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Protein

Nuclear receptor corepressor 2

Gene

NCOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692 Regulation of MECP2 expression and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9Y618

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y618

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor corepressor 2Curated
Short name:
N-CoR2Curated
Alternative name(s):
CTG repeat protein 26
SMAP270
Silencing mediator of retinoic acid and thyroid hormone receptorCurated
Short name:
SMRTCurated
T3 receptor-associating factor
Short name:
TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOR2Imported
Synonyms:CTG26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196498.13

Human Gene Nomenclature Database

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HGNCi
HGNC:7673 NCOR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600848 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y618

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi242 – 245HRIL → AEIA: Abolishes interaction with TBL1X. 1 Publication4
Mutagenesisi2128R → A: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2130V → P: Abolishes interaction with the apo LBD of RARA. No change on interaction on the addition of inverse agonist BMS493. 1 Publication1
Mutagenesisi2131T → G: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9612

Open Targets

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OpenTargetsi
ENSG00000196498

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31478

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3885591

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCOR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226713806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000556221 – 2514Nuclear receptor corepressor 2Add BLAST2514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Asymmetric dimethylarginineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei156PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei553PhosphothreonineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei878N6-acetyllysineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei946PhosphothreonineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Modified residuei959N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1173PhosphoserineCombined sources1
Modified residuei1210N6-acetyllysineCombined sources1
Modified residuei1240N6-acetyllysineCombined sources1
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1383PhosphothreonineCombined sources1
Modified residuei1479PhosphoserineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1595PhosphoserineBy similarity1
Modified residuei1619PhosphoserineCombined sources1
Modified residuei1653Asymmetric dimethylarginineCombined sources1
Modified residuei1775PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1
Modified residuei1861PhosphoserineCombined sources1
Modified residuei1959N6-acetyllysineCombined sources1
Modified residuei2005PhosphoserineCombined sources1
Modified residuei2026N6-acetyllysineCombined sources1
Modified residuei2046PhosphoserineCombined sources1
Modified residuei2054PhosphoserineCombined sources1
Modified residuei2057PhosphoserineCombined sources1
Modified residuei2058PhosphoserineCombined sources1
Modified residuei2060PhosphoserineBy similarity1
Modified residuei2062PhosphothreonineCombined sources1
Modified residuei2077PhosphoserineCombined sources1
Modified residuei2203PhosphoserineCombined sources1
Modified residuei2223PhosphoserineCombined sources1
Modified residuei2258PhosphoserineCombined sources1
Modified residuei2413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y618

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y618

PeptideAtlas

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PeptideAtlasi
Q9Y618

PRoteomics IDEntifications database

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PRIDEi
Q9Y618

ProteomicsDB human proteome resource

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ProteomicsDBi
86583 [Q9Y618-2]
86584 [Q9Y618-1]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y618

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y618

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Regulated during cell cycle progression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196498 Expressed in 238 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

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CleanExi
HS_NCOR2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y618 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y618 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001928

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024).By similarity18 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114974, 125 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y618

Database of interacting proteins

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DIPi
DIP-951N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9Y618

Protein interaction database and analysis system

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IntActi
Q9Y618, 47 interactors

Molecular INTeraction database

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MINTi
Q9Y618

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384018

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9Y618

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y618

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y618

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y618

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini610 – 661SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni254 – 312Interaction with SIN3A/BBy similarityAdd BLAST59
Regioni2128 – 2131Required for interaction with RARA in the absence of its ligand4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili174 – 215Sequence analysisAdd BLAST42
Coiled coili522 – 561Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2136 – 2140CORNR box of ID15
Motifi2339 – 2343CORNR box of ID25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi494 – 510Poly-GlnAdd BLAST17
Compositional biasi682 – 685Poly-Lys4
Compositional biasi778 – 820Pro-richAdd BLAST43
Compositional biasi995 – 1003Poly-Pro9
Compositional biasi1384 – 1389Poly-Pro6
Compositional biasi1839 – 1843Poly-Gly5
Compositional biasi2476 – 2479Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1878 Eukaryota
ENOG410YDXP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159022

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052587

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y618

KEGG Orthology (KO)

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KOi
K06065

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y618

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00717 SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293 SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y618-1) [UniParc]FASTAAdd to basket
Also known as: SMRT-alpha1 Publication, TRAC-2, h-SMRT

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA
60 70 80 90 100
SHLSPGSIIQ PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM
110 120 130 140 150
EFIESKRPRL ELLPDPLLRP SPLLATGQPA GSEDLTKDRS LTGKLEPVSP
160 170 180 190 200
PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL
210 220 230 240 250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP
260 270 280 290 300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
310 320 330 340 350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM
360 370 380 390 400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY
410 420 430 440 450
DADQQRIKFI NMNGLMADPM KVYKDRQVMN MWSEQEKETF REKFMQHPKN
460 470 480 490 500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ
510 520 530 540 550
QQQQQQQQQQ PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT
560 570 580 590 600
DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA NSEEAITPQQ
610 620 630 640 650
SAELASMELN ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK
660 670 680 690 700
NFYFNYKKRQ NLDEILQQHK LKMEKERNAR RKKKKAPAAA SEEAAFPPVV
710 720 730 740 750
EDEEMEASGV SGNEEEMVEE AEALHASGNE VPRGECSGPA TVNNSSDTES
760 770 780 790 800
IPSPHTEAAK DTGQNGPKPP ATLGADGPPP GPPTPPPEDI PAPTEPTPAS
810 820 830 840 850
EATGAPTPPP APPSPSAPPP VVPKEEKEEE TAAAPPVEEG EEQKPPAAEE
860 870 880 890 900
LAVDTGKAEE PVKSECTEEA EEGPAKGKDA EAAEATAEGA LKAEKKEGGS
910 920 930 940 950
GRATTAKSSG APQDSDSSAT CSADEVDEAE GGDKNRLLSP RPSLLTPTGD
960 970 980 990 1000
PRANASPQKP LDLKQLKQRA AAIPPIQVTK VHEPPREDAA PTKPAPPAPP
1010 1020 1030 1040 1050
PPQNLQPESD APQQPGSSPR GKSRSPAPPA DKEAFAAEAQ KLPGDPPCWT
1060 1070 1080 1090 1100
SGLPFPVPPR EVIKASPHAP DPSAFSYAPP GHPLPLGLHD TARPVLPRPP
1110 1120 1130 1140 1150
TISNPPPLIS SAKHPSVLER QIGAISQGMS VQLHVPYSEH AKAPVGPVTM
1160 1170 1180 1190 1200
GLPLPMDPKK LAPFSGVKQE QLSPRGQAGP PESLGVPTAQ EASVLRGTAL
1210 1220 1230 1240 1250
GSVPGGSITK GIPSTRVPSD SAITYRGSIT HGTPADVLYK GTITRIIGED
1260 1270 1280 1290 1300
SPSRLDRGRE DSLPKGHVIY EGKKGHVLSY EGGMSVTQCS KEDGRSSSGP
1310 1320 1330 1340 1350
PHETAAPKRT YDMMEGRVGR AISSASIEGL MGRAIPPERH SPHHLKEQHH
1360 1370 1380 1390 1400
IRGSITQGIP RSYVEAQEDY LRREAKLLKR EGTPPPPPPS RDLTEAYKTQ
1410 1420 1430 1440 1450
ALGPLKLKPA HEGLVATVKE AGRSIHEIPR EELRHTPELP LAPRPLKEGS
1460 1470 1480 1490 1500
ITQGTPLKYD TGASTTGSKK HDVRSLIGSP GRTFPPVHPL DVMADARALE
1510 1520 1530 1540 1550
RACYEESLKS RPGTASSSGG SIARGAPVIV PELGKPRQSP LTYEDHGAPF
1560 1570 1580 1590 1600
AGHLPRGSPV TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSTV
1610 1620 1630 1640 1650
PEHHPHPISP YEHLLRGVSG VDLYRSHIPL AFDPTSIPRG IPLDAAAAYY
1660 1670 1680 1690 1700
LPRHLAPNPT YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA
1710 1720 1730 1740 1750
TAMAQRADML RGLSPRESSL ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT
1760 1770 1780 1790 1800
PATAMDRLAY LPTAPQPFSS RHSSSPLSPG GPTHLTKPTT TSSSERERDR
1810 1820 1830 1840 1850
DRERDRDRER EKSILTSTTT VEHAPIWRPG TEQSSGSSGG GGGSSSRPAS
1860 1870 1880 1890 1900
HSHAHQHSPI SPRTQDALQQ RPSVLHNTGM KGIITAVEPS TPTVLRSTST
1910 1920 1930 1940 1950
SSPVRPAATF PPATHCPLGG TLDGVYPTLM EPVLLPKEAP RVARPERPRA
1960 1970 1980 1990 2000
DTGHAFLAKP PARSGLEPAS SPSKGSEPRP LVPPVSGHAT IARTPAKNLA
2010 2020 2030 2040 2050
PHHASPDPPA PPASASDPHR EKTQSKPFSI QELELRSLGY HGSSYSPEGV
2060 2070 2080 2090 2100
EPVSPVSSPS LTHDKGLPKH LEELDKSHLE GELRPKQPGP VKLGGEAAHL
2110 2120 2130 2140 2150
PHLRPLPESQ PSSSPLLQTA PGVKGHQRVV TLAQHISEVI TQDYTRHHPQ
2160 2170 2180 2190 2200
QLSAPLPAPL YSFPGASCPV LDLRRPPSDL YLPPPDHGAP ARGSPHSEGG
2210 2220 2230 2240 2250
KRSPEPNKTS VLGGGEDGIE PVSPPEGMTE PGHSRSAVYP LLYRDGEQTE
2260 2270 2280 2290 2300
PSRMGSKSPG NTSQPPAFFS KLTESNSAMV KSKKQEINKK LNTHNRNEPE
2310 2320 2330 2340 2350
YNISQPGTEI FNMPAITGTG LMTYRSQAVQ EHASTNMGLE AIIRKALMGK
2360 2370 2380 2390 2400
YDQWEESPPL SANAFNPLNA SASLPAAMPI TAADGRSDHT LTSPGGGGKA
2410 2420 2430 2440 2450
KVSGRPSSRK AKSPAPGLAS GDRPPSVSSV HSEGDCNRRT PLTNRVWEDR
2460 2470 2480 2490 2500
PSSAGSTPFP YNPLIMRLQA GVMASPPPPG LPAGSGPLAG PHHAWDEEPK
2510
PLLCSQYETL SDSE
Length:2,514
Mass (Da):273,657
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A89C9A19612AAD
GO
Isoform 2 (identifier: Q9Y618-2) [UniParc]FASTAAdd to basket
Also known as: TRAC-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1702: Missing.
     2350-2395: Missing.

Note: Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.
Show »
Length:766
Mass (Da):81,377
Checksum:iEFC383C83199A1D0
GO
Isoform 3 (identifier: Q9Y618-4) [UniParc]FASTAAdd to basket
Also known as: SMRTe

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.

Show »
Length:2,497
Mass (Da):271,994
Checksum:i34566D11BC2E2414
GO
Isoform 4 (identifier: Q9Y618-5) [UniParc]FASTAAdd to basket
Also known as: SMRT-tau1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     724-740: Missing.
     2350-2395: Missing.

Show »
Length:2,451
Mass (Da):267,214
Checksum:i24299917E937ED2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFD3C9JFD3_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,514Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Q5C9J0Q5_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JE98C9JE98_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQE8C9JQE8_HUMAN
Nuclear receptor corepressor 2
NCOR2
1,451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7T7C9J7T7_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,062Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J330C9J330_HUMAN
Nuclear receptor corepressor 2
NCOR2
493Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNV9C9JNV9_HUMAN
Nuclear receptor corepressor 2
NCOR2
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384DVL6A0A384DVL6_HUMAN
Nuclear receptor corepressor 2
NCOR2
2,079Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGK8H0YGK8_HUMAN
Nuclear receptor corepressor 2
NCOR2
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1Y3H7C1Y3_HUMAN
Nuclear receptor corepressor 2
NCOR2
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB91452 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAC50236 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAD20946 differs from that shown. Reason: Frameshift at positions 787 and 794.Curated
The sequence BAD92326 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7P → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti295E → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti309W → L in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti352Missing in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti352Missing in AAX77219 (Ref. 4) Curated1
Sequence conflicti365A → P in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti365A → P in AAX77219 (Ref. 4) Curated1
Sequence conflicti612 – 613SS → EF in AAB91446 (PubMed:9225980).Curated2
Sequence conflicti711S → T in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti711S → T in AAX77219 (Ref. 4) Curated1
Sequence conflicti796P → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti796P → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti804G → L in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti804G → L in AAX77219 (Ref. 4) Curated1
Sequence conflicti814S → F in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti814S → F in AAX77219 (Ref. 4) Curated1
Sequence conflicti817A → S in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti817A → S in AAX77219 (Ref. 4) Curated1
Sequence conflicti889G → R in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti889G → R in AAX77219 (Ref. 4) Curated1
Sequence conflicti1562T → M in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1562T → M in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1562T → M in AAX77219 (Ref. 4) Curated1
Sequence conflicti1562T → M in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti1839G → GSSG in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1891T → K in AAD20946 (PubMed:10077563).Curated1
Sequence conflicti1891T → K in AAD22973 (PubMed:10097068).Curated1
Sequence conflicti1891T → K in AAX77219 (Ref. 4) Curated1
Sequence conflicti1891T → K in AAC50236 (PubMed:7566127).Curated1
Sequence conflicti2491P → A in AAB50847 (PubMed:8813722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060073781G → E1 PublicationCorresponds to variant dbSNP:rs7978237Ensembl.1
Natural variantiVAR_0547511699A → T4 PublicationsCorresponds to variant dbSNP:rs2229840Ensembl.1
Natural variantiVAR_0600742001P → S. Corresponds to variant dbSNP:rs2230944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0034121 – 1702Missing in isoform 2. 1 PublicationAdd BLAST1702
Alternative sequenceiVSP_036595724 – 740Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_0034132350 – 2395Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41858.2 [Q9Y618-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S60255

NCBI Reference Sequences

More...
RefSeqi
NP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5 [Q9Y618-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.137510

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000405201; ENSP00000384018; ENSG00000196498 [Q9Y618-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9612

UCSC genome browser

More...
UCSCi
uc058uwu.1 human [Q9Y618-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83390 mRNA Translation: AAB50847.1
AF113003 mRNA Translation: AAD20946.1 Frameshift.
AF125672 mRNA Translation: AAD22973.1
AY965853 mRNA Translation: AAX77219.1
AC069261 Genomic DNA No translation available.
AC073916 Genomic DNA No translation available.
AB209089 mRNA Translation: BAD92326.1 Different initiation.
U80750 mRNA Translation: AAB91446.1
U80761 mRNA Translation: AAB91452.1 Sequence problems.
U37146 mRNA Translation: AAC50236.1 Sequence problems.
CCDSiCCDS41858.2 [Q9Y618-1]
PIRiS60255
RefSeqiNP_001070729.2, NM_001077261.3
NP_001193583.1, NM_001206654.1
NP_006303.4, NM_006312.5 [Q9Y618-1]
UniGeneiHs.137510

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KKQX-ray3.00E/F/G/H2336-2354[»]
1R2BX-ray2.20C/D1414-1430[»]
1XC5NMR-A412-480[»]
2GPVX-ray2.85G/H/I2335-2356[»]
2L5GNMR-B167-207[»]
2LTPNMR-A615-685[»]
2ODDNMR-B1101-1113[»]
2RT5NMR-B2507-2514[»]
3R29X-ray2.90C/D2335-2350[»]
3R2AX-ray3.00E/F2335-2350[»]
4A69X-ray2.06C/D389-480[»]
4OARX-ray2.41B2335-2351[»]
5X8QX-ray2.20B/D/F/H2335-2356[»]
5X8XX-ray2.60B/D/F/H2335-2356[»]
ProteinModelPortaliQ9Y618
SMRiQ9Y618
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114974, 125 interactors
CORUMiQ9Y618
DIPiDIP-951N
ELMiQ9Y618
IntActiQ9Y618, 47 interactors
MINTiQ9Y618
STRINGi9606.ENSP00000384018

Chemistry databases

BindingDBiQ9Y618
ChEMBLiCHEMBL3885591

PTM databases

iPTMnetiQ9Y618
PhosphoSitePlusiQ9Y618

Polymorphism and mutation databases

BioMutaiNCOR2
DMDMi226713806

Proteomic databases

EPDiQ9Y618
PaxDbiQ9Y618
PeptideAtlasiQ9Y618
PRIDEiQ9Y618
ProteomicsDBi86583 [Q9Y618-2]
86584 [Q9Y618-1]
86585 [Q9Y618-4]
86586 [Q9Y618-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405201; ENSP00000384018; ENSG00000196498 [Q9Y618-1]
GeneIDi9612
KEGGihsa:9612
UCSCiuc058uwu.1 human [Q9Y618-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9612
DisGeNETi9612
EuPathDBiHostDB:ENSG00000196498.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCOR2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026341
HGNCiHGNC:7673 NCOR2
HPAiHPA001928
MIMi600848 gene
neXtProtiNX_Q9Y618
OpenTargetsiENSG00000196498
PharmGKBiPA31478

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1878 Eukaryota
ENOG410YDXP LUCA
GeneTreeiENSGT00940000159022
HOVERGENiHBG052587
InParanoidiQ9Y618
KOiK06065
PhylomeDBiQ9Y618

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692 Regulation of MECP2 expression and activity
SignaLinkiQ9Y618
SIGNORiQ9Y618

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCOR2 human
EvolutionaryTraceiQ9Y618

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Nuclear_receptor_co-repressor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9612

Protein Ontology

More...
PROi
PR:Q9Y618

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196498 Expressed in 238 organ(s), highest expression level in pituitary gland
CleanExiHS_NCOR2
ExpressionAtlasiQ9Y618 baseline and differential
GenevisibleiQ9Y618 HS

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y618
Secondary accession number(s): O00613
, O15416, O15421, Q13354, Q56D06, Q59GM0, Q9Y5U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 12, 2018
Last modified: December 5, 2018
This is version 206 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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