F11R

Functionⁱ

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).By similarity3 Publications

(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.1 Publication

(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
PDZ domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23885123
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actomyosin structure organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
bicellular tight junction assembly Source: Reactome
cell adhesion Source: Ensembl
establishment of endothelial intestinal barrier
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
extracellular matrix organization Source: Reactome
inflammatory response
Source: ProtInc
Traceable author statementⁱ
- 10395639
intestinal absorption
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
leukocyte migration Source: Reactome
negative regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
positive regulation of blood pressure Source: Ensembl
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
protein localization to plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
regulation of actin cytoskeleton reorganization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
regulation of cytokine production Source: Ensembl
regulation of membrane permeability
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23885123
response to radiation Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-216083 Integrin cell surface interactions R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-420029 Tight junction interactions
SIGNORⁱ	Q9Y624

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Junctional adhesion molecule A Short name: JAM-A Alternative name(s): Junctional adhesion molecule 1 Short name: JAM-1 Platelet F11 receptor Platelet adhesion molecule 1 Short name: PAM-1 CD_antigen: CD321
Gene namesⁱ	Name:F11R Synonyms:JAM1, JCAM ORF Names:UNQ264/PRO301
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158769.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14685 F11R
MIMⁱ	605721 gene
neXtProtⁱ	NX_Q9Y624

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	28 – 238	ExtracellularSequence analysisAdd BLAST	211
Transmembraneⁱ	239 – 259	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	260 – 299	CytoplasmicSequence analysisAdd BLAST	40

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50848
Open Targets More...OpenTargetsⁱ	ENSG00000158769
PharmGKBⁱ	PA29991

Polymorphism and mutation databases

BioMutaⁱ	F11R
DMDMⁱ	10720061

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	Combined sources3 PublicationsAdd BLAST		27
ChainⁱPRO_0000015066	28 – 299	Junctional adhesion molecule AAdd BLAST		272

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	50 ↔ 109	1 Publication
Disulfide bondⁱ	153 ↔ 212	1 Publication
Glycosylationⁱ	185	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	281	PhosphoserineCombined sources	1
Modified residueⁱ	284	PhosphoserineCombined sources	1
Modified residueⁱ	287	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y624
PaxDbⁱ	Q9Y624
PeptideAtlas More...PeptideAtlasⁱ	Q9Y624
PRIDEⁱ	Q9Y624
ProteomicsDBⁱ	86590

PTM databases

GlyConnectⁱ	1427
iPTMnetⁱ	Q9Y624
PhosphoSitePlusⁱ	Q9Y624
SwissPalmⁱ	Q9Y624

Expressionⁱ

Tissue specificityⁱ

Expressed in endothelium, epithelium and leukocytes (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000158769 Expressed in 158 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_F11R
ExpressionAtlasⁱ	Q9Y624 baseline and differential
Genevisibleⁱ	Q9Y624 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004671 HPA043616 HPA061700

HPAⁱ

CAB004671
HPA043616
HPA061700

Interactionⁱ

Subunit structureⁱ

Interacts with the ninth PDZ domain of MPDZ (PubMed:11489913). Interacts with the first PDZ domain of PARD3 (PubMed:11489913). The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with ITGAL (via I-domain) (PubMed:15528364).By similarity2 Publications

(Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.1 Publication

(Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PARD3	Q8TEW0	2	EBI-742600,EBI-81968
PRKCZ	Q05513	2	EBI-742600,EBI-295351
SGTA	O43765	9	EBI-742600,EBI-347996

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
PDZ domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23885123

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119153, 16 interactors
CORUMⁱ	Q9Y624
IntActⁱ	Q9Y624, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y624
STRINGⁱ	9606.ENSP00000289779

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 32	Combined sources	3
Beta strandⁱ	36 – 41	Combined sources	6
Beta strandⁱ	47 – 49	Combined sources	3
Beta strandⁱ	51 – 54	Combined sources	4
Beta strandⁱ	56 – 66	Combined sources	11
Beta strandⁱ	69 – 75	Combined sources	7
Beta strandⁱ	76 – 79	Combined sources	4
Turnⁱ	81 – 86	Combined sources	6
Beta strandⁱ	88 – 90	Combined sources	3
Beta strandⁱ	93 – 95	Combined sources	3
Helixⁱ	101 – 103	Combined sources	3
Beta strandⁱ	105 – 113	Combined sources	9
Beta strandⁱ	123 – 125	Combined sources	3
Beta strandⁱ	128 – 130	Combined sources	3
Beta strandⁱ	140 – 144	Combined sources	5
Beta strandⁱ	149 – 151	Combined sources	3
Beta strandⁱ	163 – 168	Combined sources	6
Beta strandⁱ	177 – 182	Combined sources	6
Turnⁱ	192 – 194	Combined sources	3
Beta strandⁱ	197 – 201	Combined sources	5
Helixⁱ	204 – 206	Combined sources	3
Beta strandⁱ	210 – 215	Combined sources	6
Beta strandⁱ	217 – 219	Combined sources	3
Beta strandⁱ	230 – 232	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y624
SMRⁱ	Q9Y624
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y624

EvolutionaryTraceⁱ

Q9Y624

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 125	Ig-like V-type 1Add BLAST		98
Domainⁱ	135 – 228	Ig-like V-type 2Add BLAST		94

Domainⁱ

The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.1 Publication

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWUE Eukaryota ENOG410YHHV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110678
HOVERGENⁱ	HBG000518
InParanoidⁱ	Q9Y624
KEGG Orthology (KO) More...KOⁱ	K06089
OMAⁱ	NRAFSNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q9Y624
TreeFamⁱ	TF343984

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y624-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC 
        60         70         80         90        100
AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT 
       110        120        130        140        150
REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV 
       160        170        180        190        200
LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD 
       210        220        230        240        250
PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV AAVLVTLILL 
       260        270        280        290 
GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV

Length:299

Mass (Da):32,583

Last modified:November 1, 1999 - v1

Checksum:ⁱD95DE2FEA23D2851

GO

Isoform 2 (identifier: Q9Y624-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
81-129: Missing.

« Hide

        10         20         30         40         50
MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC 
        60         70         80         90        100
AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT VPPSKPTVNI PSSATIGNRA 
       110        120        130        140        150
VLTCSEQDGS PPSEYTWFKD GIVMPTNPKS TRAFSNSSYV LNPTTGELVF 
       160        170        180        190        200
DPLSASDTGE YSCEARNGYG TPMTSNAVRM EAVERNVGVI VAAVLVTLIL 
       210        220        230        240        250
LGILVFGIWF AYSRGHFDRT KKGTSSKKVI YSQPSARSEG EFKQTSSFLV

Note: No experimental confirmation available.

Show »

Length:250

Mass (Da):27,208

Checksum:ⁱ548D39B300559F53

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WY82	A0A087WY82_HUMAN		Junctional adhesion molecule A Junctional adhesion molecule A	F11R	279	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056218	81 – 129	Missing in isoform 2. 1 PublicationAdd BLAST		49

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF111713 mRNA Translation: AAD42050.1 AF207907 mRNA Translation: AAF22829.1 AF172398 mRNA Translation: AAD48877.1 AL136649 mRNA Translation: CAB66584.1 AY358896 mRNA Translation: AAQ89255.1 AK304412 mRNA Translation: BAH14177.1 AL591806 Genomic DNA No translation available. BC001533 mRNA Translation: AAH01533.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1213.1 [Q9Y624-1] CCDS86026.1 [Q9Y624-2]
PIRⁱ	A59406 S56749
NCBI Reference Sequences More...RefSeqⁱ	NP_001335020.1, NM_001348091.1 [Q9Y624-2] NP_058642.1, NM_016946.5 [Q9Y624-1]
UniGeneⁱ	Hs.517293

Genome annotation databases

Ensemblⁱ	ENST00000368026; ENSP00000357005; ENSG00000158769 [Q9Y624-1] ENST00000537746; ENSP00000440812; ENSG00000158769 [Q9Y624-2]
GeneIDⁱ	50848
KEGGⁱ	hsa:50848
UCSC genome browser More...UCSCⁱ	uc009wtt.4 human [Q9Y624-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y624	F11 receptor		HUMAN		299	UniRef100_Q9Y624
F11 receptor		PANTR		299
Uncharacterized protein		PANPA		299
Q9Y624-2	F11 receptor		PANTR		250	UniRef100_A0A2I3SIR2
Uncharacterized protein		PANPA		250

Protein	Similar proteins		Species	Score	Length	Source
Q9Y624	F11 receptor		HUMAN		299	UniRef90_Q9Y624
F11 receptor		PANTR		299
Uncharacterized protein		PANPA		299
Uncharacterized protein		MACNE		328
Junctional adhesion molecule A (Fragment)		MACMU		117
+19
Q9Y624-2	F11 receptor		PANTR		250	UniRef90_A0A2I3SIR2
Uncharacterized protein		PANPA		250
Uncharacterized protein		MACMU		250
Uncharacterized protein		COLAP		250
Uncharacterized protein		RHIRO		250
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9Y624	Junctional adhesion molecule A		FELCA		298	UniRef50_Q9Y624
Junctional adhesion molecule A		BOVIN		298
Junctional adhesion molecule A	)	MOUSE		300
Junctional adhesion molecule A		RAT		300
F11 receptor		HUMAN		299
+167
Q9Y624-2	F11 receptor		MUSPF		270	UniRef50_M3YRV8
Uncharacterized protein		MANLE		274
Uncharacterized protein		Cebus capucinus imitator		250
F11 receptor		SAIBB		250
Uncharacterized protein		AOTNA		250
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF111713 mRNA Translation: AAD42050.1 AF207907 mRNA Translation: AAF22829.1 AF172398 mRNA Translation: AAD48877.1 AL136649 mRNA Translation: CAB66584.1 AY358896 mRNA Translation: AAQ89255.1 AK304412 mRNA Translation: BAH14177.1 AL591806 Genomic DNA No translation available. BC001533 mRNA Translation: AAH01533.1
CCDSⁱ	CCDS1213.1 [Q9Y624-1] CCDS86026.1 [Q9Y624-2]
PIRⁱ	A59406 S56749
RefSeqⁱ	NP_001335020.1, NM_001348091.1 [Q9Y624-2] NP_058642.1, NM_016946.5 [Q9Y624-1]
UniGeneⁱ	Hs.517293

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NBQ	X-ray	2.90	A/B	27-233	[»]
	3EOY	X-ray	3.40	G/H/I/J/K/L	28-129	[»]
	3TSZ	X-ray	2.50	B	288-299	[»]
	4ODB	X-ray	3.20	D/E/F	28-129	[»]
ProteinModelPortalⁱ	Q9Y624
SMRⁱ	Q9Y624
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119153, 16 interactors
CORUMⁱ	Q9Y624
IntActⁱ	Q9Y624, 21 interactors
MINTⁱ	Q9Y624
STRINGⁱ	9606.ENSP00000289779

PTM databases

GlyConnectⁱ	1427
iPTMnetⁱ	Q9Y624
PhosphoSitePlusⁱ	Q9Y624
SwissPalmⁱ	Q9Y624

Polymorphism and mutation databases

BioMutaⁱ	F11R
DMDMⁱ	10720061

Proteomic databases

EPDⁱ	Q9Y624
PaxDbⁱ	Q9Y624
PeptideAtlasⁱ	Q9Y624
PRIDEⁱ	Q9Y624
ProteomicsDBⁱ	86590

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50848
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368026; ENSP00000357005; ENSG00000158769 [Q9Y624-1] ENST00000537746; ENSP00000440812; ENSG00000158769 [Q9Y624-2]
GeneIDⁱ	50848
KEGGⁱ	hsa:50848
UCSCⁱ	uc009wtt.4 human [Q9Y624-1]

Organism-specific databases

CTDⁱ	50848
DisGeNETⁱ	50848
EuPathDBⁱ	HostDB:ENSG00000158769.17
GeneCardsⁱ	F11R
HGNCⁱ	HGNC:14685 F11R
HPAⁱ	CAB004671 HPA043616 HPA061700
MIMⁱ	605721 gene
neXtProtⁱ	NX_Q9Y624
OpenTargetsⁱ	ENSG00000158769
PharmGKBⁱ	PA29991
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWUE Eukaryota ENOG410YHHV LUCA
GeneTreeⁱ	ENSGT00730000110678
HOVERGENⁱ	HBG000518
InParanoidⁱ	Q9Y624
KOⁱ	K06089
OMAⁱ	NRAFSNS
OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q9Y624
TreeFamⁱ	TF343984

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-216083 Integrin cell surface interactions R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-420029 Tight junction interactions
SIGNORⁱ	Q9Y624

Miscellaneous databases

ChiTaRSⁱ	F11R human
EvolutionaryTraceⁱ	Q9Y624
GeneWikiⁱ	F11_receptor
GenomeRNAiⁱ	50848
Protein Ontology More...PROⁱ	PR:Q9Y624
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158769 Expressed in 158 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_F11R
ExpressionAtlasⁱ	Q9Y624 baseline and differential
Genevisibleⁱ	Q9Y624 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JAM1_HUMAN
Accessionⁱ	Q9Y624Primary (citable) accession number: Q9Y624 Secondary accession number(s): B7Z941
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y624 (JAM1_HUMAN)

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Junctional adhesion molecule A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ