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Protein

Interleukin-1 receptor-associated kinase 3

Gene

IRAK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.By similarity1 Publication

Caution

Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an inactive kinase.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei192ATPPROSITE-ProRule annotationBy similarity1
Binding sitei311ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi171 – 179ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi295 – 298ATPPROSITE-ProRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-9020702 Interleukin-1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y616

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y616

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase 3 (EC:2.7.11.1)
Short name:
IRAK-3
Alternative name(s):
IL-1 receptor-associated kinase M
Short name:
IRAK-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRAK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000090376.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17020 IRAK3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604459 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y616

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Asthma-related traits 5 (ASRT5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAsthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
See also OMIM:611064

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNET

More...
DisGeNETi
11213

MalaCards human disease database

More...
MalaCardsi
IRAK3
MIMi611064 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000090376

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38431

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5081

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IRAK3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510038

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860331 – 596Interleukin-1 receptor-associated kinase 3Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei467PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y616

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y616

PeptideAtlas

More...
PeptideAtlasi
Q9Y616

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y616

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86578
86579 [Q9Y616-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y616

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y616

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in peripheral blood lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090376 Expressed in 188 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_IRAK3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y616 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y616 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043097

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116382, 24 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y616

Protein interaction database and analysis system

More...
IntActi
Q9Y616, 17 interactors

Molecular INTeraction database

More...
MINTi
Q9Y616

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261233

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y616

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1596
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UKENMR-A1-119[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y616

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y616

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 106DeathPROSITE-ProRule annotationAdd BLAST66
Domaini165 – 452Protein kinasePROSITE-ProRule annotationAdd BLAST288

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1187 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161222

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060319

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052146

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y616

KEGG Orthology (KO)

More...
KOi
K04732

Identification of Orthologs from Complete Genome Data

More...
OMAi
LQEMGHH

Database of Orthologous Groups

More...
OrthoDBi
933071at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y616

TreeFam database of animal gene trees

More...
TreeFami
TF328924

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033610 IRAK3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24419:SF7 PTHR24419:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00005 DEATH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y616-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS
60 70 80 90 100
SWLDVRHIEK YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH
110 120 130 140 150
LITNYGAVLS PSEKSYQEGG FPNILFKETA NVTVDNVLIP EHNEKGILLK
160 170 180 190 200
SSISFQNIIE GTRNFHKDFL IGEGEIFEVY RVEIQNLTYA VKLFKQEKKM
210 220 230 240 250
QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI YPYMRNGTLF
260 270 280 290 300
DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL
310 320 330 340 350
LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK
360 370 380 390 400
LSIKTDVYSF GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL
410 420 430 440 450
SFLDKKVPPC PRNFSAKLFC LAGRCAATRA KLRPSMDEVL NTLESTQASL
460 470 480 490 500
YFAEDPPTSL KSFRCPSPLF LENVPSIPVE DDESQNNNLL PSDEGLRIDR
510 520 530 540 550
MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE ESWFPKYIVP
560 570 580 590
SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE
Length:596
Mass (Da):67,767
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD050150B7BDA5B9A
GO
Isoform 2 (identifier: Q9Y616-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-105: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):60,608
Checksum:i54DEDA8A162DD662
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYN6F5GYN6_HUMAN
Interleukin-1 receptor-associated k...
IRAK3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560N → D in BAG60819 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03521222P → L May be associated with ASRT5. 1 PublicationCorresponds to variant dbSNP:rs536546109Ensembl.1
Natural variantiVAR_04058157H → R1 PublicationCorresponds to variant dbSNP:rs35239505Ensembl.1
Natural variantiVAR_04058284G → S1 PublicationCorresponds to variant dbSNP:rs34443407Ensembl.1
Natural variantiVAR_035213111P → A May be associated with ASRT5. 1 PublicationCorresponds to variant dbSNP:rs373806603Ensembl.1
Natural variantiVAR_035214134V → M May be associated with ASRT5. 1 PublicationCorresponds to variant dbSNP:rs138559915Ensembl.1
Natural variantiVAR_019812147I → V4 PublicationsCorresponds to variant dbSNP:rs1152888Ensembl.1
Natural variantiVAR_040583171I → V1 PublicationCorresponds to variant dbSNP:rs34682166Ensembl.1
Natural variantiVAR_033901269G → S. Corresponds to variant dbSNP:rs35823766Ensembl.1
Natural variantiVAR_031077270I → V. Corresponds to variant dbSNP:rs11465972Ensembl.1
Natural variantiVAR_040584288S → L1 PublicationCorresponds to variant dbSNP:rs35574245Ensembl.1
Natural variantiVAR_040585384R → Q1 PublicationCorresponds to variant dbSNP:rs34272472Ensembl.1
Natural variantiVAR_040586391M → T1 PublicationCorresponds to variant dbSNP:rs35737689Ensembl.1
Natural variantiVAR_035215400L → V May be associated with ASRT5. 1 PublicationCorresponds to variant dbSNP:rs146120640Ensembl.1
Natural variantiVAR_035216429R → Q May be associated with ASRT5. 1 PublicationCorresponds to variant dbSNP:rs140671957Ensembl.1
Natural variantiVAR_040587482D → N1 PublicationCorresponds to variant dbSNP:rs35756811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04102045 – 105Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF113136 mRNA Translation: AAD40879.1
AK298645 mRNA Translation: BAG60819.1
AC078889 Genomic DNA No translation available.
AC078927 Genomic DNA No translation available.
BC057800 mRNA Translation: AAH57800.1
BC069388 mRNA Translation: AAH69388.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44937.1 [Q9Y616-2]
CCDS8975.1 [Q9Y616-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001135995.1, NM_001142523.1 [Q9Y616-2]
NP_009130.2, NM_007199.2 [Q9Y616-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.369265

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261233; ENSP00000261233; ENSG00000090376 [Q9Y616-1]
ENST00000457197; ENSP00000409852; ENSG00000090376 [Q9Y616-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11213

UCSC genome browser

More...
UCSCi
uc001sth.4 human [Q9Y616-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113136 mRNA Translation: AAD40879.1
AK298645 mRNA Translation: BAG60819.1
AC078889 Genomic DNA No translation available.
AC078927 Genomic DNA No translation available.
BC057800 mRNA Translation: AAH57800.1
BC069388 mRNA Translation: AAH69388.1
CCDSiCCDS44937.1 [Q9Y616-2]
CCDS8975.1 [Q9Y616-1]
RefSeqiNP_001135995.1, NM_001142523.1 [Q9Y616-2]
NP_009130.2, NM_007199.2 [Q9Y616-1]
UniGeneiHs.369265

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UKENMR-A1-119[»]
ProteinModelPortaliQ9Y616
SMRiQ9Y616
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116382, 24 interactors
CORUMiQ9Y616
IntActiQ9Y616, 17 interactors
MINTiQ9Y616
STRINGi9606.ENSP00000261233

Chemistry databases

BindingDBiQ9Y616
ChEMBLiCHEMBL5081

PTM databases

iPTMnetiQ9Y616
PhosphoSitePlusiQ9Y616

Polymorphism and mutation databases

BioMutaiIRAK3
DMDMi322510038

Proteomic databases

EPDiQ9Y616
PaxDbiQ9Y616
PeptideAtlasiQ9Y616
PRIDEiQ9Y616
ProteomicsDBi86578
86579 [Q9Y616-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11213
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261233; ENSP00000261233; ENSG00000090376 [Q9Y616-1]
ENST00000457197; ENSP00000409852; ENSG00000090376 [Q9Y616-2]
GeneIDi11213
KEGGihsa:11213
UCSCiuc001sth.4 human [Q9Y616-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11213
DisGeNETi11213
EuPathDBiHostDB:ENSG00000090376.8

GeneCards: human genes, protein and diseases

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GeneCardsi
IRAK3
HGNCiHGNC:17020 IRAK3
HPAiHPA043097
MalaCardsiIRAK3
MIMi604459 gene
611064 phenotype
neXtProtiNX_Q9Y616
OpenTargetsiENSG00000090376
PharmGKBiPA38431

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000161222
HOGENOMiHOG000060319
HOVERGENiHBG052146
InParanoidiQ9Y616
KOiK04732
OMAiLQEMGHH
OrthoDBi933071at2759
PhylomeDBiQ9Y616
TreeFamiTF328924

Enzyme and pathway databases

ReactomeiR-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiQ9Y616
SIGNORiQ9Y616

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IRAK3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11213

Protein Ontology

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PROi
PR:Q9Y616

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090376 Expressed in 188 organ(s), highest expression level in blood
CleanExiHS_IRAK3
ExpressionAtlasiQ9Y616 baseline and differential
GenevisibleiQ9Y616 HS

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033610 IRAK3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PANTHERiPTHR24419:SF7 PTHR24419:SF7, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRAK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y616
Secondary accession number(s): B4DQ57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: February 8, 2011
Last modified: January 16, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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