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Protein

Phosphoserine aminotransferase

Gene

PSAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateBy similarityNote: Binds 1 pyridoxal phosphate per subunit.By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5 µM for phosphoserine1 Publication
  1. Vmax=1.35 µmol/min/mg enzyme1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (HEL-S-113), D-3-phosphoglycerate dehydrogenase (PHGDH), D-3-phosphoglycerate dehydrogenase (PHGDH), D-3-phosphoglycerate dehydrogenase (serA), D-3-phosphoglycerate dehydrogenase (PHGDH)
  2. Phosphoserine aminotransferase, Phosphoserine aminotransferase (PSAT1), Phosphoserine aminotransferase (PSAT1)
  3. Phosphoserine phosphatase (PSPH)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphoserine aminotransferase (PSAT1)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei45L-glutamateBy similarity1
Binding sitei107Pyridoxal phosphateBy similarity1
Binding sitei156Pyridoxal phosphateBy similarity1
Binding sitei176Pyridoxal phosphateBy similarity1
Binding sitei199Pyridoxal phosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: GO_Central

GO - Biological processi

  • L-serine biosynthetic process Source: GO_Central
  • pyridoxine biosynthetic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05946-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.6.1.52 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977347 Serine biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00135;UER00197

UPA00244;UER00311

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoserine aminotransferase (EC:2.6.1.52)
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Short name:
PSAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSAT1
Synonyms:PSA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135069.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19129 PSAT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610936 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y617

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Phosphoserine aminotransferase deficiency (PSATD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
See also OMIM:610992
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037252100D → A in PSATD; reduced Vmax. 1 PublicationCorresponds to variant dbSNP:rs118203967EnsemblClinVar.1
Neu-Laxova syndrome 2 (NLS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Neu-Laxova syndrome, a lethal, autosomal recessive multiple malformation syndrome characterized by ichthyosis, marked intrauterine growth restriction, microcephaly, short neck, limb deformities, hypoplastic lungs, edema, and central nervous system anomalies. These include lissencephaly, cerebellar hypoplasia and/or abnormal/agenesis of the corpus callosum. Abnormal facial features include severe proptosis with ectropion, hypertelorism, micrognathia, flattened nose, and malformed ears.
See also OMIM:616038
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07257199A → V in NLS2. 1 PublicationCorresponds to variant dbSNP:rs587777778EnsemblClinVar.1
Natural variantiVAR_072572179S → L in NLS2. 1 PublicationCorresponds to variant dbSNP:rs587777777EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
29968

MalaCards human disease database

More...
MalaCardsi
PSAT1
MIMi610992 phenotype
616038 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135069

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2671 Neu-Laxova syndrome
284417 Phosphoserine aminotransferase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128395782

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00142 L-Glutamic Acid
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

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DMDMi
20141815

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001501351 – 370Phosphoserine aminotransferaseAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei51N6-acetyllysineCombined sources1
Modified residuei127N6-acetyllysineBy similarity1
Modified residuei200N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei269N6-acetyllysineCombined sources1
Modified residuei318N6-acetyllysineCombined sources1
Modified residuei323N6-acetyllysineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei333N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y617

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y617

PeptideAtlas

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PeptideAtlasi
Q9Y617

PRoteomics IDEntifications database

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PRIDEi
Q9Y617

ProteomicsDB human proteome resource

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ProteomicsDBi
86580
86581 [Q9Y617-2]

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00001734

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y617

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y617

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y617

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135069 Expressed in 207 organ(s), highest expression level in amygdala

CleanEx database of gene expression profiles

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CleanExi
HS_PSAT1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y617 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y617 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB014882
CAB040567
HPA042924

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119001, 39 interactors

Protein interaction database and analysis system

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IntActi
Q9Y617, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9Y617

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365773

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1370
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y617

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y617

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y617

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 80Pyridoxal phosphate bindingBy similarity2
Regioni241 – 242Pyridoxal phosphate bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2790 Eukaryota
COG1932 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000088965

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001218

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y617

KEGG Orthology (KO)

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KOi
K00831

Identification of Orthologs from Complete Genome Data

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OMAi
GAQKNMG

Database of Orthologous Groups

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OrthoDBi
EOG091G0964

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y617

TreeFam database of animal gene trees

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TreeFami
TF312975

Family and domain databases

Conserved Domains Database

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CDDi
cd00611 PSAT_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00160 SerC_aminotrans_5, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR022278 Pser_aminoTfrase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

Pfam protein domain database

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Pfami
View protein in Pfam
PF00266 Aminotran_5, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000525 SerC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53383 SSF53383, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01364 serC_1, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y617-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAPRQVVNF GPGPAKLPHS VLLEIQKELL DYKGVGISVL EMSHRSSDFA
60 70 80 90 100
KIINNTENLV RELLAVPDNY KVIFLQGGGC GQFSAVPLNL IGLKAGRCAD
110 120 130 140 150
YVVTGAWSAK AAEEAKKFGT INIVHPKLGS YTKIPDPSTW NLNPDASYVY
160 170 180 190 200
YCANETVHGV EFDFIPDVKG AVLVCDMSSN FLSKPVDVSK FGVIFAGAQK
210 220 230 240 250
NVGSAGVTVV IVRDDLLGFA LRECPSVLEY KVQAGNSSLY NTPPCFSIYV
260 270 280 290 300
MGLVLEWIKN NGGAAAMEKL SSIKSQTIYE IIDNSQGFYV CPVEPQNRSK
310 320 330 340 350
MNIPFRIGNA KGDDALEKRF LDKALELNML SLKGHRSVGG IRASLYNAVT
360 370
IEDVQKLAAF MKKFLEMHQL
Length:370
Mass (Da):40,423
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAF9A10E71B165B4
GO
Isoform 2 (identifier: Q9Y617-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     291-336: Missing.

Show »
Length:324
Mass (Da):35,189
Checksum:i4F83811D3593DDA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40L → V in AAH16645 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04823587P → A. Corresponds to variant dbSNP:rs11540974Ensembl.1
Natural variantiVAR_07257199A → V in NLS2. 1 PublicationCorresponds to variant dbSNP:rs587777778EnsemblClinVar.1
Natural variantiVAR_037252100D → A in PSATD; reduced Vmax. 1 PublicationCorresponds to variant dbSNP:rs118203967EnsemblClinVar.1
Natural variantiVAR_072572179S → L in NLS2. 1 PublicationCorresponds to variant dbSNP:rs587777777EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000237291 – 336Missing in isoform 2. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF113132 mRNA Translation: AAD42052.1
AY131232 mRNA Translation: AAN71736.1
BT006840 mRNA Translation: AAP35486.1
AL353594 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62621.1
CH471089 Genomic DNA Translation: EAW62617.1
BC000971 mRNA Translation: AAH00971.1
BC004863 mRNA Translation: AAH04863.1
BC016645 mRNA Translation: AAH16645.1
BC018129 mRNA Translation: AAH18129.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6659.1 [Q9Y617-2]
CCDS6660.1 [Q9Y617-1]

NCBI Reference Sequences

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RefSeqi
NP_066977.1, NM_021154.4 [Q9Y617-2]
NP_478059.1, NM_058179.3 [Q9Y617-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.494261

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000347159; ENSP00000317606; ENSG00000135069 [Q9Y617-2]
ENST00000376588; ENSP00000365773; ENSG00000135069 [Q9Y617-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29968

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29968

UCSC genome browser

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UCSCi
uc004ala.5 human [Q9Y617-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113132 mRNA Translation: AAD42052.1
AY131232 mRNA Translation: AAN71736.1
BT006840 mRNA Translation: AAP35486.1
AL353594 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62621.1
CH471089 Genomic DNA Translation: EAW62617.1
BC000971 mRNA Translation: AAH00971.1
BC004863 mRNA Translation: AAH04863.1
BC016645 mRNA Translation: AAH16645.1
BC018129 mRNA Translation: AAH18129.1
CCDSiCCDS6659.1 [Q9Y617-2]
CCDS6660.1 [Q9Y617-1]
RefSeqiNP_066977.1, NM_021154.4 [Q9Y617-2]
NP_478059.1, NM_058179.3 [Q9Y617-1]
UniGeneiHs.494261

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E77X-ray2.50A/B/C17-370[»]
ProteinModelPortaliQ9Y617
SMRiQ9Y617
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119001, 39 interactors
IntActiQ9Y617, 4 interactors
MINTiQ9Y617
STRINGi9606.ENSP00000365773

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid
DB00114 Pyridoxal Phosphate

PTM databases

iPTMnetiQ9Y617
PhosphoSitePlusiQ9Y617
SwissPalmiQ9Y617

Polymorphism and mutation databases

DMDMi20141815

2D gel databases

REPRODUCTION-2DPAGEiIPI00001734

Proteomic databases

EPDiQ9Y617
PaxDbiQ9Y617
PeptideAtlasiQ9Y617
PRIDEiQ9Y617
ProteomicsDBi86580
86581 [Q9Y617-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
29968
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347159; ENSP00000317606; ENSG00000135069 [Q9Y617-2]
ENST00000376588; ENSP00000365773; ENSG00000135069 [Q9Y617-1]
GeneIDi29968
KEGGihsa:29968
UCSCiuc004ala.5 human [Q9Y617-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29968
DisGeNETi29968
EuPathDBiHostDB:ENSG00000135069.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PSAT1
HGNCiHGNC:19129 PSAT1
HPAiCAB014882
CAB040567
HPA042924
MalaCardsiPSAT1
MIMi610936 gene
610992 phenotype
616038 phenotype
neXtProtiNX_Q9Y617
OpenTargetsiENSG00000135069
Orphaneti2671 Neu-Laxova syndrome
284417 Phosphoserine aminotransferase deficiency
PharmGKBiPA128395782

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2790 Eukaryota
COG1932 LUCA
GeneTreeiENSGT00940000153241
HOGENOMiHOG000088965
HOVERGENiHBG001218
InParanoidiQ9Y617
KOiK00831
OMAiGAQKNMG
OrthoDBiEOG091G0964
PhylomeDBiQ9Y617
TreeFamiTF312975

Enzyme and pathway databases

UniPathwayi
UPA00135;UER00197

UPA00244;UER00311

BioCyciMetaCyc:HS05946-MONOMER
BRENDAi2.6.1.52 2681
ReactomeiR-HSA-977347 Serine biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PSAT1 human
EvolutionaryTraceiQ9Y617

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PSAT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29968

Protein Ontology

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PROi
PR:Q9Y617

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135069 Expressed in 207 organ(s), highest expression level in amygdala
CleanExiHS_PSAT1
ExpressionAtlasiQ9Y617 baseline and differential
GenevisibleiQ9Y617 HS

Family and domain databases

CDDicd00611 PSAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00160 SerC_aminotrans_5, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR022278 Pser_aminoTfrase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000525 SerC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01364 serC_1, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y617
Secondary accession number(s): Q5T7G5
, Q5T7G6, Q96AW2, Q9BQ12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2002
Last modified: December 5, 2018
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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