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UniProtKB - Q9Y605 (MOFA1_HUMAN)
Protein
MORF4 family-associated protein 1
Gene
MRFAP1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: MORF4 family-associated protein 1Alternative name(s): Protein PGR1 Protein associated with MRG of 14 kDa |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24549, MRFAP1 |
MIMi | 616905, gene |
neXtProti | NX_Q9Y605 |
VEuPathDBi | HostDB:ENSG00000179010 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Other locations
- perinuclear region 2 Publications
Note: Colocalizes with MORF4L1 to cell nuclei.2 Publications
Nucleus
- nucleoplasm Source: HPA
Other locations
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 93621 |
OpenTargetsi | ENSG00000179010 |
PharmGKBi | PA142671332 |
Miscellaneous databases
Pharosi | Q9Y605, Tbio |
Genetic variation databases
BioMutai | MRFAP1 |
DMDMi | 74735297 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306176 | 1 – 127 | MORF4 family-associated protein 1Add BLAST | 127 |
Proteomic databases
EPDi | Q9Y605 |
jPOSTi | Q9Y605 |
MassIVEi | Q9Y605 |
MaxQBi | Q9Y605 |
PaxDbi | Q9Y605 |
PeptideAtlasi | Q9Y605 |
PRIDEi | Q9Y605 |
ProteomicsDBi | 86568 |
PTM databases
iPTMneti | Q9Y605 |
PhosphoSitePlusi | Q9Y605 |
SwissPalmi | Q9Y605 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179010, Expressed in epithelial cell of pancreas and 228 other tissues |
ExpressionAtlasi | Q9Y605, baseline and differential |
Genevisiblei | Q9Y605, HS |
Organism-specific databases
HPAi | ENSG00000179010, Low tissue specificity |
Interactioni
Subunit structurei
Found in a complex composed of MORF4L1, MRFAP1 and RB1.
Interacts via its N-terminus with MORF4L1.
Interacts with CSTB and MORF4L2.
By similarity4 PublicationsBinary interactionsi
Q9Y605
Protein-protein interaction databases
BioGRIDi | 125039, 73 interactors |
CORUMi | Q9Y605 |
IntActi | Q9Y605, 62 interactors |
MINTi | Q9Y605 |
STRINGi | 9606.ENSP00000318352 |
Miscellaneous databases
RNActi | Q9Y605, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 92 – 126 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the MORF4 family-associated protein family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RU25, Eukaryota |
GeneTreei | ENSGT00940000155541 |
HOGENOMi | CLU_166966_1_0_1 |
InParanoidi | Q9Y605 |
OMAi | RGTKRCE |
OrthoDBi | 1557272at2759 |
PhylomeDBi | Q9Y605 |
TreeFami | TF338232 |
Family and domain databases
InterProi | View protein in InterPro IPR029254, MRFAP1 |
PANTHERi | PTHR31324, PTHR31324, 1 hit |
Pfami | View protein in Pfam PF15155, MRFAP1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y605-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY
60 70 80 90 100
LRNRSKLWEM DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA
110 120
EEKAKEIAKM AEMLVELVRR IEKSESS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WTY9 | A0A087WTY9_HUMAN | MORF4 family-associated protein 1 | MRFAP1 | 103 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF116272 Genomic DNA Translation: AAD38498.1 CR457144 mRNA Translation: CAG33425.1 AK123360 mRNA Translation: BAG53894.1 CH471131 Genomic DNA Translation: EAW82386.1 CH471131 Genomic DNA Translation: EAW82387.1 BC022797 mRNA Translation: AAH22797.1 |
CCDSi | CCDS3389.1 |
RefSeqi | NP_001258982.1, NM_001272053.1 NP_150638.1, NM_033296.2 |
Genome annotation databases
Ensembli | ENST00000320912; ENSP00000318352; ENSG00000179010 ENST00000382581; ENSP00000372024; ENSG00000179010 ENST00000507420; ENSP00000422065; ENSG00000179010 |
GeneIDi | 93621 |
KEGGi | hsa:93621 |
MANE-Selecti | ENST00000382581.5; ENSP00000372024.4; NM_033296.3; NP_150638.1 |
UCSCi | uc003gjg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF116272 Genomic DNA Translation: AAD38498.1 CR457144 mRNA Translation: CAG33425.1 AK123360 mRNA Translation: BAG53894.1 CH471131 Genomic DNA Translation: EAW82386.1 CH471131 Genomic DNA Translation: EAW82387.1 BC022797 mRNA Translation: AAH22797.1 |
CCDSi | CCDS3389.1 |
RefSeqi | NP_001258982.1, NM_001272053.1 NP_150638.1, NM_033296.2 |
3D structure databases
SMRi | Q9Y605 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125039, 73 interactors |
CORUMi | Q9Y605 |
IntActi | Q9Y605, 62 interactors |
MINTi | Q9Y605 |
STRINGi | 9606.ENSP00000318352 |
PTM databases
iPTMneti | Q9Y605 |
PhosphoSitePlusi | Q9Y605 |
SwissPalmi | Q9Y605 |
Genetic variation databases
BioMutai | MRFAP1 |
DMDMi | 74735297 |
Proteomic databases
EPDi | Q9Y605 |
jPOSTi | Q9Y605 |
MassIVEi | Q9Y605 |
MaxQBi | Q9Y605 |
PaxDbi | Q9Y605 |
PeptideAtlasi | Q9Y605 |
PRIDEi | Q9Y605 |
ProteomicsDBi | 86568 |
Protocols and materials databases
Antibodypediai | 43334, 99 antibodies from 20 providers |
DNASUi | 93621 |
Genome annotation databases
Ensembli | ENST00000320912; ENSP00000318352; ENSG00000179010 ENST00000382581; ENSP00000372024; ENSG00000179010 ENST00000507420; ENSP00000422065; ENSG00000179010 |
GeneIDi | 93621 |
KEGGi | hsa:93621 |
MANE-Selecti | ENST00000382581.5; ENSP00000372024.4; NM_033296.3; NP_150638.1 |
UCSCi | uc003gjg.3, human |
Organism-specific databases
CTDi | 93621 |
DisGeNETi | 93621 |
GeneCardsi | MRFAP1 |
HGNCi | HGNC:24549, MRFAP1 |
HPAi | ENSG00000179010, Low tissue specificity |
MIMi | 616905, gene |
neXtProti | NX_Q9Y605 |
OpenTargetsi | ENSG00000179010 |
PharmGKBi | PA142671332 |
VEuPathDBi | HostDB:ENSG00000179010 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU25, Eukaryota |
GeneTreei | ENSGT00940000155541 |
HOGENOMi | CLU_166966_1_0_1 |
InParanoidi | Q9Y605 |
OMAi | RGTKRCE |
OrthoDBi | 1557272at2759 |
PhylomeDBi | Q9Y605 |
TreeFami | TF338232 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y605 |
SignaLinki | Q9Y605 |
Miscellaneous databases
BioGRID-ORCSi | 93621, 11 hits in 1045 CRISPR screens |
ChiTaRSi | MRFAP1, human |
GeneWikii | MRFAP1 |
GenomeRNAii | 93621 |
Pharosi | Q9Y605, Tbio |
PROi | PR:Q9Y605 |
RNActi | Q9Y605, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179010, Expressed in epithelial cell of pancreas and 228 other tissues |
ExpressionAtlasi | Q9Y605, baseline and differential |
Genevisiblei | Q9Y605, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029254, MRFAP1 |
PANTHERi | PTHR31324, PTHR31324, 1 hit |
Pfami | View protein in Pfam PF15155, MRFAP1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOFA1_HUMAN | |
Accessioni | Q9Y605Primary (citable) accession number: Q9Y605 Secondary accession number(s): B3KVT2, D3DVT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families