MRFAP1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MORF4 family-associated protein 1 Alternative name(s): Protein PGR1 Protein associated with MRG of 14 kDa
Gene namesⁱ	Name:MRFAP1Imported Synonyms:PAM141 Publication, PGR1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179010.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24549 MRFAP1
MIMⁱ	616905 gene
neXtProtⁱ	NX_Q9Y605

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	93621
Open Targets More...OpenTargetsⁱ	ENSG00000179010
PharmGKBⁱ	PA142671332

Polymorphism and mutation databases

DMDMⁱ	74735297

DMDMⁱ

74735297

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000306176	1 – 127	MORF4 family-associated protein 1Add BLAST		127

Proteomic databases

EPDⁱ	Q9Y605
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y605
PaxDbⁱ	Q9Y605
PeptideAtlas More...PeptideAtlasⁱ	Q9Y605
PRIDEⁱ	Q9Y605
ProteomicsDBⁱ	86568

PTM databases

iPTMnetⁱ	Q9Y605
PhosphoSitePlusⁱ	Q9Y605
SwissPalmⁱ	Q9Y605

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179010 Expressed in 212 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_MRFAP1
ExpressionAtlasⁱ	Q9Y605 baseline and differential
Genevisibleⁱ	Q9Y605 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB042447 HPA056367

HPAⁱ

CAB042447
HPA056367

Interactionⁱ

Subunit structureⁱ

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
C14orf93	Q9H972	3	EBI-995714,EBI-10329620
C3orf62	Q6ZUJ4	3	EBI-995714,EBI-2837036
DCDC2	Q9UHG0	3	EBI-995714,EBI-10303987
GOLGA8G	Q08AF8	3	EBI-995714,EBI-10181260
MORF4L1	Q9UBU8	6	EBI-995714,EBI-399246
MORF4L1	Q9UBU8-2	13	EBI-995714,EBI-10288852
MORF4L2	Q15014	12	EBI-995714,EBI-399257
MRFAP1L1	Q96HT8	5	EBI-995714,EBI-748896
SUV39H2	Q9H5I1	2	EBI-995714,EBI-723127

Protein-protein interaction databases

BioGridⁱ	125039, 24 interactors
CORUMⁱ	Q9Y605
IntActⁱ	Q9Y605, 44 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y605
STRINGⁱ	9606.ENSP00000318352

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y605
SMRⁱ	Q9Y605
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	92 – 126	Sequence analysisAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the MORF4 family-associated protein family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410J03M Eukaryota ENOG4111AYE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048749
HOGENOMⁱ	HOG000070216
HOVERGENⁱ	HBG104090
InParanoidⁱ	Q9Y605
OMAⁱ	RGTKRCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10XY
PhylomeDBⁱ	Q9Y605
TreeFamⁱ	TF338232

Family and domain databases

InterProⁱ	View protein in InterPro IPR029254 MRFAP1
PANTHERⁱ	PTHR31324 PTHR31324, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15155 MRFAP1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y605-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY 
        60         70         80         90        100
LRNRSKLWEM DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA 
       110        120 
EEKAKEIAKM AEMLVELVRR IEKSESS

Length:127

Mass (Da):14,650

Last modified:November 1, 1999 - v1

Checksum:ⁱ11B115C2CCD661C8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WTY9	A0A087WTY9_HUMAN		MORF4 family-associated protein 1 MORF4 family-associated protein 1	MRFAP1	103	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF116272 Genomic DNA Translation: AAD38498.1 CR457144 mRNA Translation: CAG33425.1 AK123360 mRNA Translation: BAG53894.1 CH471131 Genomic DNA Translation: EAW82386.1 CH471131 Genomic DNA Translation: EAW82387.1 BC022797 mRNA Translation: AAH22797.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3389.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001258982.1, NM_001272053.1 NP_150638.1, NM_033296.2
UniGeneⁱ	Hs.406590

Genome annotation databases

Ensemblⁱ	ENST00000320912; ENSP00000318352; ENSG00000179010 ENST00000382581; ENSP00000372024; ENSG00000179010 ENST00000507420; ENSP00000422065; ENSG00000179010
GeneIDⁱ	93621
KEGGⁱ	hsa:93621
UCSC genome browser More...UCSCⁱ	uc003gjg.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y605	MORF4 family-associated protein 1		MACMU		127	UniRef100_Q9Y605
MRFAP1 isoform 2		PANTR		127
MORF4 family-associated protein 1		PONAB		127
Uncharacterized protein		CHLSB		127
Macaca fascicularis brain cDNA clone: QbsB-10002, similar to human T-cell activation protein (PGR1), mRNA, RefSeq: NM_033296.1		MACFA		127

Protein	Similar proteins		Species	Score	Length	Source
Q9Y605	MORF4 family-associated protein 1		BOVIN		127	UniRef90_Q9Y605
MORF4 family-associated protein 1		MACMU		127
MRFAP1 isoform 2		PANTR		127
MORF4 family-associated protein 1		PONAB		127
Uncharacterized protein		CHLSB		127
+45

Protein	Similar proteins		Species	Score	Length	Source
Q9Y605	MORF4 family-associated protein 1-like 1		HUMAN		127	UniRef50_Q96HT8
MORF4 family-associated protein 1		PONAB		127
MORF4 family-associated protein 1		BOVIN		127
MRFAP1L1 isoform 1		PANTR		127
MORF4 family-associated protein 1-like 1		MACMU		127
+99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF116272 Genomic DNA Translation: AAD38498.1 CR457144 mRNA Translation: CAG33425.1 AK123360 mRNA Translation: BAG53894.1 CH471131 Genomic DNA Translation: EAW82386.1 CH471131 Genomic DNA Translation: EAW82387.1 BC022797 mRNA Translation: AAH22797.1
CCDSⁱ	CCDS3389.1
RefSeqⁱ	NP_001258982.1, NM_001272053.1 NP_150638.1, NM_033296.2
UniGeneⁱ	Hs.406590

3D structure databases

ProteinModelPortalⁱ	Q9Y605
SMRⁱ	Q9Y605
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125039, 24 interactors
CORUMⁱ	Q9Y605
IntActⁱ	Q9Y605, 44 interactors
MINTⁱ	Q9Y605
STRINGⁱ	9606.ENSP00000318352

PTM databases

iPTMnetⁱ	Q9Y605
PhosphoSitePlusⁱ	Q9Y605
SwissPalmⁱ	Q9Y605

Polymorphism and mutation databases

DMDMⁱ	74735297

DMDMⁱ

74735297

Proteomic databases

EPDⁱ	Q9Y605
MaxQBⁱ	Q9Y605
PaxDbⁱ	Q9Y605
PeptideAtlasⁱ	Q9Y605
PRIDEⁱ	Q9Y605
ProteomicsDBⁱ	86568

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	93621
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000320912; ENSP00000318352; ENSG00000179010 ENST00000382581; ENSP00000372024; ENSG00000179010 ENST00000507420; ENSP00000422065; ENSG00000179010
GeneIDⁱ	93621
KEGGⁱ	hsa:93621
UCSCⁱ	uc003gjg.3 human

Organism-specific databases

CTDⁱ	93621
DisGeNETⁱ	93621
EuPathDBⁱ	HostDB:ENSG00000179010.14
GeneCardsⁱ	MRFAP1
HGNCⁱ	HGNC:24549 MRFAP1
HPAⁱ	CAB042447 HPA056367
MIMⁱ	616905 gene
neXtProtⁱ	NX_Q9Y605
OpenTargetsⁱ	ENSG00000179010
PharmGKBⁱ	PA142671332
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J03M Eukaryota ENOG4111AYE LUCA
GeneTreeⁱ	ENSGT00510000048749
HOGENOMⁱ	HOG000070216
HOVERGENⁱ	HBG104090
InParanoidⁱ	Q9Y605
OMAⁱ	RGTKRCE
OrthoDBⁱ	EOG091G10XY
PhylomeDBⁱ	Q9Y605
TreeFamⁱ	TF338232

Miscellaneous databases

ChiTaRSⁱ	MRFAP1 human
GeneWikiⁱ	MRFAP1
GenomeRNAiⁱ	93621
Protein Ontology More...PROⁱ	PR:Q9Y605
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179010 Expressed in 212 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_MRFAP1
ExpressionAtlasⁱ	Q9Y605 baseline and differential
Genevisibleⁱ	Q9Y605 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029254 MRFAP1
PANTHERⁱ	PTHR31324 PTHR31324, 1 hit
Pfamⁱ	View protein in Pfam PF15155 MRFAP1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOFA1_HUMAN
Accessionⁱ	Q9Y605Primary (citable) accession number: Q9Y605 Secondary accession number(s): B3KVT2, D3DVT3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y605 (MOFA1_HUMAN)

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MORF4 family-associated protein 1

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ