UniProtKB - Q9Y608 (LRRF2_HUMAN)

BLAST

>sp|Q9Y608|LRRF2_HUMAN Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY
SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR
LSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDP
LATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFT
NDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQY
AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGR
YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE
NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETL
LWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSH
EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR
NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR
YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ
Q

Align

Format
Add to basket Added to basket
History
Entry version 136 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Leucine-rich repeat flightless-interacting protein 2

Gene

LRRFIP2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.2 Publications

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
LRR domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10366446

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Wnt signaling pathway

Biological process

Wnt signaling pathway

Enzyme and pathway databases

SignaLinkⁱ	Q9Y608
SIGNORⁱ	Q9Y608

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich repeat flightless-interacting protein 2 Short name: LRR FLII-interacting protein 2
Gene namesⁱ	Name:LRRFIP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000093167.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6703 LRRFIP2
MIMⁱ	614043 gene
neXtProtⁱ	NX_Q9Y608

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	190	S → A: No change in LPS-induced NFKB activity. 1 Publication	1
Mutagenesisⁱ	200	S → A: No change in LPS-induced NFKB activity. 1 Publication	1
Mutagenesisⁱ	202	S → A: Reduction in LPS-induced NFKB activity. 1 Publication	1
Mutagenesisⁱ	202	S → E: No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9209
Open Targets More...OpenTargetsⁱ	ENSG00000093167
PharmGKBⁱ	PA30466

Polymorphism and mutation databases

BioMutaⁱ	LRRFIP2
DMDMⁱ	74721508

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000245246	1 – 721	Leucine-rich repeat flightless-interacting protein 2Add BLAST		721

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	PhosphoserineCombined sources	1
Modified residueⁱ	190	Phosphoserine1 Publication	1
Modified residueⁱ	202	Phosphoserine1 Publication	1
Modified residueⁱ	309	PhosphoserineCombined sources	1
Modified residueⁱ	312	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources	1
Modified residueⁱ	324	PhosphoserineCombined sources	1
Modified residueⁱ	328	PhosphoserineCombined sources	1
Modified residueⁱ	331	PhosphothreonineBy similarity	1
Modified residueⁱ	332	PhosphoserineBy similarity	1
Modified residueⁱ	333	PhosphoserineBy similarity	1
Isoform 2 (identifier: Q9Y608-2)
Modified residueⁱ	96	PhosphoserineCombined sources	1
Modified residueⁱ	101	PhosphoserineCombined sources	1
Isoform 5 (identifier: Q9Y608-5)
Modified residueⁱ	168	PhosphoserineCombined sources	1
Modified residueⁱ	173	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y608
PaxDbⁱ	Q9Y608
PeptideAtlas More...PeptideAtlasⁱ	Q9Y608
PRIDEⁱ	Q9Y608
ProteomicsDBⁱ	86571 86572 [Q9Y608-2] 86573 [Q9Y608-3] 86574 [Q9Y608-4]

PTM databases

iPTMnetⁱ	Q9Y608
PhosphoSitePlusⁱ	Q9Y608

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000093167 Expressed in 221 organ(s), highest expression level in testis
CleanExⁱ	HS_LRRFIP2
ExpressionAtlasⁱ	Q9Y608 baseline and differential
Genevisibleⁱ	Q9Y608 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035956 HPA042023

HPAⁱ

HPA035956
HPA042023

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus) with DVL3. Interacts with FLII. Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation at Ser-202. In the presence of LPS, competes with FLII for MYD88-binding.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATPAF2	Q8N5M1	3	EBI-12696250,EBI-1166928
DVL3	Q92997	2	EBI-1023718,EBI-739789

GO - Molecular functionⁱ

LRR domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10366446

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114643, 47 interactors
IntActⁱ	Q9Y608, 40 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y608
STRINGⁱ	9606.ENSP00000338727

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y608
SMRⁱ	Q9Y608
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 370	DVL3-bindingAdd BLAST		370

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	22 – 49	Sequence analysisAdd BLAST	28
Coiled coilⁱ	349 – 524	Sequence analysisAdd BLAST	176
Coiled coilⁱ	566 – 714	Sequence analysisAdd BLAST	149

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	118 – 342	Ser-richAdd BLAST		225

Sequence similaritiesⁱ

Belongs to the LRRFIP family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2010 Eukaryota ENOG4111H1S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063564
HOGENOMⁱ	HOG000294125
HOVERGENⁱ	HBG061558
InParanoidⁱ	Q9Y608
OMAⁱ	RQQKEHS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C5Y
PhylomeDBⁱ	Q9Y608
TreeFamⁱ	TF314109

Family and domain databases

InterProⁱ	View protein in InterPro IPR019139 LRRFIP1/2
PANTHERⁱ	PTHR19212 PTHR19212, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09738 LRRFIP, 3 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y608-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM 
        60         70         80         90        100
RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA 
       110        120        130        140        150
LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY 
       160        170        180        190        200
FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS 
       210        220        230        240        250
ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS 
       260        270        280        290        300
DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY 
       310        320        330        340        350
AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL 
       360        370        380        390        400
KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV 
       410        420        430        440        450
DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR 
       460        470        480        490        500
QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL 
       510        520        530        540        550
RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV 
       560        570        580        590        600
SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR 
       610        620        630        640        650
NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS 
       660        670        680        690        700
ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN 
       710        720 
SHLAKRLEKM KANRTALLAQ Q

Length:721

Mass (Da):82,171

Last modified:November 1, 1999 - v1

Checksum:ⁱ94B18B274656CB0B

Isoform 2 (identifier: Q9Y608-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     346-369: Missing.
     457-521: Missing.

« Hide

        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM 
        60         70         80         90        100
RELERQQKEL DEKSDKQYAE NYTRPSSRNS ASATTPLSGN SSRRGSGDTS 
       110        120        130        140        150
SLIDPDTSLS ELRESLSEVE EKYKKAMVSN AQLDNEKNNL IYQVDTLKDV 
       160        170        180        190        200
IEEQEEQMAE FYRENEEKSK ELERQKHMCS VLQHKMEELK EGLRQRDELI 
       210        220        230        240        250
EKHGLVIIPD GTPNGDVSHE PVAGAITVVS QEAAQVLESA GEGPLDVRLR 
       260        270        280        290        300
KLAGEKEELL SQIRKLKLQL EEERQKCSRN DGTVGDLAGL QNGSDLQFIE 
       310        320        330        340        350
MQRDANRQIS EYKFKLSKAE QDITTLEQSI SRLEGQVLRY KTAAENAEKV 
       360        370        380        390        400
EDELKAEKRK LQRELRTALD KIEEMEMTNS HLAKRLEKMK ANRTALLAQQ

Show »

Length:400

Mass (Da):45,414

Checksum:ⁱAD687735EAFE04F6

Isoform 3 (identifier: Q9Y608-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-621: Missing.

« Hide

        10         20         30         40         50
MQRDANRQIS EYKFKLSKAE QDITTLEQSI SRLEGQVLRY KTAAENAEKV 
        60         70         80         90        100
EDELKAEKRK LQRELRTALD KIEEMEMTNS HLAKRLEKMK ANRTALLAQQ

Show »

Length:100

Mass (Da):11,736

Checksum:ⁱEFCDC5B6AC68785F

Isoform 4 (identifier: Q9Y608-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
60-291: Missing.
457-521: Missing.

« Hide

        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM 
        60         70         80         90        100
RELERQQKEL DEKSDKQYAE NYTRPSSRNS ASATTPLSGN SSRRGSGDTS 
       110        120        130        140        150
SLIDPDTSLS ELRDIYDLKD QIQDVEGRYM QGLKELKESL SEVEEKYKKA 
       160        170        180        190        200
MVSNAQLDNE KNNLIYQVDT LKDVIEEQEE QMAEFYRENE EKSKELERQK 
       210        220        230        240        250
HMCSVLQHKM EELKEGLRQR DELIEKHGLV IIPDGTPNGD VSHEPVAGAI 
       260        270        280        290        300
TVVSQEAAQV LESAGEGPLD VRLRKLAGEK EELLSQIRKL KLQLEEERQK 
       310        320        330        340        350
CSRNDGTVGD LAGLQNGSDL QFIEMQRDAN RQISEYKFKL SKAEQDITTL 
       360        370        380        390        400
EQSISRLEGQ VLRYKTAAEN AEKVEDELKA EKRKLQRELR TALDKIEEME 
       410        420 
MTNSHLAKRL EKMKANRTAL LAQQ

Show »

Length:424

Mass (Da):48,294

Checksum:ⁱA5BFF9F6869503DE

Isoform 5 (identifier: Q9Y608-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-76: Missing.
     111-124: Missing.
     146-202: Missing.
     220-291: Missing.
     346-369: Missing.
     489-522: Missing.

« Hide

        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM 
        60         70         80         90        100
RELERQQKEE DSERARYSHR SSHHRPYLGV EDALSIRSVG SHRNHSYSHS 
       110        120        130        140        150
HGMKKRSSDS HKDLLASLYN GGLYNPYGPR TLDEKSDKQY AENYTRPSSR 
       160        170        180        190        200
NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRESLSE VEEKYKKAMV 
       210        220        230        240        250
SNAQLDNEKN NLIYQVDTLK DVIEEQEEQM AEFYRENEEK SKELERQKHM 
       260        270        280        290        300
CSVLQHKMEE LKEGLRQRDE LIEEKQRMQQ KIDTMTKEVF DLQETLLWKD 
       310        320        330        340        350
KKIGKHGLVI IPDGTPNGDV SHEPVAGAIT VVSQEAAQVL ESAGEGPLDV 
       360        370        380        390        400
RLRKLAGEKE ELLSQIRKLK LQLEEERQKC SRNDGTVGDL AGLQNGSDLQ 
       410        420        430        440        450
FIEMQRDANR QISEYKFKLS KAEQDITTLE QSISRLEGQV LRYKTAAENA 
       460        470        480        490        500
EKVEDELKAE KRKLQRELRT ALDKIEEMEM TNSHLAKRLE KMKANRTALL 

AQQ

Note: No experimental confirmation available.Combined sources

Show »

Length:503

Mass (Da):57,394

Checksum:ⁱ965FF6DABB76907F

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JSU1	C9JSU1_HUMAN	Leucine-rich repeat flightless-inte... Leucine-rich repeat flightless-interacting protein 2	LRRFIP2	225	Annotation score:
C9JJC9	C9JJC9_HUMAN	Leucine-rich repeat flightless-inte... Leucine-rich repeat flightless-interacting protein 2	LRRFIP2	59	Annotation score:
C9J321	C9J321_HUMAN	Leucine-rich repeat flightless-inte... Leucine-rich repeat flightless-interacting protein 2	LRRFIP2	59	Annotation score:
H7C3N9	H7C3N9_HUMAN	Leucine-rich repeat flightless-inte... Leucine-rich repeat flightless-interacting protein 2	LRRFIP2	182	Annotation score:
C9J0U5	C9J0U5_HUMAN	Leucine-rich repeat flightless-inte... Leucine-rich repeat flightless-interacting protein 2	LRRFIP2	67	Annotation score:
C9JC17	C9JC17_HUMAN	Leucine-rich repeat flightless-inte... Leucine-rich repeat flightless-interacting protein 2	LRRFIP2	59	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050001	143	K → E. Corresponds to variant dbSNP:rs34902788Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019674	1 – 621	Missing in isoform 3. 1 PublicationAdd BLAST	621
Alternative sequenceⁱVSP_019675	60 – 291	Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST	232
Alternative sequenceⁱVSP_056969	60 – 76	Missing in isoform 5. 1 PublicationAdd BLAST	17
Alternative sequenceⁱVSP_056970	111 – 124	Missing in isoform 5. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_056971	146 – 202	Missing in isoform 5. 1 PublicationAdd BLAST	57
Alternative sequenceⁱVSP_056972	220 – 291	Missing in isoform 5. 1 PublicationAdd BLAST	72
Alternative sequenceⁱVSP_019676	346 – 369	Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST	24
Alternative sequenceⁱVSP_019677	457 – 521	Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST	65
Alternative sequenceⁱVSP_056973	489 – 522	Missing in isoform 5. 1 PublicationAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF115509 mRNA Translation: AAD41257.1 AK000255 mRNA Translation: BAA91035.1 AK291514 mRNA Translation: BAF84203.1 AK302282 mRNA Translation: BAG63625.1 CR749705 mRNA Translation: CAH18481.1 AC006583 Genomic DNA No translation available. AC126118 Genomic DNA No translation available. BC053668 mRNA Translation: AAH53668.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2664.1 [Q9Y608-1] CCDS2665.1 [Q9Y608-2] CCDS46791.1 [Q9Y608-4] CCDS63592.1 [Q9Y608-5]
PIRⁱ	T50611
NCBI Reference Sequences More...RefSeqⁱ	NP_001127841.1, NM_001134369.2 [Q9Y608-4] NP_001269620.1, NM_001282691.1 [Q9Y608-5] NP_001335239.1, NM_001348310.1 [Q9Y608-4] NP_001335240.1, NM_001348311.1 [Q9Y608-2] NP_006300.1, NM_006309.3 [Q9Y608-1] NP_060194.1, NM_017724.2 [Q9Y608-2] XP_005265596.1, XM_005265539.2 [Q9Y608-1] XP_005265597.1, XM_005265540.1 [Q9Y608-1] XP_011532519.1, XM_011534217.1 [Q9Y608-1] XP_011532520.1, XM_011534218.1 [Q9Y608-1] XP_011532521.1, XM_011534219.1 [Q9Y608-1] XP_016862973.1, XM_017007484.1 [Q9Y608-4]
UniGeneⁱ	Hs.740522

Genome annotation databases

Ensemblⁱ	ENST00000336686; ENSP00000338727; ENSG00000093167 [Q9Y608-1] ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2] ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5] ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4] ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]
GeneIDⁱ	9209
KEGGⁱ	hsa:9209
UCSC genome browser More...UCSCⁱ	uc003cgs.4 human [Q9Y608-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9Y608	Leucine rich repeat (In FLII) interacting protein 2, isoform CRA_b		HUMAN		742	UniRef90_Q9Y608
LRR binding FLII interacting protein 2		HORSE		722
leucine-rich repeat flightless-interacting protein 2 isoform X1		MESAU		722
Leucine-rich repeat flightless-interacting protein 2		HETGA		722
LRR binding FLII interacting protein 2		MACMU		721
+123
Q9Y608-2	Leucine-rich repeat flightless-interacting protein 2		MOUSE		415	UniRef90_Q9Y608-2
Leucine-rich repeat flightless-interacting protein 2		BOVIN		400
Putative double stranded rna binding protein		DESRO		416
Uncharacterized protein		CAVPO		415
Uncharacterized protein		ICTTR		415
+101
Q9Y608-3	Leucine rich repeat interacting protein 2 (Fragment)		MUSPF		178	UniRef90_Q9Y608-3
Uncharacterized protein		PAPAN		764
leucine-rich repeat flightless-interacting protein 2 isoform X1		BALAS		744
Uncharacterized protein		CERAT		743
Uncharacterized protein		CHLSB		743
+111
Q9Y608-4	Putative double stranded rna binding protein		DESRO		440	UniRef90_Q9Y608-4
Uncharacterized protein		MACMU		439
leucine-rich repeat flightless-interacting protein 2 isoform X8		BALAS		424
LRR binding FLII interacting protein 2		SAIBB		424
Uncharacterized protein		Cebus capucinus imitator		394
+120
Q9Y608-5	leucine-rich repeat flightless-interacting protein 2 isoform X2		ERIEU		504	UniRef90_Q9Y608-5
LRR binding FLII interacting protein 2		PANTR		503
LRR binding FLII interacting protein 2		SAIBB		503
Uncharacterized protein		CALJA		503
Uncharacterized protein		MACMU		503
+28

Protein	Similar proteins		Species	Score	Length	Source
Q9Y608	Leucine-rich repeat flightless-interacting protein 2		XENLA		729	UniRef50_Q9Y608
Leucine rich repeat (In FLII) interacting protein 2, isoform CRA_b		HUMAN		742
leucine-rich repeat flightless-interacting protein 2 isoform X1		MESAU		722
LRR binding FLII interacting protein 2		HORSE		722
Leucine-rich repeat flightless-interacting protein 2		HETGA		722
+1043
Q9Y608-2	Isoform 5 of Leucine-rich repeat flightless-interacting protein 2		HUMAN		503	UniRef50_Q9Y608-5
Leucine-rich repeat flightless-interacting protein 2		MOUSE		415
Leucine-rich repeat flightless-interacting protein 2		BOVIN		400
Leucine-rich repeat flightless-interacting protein 2		RAT		437
leucine-rich repeat flightless-interacting protein 2 isoform X2		ERIEU		504
+596
Q9Y608-4	Isoform 5 of Leucine-rich repeat flightless-interacting protein 2		HUMAN		503	UniRef50_Q9Y608-5
Leucine-rich repeat flightless-interacting protein 2		MOUSE		415
Leucine-rich repeat flightless-interacting protein 2		BOVIN		400
Leucine-rich repeat flightless-interacting protein 2		RAT		437
leucine-rich repeat flightless-interacting protein 2 isoform X2		ERIEU		504
+596
Q9Y608-5	Leucine-rich repeat flightless-interacting protein 2		MOUSE		415	UniRef50_Q9Y608-5
Leucine-rich repeat flightless-interacting protein 2		BOVIN		400
Leucine-rich repeat flightless-interacting protein 2		RAT		437
leucine-rich repeat flightless-interacting protein 2 isoform X2		ERIEU		504
LRR binding FLII interacting protein 2		GORGO		503
+596

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF115509 mRNA Translation: AAD41257.1 AK000255 mRNA Translation: BAA91035.1 AK291514 mRNA Translation: BAF84203.1 AK302282 mRNA Translation: BAG63625.1 CR749705 mRNA Translation: CAH18481.1 AC006583 Genomic DNA No translation available. AC126118 Genomic DNA No translation available. BC053668 mRNA Translation: AAH53668.1
CCDSⁱ	CCDS2664.1 [Q9Y608-1] CCDS2665.1 [Q9Y608-2] CCDS46791.1 [Q9Y608-4] CCDS63592.1 [Q9Y608-5]
PIRⁱ	T50611
RefSeqⁱ	NP_001127841.1, NM_001134369.2 [Q9Y608-4] NP_001269620.1, NM_001282691.1 [Q9Y608-5] NP_001335239.1, NM_001348310.1 [Q9Y608-4] NP_001335240.1, NM_001348311.1 [Q9Y608-2] NP_006300.1, NM_006309.3 [Q9Y608-1] NP_060194.1, NM_017724.2 [Q9Y608-2] XP_005265596.1, XM_005265539.2 [Q9Y608-1] XP_005265597.1, XM_005265540.1 [Q9Y608-1] XP_011532519.1, XM_011534217.1 [Q9Y608-1] XP_011532520.1, XM_011534218.1 [Q9Y608-1] XP_011532521.1, XM_011534219.1 [Q9Y608-1] XP_016862973.1, XM_017007484.1 [Q9Y608-4]
UniGeneⁱ	Hs.740522

3D structure databases

ProteinModelPortalⁱ	Q9Y608
SMRⁱ	Q9Y608
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114643, 47 interactors
IntActⁱ	Q9Y608, 40 interactors
MINTⁱ	Q9Y608
STRINGⁱ	9606.ENSP00000338727

PTM databases

iPTMnetⁱ	Q9Y608
PhosphoSitePlusⁱ	Q9Y608

Polymorphism and mutation databases

BioMutaⁱ	LRRFIP2
DMDMⁱ	74721508

Proteomic databases

EPDⁱ	Q9Y608
PaxDbⁱ	Q9Y608
PeptideAtlasⁱ	Q9Y608
PRIDEⁱ	Q9Y608
ProteomicsDBⁱ	86571 86572 [Q9Y608-2] 86573 [Q9Y608-3] 86574 [Q9Y608-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000336686; ENSP00000338727; ENSG00000093167 [Q9Y608-1] ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2] ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5] ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4] ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]
GeneIDⁱ	9209
KEGGⁱ	hsa:9209
UCSCⁱ	uc003cgs.4 human [Q9Y608-1]

Organism-specific databases

CTDⁱ	9209
DisGeNETⁱ	9209
EuPathDBⁱ	HostDB:ENSG00000093167.17
GeneCardsⁱ	LRRFIP2
HGNCⁱ	HGNC:6703 LRRFIP2
HPAⁱ	HPA035956 HPA042023
MIMⁱ	614043 gene
neXtProtⁱ	NX_Q9Y608
OpenTargetsⁱ	ENSG00000093167
PharmGKBⁱ	PA30466
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2010 Eukaryota ENOG4111H1S LUCA
GeneTreeⁱ	ENSGT00530000063564
HOGENOMⁱ	HOG000294125
HOVERGENⁱ	HBG061558
InParanoidⁱ	Q9Y608
OMAⁱ	RQQKEHS
OrthoDBⁱ	EOG091G0C5Y
PhylomeDBⁱ	Q9Y608
TreeFamⁱ	TF314109

Enzyme and pathway databases

SignaLinkⁱ	Q9Y608
SIGNORⁱ	Q9Y608

Miscellaneous databases

ChiTaRSⁱ	LRRFIP2 human
GenomeRNAiⁱ	9209
Protein Ontology More...PROⁱ	PR:Q9Y608
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000093167 Expressed in 221 organ(s), highest expression level in testis
CleanExⁱ	HS_LRRFIP2
ExpressionAtlasⁱ	Q9Y608 baseline and differential
Genevisibleⁱ	Q9Y608 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019139 LRRFIP1/2
PANTHERⁱ	PTHR19212 PTHR19212, 1 hit
Pfamⁱ	View protein in Pfam PF09738 LRRFIP, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRRF2_HUMAN
Accessionⁱ	Q9Y608Primary (citable) accession number: Q9Y608 Secondary accession number(s): A8K649 , A8MXR0, B4DY63, Q68CV3, Q9NXH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y608 (LRRF2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Leucine-rich repeat flightless-interacting protein 2

LRRFIP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ