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Entry version 155 (08 May 2019)
Sequence version 2 (15 Jun 2010)
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Protein

Neuroplastin

Gene

NPTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977443 GABA receptor activation

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.23.1.8 the basigin (basigin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroplastin
Alternative name(s):
Stromal cell-derived receptor 1
Short name:
SDR-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPTN
Synonyms:SDFR1, SDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17867 NPTN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612820 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 339ExtracellularSequence analysisAdd BLAST311
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei340 – 360Helical1 PublicationAdd BLAST21
Topological domaini361 – 398CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27020

Open Targets

More...
OpenTargetsi
ENSG00000156642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927704

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NPTN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
298286871

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Add BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039447029 – 398NeuroplastinAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi52 ↔ 116PROSITE-ProRule annotation
Disulfide bondi170 ↔ 218PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi259 ↔ 3161 Publication
Glycosylationi284N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi296N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y639

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y639

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y639

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y639

PeptideAtlas

More...
PeptideAtlasi
Q9Y639

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y639

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86593
86594 [Q9Y639-1]
86595 [Q9Y639-3]
86596 [Q9Y639-4]
86597 [Q9Y639-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1558

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156642 Expressed in 240 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y639 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y639 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051497
HPA072453

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATP2B1; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117958, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y639, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9Y639

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290401

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y639

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 134Ig-like 1PROSITE-ProRule annotationAdd BLAST106
Domaini148 – 235Ig-like 2PROSITE-ProRule annotationAdd BLAST88
Domaini238 – 329Ig-like 3PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 161Narpin; mediates binding with FGFR1 and has antidepressant-like activityBy similarityAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity).By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJET Eukaryota
ENOG4111V1Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156195

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y639

KEGG Orthology (KO)

More...
KOi
K22653

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKPRINA

Database of Orthologous Groups

More...
OrthoDBi
1021787at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y639

TreeFam database of animal gene trees

More...
TreeFami
TF326759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR027112 Neuroplastin/Basigin

The PANTHER Classification System

More...
PANTHERi
PTHR10075:SF5 PTHR10075:SF5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9Y639-2) [UniParc]FASTAAdd to basket
Also known as: SDR-1-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSSLPSAL ALSLLLVSGS LLPGPGAAQN AGFVKSPMSE TKLTGDAFEL
60 70 80 90 100
YCDVVGSPTP EIQWWYAEVN RAESFRQLWD GARKRRVTVN TAYGSNGVSV
110 120 130 140 150
LRITRLTLED SGTYECRASN DPKRNDLRQN PSITWIRAQA TISVLQKPRI
160 170 180 190 200
VTSEEVIIRD SPVLPVTLQC NLTSSSHTLT YSYWTKNGVE LSATRKNASN
210 220 230 240 250
MEYRINKPRA EDSGEYHCVY HFVSAPKANA TIEVKAAPDI TGHKRSENKN
260 270 280 290 300
EGQDATMYCK SVGYPHPDWI WRKKENGMPM DIVNTSGRFF IINKENYTEL
310 320 330 340 350
NIVNLQITED PGEYECNATN AIGSASVVTV LRVRSHLAPL WPFLGILAEI
360 370 380 390
IILVVIIVVY EKRKRPDEVP DDDEPAGPMK TNSTNNHKDK NLRQRNTN
Length:398
Mass (Da):44,387
Last modified:June 15, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5109E3C03B4967EA
GO
Isoform 1 (identifier: Q9Y639-1) [UniParc]FASTAAdd to basket
Also known as: SDR-1-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     31-147: AGFVKSPMSE...AQATISVLQK → E

Show »
Length:282
Mass (Da):31,291
Checksum:iB3E48A23984A6C4A
GO
Isoform 3 (identifier: Q9Y639-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-147: AGFVKSPMSE...AQATISVLQK → E
     372-375: Missing.

Show »
Length:278
Mass (Da):30,835
Checksum:i458E026CC87DD657
GO
Isoform 4 (identifier: Q9Y639-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-398: NAIGSASVVT...DKNLRQRNTN → WPHSGLSWEFWLKLSSLW

Note: No experimental confirmation available.
Show »
Length:337
Mass (Da):37,792
Checksum:i8C043513B3BCD50C
GO
Isoform 5 (identifier: Q9Y639-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-375: Missing.

Show »
Length:394
Mass (Da):43,931
Checksum:iC68D09CC61FB4B49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BU51H3BU51_HUMAN
Neuroplastin
NPTN
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9UFM8Q9UFM8_HUMAN
Neuroplastin
NPTN DKFZp566H1924
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ94H3BQ94_HUMAN
Neuroplastin
NPTN
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93049 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti299E → K in BAH12519 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03925131 – 147AGFVK…SVLQK → E in isoform 1 and isoform 3. 3 PublicationsAdd BLAST117
Alternative sequenceiVSP_039252320 – 398NAIGS…QRNTN → WPHSGLSWEFWLKLSSLW in isoform 4. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_039253372 – 375Missing in isoform 3 and isoform 5. 3 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF109126 mRNA Translation: AAD43217.1
AF109127 mRNA Translation: AAD43218.1
AK297184 mRNA Translation: BAH12519.1
AK314248 mRNA Translation: BAG36914.1
AB209812 mRNA Translation: BAD93049.1 Different initiation.
CH471082 Genomic DNA Translation: EAW77931.1
BC105979 mRNA Translation: AAI05980.1
BC117462 mRNA Translation: AAI17463.1
BC143880 mRNA Translation: AAI43881.1
BC143881 mRNA Translation: AAI43882.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10249.1 [Q9Y639-2]
CCDS10250.1 [Q9Y639-1]
CCDS58379.1 [Q9Y639-3]
CCDS58380.1 [Q9Y639-5]

Protein sequence database of the Protein Information Resource

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PIRi
T17219

NCBI Reference Sequences

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RefSeqi
NP_001154835.1, NM_001161363.1 [Q9Y639-5]
NP_001154836.1, NM_001161364.1 [Q9Y639-3]
NP_036560.1, NM_012428.3 [Q9Y639-2]
NP_059429.1, NM_017455.3 [Q9Y639-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345330; ENSP00000290401; ENSG00000156642 [Q9Y639-2]
ENST00000351217; ENSP00000342958; ENSG00000156642 [Q9Y639-1]
ENST00000562924; ENSP00000456349; ENSG00000156642 [Q9Y639-3]
ENST00000563691; ENSP00000457028; ENSG00000156642 [Q9Y639-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27020

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27020

UCSC genome browser

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UCSCi
uc002avr.4 human [Q9Y639-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109126 mRNA Translation: AAD43217.1
AF109127 mRNA Translation: AAD43218.1
AK297184 mRNA Translation: BAH12519.1
AK314248 mRNA Translation: BAG36914.1
AB209812 mRNA Translation: BAD93049.1 Different initiation.
CH471082 Genomic DNA Translation: EAW77931.1
BC105979 mRNA Translation: AAI05980.1
BC117462 mRNA Translation: AAI17463.1
BC143880 mRNA Translation: AAI43881.1
BC143881 mRNA Translation: AAI43882.1
CCDSiCCDS10249.1 [Q9Y639-2]
CCDS10250.1 [Q9Y639-1]
CCDS58379.1 [Q9Y639-3]
CCDS58380.1 [Q9Y639-5]
PIRiT17219
RefSeqiNP_001154835.1, NM_001161363.1 [Q9Y639-5]
NP_001154836.1, NM_001161364.1 [Q9Y639-3]
NP_036560.1, NM_012428.3 [Q9Y639-2]
NP_059429.1, NM_017455.3 [Q9Y639-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6A69electron microscopy4.11B146-398[»]
SMRiQ9Y639
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117958, 13 interactors
IntActiQ9Y639, 7 interactors
MINTiQ9Y639
STRINGi9606.ENSP00000290401

Protein family/group databases

TCDBi8.A.23.1.8 the basigin (basigin) family

PTM databases

GlyConnecti1558
iPTMnetiQ9Y639
PhosphoSitePlusiQ9Y639

Polymorphism and mutation databases

BioMutaiNPTN
DMDMi298286871

Proteomic databases

EPDiQ9Y639
jPOSTiQ9Y639
MaxQBiQ9Y639
PaxDbiQ9Y639
PeptideAtlasiQ9Y639
PRIDEiQ9Y639
ProteomicsDBi86593
86594 [Q9Y639-1]
86595 [Q9Y639-3]
86596 [Q9Y639-4]
86597 [Q9Y639-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
27020
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345330; ENSP00000290401; ENSG00000156642 [Q9Y639-2]
ENST00000351217; ENSP00000342958; ENSG00000156642 [Q9Y639-1]
ENST00000562924; ENSP00000456349; ENSG00000156642 [Q9Y639-3]
ENST00000563691; ENSP00000457028; ENSG00000156642 [Q9Y639-5]
GeneIDi27020
KEGGihsa:27020
UCSCiuc002avr.4 human [Q9Y639-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27020
DisGeNETi27020

GeneCards: human genes, protein and diseases

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GeneCardsi
NPTN
HGNCiHGNC:17867 NPTN
HPAiHPA051497
HPA072453
MIMi612820 gene
neXtProtiNX_Q9Y639
OpenTargetsiENSG00000156642
PharmGKBiPA134927704

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJET Eukaryota
ENOG4111V1Q LUCA
GeneTreeiENSGT00940000156195
InParanoidiQ9Y639
KOiK22653
OMAiQKPRINA
OrthoDBi1021787at2759
PhylomeDBiQ9Y639
TreeFamiTF326759

Enzyme and pathway databases

ReactomeiR-HSA-977443 GABA receptor activation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NPTN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NPTN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27020

Protein Ontology

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PROi
PR:Q9Y639

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156642 Expressed in 240 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9Y639 baseline and differential
GenevisibleiQ9Y639 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR027112 Neuroplastin/Basigin
PANTHERiPTHR10075:SF5 PTHR10075:SF5, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPTN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y639
Secondary accession number(s): B2RAL7
, B7Z4D3, B7ZLL2, Q17R52, Q59EJ9, Q6NVX7, Q9Y640
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 15, 2010
Last modified: May 8, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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