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Protein

Leucine-rich repeat flightless-interacting protein 2

Gene

LRRFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ9Y608
SIGNORiQ9Y608

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat flightless-interacting protein 2
Short name:
LRR FLII-interacting protein 2
Gene namesi
Name:LRRFIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000093167.17
HGNCiHGNC:6703 LRRFIP2
MIMi614043 gene
neXtProtiNX_Q9Y608

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi190S → A: No change in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi200S → A: No change in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi202S → A: Reduction in LPS-induced NFKB activity. 1 Publication1
Mutagenesisi202S → E: No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner. 1 Publication1

Organism-specific databases

DisGeNETi9209
OpenTargetsiENSG00000093167
PharmGKBiPA30466

Polymorphism and mutation databases

BioMutaiLRRFIP2
DMDMi74721508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452461 – 721Leucine-rich repeat flightless-interacting protein 2Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei190Phosphoserine1 Publication1
Modified residuei202Phosphoserine1 Publication1
Modified residuei309PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei331PhosphothreonineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Isoform 2 (identifier: Q9Y608-2)
Modified residuei96PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Isoform 5 (identifier: Q9Y608-5)
Modified residuei168PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1

Post-translational modificationi

Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y608
PaxDbiQ9Y608
PeptideAtlasiQ9Y608
PRIDEiQ9Y608
ProteomicsDBi86571
86572 [Q9Y608-2]
86573 [Q9Y608-3]
86574 [Q9Y608-4]

PTM databases

iPTMnetiQ9Y608
PhosphoSitePlusiQ9Y608

Expressioni

Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000093167 Expressed in 221 organ(s), highest expression level in testis
CleanExiHS_LRRFIP2
ExpressionAtlasiQ9Y608 baseline and differential
GenevisibleiQ9Y608 HS

Organism-specific databases

HPAiHPA035956
HPA042023

Interactioni

Subunit structurei

Interacts (via N-terminus) with DVL3. Interacts with FLII. Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation at Ser-202. In the presence of LPS, competes with FLII for MYD88-binding.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114643, 47 interactors
IntActiQ9Y608, 40 interactors
MINTiQ9Y608
STRINGi9606.ENSP00000338727

Structurei

3D structure databases

ProteinModelPortaliQ9Y608
SMRiQ9Y608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 370DVL3-bindingAdd BLAST370

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 49Sequence analysisAdd BLAST28
Coiled coili349 – 524Sequence analysisAdd BLAST176
Coiled coili566 – 714Sequence analysisAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 342Ser-richAdd BLAST225

Sequence similaritiesi

Belongs to the LRRFIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2010 Eukaryota
ENOG4111H1S LUCA
GeneTreeiENSGT00530000063564
HOGENOMiHOG000294125
HOVERGENiHBG061558
InParanoidiQ9Y608
OMAiRQQKEHS
OrthoDBiEOG091G0C5Y
PhylomeDBiQ9Y608
TreeFamiTF314109

Family and domain databases

InterProiView protein in InterPro
IPR019139 LRRFIP1/2
PANTHERiPTHR19212 PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738 LRRFIP, 3 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM
60 70 80 90 100
RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA
110 120 130 140 150
LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY
160 170 180 190 200
FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS
210 220 230 240 250
ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS
260 270 280 290 300
DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY
310 320 330 340 350
AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL
360 370 380 390 400
KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV
410 420 430 440 450
DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR
460 470 480 490 500
QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL
510 520 530 540 550
RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV
560 570 580 590 600
SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR
610 620 630 640 650
NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS
660 670 680 690 700
ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN
710 720
SHLAKRLEKM KANRTALLAQ Q
Length:721
Mass (Da):82,171
Last modified:November 1, 1999 - v1
Checksum:i94B18B274656CB0B
GO
Isoform 2 (identifier: Q9Y608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     346-369: Missing.
     457-521: Missing.

Show »
Length:400
Mass (Da):45,414
Checksum:iAD687735EAFE04F6
GO
Isoform 3 (identifier: Q9Y608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-621: Missing.

Show »
Length:100
Mass (Da):11,736
Checksum:iEFCDC5B6AC68785F
GO
Isoform 4 (identifier: Q9Y608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-291: Missing.
     457-521: Missing.

Show »
Length:424
Mass (Da):48,294
Checksum:iA5BFF9F6869503DE
GO
Isoform 5 (identifier: Q9Y608-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-76: Missing.
     111-124: Missing.
     146-202: Missing.
     220-291: Missing.
     346-369: Missing.
     489-522: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:503
Mass (Da):57,394
Checksum:i965FF6DABB76907F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSU1C9JSU1_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
225Annotation score:
C9JJC9C9JJC9_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:
C9J321C9J321_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:
H7C3N9H7C3N9_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
182Annotation score:
C9J0U5C9J0U5_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
67Annotation score:
C9JC17C9JC17_HUMAN
Leucine-rich repeat flightless-inte...
LRRFIP2
59Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050001143K → E. Corresponds to variant dbSNP:rs34902788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196741 – 621Missing in isoform 3. 1 PublicationAdd BLAST621
Alternative sequenceiVSP_01967560 – 291Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST232
Alternative sequenceiVSP_05696960 – 76Missing in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056970111 – 124Missing in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_056971146 – 202Missing in isoform 5. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_056972220 – 291Missing in isoform 5. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_019676346 – 369Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_019677457 – 521Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_056973489 – 522Missing in isoform 5. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115509 mRNA Translation: AAD41257.1
AK000255 mRNA Translation: BAA91035.1
AK291514 mRNA Translation: BAF84203.1
AK302282 mRNA Translation: BAG63625.1
CR749705 mRNA Translation: CAH18481.1
AC006583 Genomic DNA No translation available.
AC126118 Genomic DNA No translation available.
BC053668 mRNA Translation: AAH53668.1
CCDSiCCDS2664.1 [Q9Y608-1]
CCDS2665.1 [Q9Y608-2]
CCDS46791.1 [Q9Y608-4]
CCDS63592.1 [Q9Y608-5]
PIRiT50611
RefSeqiNP_001127841.1, NM_001134369.2 [Q9Y608-4]
NP_001269620.1, NM_001282691.1 [Q9Y608-5]
NP_001335239.1, NM_001348310.1 [Q9Y608-4]
NP_001335240.1, NM_001348311.1 [Q9Y608-2]
NP_006300.1, NM_006309.3 [Q9Y608-1]
NP_060194.1, NM_017724.2 [Q9Y608-2]
XP_005265596.1, XM_005265539.2 [Q9Y608-1]
XP_005265597.1, XM_005265540.1 [Q9Y608-1]
XP_011532519.1, XM_011534217.1 [Q9Y608-1]
XP_011532520.1, XM_011534218.1 [Q9Y608-1]
XP_011532521.1, XM_011534219.1 [Q9Y608-1]
XP_016862973.1, XM_017007484.1 [Q9Y608-4]
UniGeneiHs.740522

Genome annotation databases

EnsembliENST00000336686; ENSP00000338727; ENSG00000093167 [Q9Y608-1]
ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2]
ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5]
ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4]
ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]
GeneIDi9209
KEGGihsa:9209
UCSCiuc003cgs.4 human [Q9Y608-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115509 mRNA Translation: AAD41257.1
AK000255 mRNA Translation: BAA91035.1
AK291514 mRNA Translation: BAF84203.1
AK302282 mRNA Translation: BAG63625.1
CR749705 mRNA Translation: CAH18481.1
AC006583 Genomic DNA No translation available.
AC126118 Genomic DNA No translation available.
BC053668 mRNA Translation: AAH53668.1
CCDSiCCDS2664.1 [Q9Y608-1]
CCDS2665.1 [Q9Y608-2]
CCDS46791.1 [Q9Y608-4]
CCDS63592.1 [Q9Y608-5]
PIRiT50611
RefSeqiNP_001127841.1, NM_001134369.2 [Q9Y608-4]
NP_001269620.1, NM_001282691.1 [Q9Y608-5]
NP_001335239.1, NM_001348310.1 [Q9Y608-4]
NP_001335240.1, NM_001348311.1 [Q9Y608-2]
NP_006300.1, NM_006309.3 [Q9Y608-1]
NP_060194.1, NM_017724.2 [Q9Y608-2]
XP_005265596.1, XM_005265539.2 [Q9Y608-1]
XP_005265597.1, XM_005265540.1 [Q9Y608-1]
XP_011532519.1, XM_011534217.1 [Q9Y608-1]
XP_011532520.1, XM_011534218.1 [Q9Y608-1]
XP_011532521.1, XM_011534219.1 [Q9Y608-1]
XP_016862973.1, XM_017007484.1 [Q9Y608-4]
UniGeneiHs.740522

3D structure databases

ProteinModelPortaliQ9Y608
SMRiQ9Y608
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114643, 47 interactors
IntActiQ9Y608, 40 interactors
MINTiQ9Y608
STRINGi9606.ENSP00000338727

PTM databases

iPTMnetiQ9Y608
PhosphoSitePlusiQ9Y608

Polymorphism and mutation databases

BioMutaiLRRFIP2
DMDMi74721508

Proteomic databases

EPDiQ9Y608
PaxDbiQ9Y608
PeptideAtlasiQ9Y608
PRIDEiQ9Y608
ProteomicsDBi86571
86572 [Q9Y608-2]
86573 [Q9Y608-3]
86574 [Q9Y608-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336686; ENSP00000338727; ENSG00000093167 [Q9Y608-1]
ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2]
ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5]
ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4]
ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4]
GeneIDi9209
KEGGihsa:9209
UCSCiuc003cgs.4 human [Q9Y608-1]

Organism-specific databases

CTDi9209
DisGeNETi9209
EuPathDBiHostDB:ENSG00000093167.17
GeneCardsiLRRFIP2
HGNCiHGNC:6703 LRRFIP2
HPAiHPA035956
HPA042023
MIMi614043 gene
neXtProtiNX_Q9Y608
OpenTargetsiENSG00000093167
PharmGKBiPA30466
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2010 Eukaryota
ENOG4111H1S LUCA
GeneTreeiENSGT00530000063564
HOGENOMiHOG000294125
HOVERGENiHBG061558
InParanoidiQ9Y608
OMAiRQQKEHS
OrthoDBiEOG091G0C5Y
PhylomeDBiQ9Y608
TreeFamiTF314109

Enzyme and pathway databases

SignaLinkiQ9Y608
SIGNORiQ9Y608

Miscellaneous databases

ChiTaRSiLRRFIP2 human
GenomeRNAii9209
PROiPR:Q9Y608
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000093167 Expressed in 221 organ(s), highest expression level in testis
CleanExiHS_LRRFIP2
ExpressionAtlasiQ9Y608 baseline and differential
GenevisibleiQ9Y608 HS

Family and domain databases

InterProiView protein in InterPro
IPR019139 LRRFIP1/2
PANTHERiPTHR19212 PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738 LRRFIP, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRRF2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y608
Secondary accession number(s): A8K649
, A8MXR0, B4DY63, Q68CV3, Q9NXH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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