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Protein

Nuclear receptor corepressor 2

Gene

NCOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SignaLinkiQ9Y618
SIGNORiQ9Y618

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor corepressor 2Curated
Short name:
N-CoR2Curated
Alternative name(s):
CTG repeat protein 26
SMAP270
Silencing mediator of retinoic acid and thyroid hormone receptorCurated
Short name:
SMRTCurated
T3 receptor-associating factor
Short name:
TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
Gene namesi
Name:NCOR2Imported
Synonyms:CTG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196498.13
HGNCiHGNC:7673 NCOR2
MIMi600848 gene
neXtProtiNX_Q9Y618

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242 – 245HRIL → AEIA: Abolishes interaction with TBL1X. 1 Publication4
Mutagenesisi2128R → A: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2130V → P: Abolishes interaction with the apo LBD of RARA. No change on interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2131T → G: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1

Organism-specific databases

DisGeNETi9612
OpenTargetsiENSG00000196498
PharmGKBiPA31478

Chemistry databases

ChEMBLiCHEMBL3885591

Polymorphism and mutation databases

BioMutaiNCOR2
DMDMi226713806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556221 – 2514Nuclear receptor corepressor 2Add BLAST2514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Asymmetric dimethylarginineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei553PhosphothreonineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei878N6-acetyllysineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei946PhosphothreonineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Modified residuei959N6-acetyllysineCombined sources1
Cross-linki1168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1173PhosphoserineCombined sources1
Modified residuei1210N6-acetyllysineCombined sources1
Modified residuei1240N6-acetyllysineCombined sources1
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1383PhosphothreonineCombined sources1
Modified residuei1479PhosphoserineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1595PhosphoserineBy similarity1
Modified residuei1619PhosphoserineCombined sources1
Modified residuei1653Asymmetric dimethylarginineCombined sources1
Modified residuei1775PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1
Modified residuei1861PhosphoserineCombined sources1
Modified residuei1959N6-acetyllysineCombined sources1
Modified residuei2005PhosphoserineCombined sources1
Modified residuei2026N6-acetyllysineCombined sources1
Modified residuei2046PhosphoserineCombined sources1
Modified residuei2054PhosphoserineCombined sources1
Modified residuei2057PhosphoserineCombined sources1
Modified residuei2058PhosphoserineCombined sources1
Modified residuei2060PhosphoserineBy similarity1
Modified residuei2062PhosphothreonineCombined sources1
Modified residuei2077PhosphoserineCombined sources1
Modified residuei2203PhosphoserineCombined sources1
Modified residuei2223PhosphoserineCombined sources1
Modified residuei2258PhosphoserineCombined sources1
Modified residuei2413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y618
PaxDbiQ9Y618
PeptideAtlasiQ9Y618
PRIDEiQ9Y618
ProteomicsDBi86583 [Q9Y618-2]
86584 [Q9Y618-1]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

PTM databases

iPTMnetiQ9Y618
PhosphoSitePlusiQ9Y618

Expressioni

Tissue specificityi

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Inductioni

Regulated during cell cycle progression.

Gene expression databases

BgeeiENSG00000196498 Expressed in 238 organ(s), highest expression level in pituitary gland
CleanExiHS_NCOR2
ExpressionAtlasiQ9Y618 baseline and differential
GenevisibleiQ9Y618 HS

Organism-specific databases

HPAiHPA001928

Interactioni

Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024).By similarity18 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114974, 124 interactors
CORUMiQ9Y618
DIPiDIP-951N
ELMiQ9Y618
IntActiQ9Y618, 49 interactors
MINTiQ9Y618
STRINGi9606.ENSP00000384018

Chemistry databases

BindingDBiQ9Y618

Structurei

Secondary structure

12514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y618
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y618

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini610 – 661SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 312Interaction with SIN3A/BBy similarityAdd BLAST59
Regioni2128 – 2131Required for interaction with RARA in the absence of its ligand4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili174 – 215Sequence analysisAdd BLAST42
Coiled coili522 – 561Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2136 – 2140CORNR box of ID15
Motifi2339 – 2343CORNR box of ID25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi494 – 510Poly-GlnAdd BLAST17
Compositional biasi682 – 685Poly-Lys4
Compositional biasi778 – 820Pro-richAdd BLAST43
Compositional biasi995 – 1003Poly-Pro9
Compositional biasi1384 – 1389Poly-Pro6
Compositional biasi1839 – 1843Poly-Gly5
Compositional biasi2476 – 2479Poly-Pro4

Domaini

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1878 Eukaryota
ENOG410YDXP LUCA
GeneTreeiENSGT00840000129748
HOVERGENiHBG052587
InParanoidiQ9Y618
KOiK06065
PhylomeDBiQ9Y618

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y618-1) [UniParc]FASTAAdd to basket
Also known as: SMRT-alpha1 Publication, TRAC-2, h-SMRT

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA
60 70 80 90 100
SHLSPGSIIQ PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM
110 120 130 140 150
EFIESKRPRL ELLPDPLLRP SPLLATGQPA GSEDLTKDRS LTGKLEPVSP
160 170 180 190 200
PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL
210 220 230 240 250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP
260 270 280 290 300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
310 320 330 340 350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM
360 370 380 390 400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY
410 420 430 440 450
DADQQRIKFI NMNGLMADPM KVYKDRQVMN MWSEQEKETF REKFMQHPKN
460 470 480 490 500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ
510 520 530 540 550
QQQQQQQQQQ PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT
560 570 580 590 600
DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA NSEEAITPQQ
610 620 630 640 650
SAELASMELN ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK
660 670 680 690 700
NFYFNYKKRQ NLDEILQQHK LKMEKERNAR RKKKKAPAAA SEEAAFPPVV
710 720 730 740 750
EDEEMEASGV SGNEEEMVEE AEALHASGNE VPRGECSGPA TVNNSSDTES
760 770 780 790 800
IPSPHTEAAK DTGQNGPKPP ATLGADGPPP GPPTPPPEDI PAPTEPTPAS
810 820 830 840 850
EATGAPTPPP APPSPSAPPP VVPKEEKEEE TAAAPPVEEG EEQKPPAAEE
860 870 880 890 900
LAVDTGKAEE PVKSECTEEA EEGPAKGKDA EAAEATAEGA LKAEKKEGGS
910 920 930 940 950
GRATTAKSSG APQDSDSSAT CSADEVDEAE GGDKNRLLSP RPSLLTPTGD
960 970 980 990 1000
PRANASPQKP LDLKQLKQRA AAIPPIQVTK VHEPPREDAA PTKPAPPAPP
1010 1020 1030 1040 1050
PPQNLQPESD APQQPGSSPR GKSRSPAPPA DKEAFAAEAQ KLPGDPPCWT
1060 1070 1080 1090 1100
SGLPFPVPPR EVIKASPHAP DPSAFSYAPP GHPLPLGLHD TARPVLPRPP
1110 1120 1130 1140 1150
TISNPPPLIS SAKHPSVLER QIGAISQGMS VQLHVPYSEH AKAPVGPVTM
1160 1170 1180 1190 1200
GLPLPMDPKK LAPFSGVKQE QLSPRGQAGP PESLGVPTAQ EASVLRGTAL
1210 1220 1230 1240 1250
GSVPGGSITK GIPSTRVPSD SAITYRGSIT HGTPADVLYK GTITRIIGED
1260 1270 1280 1290 1300
SPSRLDRGRE DSLPKGHVIY EGKKGHVLSY EGGMSVTQCS KEDGRSSSGP
1310 1320 1330 1340 1350
PHETAAPKRT YDMMEGRVGR AISSASIEGL MGRAIPPERH SPHHLKEQHH
1360 1370 1380 1390 1400
IRGSITQGIP RSYVEAQEDY LRREAKLLKR EGTPPPPPPS RDLTEAYKTQ
1410 1420 1430 1440 1450
ALGPLKLKPA HEGLVATVKE AGRSIHEIPR EELRHTPELP LAPRPLKEGS
1460 1470 1480 1490 1500
ITQGTPLKYD TGASTTGSKK HDVRSLIGSP GRTFPPVHPL DVMADARALE
1510 1520 1530 1540 1550
RACYEESLKS RPGTASSSGG SIARGAPVIV PELGKPRQSP LTYEDHGAPF
1560 1570 1580 1590 1600
AGHLPRGSPV TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSTV
1610 1620 1630 1640 1650
PEHHPHPISP YEHLLRGVSG VDLYRSHIPL AFDPTSIPRG IPLDAAAAYY
1660 1670 1680 1690 1700
LPRHLAPNPT YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA
1710 1720 1730 1740 1750
TAMAQRADML RGLSPRESSL ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT
1760 1770 1780 1790 1800
PATAMDRLAY LPTAPQPFSS RHSSSPLSPG GPTHLTKPTT TSSSERERDR
1810 1820 1830 1840 1850
DRERDRDRER EKSILTSTTT VEHAPIWRPG TEQSSGSSGG GGGSSSRPAS
1860 1870 1880 1890 1900
HSHAHQHSPI SPRTQDALQQ RPSVLHNTGM KGIITAVEPS TPTVLRSTST
1910 1920 1930 1940 1950
SSPVRPAATF PPATHCPLGG TLDGVYPTLM EPVLLPKEAP RVARPERPRA
1960 1970 1980 1990 2000
DTGHAFLAKP PARSGLEPAS SPSKGSEPRP LVPPVSGHAT IARTPAKNLA
2010 2020 2030 2040 2050
PHHASPDPPA PPASASDPHR EKTQSKPFSI QELELRSLGY HGSSYSPEGV
2060 2070 2080 2090 2100
EPVSPVSSPS LTHDKGLPKH LEELDKSHLE GELRPKQPGP VKLGGEAAHL
2110 2120 2130 2140 2150
PHLRPLPESQ PSSSPLLQTA PGVKGHQRVV TLAQHISEVI TQDYTRHHPQ
2160 2170 2180 2190 2200
QLSAPLPAPL YSFPGASCPV LDLRRPPSDL YLPPPDHGAP ARGSPHSEGG
2210 2220 2230 2240 2250
KRSPEPNKTS VLGGGEDGIE PVSPPEGMTE PGHSRSAVYP LLYRDGEQTE
2260 2270 2280 2290 2300
PSRMGSKSPG NTSQPPAFFS KLTESNSAMV KSKKQEINKK LNTHNRNEPE
2310 2320 2330 2340 2350
YNISQPGTEI FNMPAITGTG LMTYRSQAVQ EHASTNMGLE AIIRKALMGK
2360 2370 2380 2390 2400
YDQWEESPPL SANAFNPLNA SASLPAAMPI TAADGRSDHT LTSPGGGGKA
2410 2420 2430 2440 2450
KVSGRPSSRK AKSPAPGLAS GDRPPSVSSV HSEGDCNRRT PLTNRVWEDR
2460 2470 2480 2490 2500
PSSAGSTPFP YNPLIMRLQA GVMASPPPPG LPAGSGPLAG PHHAWDEEPK
2510
PLLCSQYETL SDSE
Length:2,514
Mass (Da):273,657
Last modified:September 12, 2018 - v3
Checksum:i70A89C9A19612AAD
GO
Isoform 2 (identifier: Q9Y618-2) [UniParc]FASTAAdd to basket
Also known as: TRAC-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1702: Missing.
     2350-2395: Missing.

Note: Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.
Show »
Length:766
Mass (Da):81,377
Checksum:iEFC383C83199A1D0
GO
Isoform 3 (identifier: Q9Y618-4) [UniParc]FASTAAdd to basket
Also known as: SMRTe

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.

Show »
Length:2,497
Mass (Da):271,994
Checksum:i34566D11BC2E2414
GO
Isoform 4 (identifier: Q9Y618-5) [UniParc]FASTAAdd to basket
Also known as: SMRT-tau1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.
     2350-2395: Missing.

Show »
Length:2,451
Mass (Da):267,214
Checksum:i24299917E937ED2A
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFD3C9JFD3_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,514Annotation score:
C9JE98C9JE98_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,458Annotation score:
C9J0Q5C9J0Q5_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,504Annotation score:
C9JQE8C9JQE8_HUMAN
Nuclear receptor corepressor 2
NCOR2
1,451Annotation score:
C9J7T7C9J7T7_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,062Annotation score:
C9J330C9J330_HUMAN
Nuclear receptor corepressor 2
NCOR2
493Annotation score:
C9JNV9C9JNV9_HUMAN
Nuclear receptor corepressor 2
NCOR2
162Annotation score:
H7C1Y3H7C1Y3_HUMAN
Nuclear receptor corepressor 2
NCOR2
245Annotation score:
H0YGK8H0YGK8_HUMAN
Nuclear receptor corepressor 2
NCOR2
275Annotation score:
H7C184H7C184_HUMAN
Nuclear receptor corepressor 2
NCOR2
134Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAB91452 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAC50236 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAD20946 differs from that shown. Reason: Frameshift at positions 787 and 794.Curated
The sequence BAD92326 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7P → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti295E → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti309W → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti352Missing in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti352Missing in AAX77219 (Ref. 4) Curated1
Sequence conflicti365A → P in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti365A → P in AAX77219 (Ref. 4) Curated1
Sequence conflicti612 – 613SS → EF in AAB91446 (PubMed:9225980).Curated2
Sequence conflicti711S → T in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti711S → T in AAX77219 (Ref. 4) Curated1
Sequence conflicti796P → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti796P → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti804G → L in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti804G → L in AAX77219 (Ref. 4) Curated1
Sequence conflicti814S → F in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti814S → F in AAX77219 (Ref. 4) Curated1
Sequence conflicti817A → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti817A → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti889G → R in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti889G → R in AAX77219 (Ref. 4) Curated1
Sequence conflicti1562T → M in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1562T → M in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1562T → M in AAX77219 (Ref. 4) Curated1
Sequence conflicti1562T → M in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti1839G → GSSG in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1891T → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1891T → K in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1891T → K in AAX77219 (Ref. 4) Curated1
Sequence conflicti1891T → K in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti2491P → A in AAB50847 (PubMed:8813722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060073781G → E1 PublicationCorresponds to variant dbSNP:rs7978237Ensembl.1
Natural variantiVAR_0547511699A → T4 PublicationsCorresponds to variant dbSNP:rs2229840Ensembl.1
Natural variantiVAR_0600742001P → S. Corresponds to variant dbSNP:rs2230944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0034121 – 1702Missing in isoform 2. 1 PublicationAdd BLAST1702
Alternative sequenceiVSP_036595724 – 740Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_0034132350 – 2395Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.
CCDSiCCDS41858.2 [Q9Y618-1]
PIRiS60255
RefSeqiNP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5 [Q9Y618-1]
UniGeneiHs.137510

Genome annotation databases

EnsembliENST00000405201; ENSP00000384018; ENSG00000196498 [Q9Y618-1]
GeneIDi9612
KEGGihsa:9612
UCSCiuc058uwu.1 human [Q9Y618-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.
CCDSiCCDS41858.2 [Q9Y618-1]
PIRiS60255
RefSeqiNP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5 [Q9Y618-1]
UniGeneiHs.137510

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKQX-ray3.00E/F/G/H2336-2354[»]
1R2BX-ray2.20C/D1414-1430[»]
1XC5NMR-A412-480[»]
2GPVX-ray2.85G/H/I2335-2356[»]
2L5GNMR-B167-207[»]
2LTPNMR-A615-685[»]
2ODDNMR-B1101-1113[»]
2RT5NMR-B2507-2514[»]
3R29X-ray2.90C/D2335-2350[»]
3R2AX-ray3.00E/F2335-2350[»]
4A69X-ray2.06C/D389-480[»]
4OARX-ray2.41B2335-2351[»]
5X8QX-ray2.20B/D/F/H2335-2356[»]
5X8XX-ray2.60B/D/F/H2335-2356[»]
ProteinModelPortaliQ9Y618
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114974, 124 interactors
CORUMiQ9Y618
DIPiDIP-951N
ELMiQ9Y618
IntActiQ9Y618, 49 interactors
MINTiQ9Y618
STRINGi9606.ENSP00000384018

Chemistry databases

BindingDBiQ9Y618
ChEMBLiCHEMBL3885591

PTM databases

iPTMnetiQ9Y618
PhosphoSitePlusiQ9Y618

Polymorphism and mutation databases

BioMutaiNCOR2
DMDMi226713806

Proteomic databases

EPDiQ9Y618
PaxDbiQ9Y618
PeptideAtlasiQ9Y618
PRIDEiQ9Y618
ProteomicsDBi86583 [Q9Y618-2]
86584 [Q9Y618-1]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405201; ENSP00000384018; ENSG00000196498 [Q9Y618-1]
GeneIDi9612
KEGGihsa:9612
UCSCiuc058uwu.1 human [Q9Y618-1]

Organism-specific databases

CTDi9612
DisGeNETi9612
EuPathDBiHostDB:ENSG00000196498.13
GeneCardsiNCOR2
H-InvDBiHIX0026341
HGNCiHGNC:7673 NCOR2
HPAiHPA001928
MIMi600848 gene
neXtProtiNX_Q9Y618
OpenTargetsiENSG00000196498
PharmGKBiPA31478
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1878 Eukaryota
ENOG410YDXP LUCA
GeneTreeiENSGT00840000129748
HOVERGENiHBG052587
InParanoidiQ9Y618
KOiK06065
PhylomeDBiQ9Y618

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SignaLinkiQ9Y618
SIGNORiQ9Y618

Miscellaneous databases

ChiTaRSiNCOR2 human
EvolutionaryTraceiQ9Y618
GeneWikiiNuclear_receptor_co-repressor_2
GenomeRNAii9612
PROiPR:Q9Y618
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196498 Expressed in 238 organ(s), highest expression level in pituitary gland
CleanExiHS_NCOR2
ExpressionAtlasiQ9Y618 baseline and differential
GenevisibleiQ9Y618 HS

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNCOR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y618
Secondary accession number(s): O00613
, O15416, O15421, Q13354, Q56D06, Q59GM0, Q9Y5U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 12, 2018
Last modified: November 7, 2018
This is version 205 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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