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Protein

Actin-like protein 7A

Gene

ACTL7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

Enzyme and pathway databases

SignaLinkiQ9Y615

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 7A
Alternative name(s):
Actin-like-7-alpha
Gene namesi
Name:ACTL7A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187003.6
HGNCiHGNC:161 ACTL7A
MIMi604303 gene
neXtProtiNX_Q9Y615

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31A → Y: Abolishes interaction with TES. 1 Publication1
Mutagenesisi41A → Y: Abolishes interaction with TES. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000187003
PharmGKBiPA24483

Polymorphism and mutation databases

BioMutaiACTL7A
DMDMi27923725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000891371 – 435Actin-like protein 7AAdd BLAST435

Proteomic databases

EPDiQ9Y615
PaxDbiQ9Y615
PeptideAtlasiQ9Y615
PRIDEiQ9Y615
ProteomicsDBi86577

PTM databases

iPTMnetiQ9Y615
PhosphoSitePlusiQ9Y615

Expressioni

Tissue specificityi

Strongly expressed in testis. Also expressed in other tissues.1 Publication

Gene expression databases

BgeeiENSG00000187003 Expressed in 39 organ(s), highest expression level in right testis
CleanExiHS_ACTL7A
ExpressionAtlasiQ9Y615 baseline and differential
GenevisibleiQ9Y615 HS

Organism-specific databases

HPAiHPA021624

Interactioni

Subunit structurei

Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TESQ9UGI89EBI-10825302,EBI-2561654

Protein-protein interaction databases

BioGridi116089, 1 interactor
IntActiQ9Y615, 2 interactors
STRINGi9606.ENSP00000334300

Structurei

Secondary structure

1435
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y615
SMRiQ9Y615
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y615

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 51Required for interaction with TESAdd BLAST21

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ9Y615
OMAiGKHFTED
OrthoDBiEOG091G07GC
PhylomeDBiQ9Y615
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR027679 ACTL7A
IPR031769 ACTL7A_N
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF167 PTHR11937:SF167, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PF16840 ACTL7A_N, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y615-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWAPPAAIMG DGPTKKVGNQ APLQTQALQT ASLRDGPAKR AVWVRHTSSE
60 70 80 90 100
PQEPTESKAA KERPKQEVTK AVVVDLGTGY CKCGFAGLPR PTHKISTTVG
110 120 130 140 150
KPYMETAKTG DNRKETFVGQ ELNNTNVHLK LVNPLRHGII VDWDTVQDIW
160 170 180 190 200
EYLFRQEMKI APEEHAVLVS DPPLSPHTNR EKYAEMLFEA FNTPAMHIAY
210 220 230 240 250
QSRLSMYSYG RTSGLVVEVG HGVSYVVPIY EGYPLPSITG RLDYAGSDLT
260 270 280 290 300
AYLLGLLNSA GNEFTQDQMG IVEDIKKKCC FVALDPIEEK KVPLSEHTIR
310 320 330 340 350
YVLPDGKEIQ LCQERFLCSE MFFKPSLIKS MQLGLHTQTV SCLNKCDIAL
360 370 380 390 400
KRDLMGNILL CGGSTMLSGF PNRLQKELSS MCPNDTPQVN VLPERDSAVW
410 420 430
TGGSILASLQ GFQPLWVHRF EYEEHGPFFL YRRCF
Length:435
Mass (Da):48,644
Last modified:November 1, 1999 - v1
Checksum:iFE73995971B5600C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03142545R → C1 PublicationCorresponds to variant dbSNP:rs368653764Ensembl.1
Natural variantiVAR_033460161A → P. Corresponds to variant dbSNP:rs35995497Ensembl.1
Natural variantiVAR_024362340V → M1 PublicationCorresponds to variant dbSNP:rs7872077Ensembl.1
Natural variantiVAR_060998343L → V. Corresponds to variant dbSNP:rs56031956Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113526 Genomic DNA Translation: AAD44109.1
AB284520 Genomic DNA Translation: BAF41971.1
AK314981 mRNA Translation: BAG37480.1
AL359692 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59026.1
BC014610 mRNA Translation: AAH14610.1
CCDSiCCDS6772.1
RefSeqiNP_006678.1, NM_006687.3
UniGeneiHs.123530

Genome annotation databases

EnsembliENST00000333999; ENSP00000334300; ENSG00000187003
GeneIDi10881
KEGGihsa:10881
UCSCiuc004bdj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113526 Genomic DNA Translation: AAD44109.1
AB284520 Genomic DNA Translation: BAF41971.1
AK314981 mRNA Translation: BAG37480.1
AL359692 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59026.1
BC014610 mRNA Translation: AAH14610.1
CCDSiCCDS6772.1
RefSeqiNP_006678.1, NM_006687.3
UniGeneiHs.123530

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XQNX-ray2.62A1-65[»]
ProteinModelPortaliQ9Y615
SMRiQ9Y615
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116089, 1 interactor
IntActiQ9Y615, 2 interactors
STRINGi9606.ENSP00000334300

PTM databases

iPTMnetiQ9Y615
PhosphoSitePlusiQ9Y615

Polymorphism and mutation databases

BioMutaiACTL7A
DMDMi27923725

Proteomic databases

EPDiQ9Y615
PaxDbiQ9Y615
PeptideAtlasiQ9Y615
PRIDEiQ9Y615
ProteomicsDBi86577

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333999; ENSP00000334300; ENSG00000187003
GeneIDi10881
KEGGihsa:10881
UCSCiuc004bdj.3 human

Organism-specific databases

CTDi10881
EuPathDBiHostDB:ENSG00000187003.6
GeneCardsiACTL7A
HGNCiHGNC:161 ACTL7A
HPAiHPA021624
MIMi604303 gene
neXtProtiNX_Q9Y615
OpenTargetsiENSG00000187003
PharmGKBiPA24483
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ9Y615
OMAiGKHFTED
OrthoDBiEOG091G07GC
PhylomeDBiQ9Y615
TreeFamiTF354237

Enzyme and pathway databases

SignaLinkiQ9Y615

Miscellaneous databases

EvolutionaryTraceiQ9Y615
GeneWikiiACTL7A
GenomeRNAii10881
PROiPR:Q9Y615
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187003 Expressed in 39 organ(s), highest expression level in right testis
CleanExiHS_ACTL7A
ExpressionAtlasiQ9Y615 baseline and differential
GenevisibleiQ9Y615 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR027679 ACTL7A
IPR031769 ACTL7A_N
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF167 PTHR11937:SF167, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PF16840 ACTL7A_N, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACL7A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y615
Secondary accession number(s): B2RC83, Q5JSV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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