UniProtKB - Q9Y608 (LRRF2_HUMAN)
Leucine-rich repeat flightless-interacting protein 2
LRRFIP2
Functioni
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
2 PublicationsGO - Molecular functioni
- LRR domain binding Source: UniProtKB
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9Y608 |
SignaLinki | Q9Y608 |
SIGNORi | Q9Y608 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat flightless-interacting protein 2Short name: LRR FLII-interacting protein 2 |
Gene namesi | Name:LRRFIP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6703, LRRFIP2 |
MIMi | 614043, gene |
neXtProti | NX_Q9Y608 |
VEuPathDBi | HostDB:ENSG00000093167 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 190 | S → A: No change in LPS-induced NFKB activity. 1 Publication | 1 | |
Mutagenesisi | 200 | S → A: No change in LPS-induced NFKB activity. 1 Publication | 1 | |
Mutagenesisi | 202 | S → A: Reduction in LPS-induced NFKB activity. 1 Publication | 1 | |
Mutagenesisi | 202 | S → E: No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9209 |
OpenTargetsi | ENSG00000093167 |
PharmGKBi | PA30466 |
Miscellaneous databases
Pharosi | Q9Y608, Tbio |
Genetic variation databases
BioMutai | LRRFIP2 |
DMDMi | 74721508 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245246 | 1 – 721 | Leucine-rich repeat flightless-interacting protein 2Add BLAST | 721 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 18 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 190 | Phosphoserine1 Publication | 1 | ||
Modified residuei | 202 | Phosphoserine1 Publication | 1 | ||
Modified residuei | 309 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 312 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 320 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 324 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 328 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 331 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 332 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 333 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: Q9Y608-2) | |||||
Modified residuei | 96 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 101 | PhosphoserineCombined sources | 1 | ||
Isoform 5 (identifier: Q9Y608-5) | |||||
Modified residuei | 168 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 173 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y608 |
jPOSTi | Q9Y608 |
MassIVEi | Q9Y608 |
MaxQBi | Q9Y608 |
PaxDbi | Q9Y608 |
PeptideAtlasi | Q9Y608 |
PRIDEi | Q9Y608 |
ProteomicsDBi | 2344 86571 [Q9Y608-1] 86572 [Q9Y608-2] 86573 [Q9Y608-3] 86574 [Q9Y608-4] |
PTM databases
iPTMneti | Q9Y608 |
MetOSitei | Q9Y608 |
PhosphoSitePlusi | Q9Y608 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000093167, Expressed in testis and 233 other tissues |
ExpressionAtlasi | Q9Y608, baseline and differential |
Genevisiblei | Q9Y608, HS |
Organism-specific databases
HPAi | ENSG00000093167, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via N-terminus) with DVL3.
Interacts with FLII. Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation at Ser-202. In the presence of LPS, competes with FLII for MYD88-binding.
3 PublicationsBinary interactionsi
Q9Y608
With | #Exp. | IntAct |
---|---|---|
ATPAF2 [Q8N5M1] | 4 | EBI-1023718,EBI-1166928 |
DVL3 [Q92997] | 2 | EBI-1023718,EBI-739789 |
Isoform 2 [Q9Y608-2]
With | #Exp. | IntAct |
---|---|---|
ATPAF2 [Q8N5M1] | 3 | EBI-12696250,EBI-1166928 |
GO - Molecular functioni
- LRR domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114643, 87 interactors |
IntActi | Q9Y608, 54 interactors |
MINTi | Q9Y608 |
STRINGi | 9606.ENSP00000338727 |
Miscellaneous databases
RNActi | Q9Y608, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 370 | DVL3-bindingAdd BLAST | 370 | |
Regioni | 232 – 262 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 295 – 338 | DisorderedSequence analysisAdd BLAST | 44 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 22 – 49 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 349 – 524 | Sequence analysisAdd BLAST | 176 | |
Coiled coili | 566 – 714 | Sequence analysisAdd BLAST | 149 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 232 – 251 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 302 – 338 | Polar residuesSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2010, Eukaryota |
GeneTreei | ENSGT00530000063564 |
HOGENOMi | CLU_018871_2_0_1 |
InParanoidi | Q9Y608 |
OMAi | RASPIAN |
OrthoDBi | 1434475at2759 |
PhylomeDBi | Q9Y608 |
TreeFami | TF314109 |
Family and domain databases
InterProi | View protein in InterPro IPR019139, LRRFIP1/2 |
PANTHERi | PTHR19212, PTHR19212, 1 hit |
Pfami | View protein in Pfam PF09738, LRRFIP, 3 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM
60 70 80 90 100
RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA
110 120 130 140 150
LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY
160 170 180 190 200
FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS
210 220 230 240 250
ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS
260 270 280 290 300
DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY
310 320 330 340 350
AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL
360 370 380 390 400
KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV
410 420 430 440 450
DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR
460 470 480 490 500
QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL
510 520 530 540 550
RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV
560 570 580 590 600
SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR
610 620 630 640 650
NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS
660 670 680 690 700
ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN
710 720
SHLAKRLEKM KANRTALLAQ Q
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JSU1 | C9JSU1_HUMAN | Leucine-rich repeat flightless-inte... | LRRFIP2 | 225 | Annotation score: | ||
H7C3N9 | H7C3N9_HUMAN | Leucine-rich repeat flightless-inte... | LRRFIP2 | 182 | Annotation score: | ||
C9JJC9 | C9JJC9_HUMAN | Leucine-rich repeat flightless-inte... | LRRFIP2 | 59 | Annotation score: | ||
C9J321 | C9J321_HUMAN | Leucine-rich repeat flightless-inte... | LRRFIP2 | 59 | Annotation score: | ||
C9JC17 | C9JC17_HUMAN | Leucine-rich repeat flightless-inte... | LRRFIP2 | 59 | Annotation score: | ||
C9J0U5 | C9J0U5_HUMAN | Leucine-rich repeat flightless-inte... | LRRFIP2 | 67 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050001 | 143 | K → E. Corresponds to variant dbSNP:rs34902788Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019674 | 1 – 621 | Missing in isoform 3. 1 PublicationAdd BLAST | 621 | |
Alternative sequenceiVSP_019675 | 60 – 291 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 232 | |
Alternative sequenceiVSP_056969 | 60 – 76 | Missing in isoform 5. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_056970 | 111 – 124 | Missing in isoform 5. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_056971 | 146 – 202 | Missing in isoform 5. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_056972 | 220 – 291 | Missing in isoform 5. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_019676 | 346 – 369 | Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST | 24 | |
Alternative sequenceiVSP_019677 | 457 – 521 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 65 | |
Alternative sequenceiVSP_056973 | 489 – 522 | Missing in isoform 5. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF115509 mRNA Translation: AAD41257.1 AK000255 mRNA Translation: BAA91035.1 AK291514 mRNA Translation: BAF84203.1 AK302282 mRNA Translation: BAG63625.1 CR749705 mRNA Translation: CAH18481.1 AC006583 Genomic DNA No translation available. AC126118 Genomic DNA No translation available. BC053668 mRNA Translation: AAH53668.1 |
CCDSi | CCDS2664.1 [Q9Y608-1] CCDS2665.1 [Q9Y608-2] CCDS46791.1 [Q9Y608-4] CCDS63592.1 [Q9Y608-5] |
PIRi | T50611 |
RefSeqi | NP_001127841.1, NM_001134369.2 [Q9Y608-4] NP_001269620.1, NM_001282691.1 [Q9Y608-5] NP_001335239.1, NM_001348310.1 [Q9Y608-4] NP_001335240.1, NM_001348311.1 [Q9Y608-2] NP_006300.1, NM_006309.3 [Q9Y608-1] NP_060194.1, NM_017724.2 [Q9Y608-2] XP_005265596.1, XM_005265539.2 [Q9Y608-1] XP_005265597.1, XM_005265540.1 [Q9Y608-1] XP_011532519.1, XM_011534217.1 [Q9Y608-1] XP_011532520.1, XM_011534218.1 [Q9Y608-1] XP_011532521.1, XM_011534219.1 [Q9Y608-1] XP_016862973.1, XM_017007484.1 [Q9Y608-4] |
Genome annotation databases
Ensembli | ENST00000336686; ENSP00000338727; ENSG00000093167 ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2] ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5] ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4] ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4] |
GeneIDi | 9209 |
KEGGi | hsa:9209 |
MANE-Selecti | ENST00000336686.9; ENSP00000338727.4; NM_006309.4; NP_006300.1 |
UCSCi | uc003cgs.4, human [Q9Y608-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF115509 mRNA Translation: AAD41257.1 AK000255 mRNA Translation: BAA91035.1 AK291514 mRNA Translation: BAF84203.1 AK302282 mRNA Translation: BAG63625.1 CR749705 mRNA Translation: CAH18481.1 AC006583 Genomic DNA No translation available. AC126118 Genomic DNA No translation available. BC053668 mRNA Translation: AAH53668.1 |
CCDSi | CCDS2664.1 [Q9Y608-1] CCDS2665.1 [Q9Y608-2] CCDS46791.1 [Q9Y608-4] CCDS63592.1 [Q9Y608-5] |
PIRi | T50611 |
RefSeqi | NP_001127841.1, NM_001134369.2 [Q9Y608-4] NP_001269620.1, NM_001282691.1 [Q9Y608-5] NP_001335239.1, NM_001348310.1 [Q9Y608-4] NP_001335240.1, NM_001348311.1 [Q9Y608-2] NP_006300.1, NM_006309.3 [Q9Y608-1] NP_060194.1, NM_017724.2 [Q9Y608-2] XP_005265596.1, XM_005265539.2 [Q9Y608-1] XP_005265597.1, XM_005265540.1 [Q9Y608-1] XP_011532519.1, XM_011534217.1 [Q9Y608-1] XP_011532520.1, XM_011534218.1 [Q9Y608-1] XP_011532521.1, XM_011534219.1 [Q9Y608-1] XP_016862973.1, XM_017007484.1 [Q9Y608-4] |
3D structure databases
SMRi | Q9Y608 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114643, 87 interactors |
IntActi | Q9Y608, 54 interactors |
MINTi | Q9Y608 |
STRINGi | 9606.ENSP00000338727 |
PTM databases
iPTMneti | Q9Y608 |
MetOSitei | Q9Y608 |
PhosphoSitePlusi | Q9Y608 |
Genetic variation databases
BioMutai | LRRFIP2 |
DMDMi | 74721508 |
Proteomic databases
EPDi | Q9Y608 |
jPOSTi | Q9Y608 |
MassIVEi | Q9Y608 |
MaxQBi | Q9Y608 |
PaxDbi | Q9Y608 |
PeptideAtlasi | Q9Y608 |
PRIDEi | Q9Y608 |
ProteomicsDBi | 2344 86571 [Q9Y608-1] 86572 [Q9Y608-2] 86573 [Q9Y608-3] 86574 [Q9Y608-4] |
Protocols and materials databases
Antibodypediai | 28249, 192 antibodies from 25 providers |
DNASUi | 9209 |
Genome annotation databases
Ensembli | ENST00000336686; ENSP00000338727; ENSG00000093167 ENST00000354379; ENSP00000346349; ENSG00000093167 [Q9Y608-2] ENST00000396428; ENSP00000379705; ENSG00000093167 [Q9Y608-5] ENST00000421276; ENSP00000416364; ENSG00000093167 [Q9Y608-4] ENST00000440230; ENSP00000405480; ENSG00000093167 [Q9Y608-4] |
GeneIDi | 9209 |
KEGGi | hsa:9209 |
MANE-Selecti | ENST00000336686.9; ENSP00000338727.4; NM_006309.4; NP_006300.1 |
UCSCi | uc003cgs.4, human [Q9Y608-1] |
Organism-specific databases
CTDi | 9209 |
DisGeNETi | 9209 |
GeneCardsi | LRRFIP2 |
HGNCi | HGNC:6703, LRRFIP2 |
HPAi | ENSG00000093167, Low tissue specificity |
MIMi | 614043, gene |
neXtProti | NX_Q9Y608 |
OpenTargetsi | ENSG00000093167 |
PharmGKBi | PA30466 |
VEuPathDBi | HostDB:ENSG00000093167 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2010, Eukaryota |
GeneTreei | ENSGT00530000063564 |
HOGENOMi | CLU_018871_2_0_1 |
InParanoidi | Q9Y608 |
OMAi | RASPIAN |
OrthoDBi | 1434475at2759 |
PhylomeDBi | Q9Y608 |
TreeFami | TF314109 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y608 |
SignaLinki | Q9Y608 |
SIGNORi | Q9Y608 |
Miscellaneous databases
BioGRID-ORCSi | 9209, 5 hits in 1041 CRISPR screens |
ChiTaRSi | LRRFIP2, human |
GenomeRNAii | 9209 |
Pharosi | Q9Y608, Tbio |
PROi | PR:Q9Y608 |
RNActi | Q9Y608, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000093167, Expressed in testis and 233 other tissues |
ExpressionAtlasi | Q9Y608, baseline and differential |
Genevisiblei | Q9Y608, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019139, LRRFIP1/2 |
PANTHERi | PTHR19212, PTHR19212, 1 hit |
Pfami | View protein in Pfam PF09738, LRRFIP, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRF2_HUMAN | |
Accessioni | Q9Y608Primary (citable) accession number: Q9Y608 Secondary accession number(s): A8K649 Q9NXH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families