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Entry version 43 (07 Apr 2021)
Sequence version 1 (01 Nov 1999)
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Submitted name:


Homo sapiens (Human)
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
<p>This subsection of the <a href="">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="">IntAct database</a>. It is updated at every <a href="">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

AGGF1 - isoform 2 [Q8N302-2]3EBI-25900580,EBI-25838028
AKIP1 [Q9NQ31]3EBI-25900580,EBI-517035
APLN [D3DTF8]3EBI-25900580,EBI-22002556
ARHGEF38 - isoform 1 [Q9NXL2-1]3EBI-25900580,EBI-18172597
ARL2BP [Q9Y2Y0]3EBI-25900580,EBI-3449344
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-25900580,EBI-5280499
ASCL4 [Q6XD76]3EBI-25900580,EBI-10254793
ATXN1 [P54253]3EBI-25900580,EBI-930964
ATXN7L1 - isoform 2 [Q9ULK2-2]3EBI-25900580,EBI-21568482
AUNIP [Q9H7T9]3EBI-25900580,EBI-10693257
BAIAP2 - isoform 6 [Q9UQB8-6]3EBI-25900580,EBI-9092016
BLZF1 [Q9H2G9]3EBI-25900580,EBI-2548012
BRPF3 - isoform 2 [Q9ULD4-2]3EBI-25900580,EBI-23662416
BRWD1 - isoform D [Q9NSI6-4]3EBI-25900580,EBI-10693038
C12orf74 [Q32Q52]3EBI-25900580,EBI-12891828
C3orf36 [Q3SXR2]3EBI-25900580,EBI-18036948
CCDC120 [Q96HB5]3EBI-25900580,EBI-744556
CDKN1A [P38936]3EBI-25900580,EBI-375077
CDS2 [O95674]3EBI-25900580,EBI-3913685
CEP57 [Q86XR8]3EBI-25900580,EBI-308614
CFAP100 - isoform 2 [Q494V2-2]3EBI-25900580,EBI-11953200
CIAO2B [Q9Y3D0]3EBI-25900580,EBI-744045
COA7 [Q96BR5]3EBI-25900580,EBI-6269632
COL2A1 - isoform 1 [P02458-1]3EBI-25900580,EBI-12375799
DKFZp547K2416 [Q8NDP9]3EBI-25900580,EBI-25842538
DNAJA3 - isoform 3 [Q96EY1-3]3EBI-25900580,EBI-11526226
DPF1 - isoform 2 [Q92782-2]3EBI-25900580,EBI-23669343
DPPA2 [Q7Z7J5]3EBI-25900580,EBI-741400
DPYSL5 [Q9BPU6]3EBI-25900580,EBI-724653
E2F8 [A0AVK6]3EBI-25900580,EBI-7779316
EEF1DP3 [Q658K8]3EBI-25900580,EBI-10248874
ELAPOR1 - isoform 3 [Q6UXG2-3]3EBI-25900580,EBI-12920100
ENSA - isoform 8 [O43768-8]3EBI-25900580,EBI-25853109
ESRP1 [Q6NXG1]3EBI-25900580,EBI-10213520
FAM83A [Q86UY5]3EBI-25900580,EBI-1384254
FBXO7 [Q9Y3I1]3EBI-25900580,EBI-1161222
GABPB1 - isoform 2 [Q06547-2]3EBI-25900580,EBI-618189
GABPB1 - isoform 3 [Q06547-3]3EBI-25900580,EBI-9088619
GATA1 - isoform 2 [P15976-2]3EBI-25900580,EBI-9090198
GUSBP1 [Q15486]3EBI-25900580,EBI-712457
HAUS8 [Q9BT25]3EBI-25900580,EBI-2558143
HECTD3 - isoform 2 [Q5T447-2]3EBI-25900580,EBI-25854793
ICA1L - isoform 2 [Q8NDH6-2]3EBI-25900580,EBI-12141931
ID1 [P41134]3EBI-25900580,EBI-1215527
IFT20 - isoform 2 [Q8IY31-2]3EBI-25900580,EBI-11742277
IL37 [Q9NZH6]3EBI-25900580,EBI-3862125
IQGAP3 [Q86VI3]3EBI-25900580,EBI-1237354
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-25900580,EBI-9089060
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-25900580,EBI-14069005
KRT33B [Q14525]3EBI-25900580,EBI-1049638
LAMTOR1 [Q6IAA8]3EBI-25900580,EBI-715385
MAOB [P27338]3EBI-25900580,EBI-3911344
MBIP - isoform 4 [Q9NS73-5]3EBI-25900580,EBI-10182361
MCM7 - isoform 2 [P33993-2]3EBI-25900580,EBI-11741465
MCRS1 [Q96EZ8]3EBI-25900580,EBI-348259
MGC16703 [D3DX41]3EBI-25900580,EBI-25850974
MIIP [Q5JXC2]3EBI-25900580,EBI-2801965
MLST8 [A0A0A0MR05]3EBI-25900580,EBI-25835557
MRM1 - isoform 2 [Q6IN84-2]3EBI-25900580,EBI-25835707
MRPS14 [O60783]3EBI-25900580,EBI-1045956
MSANTD3 [Q96H12]3EBI-25900580,EBI-8466227
MYC [P01106]3EBI-25900580,EBI-447544
MYOZ2 [Q9NPC6]3EBI-25900580,EBI-746712
NFE2 [Q16621]3EBI-25900580,EBI-726369
NGEF [Q8N5V2]3EBI-25900580,EBI-718372
NPAS2 [Q99743]3EBI-25900580,EBI-3932727
NR1D2 [Q14995]3EBI-25900580,EBI-6144053
NSD3 - isoform 3 [Q9BZ95-3]3EBI-25900580,EBI-22002759
OIP5 [O43482]3EBI-25900580,EBI-536879
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-25900580,EBI-25830200
P3H3 - isoform 2 [Q8IVL6-2]3EBI-25900580,EBI-12149899
PANX2 [Q495U3]3EBI-25900580,EBI-17242559
PARP11 - isoform 4 [Q9NR21-5]3EBI-25900580,EBI-17159452
PCDHGC3 [Q9BR81]3EBI-25900580,EBI-22012354
PKM [P14618]3EBI-25900580,EBI-353408
POLR1D [P0DPB6]3EBI-25900580,EBI-359498
POLR1H [Q9P1U0]3EBI-25900580,EBI-355434
POLR2E [P19388]3EBI-25900580,EBI-395189
PRKAB2 [O43741]3EBI-25900580,EBI-1053424
PRKN - isoform 5 [O60260-5]3EBI-25900580,EBI-21251460
PSME1 [Q06323]3EBI-25900580,EBI-712149
PTMA - isoform 2 [P06454-2]3EBI-25900580,EBI-10194874
RASSF1 - isoform C [Q9NS23-4]3EBI-25900580,EBI-438710
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-25900580,EBI-1504830
RELA [Q04206]3EBI-25900580,EBI-73886
RGR - isoform 3 [P47804-3]3EBI-25900580,EBI-25834767
RHEB [Q15382]3EBI-25900580,EBI-1055287
RNF138 [Q8WVD3]3EBI-25900580,EBI-749039
RPL31 [P62899]3EBI-25900580,EBI-1053664
RPS4X [P62701]3EBI-25900580,EBI-354303
RUSC1-AS1 [Q66K80]3EBI-25900580,EBI-10248967
SDCCAG8 - isoform 2 [Q86SQ7-2]3EBI-25900580,EBI-10696955
SEMA4G - isoform 3 [Q9NTN9-3]3EBI-25900580,EBI-9089805
SF3B2 [Q13435]3EBI-25900580,EBI-749111
SMARCB1 [Q12824]3EBI-25900580,EBI-358419
SNW1 [Q13573]3EBI-25900580,EBI-632715
SPATA12 [Q7Z6I5]3EBI-25900580,EBI-10696971
SPATA24 - isoform 2 [Q86W54-2]3EBI-25900580,EBI-12041693
SPATS1 [Q496A3]3EBI-25900580,EBI-3923692
SPRYD7 - isoform 2 [Q5W111-2]3EBI-25900580,EBI-12408727
STIM1 [Q13586]3EBI-25900580,EBI-448878
TCAP [O15273]3EBI-25900580,EBI-954089
TEN1 [Q86WV5]3EBI-25900580,EBI-2562799
TENT5B [Q96A09]3EBI-25900580,EBI-752030
TEX35 - isoform 2 [Q5T0J7-2]3EBI-25900580,EBI-12833746
THAP3 [Q8WTV1]3EBI-25900580,EBI-17438286
THEM4 [Q5T1C6]3EBI-25900580,EBI-7684443
TIMM17B [O60830]3EBI-25900580,EBI-2372529
TMEM186 [Q96B77]3EBI-25900580,EBI-9089409
tmp_locus_54 [Q53NU3]3EBI-25900580,EBI-10242677
TMTC1 - isoform 4 [Q8IUR5-4]3EBI-25900580,EBI-9089156
TMUB2 - isoform 4 [Q71RG4-4]3EBI-25900580,EBI-25831574
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-25900580,EBI-17716262
TRIM69 - isoform 2 [Q86WT6-2]3EBI-25900580,EBI-11525489
TSC22D4 [Q9Y3Q8]3EBI-25900580,EBI-739485
TSNAX [Q99598]3EBI-25900580,EBI-742638
TUBGCP4 - isoform 2 [Q9UGJ1-2]3EBI-25900580,EBI-10964469
UBE2A [P49459]3EBI-25900580,EBI-2339348
USH1G [Q495M9]3EBI-25900580,EBI-8601749
VPS11 [Q9H270]3EBI-25900580,EBI-373380
VPS54 - isoform 4 [Q9P1Q0-4]3EBI-25900580,EBI-25835297
WBP1L [Q9NX94]3EBI-25900580,EBI-10316321
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-25900580,EBI-14104088
ZCCHC17 [Q9NP64]3EBI-25900580,EBI-746345
ZNF436 [Q9C0F3]3EBI-25900580,EBI-8489702

Protein-protein interaction databases

Protein interaction database and analysis system

Q9Y649, 125 interactors

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="">length</a> and <a href="">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="">Sequence</a> section indicates if the <a href="">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
Mass (Da):7,014
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5102455EA227E412

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database


GenBank nucleotide sequence database


DNA Data Bank of Japan; a nucleotide sequence database

Links Updated
AF107406 mRNA Translation: AAD44524.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
Links Updated
AF107406 mRNA Translation: AAD44524.1

3D structure databases

Database of comparative protein structure models


SWISS-MODEL Interactive Workspace

Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9Y649, 125 interactors

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins


MobiDB: a database of protein disorder and mobility annotations


<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9Y649_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y649
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: April 7, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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