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Protein

MORF4 family-associated protein 1

Gene

MRFAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein PGR1
Protein associated with MRG of 14 kDa
Gene namesi
Name:MRFAP1Imported
Synonyms:PAM141 Publication, PGR1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000179010.14
HGNCiHGNC:24549 MRFAP1
MIMi616905 gene
neXtProtiNX_Q9Y605

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi93621
OpenTargetsiENSG00000179010
PharmGKBiPA142671332

Polymorphism and mutation databases

DMDMi74735297

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061761 – 127MORF4 family-associated protein 1Add BLAST127

Proteomic databases

EPDiQ9Y605
MaxQBiQ9Y605
PaxDbiQ9Y605
PeptideAtlasiQ9Y605
PRIDEiQ9Y605
ProteomicsDBi86568

PTM databases

iPTMnetiQ9Y605
PhosphoSitePlusiQ9Y605
SwissPalmiQ9Y605

Expressioni

Gene expression databases

BgeeiENSG00000179010
CleanExiHS_MRFAP1
ExpressionAtlasiQ9Y605 baseline and differential
GenevisibleiQ9Y605 HS

Organism-specific databases

HPAiCAB042447
HPA056367

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125039, 24 interactors
CORUMiQ9Y605
IntActiQ9Y605, 48 interactors
MINTiQ9Y605
STRINGi9606.ENSP00000318352

Structurei

3D structure databases

ProteinModelPortaliQ9Y605
SMRiQ9Y605
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili92 – 126Sequence analysisAdd BLAST35

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J03M Eukaryota
ENOG4111AYE LUCA
GeneTreeiENSGT00510000048749
HOGENOMiHOG000070216
HOVERGENiHBG104090
InParanoidiQ9Y605
OMAiRGTKRCE
OrthoDBiEOG091G10XY
PhylomeDBiQ9Y605
TreeFamiTF338232

Family and domain databases

InterProiView protein in InterPro
IPR029254 MRFAP1
PANTHERiPTHR31324 PTHR31324, 1 hit
PfamiView protein in Pfam
PF15155 MRFAP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY
60 70 80 90 100
LRNRSKLWEM DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA
110 120
EEKAKEIAKM AEMLVELVRR IEKSESS
Length:127
Mass (Da):14,650
Last modified:November 1, 1999 - v1
Checksum:i11B115C2CCD661C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116272 Genomic DNA Translation: AAD38498.1
CR457144 mRNA Translation: CAG33425.1
AK123360 mRNA Translation: BAG53894.1
CH471131 Genomic DNA Translation: EAW82386.1
CH471131 Genomic DNA Translation: EAW82387.1
BC022797 mRNA Translation: AAH22797.1
CCDSiCCDS3389.1
RefSeqiNP_001258982.1, NM_001272053.1
NP_150638.1, NM_033296.2
UniGeneiHs.406590

Genome annotation databases

EnsembliENST00000320912; ENSP00000318352; ENSG00000179010
ENST00000382581; ENSP00000372024; ENSG00000179010
ENST00000507420; ENSP00000422065; ENSG00000179010
GeneIDi93621
KEGGihsa:93621
UCSCiuc003gjg.3 human

Similar proteinsi

Entry informationi

Entry nameiMOFA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y605
Secondary accession number(s): B3KVT2, D3DVT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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