UniProtKB - Q9Y624 (JAM1_HUMAN)
Junctional adhesion molecule A
F11R
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- integrin binding Source: ARUK-UCL
- PDZ domain binding Source: UniProtKB
- protein homodimerization activity Source: ARUK-UCL
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- actomyosin structure organization Source: UniProtKB
- bicellular tight junction assembly Source: Reactome
- cell-cell adhesion Source: ARUK-UCL
- cellular response to mechanical stimulus Source: ARUK-UCL
- establishment of endothelial intestinal barrier Source: UniProtKB
- extracellular matrix organization Source: Reactome
- inflammatory response Source: ProtInc
- intestinal absorption Source: UniProtKB
- leukocyte cell-cell adhesion Source: ARUK-UCL
- leukocyte migration Source: Reactome
- maintenance of blood-brain barrier Source: ARUK-UCL
- memory T cell extravasation Source: ARUK-UCL
- negative regulation of GTPase activity Source: UniProtKB
- negative regulation of stress fiber assembly Source: ARUK-UCL
- positive regulation of blood pressure Source: Ensembl
- positive regulation of establishment of endothelial barrier Source: ARUK-UCL
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of platelet aggregation Source: ARUK-UCL
- positive regulation of Rho protein signal transduction Source: ARUK-UCL
- protein localization to bicellular tight junction Source: ARUK-UCL
- protein localization to plasma membrane Source: UniProtKB
- regulation of actin cytoskeleton organization Source: ARUK-UCL
- regulation of actin cytoskeleton reorganization Source: UniProtKB
- regulation of bicellular tight junction assembly Source: ARUK-UCL
- regulation of cell shape Source: ARUK-UCL
- regulation of cytokine production Source: Ensembl
- regulation of cytoskeleton organization Source: ARUK-UCL
- regulation of membrane permeability Source: UniProtKB
- response to radiation Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9Y624 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-216083, Integrin cell surface interactions R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-420029, Tight junction interactions |
SIGNORi | Q9Y624 |
Names & Taxonomyi
Protein namesi | Recommended name: Junctional adhesion molecule AShort name: JAM-A Alternative name(s): Junctional adhesion molecule 1 Short name: JAM-1 Platelet F11 receptor Platelet adhesion molecule 1 Short name: PAM-1 CD_antigen: CD321 |
Gene namesi | Name:F11R Synonyms:JAM1, JCAM ORF Names:UNQ264/PRO301 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14685, F11R |
MIMi | 605721, gene |
neXtProti | NX_Q9Y624 |
VEuPathDBi | HostDB:ENSG00000158769.17 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Other locations
- tight junction 1 Publication
Note: Localized at tight junctions of both epithelial and endothelial cells.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: LIFEdb
Other locations
- bicellular tight junction Source: UniProtKB
- cell junction Source: Reactome
- cell-cell junction Source: ProtInc
- cytoplasmic vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: ARUK-UCL
- slit diaphragm Source: Ensembl
- tight junction Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 238 | ExtracellularSequence analysisAdd BLAST | 211 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 299 | CytoplasmicSequence analysisAdd BLAST | 40 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPathology & Biotechi
Organism-specific databases
DisGeNETi | 50848 |
OpenTargetsi | ENSG00000158769 |
PharmGKBi | PA29991 |
Miscellaneous databases
Pharosi | Q9Y624, Tbio |
Genetic variation databases
BioMutai | F11R |
DMDMi | 10720061 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Combined sources3 PublicationsAdd BLAST | 27 | |
ChainiPRO_0000015066 | 28 – 299 | Junctional adhesion molecule AAdd BLAST | 272 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 109 | 1 Publication | ||
Disulfide bondi | 153 ↔ 212 | 1 Publication | ||
Glycosylationi | 185 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 281 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 287 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9Y624 |
jPOSTi | Q9Y624 |
MassIVEi | Q9Y624 |
PaxDbi | Q9Y624 |
PeptideAtlasi | Q9Y624 |
PRIDEi | Q9Y624 |
ProteomicsDBi | 7002 86590 [Q9Y624-1] |
PTM databases
GlyConnecti | 1427, 12 N-Linked glycans (1 site) |
GlyGeni | Q9Y624, 1 site, 2 N-linked glycans (1 site) |
iPTMneti | Q9Y624 |
MetOSitei | Q9Y624 |
PhosphoSitePlusi | Q9Y624 |
SwissPalmi | Q9Y624 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000158769, Expressed in ectocervix and 172 other tissues |
ExpressionAtlasi | Q9Y624, baseline and differential |
Genevisiblei | Q9Y624, HS |
Organism-specific databases
HPAi | ENSG00000158769, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the ninth PDZ domain of MPDZ (PubMed:11489913).
Interacts with the first PDZ domain of PARD3 (PubMed:11489913). The association between PARD3 and PARD6B probably disrupts this interaction (By similarity).
Interacts with ITGAL (via I-domain) (PubMed:15528364).
By similarity2 Publications(Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.
1 Publication(Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.
1 PublicationBinary interactionsi
Hide detailsQ9Y624
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- integrin binding Source: ARUK-UCL
- PDZ domain binding Source: UniProtKB
- protein homodimerization activity Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 119153, 36 interactors |
CORUMi | Q9Y624 |
IntActi | Q9Y624, 28 interactors |
MINTi | Q9Y624 |
STRINGi | 9606.ENSP00000357005 |
Miscellaneous databases
RNActi | Q9Y624, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y624 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y624 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 125 | Ig-like V-type 1Add BLAST | 98 | |
Domaini | 135 – 228 | Ig-like V-type 2Add BLAST | 94 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWVN, Eukaryota |
GeneTreei | ENSGT00940000159186 |
HOGENOMi | CLU_067351_0_0_1 |
InParanoidi | Q9Y624 |
OMAi | YSRGYFE |
PhylomeDBi | Q9Y624 |
TreeFami | TF343984 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR042456, F11R IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR45113, PTHR45113, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC
60 70 80 90 100
AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT
110 120 130 140 150
REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV
160 170 180 190 200
LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD
210 220 230 240 250
PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV AAVLVTLILL
260 270 280 290
GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WY82 | A0A087WY82_HUMAN | Junctional adhesion molecule 1 | F11R | 279 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056218 | 81 – 129 | Missing in isoform 2. 1 PublicationAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF111713 mRNA Translation: AAD42050.1 AF207907 mRNA Translation: AAF22829.1 AF172398 mRNA Translation: AAD48877.1 AL136649 mRNA Translation: CAB66584.1 AY358896 mRNA Translation: AAQ89255.1 AK304412 mRNA Translation: BAH14177.1 AL591806 Genomic DNA No translation available. BC001533 mRNA Translation: AAH01533.1 |
CCDSi | CCDS1213.1 [Q9Y624-1] CCDS86026.1 [Q9Y624-2] |
PIRi | A59406, S56749 |
RefSeqi | NP_001335020.1, NM_001348091.1 [Q9Y624-2] NP_058642.1, NM_016946.5 [Q9Y624-1] |
Genome annotation databases
Ensembli | ENST00000368026; ENSP00000357005; ENSG00000158769 [Q9Y624-1] ENST00000537746; ENSP00000440812; ENSG00000158769 [Q9Y624-2] |
GeneIDi | 50848 |
KEGGi | hsa:50848 |
UCSCi | uc009wtt.4, human [Q9Y624-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF111713 mRNA Translation: AAD42050.1 AF207907 mRNA Translation: AAF22829.1 AF172398 mRNA Translation: AAD48877.1 AL136649 mRNA Translation: CAB66584.1 AY358896 mRNA Translation: AAQ89255.1 AK304412 mRNA Translation: BAH14177.1 AL591806 Genomic DNA No translation available. BC001533 mRNA Translation: AAH01533.1 |
CCDSi | CCDS1213.1 [Q9Y624-1] CCDS86026.1 [Q9Y624-2] |
PIRi | A59406, S56749 |
RefSeqi | NP_001335020.1, NM_001348091.1 [Q9Y624-2] NP_058642.1, NM_016946.5 [Q9Y624-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NBQ | X-ray | 2.90 | A/B | 27-233 | [»] | |
3EOY | X-ray | 3.40 | G/H/I/J/K/L | 28-129 | [»] | |
3TSZ | X-ray | 2.50 | B | 288-299 | [»] | |
4ODB | X-ray | 3.20 | D/E/F | 28-129 | [»] | |
SMRi | Q9Y624 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119153, 36 interactors |
CORUMi | Q9Y624 |
IntActi | Q9Y624, 28 interactors |
MINTi | Q9Y624 |
STRINGi | 9606.ENSP00000357005 |
PTM databases
GlyConnecti | 1427, 12 N-Linked glycans (1 site) |
GlyGeni | Q9Y624, 1 site, 2 N-linked glycans (1 site) |
iPTMneti | Q9Y624 |
MetOSitei | Q9Y624 |
PhosphoSitePlusi | Q9Y624 |
SwissPalmi | Q9Y624 |
Genetic variation databases
BioMutai | F11R |
DMDMi | 10720061 |
Proteomic databases
EPDi | Q9Y624 |
jPOSTi | Q9Y624 |
MassIVEi | Q9Y624 |
PaxDbi | Q9Y624 |
PeptideAtlasi | Q9Y624 |
PRIDEi | Q9Y624 |
ProteomicsDBi | 7002 86590 [Q9Y624-1] |
Protocols and materials databases
Antibodypediai | 3317, 620 antibodies |
DNASUi | 50848 |
Genome annotation databases
Ensembli | ENST00000368026; ENSP00000357005; ENSG00000158769 [Q9Y624-1] ENST00000537746; ENSP00000440812; ENSG00000158769 [Q9Y624-2] |
GeneIDi | 50848 |
KEGGi | hsa:50848 |
UCSCi | uc009wtt.4, human [Q9Y624-1] |
Organism-specific databases
CTDi | 50848 |
DisGeNETi | 50848 |
GeneCardsi | F11R |
HGNCi | HGNC:14685, F11R |
HPAi | ENSG00000158769, Low tissue specificity |
MIMi | 605721, gene |
neXtProti | NX_Q9Y624 |
OpenTargetsi | ENSG00000158769 |
PharmGKBi | PA29991 |
VEuPathDBi | HostDB:ENSG00000158769.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWVN, Eukaryota |
GeneTreei | ENSGT00940000159186 |
HOGENOMi | CLU_067351_0_0_1 |
InParanoidi | Q9Y624 |
OMAi | YSRGYFE |
PhylomeDBi | Q9Y624 |
TreeFami | TF343984 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y624 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-216083, Integrin cell surface interactions R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-420029, Tight junction interactions |
SIGNORi | Q9Y624 |
Miscellaneous databases
BioGRID-ORCSi | 50848, 9 hits in 996 CRISPR screens |
ChiTaRSi | F11R, human |
EvolutionaryTracei | Q9Y624 |
GeneWikii | F11_receptor |
GenomeRNAii | 50848 |
Pharosi | Q9Y624, Tbio |
PROi | PR:Q9Y624 |
RNActi | Q9Y624, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158769, Expressed in ectocervix and 172 other tissues |
ExpressionAtlasi | Q9Y624, baseline and differential |
Genevisiblei | Q9Y624, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR042456, F11R IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR45113, PTHR45113, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | JAM1_HUMAN | |
Accessioni | Q9Y624Primary (citable) accession number: Q9Y624 Secondary accession number(s): B7Z941 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 208 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families