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Protein

Junctional adhesion molecule A

Gene

F11R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).By similarity3 Publications
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.1 Publication
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • PDZ domain binding Source: UniProtKB
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
SIGNORiQ9Y624

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule A
Short name:
JAM-A
Alternative name(s):
Junctional adhesion molecule 1
Short name:
JAM-1
Platelet F11 receptor
Platelet adhesion molecule 1
Short name:
PAM-1
CD_antigen: CD321
Gene namesi
Name:F11R
Synonyms:JAM1, JCAM
ORF Names:UNQ264/PRO301
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158769.17
HGNCiHGNC:14685 F11R
MIMi605721 gene
neXtProtiNX_Q9Y624

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 238ExtracellularSequence analysisAdd BLAST211
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 299CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi50848
OpenTargetsiENSG00000158769
PharmGKBiPA29991

Polymorphism and mutation databases

BioMutaiF11R
DMDMi10720061

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Combined sources3 PublicationsAdd BLAST27
ChainiPRO_000001506628 – 299Junctional adhesion molecule AAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 1091 Publication
Disulfide bondi153 ↔ 2121 Publication
Glycosylationi185N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei281PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y624
PaxDbiQ9Y624
PeptideAtlasiQ9Y624
PRIDEiQ9Y624
ProteomicsDBi86590

PTM databases

GlyConnecti1427
iPTMnetiQ9Y624
PhosphoSitePlusiQ9Y624
SwissPalmiQ9Y624

Expressioni

Tissue specificityi

Expressed in endothelium, epithelium and leukocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000158769 Expressed in 158 organ(s), highest expression level in ectocervix
CleanExiHS_F11R
ExpressionAtlasiQ9Y624 baseline and differential
GenevisibleiQ9Y624 HS

Organism-specific databases

HPAiCAB004671
HPA043616
HPA061700

Interactioni

Subunit structurei

Interacts with the ninth PDZ domain of MPDZ (PubMed:11489913). Interacts with the first PDZ domain of PARD3 (PubMed:11489913). The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with ITGAL (via I-domain) (PubMed:15528364).By similarity2 Publications
(Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.1 Publication
(Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119153, 16 interactors
CORUMiQ9Y624
IntActiQ9Y624, 21 interactors
MINTiQ9Y624
STRINGi9606.ENSP00000289779

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y624
SMRiQ9Y624
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y624

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 125Ig-like V-type 1Add BLAST98
Domaini135 – 228Ig-like V-type 2Add BLAST94

Domaini

The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.1 Publication

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWUE Eukaryota
ENOG410YHHV LUCA
GeneTreeiENSGT00730000110678
HOVERGENiHBG000518
InParanoidiQ9Y624
KOiK06089
OMAiNRAFSNS
OrthoDBiEOG091G05PI
PhylomeDBiQ9Y624
TreeFamiTF343984

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y624-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC
60 70 80 90 100
AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT
110 120 130 140 150
REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV
160 170 180 190 200
LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD
210 220 230 240 250
PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV AAVLVTLILL
260 270 280 290
GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV
Length:299
Mass (Da):32,583
Last modified:November 1, 1999 - v1
Checksum:iD95DE2FEA23D2851
GO
Isoform 2 (identifier: Q9Y624-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-129: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):27,208
Checksum:i548D39B300559F53
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY82A0A087WY82_HUMAN
Junctional adhesion molecule A
F11R
279Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05621881 – 129Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111713 mRNA Translation: AAD42050.1
AF207907 mRNA Translation: AAF22829.1
AF172398 mRNA Translation: AAD48877.1
AL136649 mRNA Translation: CAB66584.1
AY358896 mRNA Translation: AAQ89255.1
AK304412 mRNA Translation: BAH14177.1
AL591806 Genomic DNA No translation available.
BC001533 mRNA Translation: AAH01533.1
CCDSiCCDS1213.1 [Q9Y624-1]
CCDS86026.1 [Q9Y624-2]
PIRiA59406 S56749
RefSeqiNP_001335020.1, NM_001348091.1 [Q9Y624-2]
NP_058642.1, NM_016946.5 [Q9Y624-1]
UniGeneiHs.517293

Genome annotation databases

EnsembliENST00000368026; ENSP00000357005; ENSG00000158769 [Q9Y624-1]
ENST00000537746; ENSP00000440812; ENSG00000158769 [Q9Y624-2]
GeneIDi50848
KEGGihsa:50848
UCSCiuc009wtt.4 human [Q9Y624-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111713 mRNA Translation: AAD42050.1
AF207907 mRNA Translation: AAF22829.1
AF172398 mRNA Translation: AAD48877.1
AL136649 mRNA Translation: CAB66584.1
AY358896 mRNA Translation: AAQ89255.1
AK304412 mRNA Translation: BAH14177.1
AL591806 Genomic DNA No translation available.
BC001533 mRNA Translation: AAH01533.1
CCDSiCCDS1213.1 [Q9Y624-1]
CCDS86026.1 [Q9Y624-2]
PIRiA59406 S56749
RefSeqiNP_001335020.1, NM_001348091.1 [Q9Y624-2]
NP_058642.1, NM_016946.5 [Q9Y624-1]
UniGeneiHs.517293

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NBQX-ray2.90A/B27-233[»]
3EOYX-ray3.40G/H/I/J/K/L28-129[»]
3TSZX-ray2.50B288-299[»]
4ODBX-ray3.20D/E/F28-129[»]
ProteinModelPortaliQ9Y624
SMRiQ9Y624
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119153, 16 interactors
CORUMiQ9Y624
IntActiQ9Y624, 21 interactors
MINTiQ9Y624
STRINGi9606.ENSP00000289779

PTM databases

GlyConnecti1427
iPTMnetiQ9Y624
PhosphoSitePlusiQ9Y624
SwissPalmiQ9Y624

Polymorphism and mutation databases

BioMutaiF11R
DMDMi10720061

Proteomic databases

EPDiQ9Y624
PaxDbiQ9Y624
PeptideAtlasiQ9Y624
PRIDEiQ9Y624
ProteomicsDBi86590

Protocols and materials databases

DNASUi50848
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368026; ENSP00000357005; ENSG00000158769 [Q9Y624-1]
ENST00000537746; ENSP00000440812; ENSG00000158769 [Q9Y624-2]
GeneIDi50848
KEGGihsa:50848
UCSCiuc009wtt.4 human [Q9Y624-1]

Organism-specific databases

CTDi50848
DisGeNETi50848
EuPathDBiHostDB:ENSG00000158769.17
GeneCardsiF11R
HGNCiHGNC:14685 F11R
HPAiCAB004671
HPA043616
HPA061700
MIMi605721 gene
neXtProtiNX_Q9Y624
OpenTargetsiENSG00000158769
PharmGKBiPA29991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWUE Eukaryota
ENOG410YHHV LUCA
GeneTreeiENSGT00730000110678
HOVERGENiHBG000518
InParanoidiQ9Y624
KOiK06089
OMAiNRAFSNS
OrthoDBiEOG091G05PI
PhylomeDBiQ9Y624
TreeFamiTF343984

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-420029 Tight junction interactions
SIGNORiQ9Y624

Miscellaneous databases

ChiTaRSiF11R human
EvolutionaryTraceiQ9Y624
GeneWikiiF11_receptor
GenomeRNAii50848
PROiPR:Q9Y624
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158769 Expressed in 158 organ(s), highest expression level in ectocervix
CleanExiHS_F11R
ExpressionAtlasiQ9Y624 baseline and differential
GenevisibleiQ9Y624 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiJAM1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y624
Secondary accession number(s): B7Z941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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