SLC25A15

Functionⁱ

Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline (PubMed:12807890). The stoichiometry is close to 1:1 (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

L-ornithine transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y619
Reactomeⁱ	R-HSA-70635, Urea cycle
SABIO-RKⁱ	Q9Y619

Protein family/group databases

TCDBⁱ	2.A.29.19.2, the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.19.2, the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial ornithine transporter 1 Alternative name(s): Solute carrier family 25 member 15
Gene namesⁱ	Name:SLC25A15 Synonyms:ORC11 Publication, ORNT1 ORF Names:SP1855
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102743.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10985, SLC25A15
MIMⁱ	603861, gene
neXtProtⁱ	NX_Q9Y619

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	5 – 25	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	68 – 88	Helical; Name=2Sequence analysisAdd BLAST	21
Transmembraneⁱ	110 – 130	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	168 – 188	Helical; Name=4Sequence analysisAdd BLAST	21
Transmembraneⁱ	207 – 227	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	237 – 257	Helical; Name=6Sequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHHS)8 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder of the urea cycle characterized by onset in early life. The acute phase of the disease is characterized by vomiting, ataxia, lethargy, confusion, and coma. Chronic clinical manifestations include hypotonia, developmental delay, progressive encephalopathy with mental regression, and spastic paraparesis with pyramidal signs.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012757	27	G → E in HHHS. 1 PublicationCorresponds to variant dbSNP:rs1208994024Ensembl.	1
Natural variantⁱVAR_012758	27	G → R in HHHS; incapable of catalyzing homo-exchanges of ornithine, arginine, lysine and citrulline. 4 PublicationsCorresponds to variant dbSNP:rs104894430EnsemblClinVar.	1
Natural variantⁱVAR_058948	37	M → R in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs121908533EnsemblClinVar.	1
Natural variantⁱVAR_058949	70	A → L in HHHS; requires 2 nucleotide substitutions; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1064793683EnsemblClinVar.	1
Natural variantⁱVAR_058950	71	L → Q in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs121908534EnsemblClinVar.	1
Natural variantⁱVAR_058951	113	G → C in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 2 PublicationsCorresponds to variant dbSNP:rs199894905EnsemblClinVar.	1
Natural variantⁱVAR_012759	126	P → R in HHHS. 1 Publication	1
Natural variantⁱVAR_012760	180	E → K in HHHS. 1 PublicationCorresponds to variant dbSNP:rs104894424EnsemblClinVar.	1
Natural variantⁱVAR_058952	188	F → L in HHHS. 1 PublicationCorresponds to variant dbSNP:rs141028076EnsemblClinVar.	1
Natural variantⁱVAR_012761	188	Missing in HHHS; maintains a residual transport activity of 10%. 4 Publications	1
Natural variantⁱVAR_012762	190	G → D in HHHS; maintains a residual transport activity of 35%. 3 PublicationsCorresponds to variant dbSNP:rs202247804EnsemblClinVar.	1
Natural variantⁱVAR_058953	216	G → S in HHHS. 1 PublicationCorresponds to variant dbSNP:rs1417167600Ensembl.	1
Natural variantⁱVAR_058954	272	T → I in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs121908535EnsemblClinVar.	1
Natural variantⁱVAR_058955	273	M → K in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 2 PublicationsCorresponds to variant dbSNP:rs202247808Ensembl.	1
Natural variantⁱVAR_012764	275	R → Q in HHHS. 3 PublicationsCorresponds to variant dbSNP:rs104894431EnsemblClinVar.	1
Natural variantⁱVAR_058956	283	L → F in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs202247809EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10166
GeneReviewsⁱ	SLC25A15
MalaCards human disease database More...MalaCardsⁱ	SLC25A15
MIMⁱ	238970, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000102743
Orphanetⁱ	415, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
PharmGKBⁱ	PA35861

Miscellaneous databases

Pharosⁱ	Q9Y619, Tbio

Pharosⁱ

Q9Y619, Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00129, Ornithine

DrugBankⁱ

DB00129, Ornithine

Polymorphism and mutation databases

BioMutaⁱ	SLC25A15
DMDMⁱ	20139303

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090650	1 – 301	Mitochondrial ornithine transporter 1Add BLAST		301

Proteomic databases

EPDⁱ	Q9Y619
jPOSTⁱ	Q9Y619
MassIVEⁱ	Q9Y619
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y619
PaxDbⁱ	Q9Y619
PeptideAtlas More...PeptideAtlasⁱ	Q9Y619
PRIDEⁱ	Q9Y619
ProteomicsDBⁱ	86587

PTM databases

iPTMnetⁱ	Q9Y619
PhosphoSitePlusⁱ	Q9Y619
SwissPalmⁱ	Q9Y619

Expressionⁱ

Tissue specificityⁱ

Highly expressed in liver, pancreas, testis, lung and small intestine. Lower levels are detected in spleen, kidney, brain and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000102743, Expressed in pancreas and 124 other tissues
ExpressionAtlasⁱ	Q9Y619, baseline and differential
Genevisibleⁱ	Q9Y619, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000102743, Group enriched (intestine, liver, pancreas)

HPAⁱ

ENSG00000102743, Group enriched (intestine, liver, pancreas)

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	115468, 22 interactors
IntActⁱ	Q9Y619, 10 interactors
STRINGⁱ	9606.ENSP00000342267

Miscellaneous databases

RNActⁱ	Q9Y619, protein

RNActⁱ

Q9Y619, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9Y619
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	7 – 91	Solcar 1Add BLAST	85
Repeatⁱ	104 – 197	Solcar 2Add BLAST	94
Repeatⁱ	207 – 293	Solcar 3Add BLAST	87

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0763, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110966
HOGENOMⁱ	CLU_015166_16_3_1
InParanoidⁱ	Q9Y619
KEGG Orthology (KO) More...KOⁱ	K15101
OMAⁱ	RGFWHGQ
Database of Orthologous Groups More...OrthoDBⁱ	1072378at2759
PhylomeDBⁱ	Q9Y619
TreeFamⁱ	TF314880

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153, Mito_carr, 3 hits
SUPFAMⁱ	SSF103506, SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920, SOLCAR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9Y619-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKSNPAIQAA IDLTAGAAGG TACVLTGQPF DTMKVKMQTF PDLYRGLTDC 
        60         70         80         90        100
CLKTYSQVGF RGFYKGTSPA LIANIAENSV LFMCYGFCQQ VVRKVAGLDK 
       110        120        130        140        150
QAKLSDLQNA AAGSFASAFA ALVLCPTELV KCRLQTMYEM ETSGKIAKSQ 
       160        170        180        190        200
NTVWSVIKSI LRKDGPLGFY HGLSSTLLRE VPGYFFFFGG YELSRSFFAS 
       210        220        230        240        250
GRSKDELGPV PLMLSGGVGG ICLWLAVYPV DCIKSRIQVL SMSGKQAGFI 
       260        270        280        290        300
RTFINVVKNE GITALYSGLK PTMIRAFPAN GALFLAYEYS RKLMMNQLEA 

Y

Length:301

Mass (Da):32,736

Last modified:November 1, 1999 - v1

Checksum:ⁱ34436A15B105DC53

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5VZD9	Q5VZD9_HUMAN	Mitochondrial ornithine transporter... Mitochondrial ornithine transporter 1	SLC25A15	133	Annotation score:
F2Z354	F2Z354_HUMAN	Mitochondrial ornithine transporter... Mitochondrial ornithine transporter 1	SLC25A15	57	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012757	27	G → E in HHHS. 1 PublicationCorresponds to variant dbSNP:rs1208994024Ensembl.	1
Natural variantⁱVAR_012758	27	G → R in HHHS; incapable of catalyzing homo-exchanges of ornithine, arginine, lysine and citrulline. 4 PublicationsCorresponds to variant dbSNP:rs104894430EnsemblClinVar.	1
Natural variantⁱVAR_058948	37	M → R in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs121908533EnsemblClinVar.	1
Natural variantⁱVAR_058949	70	A → L in HHHS; requires 2 nucleotide substitutions; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1064793683EnsemblClinVar.	1
Natural variantⁱVAR_058950	71	L → Q in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs121908534EnsemblClinVar.	1
Natural variantⁱVAR_058951	113	G → C in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 2 PublicationsCorresponds to variant dbSNP:rs199894905EnsemblClinVar.	1
Natural variantⁱVAR_012759	126	P → R in HHHS. 1 Publication	1
Natural variantⁱVAR_012760	180	E → K in HHHS. 1 PublicationCorresponds to variant dbSNP:rs104894424EnsemblClinVar.	1
Natural variantⁱVAR_058952	188	F → L in HHHS. 1 PublicationCorresponds to variant dbSNP:rs141028076EnsemblClinVar.	1
Natural variantⁱVAR_012761	188	Missing in HHHS; maintains a residual transport activity of 10%. 4 Publications	1
Natural variantⁱVAR_012762	190	G → D in HHHS; maintains a residual transport activity of 35%. 3 PublicationsCorresponds to variant dbSNP:rs202247804EnsemblClinVar.	1
Natural variantⁱVAR_058953	216	G → S in HHHS. 1 PublicationCorresponds to variant dbSNP:rs1417167600Ensembl.	1
Natural variantⁱVAR_012763	254	I → L. Corresponds to variant dbSNP:rs17849654EnsemblClinVar.	1
Natural variantⁱVAR_058954	272	T → I in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs121908535EnsemblClinVar.	1
Natural variantⁱVAR_058955	273	M → K in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 2 PublicationsCorresponds to variant dbSNP:rs202247808Ensembl.	1
Natural variantⁱVAR_012764	275	R → Q in HHHS. 3 PublicationsCorresponds to variant dbSNP:rs104894431EnsemblClinVar.	1
Natural variantⁱVAR_058956	283	L → F in HHHS; exhibits very low transport activity despite normal insertion in the liposomal membrane. 1 PublicationCorresponds to variant dbSNP:rs202247809EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF112968 mRNA Translation: AAD45238.1 AJ309943 Genomic DNA Translation: CAC83972.1 AF177333 mRNA Translation: AAG17977.1 AL161614 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08630.1 BC002702 mRNA Translation: AAH02702.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9373.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055067.1, NM_014252.3

Genome annotation databases

Ensemblⁱ	ENST00000338625; ENSP00000342267; ENSG00000102743
GeneIDⁱ	10166
KEGGⁱ	hsa:10166
UCSC genome browser More...UCSCⁱ	uc001uxn.4, human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y619	Uncharacterized protein		CERAT		301	UniRef100_Q9Y619
Uncharacterized protein		CHLSB		301
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9Y619	Uncharacterized protein		CERAT		301	UniRef90_Q9Y619
Uncharacterized protein		CHLSB		301
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9Y619	Mitochondrial ornithine transporter 2		HUMAN		301	UniRef50_Q9Y619
Mitochondrial ornithine transporter 1		MOUSE		301
Mitochondrial ornithine transporter 1		RAT		301
Uncharacterized protein		CERAT		301
Uncharacterized protein		CHLSB		301
+464

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF112968 mRNA Translation: AAD45238.1 AJ309943 Genomic DNA Translation: CAC83972.1 AF177333 mRNA Translation: AAG17977.1 AL161614 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08630.1 BC002702 mRNA Translation: AAH02702.1
CCDSⁱ	CCDS9373.1
RefSeqⁱ	NP_055067.1, NM_014252.3

3D structure databases

SMRⁱ	Q9Y619
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115468, 22 interactors
IntActⁱ	Q9Y619, 10 interactors
STRINGⁱ	9606.ENSP00000342267

Chemistry databases

DrugBankⁱ	DB00129, Ornithine

DrugBankⁱ

DB00129, Ornithine

Protein family/group databases

TCDBⁱ	2.A.29.19.2, the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.19.2, the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	Q9Y619
PhosphoSitePlusⁱ	Q9Y619
SwissPalmⁱ	Q9Y619

Polymorphism and mutation databases

BioMutaⁱ	SLC25A15
DMDMⁱ	20139303

Proteomic databases

EPDⁱ	Q9Y619
jPOSTⁱ	Q9Y619
MassIVEⁱ	Q9Y619
MaxQBⁱ	Q9Y619
PaxDbⁱ	Q9Y619
PeptideAtlasⁱ	Q9Y619
PRIDEⁱ	Q9Y619
ProteomicsDBⁱ	86587

Protocols and materials databases

Antibodypediaⁱ	42171, 65 antibodies
The DNASU plasmid repository More...DNASUⁱ	10166

Genome annotation databases

Ensemblⁱ	ENST00000338625; ENSP00000342267; ENSG00000102743
GeneIDⁱ	10166
KEGGⁱ	hsa:10166
UCSCⁱ	uc001uxn.4, human

Organism-specific databases

CTDⁱ	10166
DisGeNETⁱ	10166
EuPathDBⁱ	HostDB:ENSG00000102743.14
GeneCardsⁱ	SLC25A15
GeneReviewsⁱ	SLC25A15
HGNCⁱ	HGNC:10985, SLC25A15
HPAⁱ	ENSG00000102743, Group enriched (intestine, liver, pancreas)
MalaCardsⁱ	SLC25A15
MIMⁱ	238970, phenotype 603861, gene
neXtProtⁱ	NX_Q9Y619
OpenTargetsⁱ	ENSG00000102743
Orphanetⁱ	415, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
PharmGKBⁱ	PA35861
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0763, Eukaryota
GeneTreeⁱ	ENSGT00730000110966
HOGENOMⁱ	CLU_015166_16_3_1
InParanoidⁱ	Q9Y619
KOⁱ	K15101
OMAⁱ	RGFWHGQ
OrthoDBⁱ	1072378at2759
PhylomeDBⁱ	Q9Y619
TreeFamⁱ	TF314880

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y619
Reactomeⁱ	R-HSA-70635, Urea cycle
SABIO-RKⁱ	Q9Y619

Miscellaneous databases

BioGRID-ORCSⁱ	10166, 4 hits in 870 CRISPR screens
ChiTaRSⁱ	SLC25A15, human
GenomeRNAiⁱ	10166
Pharosⁱ	Q9Y619, Tbio
Protein Ontology More...PROⁱ	PR:Q9Y619
RNActⁱ	Q9Y619, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102743, Expressed in pancreas and 124 other tissues
ExpressionAtlasⁱ	Q9Y619, baseline and differential
Genevisibleⁱ	Q9Y619, HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf
Pfamⁱ	View protein in Pfam PF00153, Mito_carr, 3 hits
SUPFAMⁱ	SSF103506, SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920, SOLCAR, 3 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ORNT1_HUMAN
Accessionⁱ	Q9Y619Primary (citable) accession number: Q9Y619 Secondary accession number(s): Q5VZD8, Q9HC45
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	November 1, 1999
	Last modified:	October 7, 2020
	This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q9Y619 (ORNT1_HUMAN)

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Mitochondrial ornithine transporter 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ