UniProtKB - Q9Y620 (RA54B_HUMAN)

BLAST

>sp|Q9Y620|RA54B_HUMAN DNA repair and recombination protein RAD54B OS=Homo sapiens OX=9606 GN=RAD54B PE=1 SV=1
MRRSAAPSQLQGNSFKKPKFIPPGRSNPGLNEEITKLNPDIKLFEGVAINNTFLPSQNDL
RICSLNLPSEESTREINNRDNCSGKYCFEAPTLATLDPPHTVHSAPKEVAVSKEQEEKSD
SLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKDIGRGIGYKFKELEKIEE
GQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSS
KENRQNDFQNCKPRHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQ
KEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPVIKKTLI
VTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHKVEEFIKSIFYSVLIISYEMLLRSLDQI
KNIKFDLLICDEGHRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPG
ILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLTGLFILRRTQEIINKYLP
PKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLICIGALKKLCNHPCLLFN
SIKEKECSSTCDKNEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPT
EKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIVDGFNSQHSSFFIFLLSS
KAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQ
RQISKQGLCGAVVDLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGD
SLEKFIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLNLTDPFLERITENVSFIF
QNITTQATGT

Align

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History
Entry version 149 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

DNA repair and recombination protein RAD54B

Gene

RAD54B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	326 – 333	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
DNA binding Source: UniProtKB-KW
DNA helicase activity
Source: ProtInc
Traceable author statementⁱ
- 10362364
DNA translocase activity
Source: MGI
Inferred from direct assayⁱ
- 16428451
RNA helicase activity
Source: ProtInc
Traceable author statementⁱ
- 10362364

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

double-strand break repair via homologous recombination
Source: MGI
Inferred from direct assayⁱ
- 16428451
mitotic recombination
Source: ProtInc
Traceable author statementⁱ
- 10362364
reciprocal meiotic recombination
Source: ProtInc
Traceable author statementⁱ
- 10362364

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Helicase, Hydrolase
Biological process	DNA damage, DNA repair
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA repair and recombination protein RAD54B (EC:3.6.4.-) Alternative name(s): RAD54 homolog B
Gene namesⁱ	Name:RAD54B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197275.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17228 RAD54B
MIMⁱ	604289 gene
neXtProtⁱ	NX_Q9Y620

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100861412 25788
MalaCards human disease database More...MalaCardsⁱ	RAD54B
Open Targets More...OpenTargetsⁱ	ENSG00000197275
PharmGKBⁱ	PA134927202

Polymorphism and mutation databases

BioMutaⁱ	RAD54B
DMDMⁱ	51316548

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000074340	1 – 910	DNA repair and recombination protein RAD54BAdd BLAST		910

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	14	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y620
PaxDbⁱ	Q9Y620
PeptideAtlas More...PeptideAtlasⁱ	Q9Y620
PRIDEⁱ	Q9Y620
ProteomicsDBⁱ	86588

PTM databases

iPTMnetⁱ	Q9Y620
PhosphoSitePlusⁱ	Q9Y620

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197275 Expressed in 159 organ(s), highest expression level in kidney
CleanExⁱ	HS_RAD54B
ExpressionAtlasⁱ	Q9Y620 baseline and differential
Genevisibleⁱ	Q9Y620 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007087

HPAⁱ

HPA007087

Interactionⁱ

Subunit structureⁱ

Interacts with RAD51 through the NH2-terminal domain. Immunoprecipitation experiments show that the interaction is constitutive and not induced by ionizing radiation. The interaction may be indirect.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LNX1	Q8TBB1	3	EBI-740830,EBI-739832

With

Entry

#Exp.

IntAct

Notes

LNX1

Q8TBB1

EBI-740830,EBI-739832

Protein-protein interaction databases

BioGridⁱ	117321, 38 interactors
IntActⁱ	Q9Y620, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y620
STRINGⁱ	9606.ENSP00000336606

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y620
SMRⁱ	Q9Y620
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	313 – 480	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		168
Domainⁱ	649 – 810	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		162

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	431 – 434	DEGH box		4

Sequence similaritiesⁱ

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0390 Eukaryota COG0553 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149014
HOGENOMⁱ	HOG000204521
HOVERGENⁱ	HBG058654
InParanoidⁱ	Q9Y620
KEGG Orthology (KO) More...KOⁱ	K10877
OMAⁱ	YALIEFV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01Z3
PhylomeDBⁱ	Q9Y620
TreeFamⁱ	TF101223

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.40.50.10810, 1 hit
InterProⁱ	View protein in InterPro IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y620-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRSAAPSQL QGNSFKKPKF IPPGRSNPGL NEEITKLNPD IKLFEGVAIN 
        60         70         80         90        100
NTFLPSQNDL RICSLNLPSE ESTREINNRD NCSGKYCFEA PTLATLDPPH 
       110        120        130        140        150
TVHSAPKEVA VSKEQEEKSD SLVKYFSVVW CKPSKKKHKK WEGDAVLIVK 
       160        170        180        190        200
GKSFILKNLE GKDIGRGIGY KFKELEKIEE GQTLMICGKE IEVMGVISPD 
       210        220        230        240        250
DFSSGRCFQL GGGSTAISHS SQVARKCFSN PFKSVCKPSS KENRQNDFQN 
       260        270        280        290        300
CKPRHDPYTP NSLVMPRPDK NHQWVFNKNC FPLVDVVIDP YLVYHLRPHQ 
       310        320        330        340        350
KEGIIFLYEC VMGMRMNGRC GAILADEMGL GKTLQCISLI WTLQCQGPYG 
       360        370        380        390        400
GKPVIKKTLI VTPGSLVNNW KKEFQKWLGS ERIKIFTVDQ DHKVEEFIKS 
       410        420        430        440        450
IFYSVLIISY EMLLRSLDQI KNIKFDLLIC DEGHRLKNSA IKTTTALISL 
       460        470        480        490        500
SCEKRIILTG TPIQNDLQEF FALIDFVNPG ILGSLSSYRK IYEEPIILSR 
       510        520        530        540        550
EPSASEEEKE LGERRAAELT CLTGLFILRR TQEIINKYLP PKIENVVFCR 
       560        570        580        590        600
PGALQIELYR KLLNSQVVRF CLQGLLENSP HLICIGALKK LCNHPCLLFN 
       610        620        630        640        650
SIKEKECSST CDKNEEKSLY KGLLSVFPAD YNPLLFTEKE SGKLQVLSKL 
       660        670        680        690        700
LAVIHELRPT EKVVLVSNYT QTLNILQEVC KRHGYAYTRL DGQTPISQRQ 
       710        720        730        740        750
QIVDGFNSQH SSFFIFLLSS KAGGVGLNLI GGSHLILYDI DWNPATDIQA 
       760        770        780        790        800
MSRVWRDGQK YPVHIYRLLT TGTIEEKIYQ RQISKQGLCG AVVDLTKTSE 
       810        820        830        840        850
HIQFSVEELK NLFTLHESSD CVTHDLLDCE CTGEEVHTGD SLEKFIVSRD 
       860        870        880        890        900
CQLGPHHQKS NSLKPLSMSQ LKQWKHFSGD HLNLTDPFLE RITENVSFIF 
       910
QNITTQATGT

Length:910

Mass (Da):102,967

Last modified:November 1, 1999 - v1

Checksum:ⁱ0167288FBA95FBC5

Isoform 2 (identifier: Q9Y620-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
103-117: HSAPKEVAVSKEQEE → QTWMRRHRLVPVHYR
118-910: Missing.

« Hide

        10         20         30         40         50
MRRSAAPSQL QGNSFKKPKF IPPGRSNPGL NEEITKLNPD IKLFEGVAIN 
        60         70         80         90        100
NTFLPSQNDL RICSLNLPSE ESTREINNRD NCSGKYCFEA PTLATLDPPH 
       110 
TVQTWMRRHR LVPVHYR

Note: No experimental confirmation available.

Show »

Length:117

Mass (Da):13,330

Checksum:ⁱFF14E8FF9AD2946E

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RI14	E5RI14_HUMAN	DNA repair and recombination protei... DNA repair and recombination protein RAD54B	RAD54B	121	Annotation score:
E5RHN9	E5RHN9_HUMAN	DNA repair and recombination protei... DNA repair and recombination protein RAD54B	RAD54B	125	Annotation score:
E5RJF7	E5RJF7_HUMAN	DNA repair and recombination protei... DNA repair and recombination protein RAD54B	RAD54B	52	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034430	30	L → V. Corresponds to variant dbSNP:rs28910279Ensembl.	1
Natural variantⁱVAR_037885	97	D → H. Corresponds to variant dbSNP:rs2919661Ensembl.	1
Natural variantⁱVAR_019563	418	D → Y in a colon cancer sample. 1 PublicationCorresponds to variant dbSNP:rs119490107EnsemblClinVar.	1
Natural variantⁱVAR_019564	593	N → S in a non-Hodgkin lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs114216685EnsemblClinVar.	1
Natural variantⁱVAR_075089	833	G → E1 PublicationCorresponds to variant dbSNP:rs752511501Ensembl.	1
Natural variantⁱVAR_075090	899	I → V1 PublicationCorresponds to variant dbSNP:rs150017319Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045956	103 – 117	HSAPK…KEQEE → QTWMRRHRLVPVHYR in isoform 2. 1 PublicationAdd BLAST		15
Alternative sequenceⁱVSP_045957	118 – 910	Missing in isoform 2. 1 PublicationAdd BLAST		793

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF112481 mRNA Translation: AAD34331.1 AL523600 mRNA No translation available. AC023632 Genomic DNA No translation available. AP003534 Genomic DNA No translation available. BC001965 mRNA Translation: AAH01965.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56546.1 [Q9Y620-2] CCDS6262.1 [Q9Y620-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001192192.1, NM_001205263.1 NP_036547.1, NM_012415.3 [Q9Y620-1]
UniGeneⁱ	Hs.30561 Hs.744229

Genome annotation databases

Ensemblⁱ	ENST00000297592; ENSP00000430153; ENSG00000197275 [Q9Y620-2] ENST00000336148; ENSP00000336606; ENSG00000197275 [Q9Y620-1]
GeneIDⁱ	25788
KEGGⁱ	hsa:25788
UCSC genome browser More...UCSCⁱ	uc003ygk.4 human [Q9Y620-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y620	DNA repair and recombination protein RAD54B (Fragment)		HUMAN		125	UniRef100_Q9Y620
Fibrinogen silencer-binding protein		HUMAN		726

Protein	Similar proteins		Species	Score	Length	Source
Q9Y620	DNA repair and recombination protein RAD54B (Fragment)		HUMAN		125	UniRef90_Q9Y620
Uncharacterized protein		GORGO		915
Uncharacterized protein		PROCO		911
Uncharacterized protein		NOMLE		911
RAD54 homolog B		PANTR		910
+51
Q9Y620-2	Uncharacterized protein		GORGO		122	UniRef90_Q9Y620-2
DNA repair and recombination protein RAD54B		HUMAN		121
Uncharacterized protein		PANPA		117
Uncharacterized protein		PANTR		117

Protein	Similar proteins		Species	Score	Length	Source
Q9Y620	DNA repair and recombination protein RAD54B (Fragment)		HUMAN		125	UniRef50_Q9Y620
Uncharacterized protein		GORGO		915
Uncharacterized protein		PROCO		911
Uncharacterized protein		NOMLE		911
Uncharacterized protein		SAIBB		910
+225
Q9Y620-2	Uncharacterized protein		GORGO		122	UniRef50_Q9Y620-2
DNA repair and recombination protein RAD54B		HUMAN		121
Uncharacterized protein		PANPA		117
Uncharacterized protein		PANTR		117
Uncharacterized protein		COLAP		117
+26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF112481 mRNA Translation: AAD34331.1 AL523600 mRNA No translation available. AC023632 Genomic DNA No translation available. AP003534 Genomic DNA No translation available. BC001965 mRNA Translation: AAH01965.1
CCDSⁱ	CCDS56546.1 [Q9Y620-2] CCDS6262.1 [Q9Y620-1]
RefSeqⁱ	NP_001192192.1, NM_001205263.1 NP_036547.1, NM_012415.3 [Q9Y620-1]
UniGeneⁱ	Hs.30561 Hs.744229

3D structure databases

ProteinModelPortalⁱ	Q9Y620
SMRⁱ	Q9Y620
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117321, 38 interactors
IntActⁱ	Q9Y620, 15 interactors
MINTⁱ	Q9Y620
STRINGⁱ	9606.ENSP00000336606

PTM databases

iPTMnetⁱ	Q9Y620
PhosphoSitePlusⁱ	Q9Y620

Polymorphism and mutation databases

BioMutaⁱ	RAD54B
DMDMⁱ	51316548

Proteomic databases

EPDⁱ	Q9Y620
PaxDbⁱ	Q9Y620
PeptideAtlasⁱ	Q9Y620
PRIDEⁱ	Q9Y620
ProteomicsDBⁱ	86588

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000297592; ENSP00000430153; ENSG00000197275 [Q9Y620-2] ENST00000336148; ENSP00000336606; ENSG00000197275 [Q9Y620-1]
GeneIDⁱ	25788
KEGGⁱ	hsa:25788
UCSCⁱ	uc003ygk.4 human [Q9Y620-1]

Organism-specific databases

CTDⁱ	25788
DisGeNETⁱ	100861412 25788
EuPathDBⁱ	HostDB:ENSG00000197275.12
GeneCardsⁱ	RAD54B
HGNCⁱ	HGNC:17228 RAD54B
HPAⁱ	HPA007087
MalaCardsⁱ	RAD54B
MIMⁱ	604289 gene
neXtProtⁱ	NX_Q9Y620
OpenTargetsⁱ	ENSG00000197275
PharmGKBⁱ	PA134927202
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0390 Eukaryota COG0553 LUCA
GeneTreeⁱ	ENSGT00920000149014
HOGENOMⁱ	HOG000204521
HOVERGENⁱ	HBG058654
InParanoidⁱ	Q9Y620
KOⁱ	K10877
OMAⁱ	YALIEFV
OrthoDBⁱ	EOG091G01Z3
PhylomeDBⁱ	Q9Y620
TreeFamⁱ	TF101223

Miscellaneous databases

ChiTaRSⁱ	RAD54B human
GenomeRNAiⁱ	25788
Protein Ontology More...PROⁱ	PR:Q9Y620
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197275 Expressed in 159 organ(s), highest expression level in kidney
CleanExⁱ	HS_RAD54B
ExpressionAtlasⁱ	Q9Y620 baseline and differential
Genevisibleⁱ	Q9Y620 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.40.50.10810, 1 hit
InterProⁱ	View protein in InterPro IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N
Pfamⁱ	View protein in Pfam PF00271 Helicase_C, 1 hit PF00176 SNF2_N, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RA54B_HUMAN
Accessionⁱ	Q9Y620Primary (citable) accession number: Q9Y620 Secondary accession number(s): F6WBS8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - Q9Y620 (RA54B_HUMAN)

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DNA repair and recombination protein RAD54B

RAD54B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

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