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Entry version 181 (07 Oct 2020)
Sequence version 3 (23 Jan 2007)
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Protein

FH1/FH2 domain-containing protein 1

Gene

FHOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y613

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y613

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FH1/FH2 domain-containing protein 1
Alternative name(s):
Formin homolog overexpressed in spleen 1
Short name:
FHOS
Formin homology 2 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHOD1
Synonyms:FHOS, FHOS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135723.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17905, FHOD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606881, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y613

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29109

Open Targets

More...
OpenTargetsi
ENSG00000135723

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28143

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y613, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FHOD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62512187

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949052 – 1164FH1/FH2 domain-containing protein 1Add BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei367PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei495PhosphothreonineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei690PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ROCK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y613

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y613

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y613

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y613

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y613

PeptideAtlas

More...
PeptideAtlasi
Q9Y613

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y613

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86575

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y613

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9Y613

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y613

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in spleen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135723, Expressed in spleen and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y613, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y613, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135723, Tissue enhanced (lymphoid tissue, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus.

Interacts with ROCK1 in a Src-dependent manner.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
118877, 42 interactors

Database of interacting proteins

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DIPi
DIP-31134N

Protein interaction database and analysis system

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IntActi
Q9Y613, 28 interactors

Molecular INTeraction database

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MINTi
Q9Y613

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258201

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y613, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y613

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y613

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 458GBD/FH3PROSITE-ProRule annotationAdd BLAST406
Domaini487 – 615FH1Add BLAST129
Domaini616 – 1013FH2PROSITE-ProRule annotationAdd BLAST398
Domaini1053 – 1133DADAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni612 – 807Interaction with ROCK11 PublicationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili884 – 921Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi583 – 593Poly-ProAdd BLAST11
Compositional biasi597 – 605Poly-Pro9
Compositional biasi996 – 1001Poly-Gln6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1925, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160212

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000814_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y613

KEGG Orthology (KO)

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KOi
K23938

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHCILAT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y613

TreeFam database of animal gene trees

More...
TreeFami
TF316268

Family and domain databases

Database of protein disorder

More...
DisProti
DP00448

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR027647, FHOD1
IPR041387, FHOD1_GBD_N
IPR014768, GBD/FH3_dom

The PANTHER Classification System

More...
PANTHERi
PTHR45920:SF2, PTHR45920:SF2, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02181, FH2, 1 hit
PF18382, Formin_GBD_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y613-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGEDRGDG EPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGALP
60 70 80 90 100
LGAQIPAVHR LLGAPLKLED CALQVSPSGY YLDTELSLEE QREMLEGFYE
110 120 130 140 150
EISKGRKPTL ILRTQLSVRV NAILEKLYSS SGPELRRSLF SLKQIFQEDK
160 170 180 190 200
DLVPEFVHSE GLSCLIRVGA AADHNYQSYI LRALGQLMLF VDGMLGVVAH
210 220 230 240 250
SDTIQWLYTL CASLSRLVVK TALKLLLVFV EYSENNAPLF IRAVNSVAST
260 270 280 290 300
TGAPPWANLV SILEEKNGAD PELLVYTVTL INKTLAALPD QDSFYDVTDA
310 320 330 340 350
LEQQGMEALV QRHLGTAGTD VDLRTQLVLY ENALKLEDGD IEEAPGAGGR
360 370 380 390 400
RERRKPSSEE GKRSRRSLEG GGCPARAPEP GPTGPASPVG PTSSTGPALL
410 420 430 440 450
TGPASSPVGP PSGLQASVNL FPTISVAPSA DTSSERSIYK ARFLENVAAA
460 470 480 490 500
ETEKQVALAQ GRAETLAGAM PNEAGGHPDA RQLWDSPETA PAARTPQSPA
510 520 530 540 550
PCVLLRAQRS LAPEPKEPLI PASPKAEPIW ELPTRAPRLS IGDLDFSDLG
560 570 580 590 600
EDEDQDMLNV ESVEAGKDIP APSPPLPLLS GVPPPPPLPP PPPIKGPFPP
610 620 630 640 650
PPPLPLAAPL PHSVPDSSAL PTKRKTVKLF WRELKLAGGH GVSASRFGPC
660 670 680 690 700
ATLWASLDPV SVDTARLEHL FESRAKEVLP SKKAGEGRRT MTTVLDPKRS
710 720 730 740 750
NAINIGLTTL PPVHVIKAAL LNFDEFAVSK DGIEKLLTMM PTEEERQKIE
760 770 780 790 800
EAQLANPDIP LGPAENFLMT LASIGGLAAR LQLWAFKLDY DSMEREIAEP
810 820 830 840 850
LFDLKVGMEQ LVQNATFRCI LATLLAVGNF LNGSQSSGFE LSYLEKVSEV
860 870 880 890 900
KDTVRRQSLL HHLCSLVLQT RPESSDLYSE IPALTRCAKV DFEQLTENLG
910 920 930 940 950
QLERRSRAAE ESLRSLAKHE LAPALRARLT HFLDQCARRV AMLRIVHRRV
960 970 980 990 1000
CNRFHAFLLY LGYTPQAARE VRIMQFCHTL REFALEYRTC RERVLQQQQK
1010 1020 1030 1040 1050
QATYRERNKT RGRMITETEK FSGVAGEAPS NPSVPVAVSS GPGRGDADSH
1060 1070 1080 1090 1100
ASMKSLLTSR PEDTTHNRRS RGMVQSSSPI MPTVGPSTAS PEEPPGSSLP
1110 1120 1130 1140 1150
SDTSDEIMDL LVQSVTKSSP RALAARERKR SRGNRKSLRR TLKSGLGDDL
1160
VQALGLSKGP GLEV
Length:1,164
Mass (Da):126,551
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6C7AE1FB8DC3FC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BVE7H3BVE7_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTH7J3KTH7_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT53J3KT53_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR24J3QR24_HUMAN
FH1/FH2 domain-containing protein 1
FHOD1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249S → T in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti249S → T in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti264E → D in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti277T → M in BAD06250 (PubMed:14576350).Curated1
Sequence conflicti307 – 308EA → DT in AAD39906 (PubMed:10352228).Curated2
Sequence conflicti307 – 308EA → DT in AAO38757 (PubMed:15138285).Curated2
Sequence conflicti359E → D in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti387S → T in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti533P → L in BAD92821 (Ref. 6) Curated1
Sequence conflicti633 – 634EL → DV in AAD39906 (PubMed:10352228).Curated2
Sequence conflicti689R → Q in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti700S → T in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti745E → G in AAO38757 (PubMed:15138285).Curated1
Sequence conflicti751E → G in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti849E → D in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti1061P → L in AAD39906 (PubMed:10352228).Curated1
Sequence conflicti1061P → L in AAO38757 (PubMed:15138285).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF113615 mRNA Translation: AAD39906.1
AB041046 mRNA Translation: BAD06250.1
AY192154 mRNA Translation: AAO38757.1
BC033084 mRNA Translation: AAH33084.1
AB209584 mRNA Translation: BAD92821.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10834.1

NCBI Reference Sequences

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RefSeqi
NP_037373.2, NM_013241.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000258201; ENSP00000258201; ENSG00000135723

Database of genes from NCBI RefSeq genomes

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GeneIDi
29109

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29109

UCSC genome browser

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UCSCi
uc002esl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113615 mRNA Translation: AAD39906.1
AB041046 mRNA Translation: BAD06250.1
AY192154 mRNA Translation: AAO38757.1
BC033084 mRNA Translation: AAH33084.1
AB209584 mRNA Translation: BAD92821.1
CCDSiCCDS10834.1
RefSeqiNP_037373.2, NM_013241.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DADX-ray2.30A/B1-339[»]
SMRiQ9Y613
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118877, 42 interactors
DIPiDIP-31134N
IntActiQ9Y613, 28 interactors
MINTiQ9Y613
STRINGi9606.ENSP00000258201

PTM databases

iPTMnetiQ9Y613
MetOSiteiQ9Y613
PhosphoSitePlusiQ9Y613

Polymorphism and mutation databases

BioMutaiFHOD1
DMDMi62512187

Proteomic databases

EPDiQ9Y613
jPOSTiQ9Y613
MassIVEiQ9Y613
MaxQBiQ9Y613
PaxDbiQ9Y613
PeptideAtlasiQ9Y613
PRIDEiQ9Y613
ProteomicsDBi86575

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15694, 148 antibodies

Genome annotation databases

EnsembliENST00000258201; ENSP00000258201; ENSG00000135723
GeneIDi29109
KEGGihsa:29109
UCSCiuc002esl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29109
DisGeNETi29109
EuPathDBiHostDB:ENSG00000135723.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FHOD1
HGNCiHGNC:17905, FHOD1
HPAiENSG00000135723, Tissue enhanced (lymphoid tissue, skeletal muscle)
MIMi606881, gene
neXtProtiNX_Q9Y613
OpenTargetsiENSG00000135723
PharmGKBiPA28143

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1925, Eukaryota
GeneTreeiENSGT00940000160212
HOGENOMiCLU_000814_0_0_1
InParanoidiQ9Y613
KOiK23938
OMAiFHCILAT
PhylomeDBiQ9Y613
TreeFamiTF316268

Enzyme and pathway databases

PathwayCommonsiQ9Y613
SIGNORiQ9Y613

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
29109, 3 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FHOD1, human
EvolutionaryTraceiQ9Y613

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FHOD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29109
PharosiQ9Y613, Tbio

Protein Ontology

More...
PROi
PR:Q9Y613
RNActiQ9Y613, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135723, Expressed in spleen and 182 other tissues
ExpressionAtlasiQ9Y613, baseline and differential
GenevisibleiQ9Y613, HS

Family and domain databases

DisProtiDP00448
Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR027647, FHOD1
IPR041387, FHOD1_GBD_N
IPR014768, GBD/FH3_dom
PANTHERiPTHR45920:SF2, PTHR45920:SF2, 2 hits
PfamiView protein in Pfam
PF02181, FH2, 1 hit
PF18382, Formin_GBD_N, 1 hit
SMARTiView protein in SMART
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHOD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y613
Secondary accession number(s): Q59F76
, Q6Y1F2, Q76MS8, Q8N521
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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