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UniProtKB - Q9Y608 (LRRF2_HUMAN)

Entry version 157 (23 Feb 2022)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
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Protein

Leucine-rich repeat flightless-interacting protein 2

Gene

LRRFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • LRR domain binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y608

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y608

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y608

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat flightless-interacting protein 2
Short name:
LRR FLII-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRFIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6703, LRRFIP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614043, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y608

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000093167

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi190S → A: No change in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi200S → A: No change in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi202S → A: Reduction in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi202S → E: No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9209

Open Targets

More...OpenTargetsi		ENSG00000093167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30466

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y608, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRFIP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74721508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452461 – 721Leucine-rich repeat flightless-interacting protein 2Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei190Phosphoserine1 Publication1
Modified residuei202Phosphoserine1 Publication1
Modified residuei309PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei331PhosphothreonineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Isoform 2 (identifier: Q9Y608-2)
Modified residuei96PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Isoform 5 (identifier: Q9Y608-5)
Modified residuei168PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y608

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y608

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y608

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y608

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y608

PeptideAtlas

More...PeptideAtlasi		Q9Y608

PRoteomics IDEntifications database

More...PRIDEi		Q9Y608

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2344
86571 [Q9Y608-1]
86572 [Q9Y608-2]
86573 [Q9Y608-3]
86574 [Q9Y608-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y608

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y608

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y608

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000093167, Expressed in testis and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y608, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y608, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000093167, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with DVL3.

Interacts with FLII. Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation at Ser-202. In the presence of LPS, competes with FLII for MYD88-binding.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114643, 87 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y608, 54 interactors

Molecular INTeraction database

More...MINTi		Q9Y608

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338727

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y608, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y608

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 370DVL3-bindingAdd BLAST370
Regioni232 – 262DisorderedSequence analysisAdd BLAST31
Regioni295 – 338DisorderedSequence analysisAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 49Sequence analysisAdd BLAST28
Coiled coili349 – 524Sequence analysisAdd BLAST176
Coiled coili566 – 714Sequence analysisAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi232 – 251Polar residuesSequence analysisAdd BLAST20
Compositional biasi302 – 338Polar residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRFIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2010, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063564

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018871_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y608

Identification of Orthologs from Complete Genome Data

More...OMAi		RASPIAN

Database of Orthologous Groups

More...OrthoDBi		1434475at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y608

TreeFam database of animal gene trees

More...TreeFami		TF314109

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019139, LRRFIP1/2

The PANTHER Classification System

More...PANTHERi		PTHR19212, PTHR19212, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09738, LRRFIP, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM 
        60         70         80         90        100
RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA 
       110        120        130        140        150
LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY 
       160        170        180        190        200
FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS 
       210        220        230        240        250
ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS 
       260        270        280        290        300
DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY 
       310        320        330        340        350
AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL 
       360        370        380        390        400
KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV 
       410        420        430        440        450
DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR 
       460        470        480        490        500
QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL 
       510        520        530        540        550
RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV 
       560        570        580        590        600
SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR 
       610        620        630        640        650
NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS 
       660        670        680        690        700
ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN 
       710        720 
SHLAKRLEKM KANRTALLAQ Q
Length:721
Mass (Da):82,171
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94B18B274656CB0B
GO
Isoform 2 (identifier: Q9Y608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     346-369: Missing.
     457-521: Missing.

Show »
Length:400
Mass (Da):45,414
Checksum:iAD687735EAFE04F6
GO
Isoform 3 (identifier: Q9Y608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.

Show »
Length:100
Mass (Da):11,736
Checksum:iEFCDC5B6AC68785F
GO
Isoform 4 (identifier: Q9Y608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     457-521: Missing.

Show »
Length:424
Mass (Da):48,294
Checksum:iA5BFF9F6869503DE
GO
Isoform 5 (identifier: Q9Y608-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-76: Missing.
     111-124: Missing.
     146-202: Missing.
     220-291: Missing.
     346-369: Missing.
     489-522: Missing.

Show »
Length:503
Mass (Da):57,394
Checksum:i965FF6DABB76907F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSU1C9JSU1_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3N9H7C3N9_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJC9C9JJC9_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J321C9J321_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JC17C9JC17_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0U5C9J0U5_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050001143K → E. Corresponds to variant dbSNP:rs34902788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0196741 – 621Missing in isoform 3. 1 PublicationAdd BLAST621
Alternative sequenceiVSP_01967560 – 291Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST232
Alternative sequenceiVSP_05696960 – 76Missing in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056970111 – 124Missing in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_056971146 – 202Missing in isoform 5. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_056972220 – 291Missing in isoform 5. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_019676346 – 369Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_019677457 – 521Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_056973489 – 522Missing in isoform 5. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF115509 mRNA Translation: AAD41257.1
AK000255 mRNA Translation: BAA91035.1
AK291514 mRNA Translation: BAF84203.1
AK302282 mRNA Translation: BAG63625.1
CR749705 mRNA Translation: CAH18481.1
AC006583 Genomic DNA No translation available.
AC126118 Genomic DNA No translation available.
BC053668 mRNA Translation: AAH53668.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2664.1 [Q9Y608-1]
CCDS2665.1 [Q9Y608-2]
CCDS46791.1 [Q9Y608-4]
CCDS63592.1 [Q9Y608-5]

Protein sequence database of the Protein Information Resource

More...PIRi		T50611

NCBI Reference Sequences

More...RefSeqi		NP_001127841.1, NM_001134369.2 [Q9Y608-4]
NP_001269620.1, NM_001282691.1 [Q9Y608-5]
NP_001335239.1, NM_001348310.1 [Q9Y608-4]
NP_001335240.1, NM_001348311.1 [Q9Y608-2]
NP_006300.1, NM_006309.3 [Q9Y608-1]
NP_060194.1, NM_017724.2 [Q9Y608-2]
XP_005265596.1, XM_005265539.2 [Q9Y608-1]
XP_005265597.1, XM_005265540.1 [Q9Y608-1]
XP_011532519.1, XM_011534217.1 [Q9Y608-1]
XP_011532520.1, XM_011534218.1 [Q9Y608-1]
XP_011532521.1, XM_011534219.1 [Q9Y608-1]
XP_016862973.1, XM_017007484.1 [Q9Y608-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336686; ENSP00000338727; ENSG00000093167
ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2]
ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5]
ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4]
ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9209

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000336686.9; ENSP00000338727.4; NM_006309.4; NP_006300.1

UCSC genome browser

More...UCSCi		uc003cgs.4, human [Q9Y608-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115509 mRNA Translation: AAD41257.1
AK000255 mRNA Translation: BAA91035.1
AK291514 mRNA Translation: BAF84203.1
AK302282 mRNA Translation: BAG63625.1
CR749705 mRNA Translation: CAH18481.1
AC006583 Genomic DNA No translation available.
AC126118 Genomic DNA No translation available.
BC053668 mRNA Translation: AAH53668.1
CCDSiCCDS2664.1 [Q9Y608-1]
CCDS2665.1 [Q9Y608-2]
CCDS46791.1 [Q9Y608-4]
CCDS63592.1 [Q9Y608-5]
PIRiT50611
RefSeqiNP_001127841.1, NM_001134369.2 [Q9Y608-4]
NP_001269620.1, NM_001282691.1 [Q9Y608-5]
NP_001335239.1, NM_001348310.1 [Q9Y608-4]
NP_001335240.1, NM_001348311.1 [Q9Y608-2]
NP_006300.1, NM_006309.3 [Q9Y608-1]
NP_060194.1, NM_017724.2 [Q9Y608-2]
XP_005265596.1, XM_005265539.2 [Q9Y608-1]
XP_005265597.1, XM_005265540.1 [Q9Y608-1]
XP_011532519.1, XM_011534217.1 [Q9Y608-1]
XP_011532520.1, XM_011534218.1 [Q9Y608-1]
XP_011532521.1, XM_011534219.1 [Q9Y608-1]
XP_016862973.1, XM_017007484.1 [Q9Y608-4]

3D structure databases

SMRiQ9Y608
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114643, 87 interactors
IntActiQ9Y608, 54 interactors
MINTiQ9Y608
STRINGi9606.ENSP00000338727

PTM databases

iPTMnetiQ9Y608
MetOSiteiQ9Y608
PhosphoSitePlusiQ9Y608

Genetic variation databases

BioMutaiLRRFIP2
DMDMi74721508

Proteomic databases

EPDiQ9Y608
jPOSTiQ9Y608
MassIVEiQ9Y608
MaxQBiQ9Y608
PaxDbiQ9Y608
PeptideAtlasiQ9Y608
PRIDEiQ9Y608
ProteomicsDBi2344
86571 [Q9Y608-1]
86572 [Q9Y608-2]
86573 [Q9Y608-3]
86574 [Q9Y608-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28249, 192 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		9209

Genome annotation databases

EnsembliENST00000336686; ENSP00000338727; ENSG00000093167
ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2]
ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5]
ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4]
ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]
GeneIDi9209
KEGGihsa:9209
MANE-SelectiENST00000336686.9; ENSP00000338727.4; NM_006309.4; NP_006300.1
UCSCiuc003cgs.4, human [Q9Y608-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9209
DisGeNETi9209

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRFIP2
HGNCiHGNC:6703, LRRFIP2
HPAiENSG00000093167, Low tissue specificity
MIMi614043, gene
neXtProtiNX_Q9Y608
OpenTargetsiENSG00000093167
PharmGKBiPA30466
VEuPathDBiHostDB:ENSG00000093167

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2010, Eukaryota
GeneTreeiENSGT00530000063564
HOGENOMiCLU_018871_2_0_1
InParanoidiQ9Y608
OMAiRASPIAN
OrthoDBi1434475at2759
PhylomeDBiQ9Y608
TreeFamiTF314109

Enzyme and pathway databases

PathwayCommonsiQ9Y608
SignaLinkiQ9Y608
SIGNORiQ9Y608

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9209, 5 hits in 1041 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRFIP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9209
PharosiQ9Y608, Tbio

Protein Ontology

More...PROi		PR:Q9Y608
RNActiQ9Y608, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000093167, Expressed in testis and 233 other tissues
ExpressionAtlasiQ9Y608, baseline and differential
GenevisibleiQ9Y608, HS

Family and domain databases

InterProiView protein in InterPro
IPR019139, LRRFIP1/2
PANTHERiPTHR19212, PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738, LRRFIP, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y608
Secondary accession number(s): A8K649
, A8MXR0, B4DY63, Q68CV3, Q9NXH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: February 23, 2022
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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