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Entry version 142 (31 Jul 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Leucine-rich repeat flightless-interacting protein 2

Gene

LRRFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • LRR domain binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y608

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y608

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat flightless-interacting protein 2
Short name:
LRR FLII-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRFIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6703 LRRFIP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614043 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y608

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi190S → A: No change in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi200S → A: No change in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi202S → A: Reduction in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi202S → E: No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9209

Open Targets

More...
OpenTargetsi
ENSG00000093167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30466

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRFIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74721508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452461 – 721Leucine-rich repeat flightless-interacting protein 2Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei190Phosphoserine1 Publication1
Modified residuei202Phosphoserine1 Publication1
Modified residuei309PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei331PhosphothreonineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Isoform 2 (identifier: Q9Y608-2)
Modified residuei96PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Isoform 5 (identifier: Q9Y608-5)
Modified residuei168PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y608

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y608

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y608

PeptideAtlas

More...
PeptideAtlasi
Q9Y608

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y608

ProteomicsDB human proteome resource

More...
ProteomicsDBi
2344
86571 [Q9Y608-1]
86572 [Q9Y608-2]
86573 [Q9Y608-3]
86574 [Q9Y608-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y608

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y608

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000093167 Expressed in 221 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y608 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y608 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035956
HPA042023

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with DVL3.

Interacts with FLII. Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation at Ser-202. In the presence of LPS, competes with FLII for MYD88-binding.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114643, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y608, 44 interactors

Molecular INTeraction database

More...
MINTi
Q9Y608

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338727

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y608

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 370DVL3-bindingAdd BLAST370

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili22 – 49Sequence analysisAdd BLAST28
Coiled coili349 – 524Sequence analysisAdd BLAST176
Coiled coili566 – 714Sequence analysisAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 342Ser-richAdd BLAST225

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRFIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2010 Eukaryota
ENOG4111H1S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063564

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294125

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y608

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHHSFDR

Database of Orthologous Groups

More...
OrthoDBi
1434475at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y608

TreeFam database of animal gene trees

More...
TreeFami
TF314109

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019139 LRRFIP1/2

The PANTHER Classification System

More...
PANTHERi
PTHR19212 PTHR19212, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09738 LRRFIP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM
60 70 80 90 100
RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA
110 120 130 140 150
LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY
160 170 180 190 200
FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS
210 220 230 240 250
ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS
260 270 280 290 300
DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY
310 320 330 340 350
AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL
360 370 380 390 400
KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV
410 420 430 440 450
DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR
460 470 480 490 500
QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL
510 520 530 540 550
RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV
560 570 580 590 600
SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR
610 620 630 640 650
NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS
660 670 680 690 700
ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN
710 720
SHLAKRLEKM KANRTALLAQ Q
Length:721
Mass (Da):82,171
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94B18B274656CB0B
GO
Isoform 2 (identifier: Q9Y608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     346-369: Missing.
     457-521: Missing.

Show »
Length:400
Mass (Da):45,414
Checksum:iAD687735EAFE04F6
GO
Isoform 3 (identifier: Q9Y608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.

Show »
Length:100
Mass (Da):11,736
Checksum:iEFCDC5B6AC68785F
GO
Isoform 4 (identifier: Q9Y608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     457-521: Missing.

Show »
Length:424
Mass (Da):48,294
Checksum:iA5BFF9F6869503DE
GO
Isoform 5 (identifier: Q9Y608-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-76: Missing.
     111-124: Missing.
     146-202: Missing.
     220-291: Missing.
     346-369: Missing.
     489-522: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:503
Mass (Da):57,394
Checksum:i965FF6DABB76907F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSU1C9JSU1_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J321C9J321_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3N9H7C3N9_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJC9C9JJC9_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JC17C9JC17_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0U5C9J0U5_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050001143K → E. Corresponds to variant dbSNP:rs34902788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0196741 – 621Missing in isoform 3. 1 PublicationAdd BLAST621
Alternative sequenceiVSP_01967560 – 291Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST232
Alternative sequenceiVSP_05696960 – 76Missing in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056970111 – 124Missing in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_056971146 – 202Missing in isoform 5. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_056972220 – 291Missing in isoform 5. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_019676346 – 369Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_019677457 – 521Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_056973489 – 522Missing in isoform 5. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF115509 mRNA Translation: AAD41257.1
AK000255 mRNA Translation: BAA91035.1
AK291514 mRNA Translation: BAF84203.1
AK302282 mRNA Translation: BAG63625.1
CR749705 mRNA Translation: CAH18481.1
AC006583 Genomic DNA No translation available.
AC126118 Genomic DNA No translation available.
BC053668 mRNA Translation: AAH53668.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2664.1 [Q9Y608-1]
CCDS2665.1 [Q9Y608-2]
CCDS46791.1 [Q9Y608-4]
CCDS63592.1 [Q9Y608-5]

Protein sequence database of the Protein Information Resource

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PIRi
T50611

NCBI Reference Sequences

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RefSeqi
NP_001127841.1, NM_001134369.2 [Q9Y608-4]
NP_001269620.1, NM_001282691.1 [Q9Y608-5]
NP_001335239.1, NM_001348310.1 [Q9Y608-4]
NP_001335240.1, NM_001348311.1 [Q9Y608-2]
NP_006300.1, NM_006309.3 [Q9Y608-1]
NP_060194.1, NM_017724.2 [Q9Y608-2]
XP_005265596.1, XM_005265539.2 [Q9Y608-1]
XP_005265597.1, XM_005265540.1 [Q9Y608-1]
XP_011532519.1, XM_011534217.1 [Q9Y608-1]
XP_011532520.1, XM_011534218.1 [Q9Y608-1]
XP_011532521.1, XM_011534219.1 [Q9Y608-1]
XP_016862973.1, XM_017007484.1 [Q9Y608-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336686; ENSP00000338727; ENSG00000093167 [Q9Y608-1]
ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2]
ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5]
ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4]
ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9209

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9209

UCSC genome browser

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UCSCi
uc003cgs.4 human [Q9Y608-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115509 mRNA Translation: AAD41257.1
AK000255 mRNA Translation: BAA91035.1
AK291514 mRNA Translation: BAF84203.1
AK302282 mRNA Translation: BAG63625.1
CR749705 mRNA Translation: CAH18481.1
AC006583 Genomic DNA No translation available.
AC126118 Genomic DNA No translation available.
BC053668 mRNA Translation: AAH53668.1
CCDSiCCDS2664.1 [Q9Y608-1]
CCDS2665.1 [Q9Y608-2]
CCDS46791.1 [Q9Y608-4]
CCDS63592.1 [Q9Y608-5]
PIRiT50611
RefSeqiNP_001127841.1, NM_001134369.2 [Q9Y608-4]
NP_001269620.1, NM_001282691.1 [Q9Y608-5]
NP_001335239.1, NM_001348310.1 [Q9Y608-4]
NP_001335240.1, NM_001348311.1 [Q9Y608-2]
NP_006300.1, NM_006309.3 [Q9Y608-1]
NP_060194.1, NM_017724.2 [Q9Y608-2]
XP_005265596.1, XM_005265539.2 [Q9Y608-1]
XP_005265597.1, XM_005265540.1 [Q9Y608-1]
XP_011532519.1, XM_011534217.1 [Q9Y608-1]
XP_011532520.1, XM_011534218.1 [Q9Y608-1]
XP_011532521.1, XM_011534219.1 [Q9Y608-1]
XP_016862973.1, XM_017007484.1 [Q9Y608-4]

3D structure databases

SMRiQ9Y608
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114643, 58 interactors
IntActiQ9Y608, 44 interactors
MINTiQ9Y608
STRINGi9606.ENSP00000338727

PTM databases

iPTMnetiQ9Y608
PhosphoSitePlusiQ9Y608

Polymorphism and mutation databases

BioMutaiLRRFIP2
DMDMi74721508

Proteomic databases

EPDiQ9Y608
jPOSTiQ9Y608
PaxDbiQ9Y608
PeptideAtlasiQ9Y608
PRIDEiQ9Y608
ProteomicsDBi2344
86571 [Q9Y608-1]
86572 [Q9Y608-2]
86573 [Q9Y608-3]
86574 [Q9Y608-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336686; ENSP00000338727; ENSG00000093167 [Q9Y608-1]
ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2]
ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5]
ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4]
ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]
GeneIDi9209
KEGGihsa:9209
UCSCiuc003cgs.4 human [Q9Y608-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9209
DisGeNETi9209

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRFIP2
HGNCiHGNC:6703 LRRFIP2
HPAiHPA035956
HPA042023
MIMi614043 gene
neXtProtiNX_Q9Y608
OpenTargetsiENSG00000093167
PharmGKBiPA30466

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2010 Eukaryota
ENOG4111H1S LUCA
GeneTreeiENSGT00530000063564
HOGENOMiHOG000294125
InParanoidiQ9Y608
OMAiSHHSFDR
OrthoDBi1434475at2759
PhylomeDBiQ9Y608
TreeFamiTF314109

Enzyme and pathway databases

SignaLinkiQ9Y608
SIGNORiQ9Y608

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRFIP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9209

Protein Ontology

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PROi
PR:Q9Y608

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000093167 Expressed in 221 organ(s), highest expression level in testis
ExpressionAtlasiQ9Y608 baseline and differential
GenevisibleiQ9Y608 HS

Family and domain databases

InterProiView protein in InterPro
IPR019139 LRRFIP1/2
PANTHERiPTHR19212 PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738 LRRFIP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y608
Secondary accession number(s): A8K649
, A8MXR0, B4DY63, Q68CV3, Q9NXH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: July 31, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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