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UniProtKB - Q9Y618 (NCOR2_HUMAN)

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Protein

Nuclear receptor corepressor 2

Gene

NCOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • histone deacetylase binding Source: UniProtKB
  • ligand-dependent nuclear receptor binding Source: GO_Central
  • Notch binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • transcription corepressor activity Source: BHF-UCL
  • transcription factor binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SignaLinkiQ9Y618
SIGNORiQ9Y618

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor corepressor 2
Short name:
N-CoR2
Alternative name(s):
CTG repeat protein 26
SMAP270
Silencing mediator of retinoic acid and thyroid hormone receptor
Short name:
SMRT
T3 receptor-associating factor
Short name:
TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
Gene namesi
Name:NCOR2
Synonyms:CTG26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196498.13
HGNCiHGNC:7673 NCOR2
MIMi600848 gene
neXtProtiNX_Q9Y618

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242 – 245HRIL → AEIA: Abolishes interaction with TBL1X. 1 Publication4
Mutagenesisi2139R → A: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2141V → P: Abolishes interaction with the apo LBD of RARA. No change on interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2142T → G: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1

Organism-specific databases

DisGeNETi9612
PharmGKBiPA31478

Chemistry databases

ChEMBLiCHEMBL2111363

Polymorphism and mutation databases

BioMutaiNCOR2
DMDMi226713806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556221 – 2525Nuclear receptor corepressor 2Add BLAST2525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Asymmetric dimethylarginineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei553PhosphothreonineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei878N6-acetyllysineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei946PhosphothreonineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Modified residuei959N6-acetyllysineCombined sources1
Cross-linki1176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1218N6-acetyllysineCombined sources1
Modified residuei1248N6-acetyllysineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Modified residuei1391PhosphothreonineCombined sources1
Modified residuei1487PhosphoserineCombined sources1
Modified residuei1547PhosphoserineCombined sources1
Modified residuei1603PhosphoserineBy similarity1
Modified residuei1627PhosphoserineCombined sources1
Modified residuei1661Asymmetric dimethylarginineCombined sources1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1786PhosphoserineCombined sources1
Modified residuei1872PhosphoserineCombined sources1
Modified residuei1970N6-acetyllysineCombined sources1
Modified residuei2016PhosphoserineCombined sources1
Modified residuei2037N6-acetyllysineCombined sources1
Modified residuei2057PhosphoserineCombined sources1
Modified residuei2065PhosphoserineCombined sources1
Modified residuei2068PhosphoserineCombined sources1
Modified residuei2069PhosphoserineCombined sources1
Modified residuei2071PhosphoserineBy similarity1
Modified residuei2073PhosphothreonineCombined sources1
Modified residuei2088PhosphoserineCombined sources1
Modified residuei2214PhosphoserineCombined sources1
Modified residuei2234PhosphoserineCombined sources1
Modified residuei2269PhosphoserineCombined sources1
Modified residuei2424PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y618
PaxDbiQ9Y618
PeptideAtlasiQ9Y618
PRIDEiQ9Y618
ProteomicsDBi86582
86583 [Q9Y618-2]
86584 [Q9Y618-3]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

PTM databases

iPTMnetiQ9Y618
PhosphoSitePlusiQ9Y618

Expressioni

Tissue specificityi

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Inductioni

Regulated during cell cycle progression.

Gene expression databases

BgeeiENSG00000196498
CleanExiHS_NCOR2
ExpressionAtlasiQ9Y618 baseline and differential
GenevisibleiQ9Y618 HS

Organism-specific databases

HPAiHPA001928

Interactioni

Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity).By similarity17 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • ligand-dependent nuclear receptor binding Source: GO_Central
  • Notch binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • transcription factor binding Source: GO_Central
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114974, 123 interactors
CORUMiQ9Y618
DIPiDIP-951N
ELMiQ9Y618
IntActiQ9Y618, 47 interactors
MINTiQ9Y618
STRINGi9606.ENSP00000384018

Chemistry databases

BindingDBiQ9Y618

Structurei

Secondary structure

12525
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi168 – 170Combined sources3
Helixi171 – 205Combined sources35
Beta strandi414 – 417Combined sources4
Helixi419 – 428Combined sources10
Helixi434 – 446Combined sources13
Helixi451 – 456Combined sources6
Turni458 – 460Combined sources3
Helixi463 – 473Combined sources11
Turni474 – 476Combined sources3
Helixi617 – 629Combined sources13
Turni630 – 632Combined sources3
Helixi634 – 640Combined sources7
Beta strandi642 – 644Combined sources3
Helixi646 – 655Combined sources10
Helixi661 – 679Combined sources19
Beta strandi1116 – 1118Combined sources3
Beta strandi1424 – 1428Combined sources5
Helixi2348 – 2358Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKQX-ray3.00E/F/G/H2347-2365[»]
1R2BX-ray2.20C/D1422-1438[»]
1XC5NMR-A412-480[»]
2GPVX-ray2.85G/H/I2346-2367[»]
2L5GNMR-B167-207[»]
2LTPNMR-A615-685[»]
2ODDNMR-B1109-1121[»]
2RT5NMR-B2518-2525[»]
3R29X-ray2.90C/D2346-2361[»]
3R2AX-ray3.00E/F2346-2361[»]
4A69X-ray2.06C/D389-480[»]
4OARX-ray2.41B2346-2362[»]
5X8QX-ray2.20B/D/F/H2346-2367[»]
5X8XX-ray2.60B/D/F/H2346-2367[»]
ProteinModelPortaliQ9Y618
SMRiQ9Y618
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y618

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini610 – 661SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 312Interaction with SIN3A/BBy similarityAdd BLAST59
Regioni2139 – 2142Required for interaction with RARA in the absence of its ligand4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili174 – 215Sequence analysisAdd BLAST42
Coiled coili522 – 561Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2147 – 2151CORNR box of ID15
Motifi2350 – 2354CORNR box of ID25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi494 – 510Poly-GlnAdd BLAST17
Compositional biasi682 – 685Poly-Lys4
Compositional biasi778 – 820Pro-richAdd BLAST43
Compositional biasi995 – 1003Poly-Pro9
Compositional biasi1392 – 1397Poly-Pro6
Compositional biasi1850 – 1854Poly-Gly5
Compositional biasi2487 – 2490Poly-Pro4

Domaini

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

Sequence similaritiesi

Belongs to the N-CoR nuclear receptor corepressors family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1878 Eukaryota
ENOG410YDXP LUCA
HOVERGENiHBG052587
InParanoidiQ9Y618
KOiK06065
PhylomeDBiQ9Y618

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y618-1) [UniParc]FASTAAdd to basket
Also known as: SMRT-alpha, TRAC-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA 
        60         70         80         90        100
SHLSPGSIIQ PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM 
       110        120        130        140        150
EFIESKRPRL ELLPDPLLRP SPLLATGQPA GSEDLTKDRS LTGKLEPVSP 
       160        170        180        190        200
PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL 
       210        220        230        240        250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP 
       260        270        280        290        300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ 
       310        320        330        340        350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM 
       360        370        380        390        400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY 
       410        420        430        440        450
DADQQRIKFI NMNGLMADPM KVYKDRQVMN MWSEQEKETF REKFMQHPKN 
       460        470        480        490        500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ 
       510        520        530        540        550
QQQQQQQQQQ PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT 
       560        570        580        590        600
DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA NSEEAITPQQ 
       610        620        630        640        650
SAELASMELN ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK 
       660        670        680        690        700
NFYFNYKKRQ NLDEILQQHK LKMEKERNAR RKKKKAPAAA SEEAAFPPVV 
       710        720        730        740        750
EDEEMEASGV SGNEEEMVEE AEALHASGNE VPRGECSGPA TVNNSSDTES 
       760        770        780        790        800
IPSPHTEAAK DTGQNGPKPP ATLGADGPPP GPPTPPPEDI PAPTEPTPAS 
       810        820        830        840        850
EATGAPTPPP APPSPSAPPP VVPKEEKEEE TAAAPPVEEG EEQKPPAAEE 
       860        870        880        890        900
LAVDTGKAEE PVKSECTEEA EEGPAKGKDA EAAEATAEGA LKAEKKEGGS 
       910        920        930        940        950
GRATTAKSSG APQDSDSSAT CSADEVDEAE GGDKNRLLSP RPSLLTPTGD 
       960        970        980        990       1000
PRANASPQKP LDLKQLKQRA AAIPPIQVTK VHEPPREDAA PTKPAPPAPP 
      1010       1020       1030       1040       1050
PPQNLQPESD APQQPGSSPR GKSRSPAPPA DKEAEKPVFF PAFAAEAQKL 
      1060       1070       1080       1090       1100
PGDPPCWTSG LPFPVPPREV IKASPHAPDP SAFSYAPPGH PLPLGLHDTA 
      1110       1120       1130       1140       1150
RPVLPRPPTI SNPPPLISSA KHPSVLERQI GAISQGMSVQ LHVPYSEHAK 
      1160       1170       1180       1190       1200
APVGPVTMGL PLPMDPKKLA PFSGVKQEQL SPRGQAGPPE SLGVPTAQEA 
      1210       1220       1230       1240       1250
SVLRGTALGS VPGGSITKGI PSTRVPSDSA ITYRGSITHG TPADVLYKGT 
      1260       1270       1280       1290       1300
ITRIIGEDSP SRLDRGREDS LPKGHVIYEG KKGHVLSYEG GMSVTQCSKE 
      1310       1320       1330       1340       1350
DGRSSSGPPH ETAAPKRTYD MMEGRVGRAI SSASIEGLMG RAIPPERHSP 
      1360       1370       1380       1390       1400
HHLKEQHHIR GSITQGIPRS YVEAQEDYLR REAKLLKREG TPPPPPPSRD 
      1410       1420       1430       1440       1450
LTEAYKTQAL GPLKLKPAHE GLVATVKEAG RSIHEIPREE LRHTPELPLA 
      1460       1470       1480       1490       1500
PRPLKEGSIT QGTPLKYDTG ASTTGSKKHD VRSLIGSPGR TFPPVHPLDV 
      1510       1520       1530       1540       1550
MADARALERA CYEESLKSRP GTASSSGGSI ARGAPVIVPE LGKPRQSPLT 
      1560       1570       1580       1590       1600
YEDHGAPFAG HLPRGSPVTT REPTPRLQEG SLSSSKASQD RKLTSTPREI 
      1610       1620       1630       1640       1650
AKSPHSTVPE HHPHPISPYE HLLRGVSGVD LYRSHIPLAF DPTSIPRGIP 
      1660       1670       1680       1690       1700
LDAAAAYYLP RHLAPNPTYP HLYPPYLIRG YPDTAALENR QTIINDYITS 
      1710       1720       1730       1740       1750
QQMHHNAATA MAQRADMLRG LSPRESSLAL NYAAGPRGII DLSQVPHLPV 
      1760       1770       1780       1790       1800
LVPPTPGTPA TAMDRLAYLP TAPQPFSSRH SSSPLSPGGP THLTKPTTTS 
      1810       1820       1830       1840       1850
SSERERDRDR ERDRDREREK SILTSTTTVE HAPIWRPGTE QSSGSSGSSG 
      1860       1870       1880       1890       1900
GGGGSSSRPA SHSHAHQHSP ISPRTQDALQ QRPSVLHNTG MKGIITAVEP 
      1910       1920       1930       1940       1950
STPTVLRSTS TSSPVRPAAT FPPATHCPLG GTLDGVYPTL MEPVLLPKEA 
      1960       1970       1980       1990       2000
PRVARPERPR ADTGHAFLAK PPARSGLEPA SSPSKGSEPR PLVPPVSGHA 
      2010       2020       2030       2040       2050
TIARTPAKNL APHHASPDPP APPASASDPH REKTQSKPFS IQELELRSLG 
      2060       2070       2080       2090       2100
YHGSSYSPEG VEPVSPVSSP SLTHDKGLPK HLEELDKSHL EGELRPKQPG 
      2110       2120       2130       2140       2150
PVKLGGEAAH LPHLRPLPES QPSSSPLLQT APGVKGHQRV VTLAQHISEV 
      2160       2170       2180       2190       2200
ITQDYTRHHP QQLSAPLPAP LYSFPGASCP VLDLRRPPSD LYLPPPDHGA 
      2210       2220       2230       2240       2250
PARGSPHSEG GKRSPEPNKT SVLGGGEDGI EPVSPPEGMT EPGHSRSAVY 
      2260       2270       2280       2290       2300
PLLYRDGEQT EPSRMGSKSP GNTSQPPAFF SKLTESNSAM VKSKKQEINK 
      2310       2320       2330       2340       2350
KLNTHNRNEP EYNISQPGTE IFNMPAITGT GLMTYRSQAV QEHASTNMGL 
      2360       2370       2380       2390       2400
EAIIRKALMG KYDQWEESPP LSANAFNPLN ASASLPAAMP ITAADGRSDH 
      2410       2420       2430       2440       2450
TLTSPGGGGK AKVSGRPSSR KAKSPAPGLA SGDRPPSVSS VHSEGDCNRR 
      2460       2470       2480       2490       2500
TPLTNRVWED RPSSAGSTPF PYNPLIMRLQ AGVMASPPPP GLPAGSGPLA 
      2510       2520 
GPHHAWDEEP KPLLCSQYET LSDSE
Length:2,525
Mass (Da):274,804
Last modified:March 24, 2009 - v2
Checksum:i9B8689CA013C4513
GO
Isoform 2 (identifier: Q9Y618-2) [UniParc]FASTAAdd to basket
Also known as: TRAC-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1710: Missing.
     2361-2406: Missing.

Note: Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.
Show »
Length:769
Mass (Da):81,608
Checksum:i399E0A5142E83975
GO
Isoform 3 (identifier: Q9Y618-3) [UniParc]FASTAAdd to basket
Also known as: h-SMRT

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1041: Missing.

Show »
Length:2,517
Mass (Da):273,888
Checksum:iD9616717A5C342DB
GO
Isoform 4 (identifier: Q9Y618-4) [UniParc]FASTAAdd to basket
Also known as: SMRTe

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.

Show »
Length:2,508
Mass (Da):273,141
Checksum:i8738AABD508422AA
GO
Isoform 5 (identifier: Q9Y618-5) [UniParc]FASTAAdd to basket
Also known as: SMRT-tau

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.
     2361-2406: Missing.

Show »
Length:2,462
Mass (Da):268,361
Checksum:i31DC105B162AFD57
GO

Sequence cautioni

The sequence AAB91452 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAC50236 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAD20946 differs from that shown. Reason: Frameshift at positions 787 and 794.Curated
The sequence BAD92326 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7P → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti295E → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti309W → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti352Missing in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti352Missing in AAX77219 (Ref. 4) Curated1
Sequence conflicti365A → P in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti365A → P in AAX77219 (Ref. 4) Curated1
Sequence conflicti612 – 613SS → EF in AAB91446 (PubMed:9225980).Curated2
Sequence conflicti711S → T in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti711S → T in AAX77219 (Ref. 4) Curated1
Sequence conflicti796P → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti796P → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti804G → L in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti804G → L in AAX77219 (Ref. 4) Curated1
Sequence conflicti814S → F in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti814S → F in AAX77219 (Ref. 4) Curated1
Sequence conflicti817A → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti817A → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti889G → R in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti889G → R in AAX77219 (Ref. 4) Curated1
Sequence conflicti1570T → M in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1570T → M in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1570T → M in AAX77219 (Ref. 4) Curated1
Sequence conflicti1570T → M in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti1902T → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1902T → K in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1902T → K in AAX77219 (Ref. 4) Curated1
Sequence conflicti1902T → K in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti2502P → A in AAB50847 (PubMed:8813722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060073781G → E1 PublicationCorresponds to variant dbSNP:rs7978237Ensembl.1
Natural variantiVAR_0547511707A → T4 PublicationsCorresponds to variant dbSNP:rs2229840Ensembl.1
Natural variantiVAR_0600742012P → S. Corresponds to variant dbSNP:rs2230944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0034121 – 1710Missing in isoform 2. 1 PublicationAdd BLAST1710
Alternative sequenceiVSP_036595724 – 740Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_0365961034 – 1041Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_0034132361 – 2406Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.
PIRiS60255
RefSeqiNP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5
UniGeneiHs.137510

Genome annotation databases

EnsembliENST00000356219; ENSP00000348551; ENSG00000196498
GeneIDi9612
KEGGihsa:9612
UCSCiuc058uwu.1 human [Q9Y618-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNCOR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y618
Secondary accession number(s): O00613
, O15416, O15421, Q13354, Q56D06, Q59GM0, Q9Y5U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 24, 2009
Last modified: June 20, 2018
This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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