005256303.1, XM_005256246.2 [Q9Y653-1]
XP_005256304.1, XM_005256247.2 [Q9Y653-1]
XP_005256305.1, XM_005256248.2 [Q9Y653-1]
XP_005256306.1, XM_005256249.3 [Q9Y653-1]
XP_005256308.1, XM_005256251.4 [Q9Y653-1]
XP_005256309.1, XM_005256252.2 [Q9Y653-1]
XP_005256311.1, XM_005256254.2 [Q9Y653-1]
XP_005256312.1, XM_005256255.2 [Q9Y653-2]
XP_006721405.1, XM_006721342.2 [Q9Y653-1]
XP_006721406.1, XM_006721343.3 [Q9Y653-1]
XP_006721407.1, XM_006721344.2 [Q9Y653-1]
XP_006721408.1, XM_006721345.3 [Q9Y653-1]
XP_006721409.1, XM_006721346.2 [Q9Y653-1]
XP_006721410.1, XM_006721347.2 [Q9Y653-3]
XP_011521765.1, XM_011523463.2 [Q9Y653-1]
XP_011521766.1, XM_011523464.2 [Q9Y653-1]
XP_011521767.1, XM_011523465.2 [Q9Y653-1]
XP_011521768.1, XM_011523466.2 [Q9Y653-1]
XP_011521769.1, XM_011523467.2 [Q9Y653-1]
XP_011521770.1, XM_011523468.2 [Q9Y653-1]
XP_016879381.1, XM_017023892.1 [Q9Y653-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.513633

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000388813; ENSP00000373465; ENSG00000205336 [Q9Y653-2]
ENST00000456916; ENSP00000398034; ENSG00000205336 [Q9Y653-3]
ENST00000540164; ENSP00000444911; ENSG00000205336 [Q9Y653-2]
ENST00000562558; ENSP00000456620; ENSG00000205336 [Q9Y653-2]
ENST00000562631; ENSP00000455351; ENSG00000205336 [Q9Y653-2]
ENST00000567835; ENSP00000456794; ENSG00000205336 [Q9Y653-1]
ENST00000568908; ENSP00000457456; ENSG00000205336 [Q9Y653-2]
ENST00000568909; ENSP00000455215; ENSG00000205336 [Q9Y653-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9289

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9289

UCSC genome browser

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UCSCi
uc002emb.3 human [Q9Y653-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106858 mRNA Translation: AAD30545.1
AJ011001 mRNA Translation: CAB37294.1
EU432119 mRNA Translation: ABY87918.1
AY358400 mRNA Translation: AAQ88766.1
AK131550 mRNA Translation: BAD18684.1
AK299110 mRNA Translation: BAG61166.1
AB065909 Genomic DNA Translation: BAC06124.1
BT007311 mRNA Translation: AAP35975.1
CR936747 mRNA No translation available.
AC018552 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82939.1
CH471092 Genomic DNA Translation: EAW82940.1
BC008770 mRNA Translation: AAH08770.1
CCDSiCCDS32460.1 [Q9Y653-1]
CCDS32461.1 [Q9Y653-2]
CCDS73893.1 [Q9Y653-3]
RefSeqiNP_001139242.1, NM_001145770.2 [Q9Y653-2]
NP_001139243.1, NM_001145771.2 [Q9Y653-1]
NP_001139244.1, NM_001145772.2 [Q9Y653-2]
NP_001139245.1, NM_001145773.2 [Q9Y653-3]
NP_001139246.1, NM_001145774.2 [Q9Y653-2]
NP_001277071.1, NM_001290142.1 [Q9Y653-4]
NP_001277072.1, NM_001290143.1 [Q9Y653-5]
NP_005673.3, NM_005682.6 [Q9Y653-1]
NP_958932.1, NM_201524.3 [Q9Y653-2]
NP_958933.1, NM_201525.3 [Q9Y653-2]
XP_005256303.1, XM_005256246.2 [Q9Y653-1]
XP_005256304.1, XM_005256247.2 [Q9Y653-1]
XP_005256305.1, XM_005256248.2 [Q9Y653-1]
XP_005256306.1, XM_005256249.3 [Q9Y653-1]
XP_005256308.1, XM_005256251.4 [Q9Y653-1]
XP_005256309.1, XM_005256252.2 [Q9Y653-1]
XP_005256311.1, XM_005256254.2 [Q9Y653-1]
XP_005256312.1, XM_005256255.2 [Q9Y653-2]
XP_006721405.1, XM_006721342.2 [Q9Y653-1]
XP_006721406.1, XM_006721343.3 [Q9Y653-1]
XP_006721407.1, XM_006721344.2 [Q9Y653-1]
XP_006721408.1, XM_006721345.3 [Q9Y653-1]
XP_006721409.1, XM_006721346.2 [Q9Y653-1]
XP_006721410.1, XM_006721347.2 [Q9Y653-3]
XP_011521765.1, XM_011523463.2 [Q9Y653-1]
XP_011521766.1, XM_011523464.2 [Q9Y653-1]
XP_011521767.1, XM_011523465.2 [Q9Y653-1]
XP_011521768.1, XM_011523466.2 [Q9Y653-1]
XP_011521769.1, XM_011523467.2 [Q9Y653-1]
XP_011521770.1, XM_011523468.2 [Q9Y653-1]
XP_016879381.1, XM_017023892.1 [Q9Y653-2]
UniGeneiHs.513633

3D structure databases

ProteinModelPortaliQ9Y653
SMRiQ9Y653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114704, 4 interactors
CORUMiQ9Y653
IntActiQ9Y653, 3 interactors
MINTiQ9Y653
STRINGi9606.ENSP00000369018

Protein family/group databases

MEROPSiP02.008

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

GlyConnecti1288
iPTMnetiQ9Y653
PhosphoSitePlusiQ9Y653

Polymorphism and mutation databases

BioMutaiGPR56
DMDMi45476992

Proteomic databases

EPDiQ9Y653
PaxDbiQ9Y653
PeptideAtlasiQ9Y653
PRIDEiQ9Y653
ProteomicsDBi86601
86602 [Q9Y653-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9289
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388813; ENSP00000373465; ENSG00000205336 [Q9Y653-2]
ENST00000456916; ENSP00000398034; ENSG00000205336 [Q9Y653-3]
ENST00000540164; ENSP00000444911; ENSG00000205336 [Q9Y653-2]
ENST00000562558; ENSP00000456620; ENSG00000205336 [Q9Y653-2]
ENST00000562631; ENSP00000455351; ENSG00000205336 [Q9Y653-2]
ENST00000567835; ENSP00000456794; ENSG00000205336 [Q9Y653-1]
ENST00000568908; ENSP00000457456; ENSG00000205336 [Q9Y653-2]
ENST00000568909; ENSP00000455215; ENSG00000205336 [Q9Y653-1]
GeneIDi9289
KEGGihsa:9289
UCSCiuc002emb.3 human [Q9Y653-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9289
DisGeNETi9289
EuPathDBiHostDB:ENSG00000205336.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRG1
HGNCiHGNC:4512 ADGRG1
HPAiHPA046065
MalaCardsiADGRG1
MIMi604110 gene
606854 phenotype
615752 phenotype
neXtProtiNX_Q9Y653
OpenTargetsiENSG00000205336
Orphaneti101070 Bilateral frontoparietal polymicrogyria
98889 Bilateral perisylvian polymicrogyria
PharmGKBiPA28901

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000160843
HOGENOMiHOG000015136
HOVERGENiHBG051814
InParanoidiQ9Y653
KOiK08450
OMAiVWKLQPT
OrthoDBiEOG091G02U6
PhylomeDBiQ9Y653
TreeFamiTF321769

Enzyme and pathway databases

SIGNORiQ9Y653

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRG1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9289

Protein Ontology

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PROi
PR:Q9Y653

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000205336 Expressed in 227 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_GPR56
ExpressionAtlasiQ9Y653 baseline and differential
GenevisibleiQ9Y653 HS

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR003910 GPR1/GPR3/GPR5
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01422 GPR56ORPHANR
SMARTiView protein in SMART
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y653
Secondary accession number(s): A6NIT7
, A6NJV9, B0M0K4, B4DR54, O95966, Q6ZMP1, Q8NGB3, Q96HB4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: December 5, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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