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UniProtKB - Q9Y618 (NCOR2_HUMAN)

Entry version 227 (23 Feb 2022)
Sequence version 3 (12 Sep 2018)
Previous versions | rss
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Protein

Nuclear receptor corepressor 2

Gene

NCOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor (PubMed:20812024).

Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y618

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815, HDACs deacetylate histones
R-HSA-350054, Notch-HLH transcription pathway
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-383280, Nuclear Receptor transcription pathway
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-9022537, Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692, Regulation of MECP2 expression and activity
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9609690, HCMV Early Events
R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
R-HSA-9707564, Cytoprotection by HMOX1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y618

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y618

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor corepressor 2Curated
Short name:
N-CoR2Curated
Alternative name(s):
CTG repeat protein 26
SMAP270
Silencing mediator of retinoic acid and thyroid hormone receptorCurated
Short name:
SMRTCurated
T3 receptor-associating factor
Short name:
TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOR2Imported
Synonyms:CTG26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7673, NCOR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600848, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y618

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196498

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi242 – 245HRIL → AEIA: Abolishes interaction with TBL1X. 1 Publication4
Mutagenesisi2128R → A: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2130V → P: Abolishes interaction with the apo LBD of RARA. No change on interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2131T → G: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9612

Open Targets

More...OpenTargetsi		ENSG00000196498

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31478

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y618, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2111363
CHEMBL3885590
CHEMBL3885591

DrugCentral

More...DrugCentrali		Q9Y618

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NCOR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		226713806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000556221 – 2514Nuclear receptor corepressor 2Add BLAST2514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Asymmetric dimethylarginineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei553PhosphothreonineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei878N6-acetyllysineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei946PhosphothreonineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Modified residuei959N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1173PhosphoserineCombined sources1
Modified residuei1210N6-acetyllysineCombined sources1
Modified residuei1240N6-acetyllysineCombined sources1
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1383PhosphothreonineCombined sources1
Modified residuei1479PhosphoserineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1595PhosphoserineBy similarity1
Modified residuei1619PhosphoserineCombined sources1
Modified residuei1653Asymmetric dimethylarginineCombined sources1
Modified residuei1775PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1
Modified residuei1861PhosphoserineCombined sources1
Modified residuei1959N6-acetyllysineCombined sources1
Modified residuei2005PhosphoserineCombined sources1
Modified residuei2026N6-acetyllysineCombined sources1
Modified residuei2046PhosphoserineCombined sources1
Modified residuei2054PhosphoserineCombined sources1
Modified residuei2057PhosphoserineCombined sources1
Modified residuei2058PhosphoserineCombined sources1
Modified residuei2060PhosphoserineBy similarity1
Modified residuei2062PhosphothreonineCombined sources1
Modified residuei2077PhosphoserineCombined sources1
Modified residuei2203PhosphoserineCombined sources1
Modified residuei2223PhosphoserineCombined sources1
Modified residuei2258PhosphoserineCombined sources1
Modified residuei2413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y618

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y618

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y618

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y618

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y618

PeptideAtlas

More...PeptideAtlasi		Q9Y618

PRoteomics IDEntifications database

More...PRIDEi		Q9Y618

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86582 [Q9Y618-1]
86583 [Q9Y618-2]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y618, 20 sites, 1 O-linked glycan (20 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y618

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y618

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y618

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Regulated during cell cycle progression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196498, Expressed in sural nerve and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y618, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y618, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196498, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB.

Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity.

Interacts (isoform SMRT) with HDAC10.

Interacts with MINT.

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272).

Interacts with CBFA2T3 and ATXN1L.

Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity.

Interacts with HDAC7 and C1D.

Interacts with NR4A2; this interaction increases in the absence of PITX3.

Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1.

Interacts with RXRA.

Interacts with MECP2 (By similarity).

Interacts with ZBTB7A (PubMed:20812024).

Interacts with AR (PubMed:20812024).

Interacts with TBL1Y (PubMed:30341416).

By similarity19 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114974, 168 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y618

Database of interacting proteins

More...DIPi		DIP-951N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9Y618

Protein interaction database and analysis system

More...IntActi		Q9Y618, 53 interactors

Molecular INTeraction database

More...MINTi		Q9Y618

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384018

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y618

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y618, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9Y618

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y618

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y618

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini610 – 661SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni120 – 162DisorderedSequence analysisAdd BLAST43
Regioni190 – 220DisorderedSequence analysisAdd BLAST31
Regioni254 – 312Interaction with SIN3A/BBy similarityAdd BLAST59
Regioni487 – 622DisorderedSequence analysisAdd BLAST136
Regioni674 – 1081DisorderedSequence analysisAdd BLAST408
Regioni1165 – 1186DisorderedSequence analysisAdd BLAST22
Regioni1287 – 1307DisorderedSequence analysisAdd BLAST21
Regioni1440 – 1482DisorderedSequence analysisAdd BLAST43
Regioni1506 – 1609DisorderedSequence analysisAdd BLAST104
Regioni1763 – 1867DisorderedSequence analysisAdd BLAST105
Regioni1937 – 2124DisorderedSequence analysisAdd BLAST188
Regioni2128 – 2131Required for interaction with RARA in the absence of its ligand4
Regioni2174 – 2235DisorderedSequence analysisAdd BLAST62
Regioni2248 – 2269DisorderedSequence analysisAdd BLAST22
Regioni2384 – 2500DisorderedSequence analysisAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili174 – 215Sequence analysisAdd BLAST42
Coiled coili522 – 561Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2136 – 2140CORNR box of ID15
Motifi2339 – 2343CORNR box of ID25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi190 – 209Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi492 – 514Polar residuesSequence analysisAdd BLAST23
Compositional biasi515 – 567Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi578 – 611Polar residuesSequence analysisAdd BLAST34
Compositional biasi738 – 760Polar residuesSequence analysisAdd BLAST23
Compositional biasi772 – 794Pro residuesSequence analysisAdd BLAST23
Compositional biasi802 – 821Pro residuesSequence analysisAdd BLAST20
Compositional biasi842 – 901Basic and acidic residuesSequence analysisAdd BLAST60
Compositional biasi902 – 922Polar residuesSequence analysisAdd BLAST21
Compositional biasi990 – 1008Pro residuesSequence analysisAdd BLAST19
Compositional biasi1049 – 1065Pro residuesSequence analysisAdd BLAST17
Compositional biasi1454 – 1472Polar residuesSequence analysisAdd BLAST19
Compositional biasi1563 – 1583Polar residuesSequence analysisAdd BLAST21
Compositional biasi1584 – 1609Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1766 – 1790Polar residuesSequence analysisAdd BLAST25
Compositional biasi1791 – 1816Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1817 – 1867Polar residuesSequence analysisAdd BLAST51
Compositional biasi2065 – 2085Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi2252 – 2269Polar residuesSequence analysisAdd BLAST18
Compositional biasi2425 – 2439Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the N-CoR nuclear receptor corepressors family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1878, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159022

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y618

Identification of Orthologs from Complete Genome Data

More...OMAi		PPIQITK

Database of Orthologous Groups

More...OrthoDBi		12227at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y618

Family and domain databases

Conserved Domains Database

More...CDDi		cd00167, SANT, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00109

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51293, SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y618-1) [UniParc]FASTAAdd to basket
Also known as: SMRT-alpha1 Publication, TRAC-2, h-SMRT

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA 
        60         70         80         90        100
SHLSPGSIIQ PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM 
       110        120        130        140        150
EFIESKRPRL ELLPDPLLRP SPLLATGQPA GSEDLTKDRS LTGKLEPVSP 
       160        170        180        190        200
PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL 
       210        220        230        240        250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP 
       260        270        280        290        300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ 
       310        320        330        340        350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM 
       360        370        380        390        400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY 
       410        420        430        440        450
DADQQRIKFI NMNGLMADPM KVYKDRQVMN MWSEQEKETF REKFMQHPKN 
       460        470        480        490        500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ 
       510        520        530        540        550
QQQQQQQQQQ PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT 
       560        570        580        590        600
DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA NSEEAITPQQ 
       610        620        630        640        650
SAELASMELN ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK 
       660        670        680        690        700
NFYFNYKKRQ NLDEILQQHK LKMEKERNAR RKKKKAPAAA SEEAAFPPVV 
       710        720        730        740        750
EDEEMEASGV SGNEEEMVEE AEALHASGNE VPRGECSGPA TVNNSSDTES 
       760        770        780        790        800
IPSPHTEAAK DTGQNGPKPP ATLGADGPPP GPPTPPPEDI PAPTEPTPAS 
       810        820        830        840        850
EATGAPTPPP APPSPSAPPP VVPKEEKEEE TAAAPPVEEG EEQKPPAAEE 
       860        870        880        890        900
LAVDTGKAEE PVKSECTEEA EEGPAKGKDA EAAEATAEGA LKAEKKEGGS 
       910        920        930        940        950
GRATTAKSSG APQDSDSSAT CSADEVDEAE GGDKNRLLSP RPSLLTPTGD 
       960        970        980        990       1000
PRANASPQKP LDLKQLKQRA AAIPPIQVTK VHEPPREDAA PTKPAPPAPP 
      1010       1020       1030       1040       1050
PPQNLQPESD APQQPGSSPR GKSRSPAPPA DKEAFAAEAQ KLPGDPPCWT 
      1060       1070       1080       1090       1100
SGLPFPVPPR EVIKASPHAP DPSAFSYAPP GHPLPLGLHD TARPVLPRPP 
      1110       1120       1130       1140       1150
TISNPPPLIS SAKHPSVLER QIGAISQGMS VQLHVPYSEH AKAPVGPVTM 
      1160       1170       1180       1190       1200
GLPLPMDPKK LAPFSGVKQE QLSPRGQAGP PESLGVPTAQ EASVLRGTAL 
      1210       1220       1230       1240       1250
GSVPGGSITK GIPSTRVPSD SAITYRGSIT HGTPADVLYK GTITRIIGED 
      1260       1270       1280       1290       1300
SPSRLDRGRE DSLPKGHVIY EGKKGHVLSY EGGMSVTQCS KEDGRSSSGP 
      1310       1320       1330       1340       1350
PHETAAPKRT YDMMEGRVGR AISSASIEGL MGRAIPPERH SPHHLKEQHH 
      1360       1370       1380       1390       1400
IRGSITQGIP RSYVEAQEDY LRREAKLLKR EGTPPPPPPS RDLTEAYKTQ 
      1410       1420       1430       1440       1450
ALGPLKLKPA HEGLVATVKE AGRSIHEIPR EELRHTPELP LAPRPLKEGS 
      1460       1470       1480       1490       1500
ITQGTPLKYD TGASTTGSKK HDVRSLIGSP GRTFPPVHPL DVMADARALE 
      1510       1520       1530       1540       1550
RACYEESLKS RPGTASSSGG SIARGAPVIV PELGKPRQSP LTYEDHGAPF 
      1560       1570       1580       1590       1600
AGHLPRGSPV TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSTV 
      1610       1620       1630       1640       1650
PEHHPHPISP YEHLLRGVSG VDLYRSHIPL AFDPTSIPRG IPLDAAAAYY 
      1660       1670       1680       1690       1700
LPRHLAPNPT YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA 
      1710       1720       1730       1740       1750
TAMAQRADML RGLSPRESSL ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT 
      1760       1770       1780       1790       1800
PATAMDRLAY LPTAPQPFSS RHSSSPLSPG GPTHLTKPTT TSSSERERDR 
      1810       1820       1830       1840       1850
DRERDRDRER EKSILTSTTT VEHAPIWRPG TEQSSGSSGG GGGSSSRPAS 
      1860       1870       1880       1890       1900
HSHAHQHSPI SPRTQDALQQ RPSVLHNTGM KGIITAVEPS TPTVLRSTST 
      1910       1920       1930       1940       1950
SSPVRPAATF PPATHCPLGG TLDGVYPTLM EPVLLPKEAP RVARPERPRA 
      1960       1970       1980       1990       2000
DTGHAFLAKP PARSGLEPAS SPSKGSEPRP LVPPVSGHAT IARTPAKNLA 
      2010       2020       2030       2040       2050
PHHASPDPPA PPASASDPHR EKTQSKPFSI QELELRSLGY HGSSYSPEGV 
      2060       2070       2080       2090       2100
EPVSPVSSPS LTHDKGLPKH LEELDKSHLE GELRPKQPGP VKLGGEAAHL 
      2110       2120       2130       2140       2150
PHLRPLPESQ PSSSPLLQTA PGVKGHQRVV TLAQHISEVI TQDYTRHHPQ 
      2160       2170       2180       2190       2200
QLSAPLPAPL YSFPGASCPV LDLRRPPSDL YLPPPDHGAP ARGSPHSEGG 
      2210       2220       2230       2240       2250
KRSPEPNKTS VLGGGEDGIE PVSPPEGMTE PGHSRSAVYP LLYRDGEQTE 
      2260       2270       2280       2290       2300
PSRMGSKSPG NTSQPPAFFS KLTESNSAMV KSKKQEINKK LNTHNRNEPE 
      2310       2320       2330       2340       2350
YNISQPGTEI FNMPAITGTG LMTYRSQAVQ EHASTNMGLE AIIRKALMGK 
      2360       2370       2380       2390       2400
YDQWEESPPL SANAFNPLNA SASLPAAMPI TAADGRSDHT LTSPGGGGKA 
      2410       2420       2430       2440       2450
KVSGRPSSRK AKSPAPGLAS GDRPPSVSSV HSEGDCNRRT PLTNRVWEDR 
      2460       2470       2480       2490       2500
PSSAGSTPFP YNPLIMRLQA GVMASPPPPG LPAGSGPLAG PHHAWDEEPK 
      2510 
PLLCSQYETL SDSE
Length:2,514
Mass (Da):273,657
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A89C9A19612AAD
GO
Isoform 2 (identifier: Q9Y618-2) [UniParc]FASTAAdd to basket
Also known as: TRAC-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1702: Missing.
     2350-2395: Missing.

Note: Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.Curated
Show »
Length:766
Mass (Da):81,377
Checksum:iEFC383C83199A1D0
GO
Isoform 3 (identifier: Q9Y618-4) [UniParc]FASTAAdd to basket
Also known as: SMRTe

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.

Show »
Length:2,497
Mass (Da):271,994
Checksum:i34566D11BC2E2414
GO
Isoform 4 (identifier: Q9Y618-5) [UniParc]FASTAAdd to basket
Also known as: SMRT-tau1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.
     2350-2395: Missing.

Show »
Length:2,451
Mass (Da):267,214
Checksum:i24299917E937ED2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JE98C9JE98_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,458Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Q5C9J0Q5_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,504Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQE8C9JQE8_HUMAN
Nuclear receptor corepressor 2
NCOR2
1,451Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J330C9J330_HUMAN
Nuclear receptor corepressor 2
NCOR2
493Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1Y3H7C1Y3_HUMAN
Nuclear receptor corepressor 2
NCOR2
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGK8H0YGK8_HUMAN
Nuclear receptor corepressor 2
NCOR2
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7T7C9J7T7_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,062Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNV9C9JNV9_HUMAN
Nuclear receptor corepressor 2
NCOR2
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384DVL6A0A384DVL6_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,079Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZU2H7BZU2_HUMAN
Nuclear receptor corepressor 2
NCOR2
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB91452 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAC50236 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAD20946 differs from that shown. Reason: Frameshift.Curated
The sequence BAD92326 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7P → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti295E → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti309W → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti352Missing in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti352Missing in AAX77219 (Ref. 4) Curated1
Sequence conflicti365A → P in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti365A → P in AAX77219 (Ref. 4) Curated1
Sequence conflicti612 – 613SS → EF in AAB91446 (PubMed:9225980).Curated2
Sequence conflicti711S → T in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti711S → T in AAX77219 (Ref. 4) Curated1
Sequence conflicti796P → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti796P → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti804G → L in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti804G → L in AAX77219 (Ref. 4) Curated1
Sequence conflicti814S → F in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti814S → F in AAX77219 (Ref. 4) Curated1
Sequence conflicti817A → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti817A → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti889G → R in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti889G → R in AAX77219 (Ref. 4) Curated1
Sequence conflicti1562T → M in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1562T → M in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1562T → M in AAX77219 (Ref. 4) Curated1
Sequence conflicti1562T → M in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti1839G → GSSG in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1891T → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1891T → K in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1891T → K in AAX77219 (Ref. 4) Curated1
Sequence conflicti1891T → K in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti2491P → A in AAB50847 (PubMed:8813722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060073781G → E1 PublicationCorresponds to variant dbSNP:rs7978237Ensembl.1
Natural variantiVAR_0547511699A → T4 PublicationsCorresponds to variant dbSNP:rs2229840Ensembl.1
Natural variantiVAR_0600742001P → S. Corresponds to variant dbSNP:rs2230944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0034121 – 1702Missing in isoform 2. 1 PublicationAdd BLAST1702
Alternative sequenceiVSP_036595724 – 740Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_0034132350 – 2395Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41858.2 [Q9Y618-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S60255

NCBI Reference Sequences

More...RefSeqi		NP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5 [Q9Y618-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000405201; ENSP00000384018; ENSG00000196498

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9612

UCSC genome browser

More...UCSCi		uc058uwu.1, human [Q9Y618-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.
CCDSiCCDS41858.2 [Q9Y618-1]
PIRiS60255
RefSeqiNP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5 [Q9Y618-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKQX-ray3.00E/F/G/H2336-2354[»]
1R2BX-ray2.20C/D1414-1430[»]
1XC5NMR-A412-480[»]
2GPVX-ray2.85G/H/I2335-2356[»]
2L5GNMR-B167-207[»]
2LTPNMR-A615-685[»]
2ODDNMR-B1101-1113[»]
2RT5NMR-B2507-2514[»]
3R29X-ray2.90C/D2335-2350[»]
3R2AX-ray3.00E/F2335-2350[»]
4A69X-ray2.06C/D389-480[»]
4OARX-ray2.41B2335-2351[»]
5X8QX-ray2.20B/D/F/H2335-2356[»]
5X8XX-ray2.60B/D/F/H2335-2356[»]
5ZOOX-ray1.85A1350-1363[»]
5ZOPX-ray2.70A1448-1459[»]
6A22X-ray2.55B/D/F/H2335-2356[»]
6IVXX-ray2.35B/D/F/H2335-2356[»]
6PDZX-ray2.10C/D2335-2356[»]
BMRBiQ9Y618
SMRiQ9Y618
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114974, 168 interactors
CORUMiQ9Y618
DIPiDIP-951N
ELMiQ9Y618
IntActiQ9Y618, 53 interactors
MINTiQ9Y618
STRINGi9606.ENSP00000384018

Chemistry databases

BindingDBiQ9Y618
ChEMBLiCHEMBL2111363
CHEMBL3885590
CHEMBL3885591
DrugCentraliQ9Y618

PTM databases

GlyGeniQ9Y618, 20 sites, 1 O-linked glycan (20 sites)
iPTMnetiQ9Y618
MetOSiteiQ9Y618
PhosphoSitePlusiQ9Y618

Genetic variation databases

BioMutaiNCOR2
DMDMi226713806

Proteomic databases

EPDiQ9Y618
jPOSTiQ9Y618
MassIVEiQ9Y618
MaxQBiQ9Y618
PaxDbiQ9Y618
PeptideAtlasiQ9Y618
PRIDEiQ9Y618
ProteomicsDBi86582 [Q9Y618-1]
86583 [Q9Y618-2]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1103, 272 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		9612

Genome annotation databases

EnsembliENST00000405201; ENSP00000384018; ENSG00000196498
GeneIDi9612
KEGGihsa:9612
UCSCiuc058uwu.1, human [Q9Y618-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9612
DisGeNETi9612

GeneCards: human genes, protein and diseases

More...GeneCardsi		NCOR2
HGNCiHGNC:7673, NCOR2
HPAiENSG00000196498, Low tissue specificity
MIMi600848, gene
neXtProtiNX_Q9Y618
OpenTargetsiENSG00000196498
PharmGKBiPA31478
VEuPathDBiHostDB:ENSG00000196498

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1878, Eukaryota
GeneTreeiENSGT00940000159022
InParanoidiQ9Y618
OMAiPPIQITK
OrthoDBi12227at2759
PhylomeDBiQ9Y618

Enzyme and pathway databases

PathwayCommonsiQ9Y618
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815, HDACs deacetylate histones
R-HSA-350054, Notch-HLH transcription pathway
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
R-HSA-383280, Nuclear Receptor transcription pathway
R-HSA-3899300, SUMOylation of transcription cofactors
R-HSA-400206, Regulation of lipid metabolism by PPARalpha
R-HSA-9022537, Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692, Regulation of MECP2 expression and activity
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9609690, HCMV Early Events
R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
R-HSA-9707564, Cytoprotection by HMOX1
SignaLinkiQ9Y618
SIGNORiQ9Y618

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9612, 37 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NCOR2, human
EvolutionaryTraceiQ9Y618

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Nuclear_receptor_co-repressor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9612
PharosiQ9Y618, Tchem

Protein Ontology

More...PROi		PR:Q9Y618
RNActiQ9Y618, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196498, Expressed in sural nerve and 247 other tissues
ExpressionAtlasiQ9Y618, baseline and differential
GenevisibleiQ9Y618, HS

Family and domain databases

CDDicd00167, SANT, 1 hit
IDEALiIID00109
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom
PfamiView protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717, SANT, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293, SANT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y618
Secondary accession number(s): O00613
, O15416, O15421, Q13354, Q56D06, Q59GM0, Q9Y5U0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 12, 2018
Last modified: February 23, 2022
This is version 227 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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