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Protein

FH1/FH2 domain-containing protein 1

Gene

FHOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.3 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • protein domain specific binding Source: CAFA
  • protein self-association Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SIGNORiQ9Y613

Names & Taxonomyi

Protein namesi
Recommended name:
FH1/FH2 domain-containing protein 1
Alternative name(s):
Formin homolog overexpressed in spleen 1
Short name:
FHOS
Formin homology 2 domain-containing protein 1
Gene namesi
Name:FHOD1
Synonyms:FHOS, FHOS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000135723.13
HGNCiHGNC:17905 FHOD1
MIMi606881 gene
neXtProtiNX_Q9Y613

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29109
OpenTargetsiENSG00000135723
PharmGKBiPA28143

Polymorphism and mutation databases

BioMutaiFHOD1
DMDMi62512187

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001949052 – 1164FH1/FH2 domain-containing protein 1Add BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei367PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei495PhosphothreonineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei690PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated by ROCK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y613
MaxQBiQ9Y613
PaxDbiQ9Y613
PeptideAtlasiQ9Y613
PRIDEiQ9Y613
ProteomicsDBi86575

PTM databases

iPTMnetiQ9Y613
PhosphoSitePlusiQ9Y613

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in spleen.

Gene expression databases

BgeeiENSG00000135723 Expressed in 165 organ(s), highest expression level in spleen
CleanExiHS_FHOD1
ExpressionAtlasiQ9Y613 baseline and differential
GenevisibleiQ9Y613 HS

Organism-specific databases

HPAiHPA024468

Interactioni

Subunit structurei

Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118877, 33 interactors
DIPiDIP-31134N
IntActiQ9Y613, 22 interactors
MINTiQ9Y613
STRINGi9606.ENSP00000258201

Structurei

Secondary structure

11164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00448
ProteinModelPortaliQ9Y613
SMRiQ9Y613
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y613

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 458GBD/FH3PROSITE-ProRule annotationAdd BLAST406
Domaini487 – 615FH1Add BLAST129
Domaini616 – 1013FH2PROSITE-ProRule annotationAdd BLAST398
Domaini1053 – 1133DADAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni612 – 807Interaction with ROCK11 PublicationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili884 – 921Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi583 – 593Poly-ProAdd BLAST11
Compositional biasi597 – 605Poly-Pro9
Compositional biasi996 – 1001Poly-Gln6

Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.1 Publication

Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1925 Eukaryota
ENOG410XRBZ LUCA
GeneTreeiENSGT00870000136417
HOGENOMiHOG000015130
HOVERGENiHBG051615
InParanoidiQ9Y613
OMAiGALPWAN
OrthoDBiEOG091G0147
PhylomeDBiQ9Y613
TreeFamiTF316268

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015425 FH2_Formin
IPR027647 FHOD1
IPR014768 GBD/FH3_dom
PANTHERiPTHR23213:SF189 PTHR23213:SF189, 2 hits
PfamiView protein in Pfam
PF02181 FH2, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y613-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGEDRGDG EPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGALP
60 70 80 90 100
LGAQIPAVHR LLGAPLKLED CALQVSPSGY YLDTELSLEE QREMLEGFYE
110 120 130 140 150
EISKGRKPTL ILRTQLSVRV NAILEKLYSS SGPELRRSLF SLKQIFQEDK
160 170 180 190 200
DLVPEFVHSE GLSCLIRVGA AADHNYQSYI LRALGQLMLF VDGMLGVVAH
210 220 230 240 250
SDTIQWLYTL CASLSRLVVK TALKLLLVFV EYSENNAPLF IRAVNSVAST
260 270 280 290 300
TGAPPWANLV SILEEKNGAD PELLVYTVTL INKTLAALPD QDSFYDVTDA
310 320 330 340 350
LEQQGMEALV QRHLGTAGTD VDLRTQLVLY ENALKLEDGD IEEAPGAGGR
360 370 380 390 400
RERRKPSSEE GKRSRRSLEG GGCPARAPEP GPTGPASPVG PTSSTGPALL
410 420 430 440 450
TGPASSPVGP PSGLQASVNL FPTISVAPSA DTSSERSIYK ARFLENVAAA
460 470 480 490 500
ETEKQVALAQ GRAETLAGAM PNEAGGHPDA RQLWDSPETA PAARTPQSPA
510 520 530 540 550
PCVLLRAQRS LAPEPKEPLI PASPKAEPIW ELPTRAPRLS IGDLDFSDLG
560 570 580 590 600
EDEDQDMLNV ESVEAGKDIP APSPPLPLLS GVPPPPPLPP PPPIKGPFPP
610 620 630 640 650
PPPLPLAAPL PHSVPDSSAL PTKRKTVKLF WRELKLAGGH GVSASRFGPC
660 670 680 690 700
ATLWASLDPV SVDTARLEHL FESRAKEVLP SKKAGEGRRT MTTVLDPKRS
710 720 730 740 750
NAINIGLTTL PPVHVIKAAL LNFDEFAVSK DGIEKLLTMM PTEEERQKIE
760 770 780 790 800
EAQLANPDIP LGPAENFLMT LASIGGLAAR LQLWAFKLDY DSMEREIAEP
810 820 830 840 850
LFDLKVGMEQ LVQNATFRCI LATLLAVGNF LNGSQSSGFE LSYLEKVSEV
860 870 880 890 900
KDTVRRQSLL HHLCSLVLQT RPESSDLYSE IPALTRCAKV DFEQLTENLG
910 920 930 940 950
QLERRSRAAE ESLRSLAKHE LAPALRARLT HFLDQCARRV AMLRIVHRRV
960 970 980 990 1000
CNRFHAFLLY LGYTPQAARE VRIMQFCHTL REFALEYRTC RERVLQQQQK
1010 1020 1030 1040 1050
QATYRERNKT RGRMITETEK FSGVAGEAPS NPSVPVAVSS GPGRGDADSH
1060 1070 1080 1090 1100
ASMKSLLTSR PEDTTHNRRS RGMVQSSSPI MPTVGPSTAS PEEPPGSSLP
1110 1120 1130 1140 1150
SDTSDEIMDL LVQSVTKSSP RALAARERKR SRGNRKSLRR TLKSGLGDDL
1160
VQALGLSKGP GLEV
Length:1,164
Mass (Da):126,551
Last modified:January 23, 2007 - v3
Checksum:iE6C7AE1FB8DC3FC7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTH7J3KTH7_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
108Annotation score:
H3BVE7H3BVE7_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
157Annotation score:
J3QR24J3QR24_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
28Annotation score:
J3KT53J3KT53_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249S → T in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti249S → T in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti264E → D in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti277T → M in BAD06250 (PubMed:14576350).Curated1
Sequence conflicti307 – 308EA → DT in AAD39906 (PubMed:10352228).Curated2
Sequence conflicti307 – 308EA → DT in AAO38757 (PubMed:15138285).Curated2
Sequence conflicti359E → D in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti387S → T in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti533P → L in BAD92821 (Ref. 6) Curated1
Sequence conflicti633 – 634EL → DV in AAD39906 (PubMed:10352228).Curated2
Sequence conflicti689R → Q in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti700S → T in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti745E → G in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti751E → G in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti849E → D in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti1061P → L in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti1061P → L in AAO38757 (PubMed:15138285).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113615 mRNA Translation: AAD39906.1
AB041046 mRNA Translation: BAD06250.1
AY192154 mRNA Translation: AAO38757.1
BC033084 mRNA Translation: AAH33084.1
AB209584 mRNA Translation: BAD92821.1
CCDSiCCDS10834.1
RefSeqiNP_037373.2, NM_013241.2
UniGeneiHs.95231

Genome annotation databases

EnsembliENST00000258201; ENSP00000258201; ENSG00000135723
GeneIDi29109
KEGGihsa:29109
UCSCiuc002esl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113615 mRNA Translation: AAD39906.1
AB041046 mRNA Translation: BAD06250.1
AY192154 mRNA Translation: AAO38757.1
BC033084 mRNA Translation: AAH33084.1
AB209584 mRNA Translation: BAD92821.1
CCDSiCCDS10834.1
RefSeqiNP_037373.2, NM_013241.2
UniGeneiHs.95231

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DADX-ray2.30A/B1-339[»]
DisProtiDP00448
ProteinModelPortaliQ9Y613
SMRiQ9Y613
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118877, 33 interactors
DIPiDIP-31134N
IntActiQ9Y613, 22 interactors
MINTiQ9Y613
STRINGi9606.ENSP00000258201

PTM databases

iPTMnetiQ9Y613
PhosphoSitePlusiQ9Y613

Polymorphism and mutation databases

BioMutaiFHOD1
DMDMi62512187

Proteomic databases

EPDiQ9Y613
MaxQBiQ9Y613
PaxDbiQ9Y613
PeptideAtlasiQ9Y613
PRIDEiQ9Y613
ProteomicsDBi86575

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258201; ENSP00000258201; ENSG00000135723
GeneIDi29109
KEGGihsa:29109
UCSCiuc002esl.4 human

Organism-specific databases

CTDi29109
DisGeNETi29109
EuPathDBiHostDB:ENSG00000135723.13
GeneCardsiFHOD1
HGNCiHGNC:17905 FHOD1
HPAiHPA024468
MIMi606881 gene
neXtProtiNX_Q9Y613
OpenTargetsiENSG00000135723
PharmGKBiPA28143
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1925 Eukaryota
ENOG410XRBZ LUCA
GeneTreeiENSGT00870000136417
HOGENOMiHOG000015130
HOVERGENiHBG051615
InParanoidiQ9Y613
OMAiGALPWAN
OrthoDBiEOG091G0147
PhylomeDBiQ9Y613
TreeFamiTF316268

Enzyme and pathway databases

SIGNORiQ9Y613

Miscellaneous databases

EvolutionaryTraceiQ9Y613
GeneWikiiFHOD1
GenomeRNAii29109
PROiPR:Q9Y613
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135723 Expressed in 165 organ(s), highest expression level in spleen
CleanExiHS_FHOD1
ExpressionAtlasiQ9Y613 baseline and differential
GenevisibleiQ9Y613 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015425 FH2_Formin
IPR027647 FHOD1
IPR014768 GBD/FH3_dom
PANTHERiPTHR23213:SF189 PTHR23213:SF189, 2 hits
PfamiView protein in Pfam
PF02181 FH2, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFHOD1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y613
Secondary accession number(s): Q59F76
, Q6Y1F2, Q76MS8, Q8N521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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