Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y605 (MOFA1_HUMAN)

Entry version 138 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

MORF4 family-associated protein 1

Gene

MRFAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y605

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein PGR1
Protein associated with MRG of 14 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRFAP1Imported
Synonyms:PAM141 Publication, PGR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000179010.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:24549, MRFAP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616905, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y605

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		93621

Open Targets

More...OpenTargetsi		ENSG00000179010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671332

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y605, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MRFAP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74735297

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003061761 – 127MORF4 family-associated protein 1Add BLAST127

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y605

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y605

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y605

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y605

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y605

PeptideAtlas

More...PeptideAtlasi		Q9Y605

PRoteomics IDEntifications database

More...PRIDEi		Q9Y605

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86568

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y605

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y605

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y605

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179010, Expressed in epithelial cell of pancreas and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y605, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y605, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000179010, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1.

Interacts via its N-terminus with MORF4L1.

Interacts with CSTB and MORF4L2.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125039, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y605

Protein interaction database and analysis system

More...IntActi		Q9Y605, 45 interactors

Molecular INTeraction database

More...MINTi		Q9Y605

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000318352

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y605, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y605

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili92 – 126Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MORF4 family-associated protein family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RU25, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_166966_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y605

Identification of Orthologs from Complete Genome Data

More...OMAi		RGTKRCE

Database of Orthologous Groups

More...OrthoDBi		1557272at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y605

TreeFam database of animal gene trees

More...TreeFami		TF338232

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029254, MRFAP1

The PANTHER Classification System

More...PANTHERi		PTHR31324, PTHR31324, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15155, MRFAP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y605-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY 
        60         70         80         90        100
LRNRSKLWEM DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA 
       110        120 
EEKAKEIAKM AEMLVELVRR IEKSESS
Length:127
Mass (Da):14,650
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11B115C2CCD661C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTY9A0A087WTY9_HUMAN
MORF4 family-associated protein 1
MRFAP1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF116272 Genomic DNA Translation: AAD38498.1
CR457144 mRNA Translation: CAG33425.1
AK123360 mRNA Translation: BAG53894.1
CH471131 Genomic DNA Translation: EAW82386.1
CH471131 Genomic DNA Translation: EAW82387.1
BC022797 mRNA Translation: AAH22797.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3389.1

NCBI Reference Sequences

More...RefSeqi		NP_001258982.1, NM_001272053.1
NP_150638.1, NM_033296.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000320912; ENSP00000318352; ENSG00000179010
ENST00000382581; ENSP00000372024; ENSG00000179010
ENST00000507420; ENSP00000422065; ENSG00000179010

Database of genes from NCBI RefSeq genomes

More...GeneIDi		93621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:93621

UCSC genome browser

More...UCSCi		uc003gjg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116272 Genomic DNA Translation: AAD38498.1
CR457144 mRNA Translation: CAG33425.1
AK123360 mRNA Translation: BAG53894.1
CH471131 Genomic DNA Translation: EAW82386.1
CH471131 Genomic DNA Translation: EAW82387.1
BC022797 mRNA Translation: AAH22797.1
CCDSiCCDS3389.1
RefSeqiNP_001258982.1, NM_001272053.1
NP_150638.1, NM_033296.2

3D structure databases

SMRiQ9Y605
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125039, 28 interactors
CORUMiQ9Y605
IntActiQ9Y605, 45 interactors
MINTiQ9Y605
STRINGi9606.ENSP00000318352

PTM databases

iPTMnetiQ9Y605
PhosphoSitePlusiQ9Y605
SwissPalmiQ9Y605

Polymorphism and mutation databases

BioMutaiMRFAP1
DMDMi74735297

Proteomic databases

EPDiQ9Y605
jPOSTiQ9Y605
MassIVEiQ9Y605
MaxQBiQ9Y605
PaxDbiQ9Y605
PeptideAtlasiQ9Y605
PRIDEiQ9Y605
ProteomicsDBi86568

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43334, 86 antibodies

The DNASU plasmid repository

More...DNASUi		93621

Genome annotation databases

EnsembliENST00000320912; ENSP00000318352; ENSG00000179010
ENST00000382581; ENSP00000372024; ENSG00000179010
ENST00000507420; ENSP00000422065; ENSG00000179010
GeneIDi93621
KEGGihsa:93621
UCSCiuc003gjg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		93621
DisGeNETi93621
EuPathDBiHostDB:ENSG00000179010.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		MRFAP1
HGNCiHGNC:24549, MRFAP1
HPAiENSG00000179010, Low tissue specificity
MIMi616905, gene
neXtProtiNX_Q9Y605
OpenTargetsiENSG00000179010
PharmGKBiPA142671332

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RU25, Eukaryota
GeneTreeiENSGT00940000155541
HOGENOMiCLU_166966_1_0_1
InParanoidiQ9Y605
OMAiRGTKRCE
OrthoDBi1557272at2759
PhylomeDBiQ9Y605
TreeFamiTF338232

Enzyme and pathway databases

PathwayCommonsiQ9Y605

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		93621, 9 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MRFAP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MRFAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		93621
PharosiQ9Y605, Tdark

Protein Ontology

More...PROi		PR:Q9Y605
RNActiQ9Y605, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000179010, Expressed in epithelial cell of pancreas and 227 other tissues
ExpressionAtlasiQ9Y605, baseline and differential
GenevisibleiQ9Y605, HS

Family and domain databases

InterProiView protein in InterPro
IPR029254, MRFAP1
PANTHERiPTHR31324, PTHR31324, 1 hit
PfamiView protein in Pfam
PF15155, MRFAP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOFA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y605
Secondary accession number(s): B3KVT2, D3DVT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again