UniProtKB - Q9Y618 (NCOR2_HUMAN)
Nuclear receptor corepressor 2
NCOR2
Functioni
GO - Molecular functioni
- chromatin binding Source: GO_Central
- glucocorticoid receptor binding Source: Ensembl
- histone deacetylase binding Source: UniProtKB
- Notch binding Source: UniProtKB
- nuclear hormone receptor binding Source: GO_Central
- protein-containing complex binding Source: Ensembl
- protein N-terminus binding Source: UniProtKB
- retinoid X receptor binding Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
- transcription corepressor activity Source: BHF-UCL
GO - Biological processi
- estrous cycle Source: Ensembl
- lactation Source: Ensembl
- negative regulation of androgen receptor signaling pathway Source: UniProtKB
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of cellular ketone metabolic process Source: BHF-UCL
- regulation of lipid metabolic process Source: Reactome
- response to estradiol Source: Ensembl
- response to organonitrogen compound Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y618 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3214815, HDACs deacetylate histones R-HSA-350054, Notch-HLH transcription pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-9022537, Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9609690, HCMV Early Events R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
SignaLinki | Q9Y618 |
SIGNORi | Q9Y618 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor corepressor 2CuratedShort name: N-CoR2Curated Alternative name(s): CTG repeat protein 26 SMAP270 Silencing mediator of retinoic acid and thyroid hormone receptorCurated Short name: SMRTCurated T3 receptor-associating factor Short name: TRAC Thyroid-, retinoic-acid-receptor-associated corepressor |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7673, NCOR2 |
MIMi | 600848, gene |
neXtProti | NX_Q9Y618 |
VEuPathDBi | HostDB:ENSG00000196498.13 |
Subcellular locationi
Nucleus
Nucleus
- histone deacetylase complex Source: GO_Central
- nuclear body Source: MGI
- nuclear chromatin Source: BHF-UCL
- nuclear matrix Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- membrane Source: UniProtKB
- transcription repressor complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 242 – 245 | HRIL → AEIA: Abolishes interaction with TBL1X. 1 Publication | 4 | |
Mutagenesisi | 2128 | R → A: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication | 1 | |
Mutagenesisi | 2130 | V → P: Abolishes interaction with the apo LBD of RARA. No change on interaction on the addition of inverse agonist BMS493. 1 Publication | 1 | |
Mutagenesisi | 2131 | T → G: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9612 |
OpenTargetsi | ENSG00000196498 |
PharmGKBi | PA31478 |
Miscellaneous databases
Pharosi | Q9Y618, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2111363 CHEMBL3885590 CHEMBL3885591 |
DrugCentrali | Q9Y618 |
Genetic variation databases
BioMutai | NCOR2 |
DMDMi | 226713806 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055622 | 1 – 2514 | Nuclear receptor corepressor 2Add BLAST | 2514 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | PhosphoserineCombined sources | 1 | |
Modified residuei | 152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 156 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 215 | PhosphoserineCombined sources | 1 | |
Modified residuei | 493 | PhosphoserineCombined sources | 1 | |
Modified residuei | 553 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineCombined sources | 1 | |
Modified residuei | 750 | PhosphoserineCombined sources | 1 | |
Modified residuei | 753 | PhosphoserineCombined sources | 1 | |
Modified residuei | 878 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 939 | PhosphoserineCombined sources | 1 | |
Modified residuei | 946 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 956 | PhosphoserineCombined sources | 1 | |
Modified residuei | 959 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 1168 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1173 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1210 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1240 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1251 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1383 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1479 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1539 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1595 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1619 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1653 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 1775 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1778 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1861 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1959 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 2005 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2026 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 2046 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2054 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2057 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2058 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2060 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2062 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2077 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2223 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2258 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2413 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y618 |
jPOSTi | Q9Y618 |
MassIVEi | Q9Y618 |
MaxQBi | Q9Y618 |
PaxDbi | Q9Y618 |
PeptideAtlasi | Q9Y618 |
PRIDEi | Q9Y618 |
ProteomicsDBi | 86582 [Q9Y618-1] 86583 [Q9Y618-2] 86585 [Q9Y618-4] 86586 [Q9Y618-5] |
PTM databases
iPTMneti | Q9Y618 |
MetOSitei | Q9Y618 |
PhosphoSitePlusi | Q9Y618 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000196498, Expressed in sural nerve and 247 other tissues |
ExpressionAtlasi | Q9Y618, baseline and differential |
Genevisiblei | Q9Y618, HS |
Organism-specific databases
HPAi | ENSG00000196498, Low tissue specificity |
Interactioni
Subunit structurei
Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB.
Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity.
Interacts (isoform SMRT) with HDAC10.
Interacts with MINT.
Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272).
Interacts with CBFA2T3 and ATXN1L.
Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity.
Interacts with HDAC7 and C1D.
Interacts with NR4A2; this interaction increases in the absence of PITX3.
Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1.
Interacts with RXRA.
Interacts with MECP2 (By similarity).
Interacts with ZBTB7A (PubMed:20812024).
Interacts with AR (PubMed:20812024).
Interacts with TBL1Y (PubMed:30341416).
By similarity19 PublicationsBinary interactionsi
Hide detailsQ9Y618
GO - Molecular functioni
- glucocorticoid receptor binding Source: Ensembl
- histone deacetylase binding Source: UniProtKB
- Notch binding Source: UniProtKB
- nuclear hormone receptor binding Source: GO_Central
- protein N-terminus binding Source: UniProtKB
- retinoid X receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114974, 141 interactors |
CORUMi | Q9Y618 |
DIPi | DIP-951N |
ELMi | Q9Y618 |
IntActi | Q9Y618, 53 interactors |
MINTi | Q9Y618 |
STRINGi | 9606.ENSP00000384018 |
Chemistry databases
BindingDBi | Q9Y618 |
Miscellaneous databases
RNActi | Q9Y618, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9Y618 |
SMRi | Q9Y618 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y618 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 427 – 478 | SANT 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 610 – 661 | SANT 2PROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 254 – 312 | Interaction with SIN3A/BBy similarityAdd BLAST | 59 | |
Regioni | 2128 – 2131 | Required for interaction with RARA in the absence of its ligand | 4 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 174 – 215 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 522 – 561 | Sequence analysisAdd BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 2136 – 2140 | CORNR box of ID1 | 5 | |
Motifi | 2339 – 2343 | CORNR box of ID2 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 494 – 510 | Poly-GlnAdd BLAST | 17 | |
Compositional biasi | 682 – 685 | Poly-Lys | 4 | |
Compositional biasi | 778 – 820 | Pro-richAdd BLAST | 43 | |
Compositional biasi | 995 – 1003 | Poly-Pro | 9 | |
Compositional biasi | 1384 – 1389 | Poly-Pro | 6 | |
Compositional biasi | 1839 – 1843 | Poly-Gly | 5 | |
Compositional biasi | 2476 – 2479 | Poly-Pro | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1878, Eukaryota |
GeneTreei | ENSGT00940000159022 |
InParanoidi | Q9Y618 |
OMAi | EPGRSIH |
OrthoDBi | 12227at2759 |
PhylomeDBi | Q9Y618 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
IDEALi | IID00109 |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR031557, N-CoR_GPS2_interact IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF15784, GPS2_interact, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51293, SANT, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA
60 70 80 90 100
SHLSPGSIIQ PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM
110 120 130 140 150
EFIESKRPRL ELLPDPLLRP SPLLATGQPA GSEDLTKDRS LTGKLEPVSP
160 170 180 190 200
PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL
210 220 230 240 250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP
260 270 280 290 300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
310 320 330 340 350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM
360 370 380 390 400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY
410 420 430 440 450
DADQQRIKFI NMNGLMADPM KVYKDRQVMN MWSEQEKETF REKFMQHPKN
460 470 480 490 500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ
510 520 530 540 550
QQQQQQQQQQ PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT
560 570 580 590 600
DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA NSEEAITPQQ
610 620 630 640 650
SAELASMELN ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK
660 670 680 690 700
NFYFNYKKRQ NLDEILQQHK LKMEKERNAR RKKKKAPAAA SEEAAFPPVV
710 720 730 740 750
EDEEMEASGV SGNEEEMVEE AEALHASGNE VPRGECSGPA TVNNSSDTES
760 770 780 790 800
IPSPHTEAAK DTGQNGPKPP ATLGADGPPP GPPTPPPEDI PAPTEPTPAS
810 820 830 840 850
EATGAPTPPP APPSPSAPPP VVPKEEKEEE TAAAPPVEEG EEQKPPAAEE
860 870 880 890 900
LAVDTGKAEE PVKSECTEEA EEGPAKGKDA EAAEATAEGA LKAEKKEGGS
910 920 930 940 950
GRATTAKSSG APQDSDSSAT CSADEVDEAE GGDKNRLLSP RPSLLTPTGD
960 970 980 990 1000
PRANASPQKP LDLKQLKQRA AAIPPIQVTK VHEPPREDAA PTKPAPPAPP
1010 1020 1030 1040 1050
PPQNLQPESD APQQPGSSPR GKSRSPAPPA DKEAFAAEAQ KLPGDPPCWT
1060 1070 1080 1090 1100
SGLPFPVPPR EVIKASPHAP DPSAFSYAPP GHPLPLGLHD TARPVLPRPP
1110 1120 1130 1140 1150
TISNPPPLIS SAKHPSVLER QIGAISQGMS VQLHVPYSEH AKAPVGPVTM
1160 1170 1180 1190 1200
GLPLPMDPKK LAPFSGVKQE QLSPRGQAGP PESLGVPTAQ EASVLRGTAL
1210 1220 1230 1240 1250
GSVPGGSITK GIPSTRVPSD SAITYRGSIT HGTPADVLYK GTITRIIGED
1260 1270 1280 1290 1300
SPSRLDRGRE DSLPKGHVIY EGKKGHVLSY EGGMSVTQCS KEDGRSSSGP
1310 1320 1330 1340 1350
PHETAAPKRT YDMMEGRVGR AISSASIEGL MGRAIPPERH SPHHLKEQHH
1360 1370 1380 1390 1400
IRGSITQGIP RSYVEAQEDY LRREAKLLKR EGTPPPPPPS RDLTEAYKTQ
1410 1420 1430 1440 1450
ALGPLKLKPA HEGLVATVKE AGRSIHEIPR EELRHTPELP LAPRPLKEGS
1460 1470 1480 1490 1500
ITQGTPLKYD TGASTTGSKK HDVRSLIGSP GRTFPPVHPL DVMADARALE
1510 1520 1530 1540 1550
RACYEESLKS RPGTASSSGG SIARGAPVIV PELGKPRQSP LTYEDHGAPF
1560 1570 1580 1590 1600
AGHLPRGSPV TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSTV
1610 1620 1630 1640 1650
PEHHPHPISP YEHLLRGVSG VDLYRSHIPL AFDPTSIPRG IPLDAAAAYY
1660 1670 1680 1690 1700
LPRHLAPNPT YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA
1710 1720 1730 1740 1750
TAMAQRADML RGLSPRESSL ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT
1760 1770 1780 1790 1800
PATAMDRLAY LPTAPQPFSS RHSSSPLSPG GPTHLTKPTT TSSSERERDR
1810 1820 1830 1840 1850
DRERDRDRER EKSILTSTTT VEHAPIWRPG TEQSSGSSGG GGGSSSRPAS
1860 1870 1880 1890 1900
HSHAHQHSPI SPRTQDALQQ RPSVLHNTGM KGIITAVEPS TPTVLRSTST
1910 1920 1930 1940 1950
SSPVRPAATF PPATHCPLGG TLDGVYPTLM EPVLLPKEAP RVARPERPRA
1960 1970 1980 1990 2000
DTGHAFLAKP PARSGLEPAS SPSKGSEPRP LVPPVSGHAT IARTPAKNLA
2010 2020 2030 2040 2050
PHHASPDPPA PPASASDPHR EKTQSKPFSI QELELRSLGY HGSSYSPEGV
2060 2070 2080 2090 2100
EPVSPVSSPS LTHDKGLPKH LEELDKSHLE GELRPKQPGP VKLGGEAAHL
2110 2120 2130 2140 2150
PHLRPLPESQ PSSSPLLQTA PGVKGHQRVV TLAQHISEVI TQDYTRHHPQ
2160 2170 2180 2190 2200
QLSAPLPAPL YSFPGASCPV LDLRRPPSDL YLPPPDHGAP ARGSPHSEGG
2210 2220 2230 2240 2250
KRSPEPNKTS VLGGGEDGIE PVSPPEGMTE PGHSRSAVYP LLYRDGEQTE
2260 2270 2280 2290 2300
PSRMGSKSPG NTSQPPAFFS KLTESNSAMV KSKKQEINKK LNTHNRNEPE
2310 2320 2330 2340 2350
YNISQPGTEI FNMPAITGTG LMTYRSQAVQ EHASTNMGLE AIIRKALMGK
2360 2370 2380 2390 2400
YDQWEESPPL SANAFNPLNA SASLPAAMPI TAADGRSDHT LTSPGGGGKA
2410 2420 2430 2440 2450
KVSGRPSSRK AKSPAPGLAS GDRPPSVSSV HSEGDCNRRT PLTNRVWEDR
2460 2470 2480 2490 2500
PSSAGSTPFP YNPLIMRLQA GVMASPPPPG LPAGSGPLAG PHHAWDEEPK
2510
PLLCSQYETL SDSE
The sequence of this isoform differs from the canonical sequence as follows:
1-1702: Missing.
2350-2395: Missing.
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JE98 | C9JE98_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 2,458 | Annotation score: | ||
C9J0Q5 | C9J0Q5_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 2,504 | Annotation score: | ||
C9JQE8 | C9JQE8_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 1,451 | Annotation score: | ||
C9J330 | C9J330_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 493 | Annotation score: | ||
H7C1Y3 | H7C1Y3_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 245 | Annotation score: | ||
H0YGK8 | H0YGK8_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 275 | Annotation score: | ||
C9J7T7 | C9J7T7_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 2,062 | Annotation score: | ||
C9JNV9 | C9JNV9_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 162 | Annotation score: | ||
H7BZU2 | H7BZU2_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 129 | Annotation score: | ||
H7C0P3 | H7C0P3_HUMAN | Nuclear receptor corepressor 2 | NCOR2 | 156 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | P → L in AAD20946 (PubMed:10077563).Curated | 1 | |
Sequence conflicti | 295 | E → K in AAD20946 (PubMed:10077563).Curated | 1 | |
Sequence conflicti | 309 | W → L in AAD20946 (PubMed:10077563).Curated | 1 | |
Sequence conflicti | 352 | Missing in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 352 | Missing in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 365 | A → P in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 365 | A → P in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 612 – 613 | SS → EF in AAB91446 (PubMed:9225980).Curated | 2 | |
Sequence conflicti | 711 | S → T in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 711 | S → T in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 796 | P → S in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 796 | P → S in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 804 | G → L in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 804 | G → L in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 814 | S → F in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 814 | S → F in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 817 | A → S in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 817 | A → S in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 889 | G → R in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 889 | G → R in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1562 | T → M in AAD20946 (PubMed:10077563).Curated | 1 | |
Sequence conflicti | 1562 | T → M in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 1562 | T → M in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1562 | T → M in AAC50236 (PubMed:7566127).Curated | 1 | |
Sequence conflicti | 1839 | G → GSSG in AAD20946 (PubMed:10077563).Curated | 1 | |
Sequence conflicti | 1891 | T → K in AAD20946 (PubMed:10077563).Curated | 1 | |
Sequence conflicti | 1891 | T → K in AAD22973 (PubMed:10097068).Curated | 1 | |
Sequence conflicti | 1891 | T → K in AAX77219 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1891 | T → K in AAC50236 (PubMed:7566127).Curated | 1 | |
Sequence conflicti | 2491 | P → A in AAB50847 (PubMed:8813722).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060073 | 781 | G → E1 PublicationCorresponds to variant dbSNP:rs7978237Ensembl. | 1 | |
Natural variantiVAR_054751 | 1699 | A → T4 PublicationsCorresponds to variant dbSNP:rs2229840Ensembl. | 1 | |
Natural variantiVAR_060074 | 2001 | P → S. Corresponds to variant dbSNP:rs2230944Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003412 | 1 – 1702 | Missing in isoform 2. 1 PublicationAdd BLAST | 1702 | |
Alternative sequenceiVSP_036595 | 724 – 740 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_003413 | 2350 – 2395 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S83390 mRNA Translation: AAB50847.1 AF113003 mRNA Translation: AAD20946.1 Frameshift. AF125672 mRNA Translation: AAD22973.1 AY965853 mRNA Translation: AAX77219.1 AC069261 Genomic DNA No translation available. AC073916 Genomic DNA No translation available. AB209089 mRNA Translation: BAD92326.1 Different initiation. U80750 mRNA Translation: AAB91446.1 U80761 mRNA Translation: AAB91452.1 Sequence problems. U37146 mRNA Translation: AAC50236.1 Sequence problems. |
CCDSi | CCDS41858.2 [Q9Y618-1] |
PIRi | S60255 |
RefSeqi | NP_001070729.2, NM_001077261.3 NP_001193583.1, NM_001206654.1 NP_006303.4, NM_006312.5 [Q9Y618-1] |
Genome annotation databases
Ensembli | ENST00000405201; ENSP00000384018; ENSG00000196498 [Q9Y618-1] |
GeneIDi | 9612 |
KEGGi | hsa:9612 |
UCSCi | uc058uwu.1, human [Q9Y618-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S83390 mRNA Translation: AAB50847.1 AF113003 mRNA Translation: AAD20946.1 Frameshift. AF125672 mRNA Translation: AAD22973.1 AY965853 mRNA Translation: AAX77219.1 AC069261 Genomic DNA No translation available. AC073916 Genomic DNA No translation available. AB209089 mRNA Translation: BAD92326.1 Different initiation. U80750 mRNA Translation: AAB91446.1 U80761 mRNA Translation: AAB91452.1 Sequence problems. U37146 mRNA Translation: AAC50236.1 Sequence problems. |
CCDSi | CCDS41858.2 [Q9Y618-1] |
PIRi | S60255 |
RefSeqi | NP_001070729.2, NM_001077261.3 NP_001193583.1, NM_001206654.1 NP_006303.4, NM_006312.5 [Q9Y618-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KKQ | X-ray | 3.00 | E/F/G/H | 2336-2354 | [»] | |
1R2B | X-ray | 2.20 | C/D | 1414-1430 | [»] | |
1XC5 | NMR | - | A | 412-480 | [»] | |
2GPV | X-ray | 2.85 | G/H/I | 2335-2356 | [»] | |
2L5G | NMR | - | B | 167-207 | [»] | |
2LTP | NMR | - | A | 615-685 | [»] | |
2ODD | NMR | - | B | 1101-1113 | [»] | |
2RT5 | NMR | - | B | 2507-2514 | [»] | |
3R29 | X-ray | 2.90 | C/D | 2335-2350 | [»] | |
3R2A | X-ray | 3.00 | E/F | 2335-2350 | [»] | |
4A69 | X-ray | 2.06 | C/D | 389-480 | [»] | |
4OAR | X-ray | 2.41 | B | 2335-2351 | [»] | |
5X8Q | X-ray | 2.20 | B/D/F/H | 2335-2356 | [»] | |
5X8X | X-ray | 2.60 | B/D/F/H | 2335-2356 | [»] | |
5ZOO | X-ray | 1.85 | A | 1350-1363 | [»] | |
5ZOP | X-ray | 2.70 | A | 1448-1459 | [»] | |
6A22 | X-ray | 2.55 | B/D/F/H | 2335-2356 | [»] | |
6IVX | X-ray | 2.35 | B/D/F/H | 2335-2356 | [»] | |
6PDZ | X-ray | 2.10 | C/D | 2335-2356 | [»] | |
BMRBi | Q9Y618 | |||||
SMRi | Q9Y618 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114974, 141 interactors |
CORUMi | Q9Y618 |
DIPi | DIP-951N |
ELMi | Q9Y618 |
IntActi | Q9Y618, 53 interactors |
MINTi | Q9Y618 |
STRINGi | 9606.ENSP00000384018 |
Chemistry databases
BindingDBi | Q9Y618 |
ChEMBLi | CHEMBL2111363 CHEMBL3885590 CHEMBL3885591 |
DrugCentrali | Q9Y618 |
PTM databases
iPTMneti | Q9Y618 |
MetOSitei | Q9Y618 |
PhosphoSitePlusi | Q9Y618 |
Genetic variation databases
BioMutai | NCOR2 |
DMDMi | 226713806 |
Proteomic databases
EPDi | Q9Y618 |
jPOSTi | Q9Y618 |
MassIVEi | Q9Y618 |
MaxQBi | Q9Y618 |
PaxDbi | Q9Y618 |
PeptideAtlasi | Q9Y618 |
PRIDEi | Q9Y618 |
ProteomicsDBi | 86582 [Q9Y618-1] 86583 [Q9Y618-2] 86585 [Q9Y618-4] 86586 [Q9Y618-5] |
Protocols and materials databases
Antibodypediai | 1103, 262 antibodies |
Genome annotation databases
Ensembli | ENST00000405201; ENSP00000384018; ENSG00000196498 [Q9Y618-1] |
GeneIDi | 9612 |
KEGGi | hsa:9612 |
UCSCi | uc058uwu.1, human [Q9Y618-1] |
Organism-specific databases
CTDi | 9612 |
DisGeNETi | 9612 |
GeneCardsi | NCOR2 |
HGNCi | HGNC:7673, NCOR2 |
HPAi | ENSG00000196498, Low tissue specificity |
MIMi | 600848, gene |
neXtProti | NX_Q9Y618 |
OpenTargetsi | ENSG00000196498 |
PharmGKBi | PA31478 |
VEuPathDBi | HostDB:ENSG00000196498.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1878, Eukaryota |
GeneTreei | ENSGT00940000159022 |
InParanoidi | Q9Y618 |
OMAi | EPGRSIH |
OrthoDBi | 12227at2759 |
PhylomeDBi | Q9Y618 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y618 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3214815, HDACs deacetylate histones R-HSA-350054, Notch-HLH transcription pathway R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-9022537, Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9609690, HCMV Early Events R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
SignaLinki | Q9Y618 |
SIGNORi | Q9Y618 |
Miscellaneous databases
BioGRID-ORCSi | 9612, 35 hits in 903 CRISPR screens |
ChiTaRSi | NCOR2, human |
EvolutionaryTracei | Q9Y618 |
GeneWikii | Nuclear_receptor_co-repressor_2 |
GenomeRNAii | 9612 |
Pharosi | Q9Y618, Tchem |
PROi | PR:Q9Y618 |
RNActi | Q9Y618, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196498, Expressed in sural nerve and 247 other tissues |
ExpressionAtlasi | Q9Y618, baseline and differential |
Genevisiblei | Q9Y618, HS |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
IDEALi | IID00109 |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR031557, N-CoR_GPS2_interact IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF15784, GPS2_interact, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51293, SANT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOR2_HUMAN | |
Accessioni | Q9Y618Primary (citable) accession number: Q9Y618 Secondary accession number(s): O00613 Q9Y5U0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 10, 2021 | |
This is version 223 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families