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Entry version 150 (08 May 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Host cell factor 2

Gene

HCFC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: ProtInc

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Host cell factor 2
Short name:
HCF-2
Alternative name(s):
C2 factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HCFC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24972 HCFC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607926 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5Z7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29915

Open Targets

More...
OpenTargetsi
ENSG00000111727

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868925

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HCFC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62900381

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190721 – 792Host cell factor 2Add BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5Z7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y5Z7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5Z7

PeptideAtlas

More...
PeptideAtlasi
Q9Y5Z7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5Z7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86554

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5Z7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5Z7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111727 Expressed in 199 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5Z7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5Z7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006227

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118959, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y5Z7

Protein interaction database and analysis system

More...
IntActi
Q9Y5Z7, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229330

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 79Kelch 1Add BLAST46
Repeati83 – 130Kelch 2Add BLAST48
Repeati207 – 255Kelch 3Add BLAST49
Repeati257 – 303Kelch 4Add BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini359 – 449Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini583 – 675Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini677 – 787Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4152 Eukaryota
ENOG410Y5AC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5Z7

KEGG Orthology (KO)

More...
KOi
K14966

Identification of Orthologs from Complete Genome Data

More...
OMAi
HNSCVVD

Database of Orthologous Groups

More...
OrthoDBi
416932at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5Z7

TreeFam database of animal gene trees

More...
TreeFami
TF314757

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR011043 Gal_Oxase/kelch_b-propeller
IPR037932 HCFC2
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller

The PANTHER Classification System

More...
PANTHERi
PTHR46003:SF2 PTHR46003:SF2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 1 hit
SSF50965 SSF50965, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5Z7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH
60 70 80 90 100
VYNTATNQWF LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL
110 120 130 140 150
YELQASRWLW KKVKPHPPPS GLPPCPRLGH SFSLYGNKCY LFGGLANESE
160 170 180 190 200
DSNNNVPRYL NDFYELELQH GSGVVGWSIP VTKGVVPSPR ESHTAVIYCK
210 220 230 240 250
KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT VPLPRSLHTA
260 270 280 290 300
SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV
310 320 330 340 350
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW
360 370 380 390 400
YLDTEKPPAP SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS
410 420 430 440 450
SDSSAAPNMQ GVRMDPHRQG SNNIVPNSIN DTINSTKTEQ PATKETSMKN
460 470 480 490 500
KPDFKALTDS NAILYPSLAS NASNHNSHVV DMLRKNEGPH TSANVGVLSS
510 520 530 540 550
CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV VKDETSLTTF
560 570 580 590 600
STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD
610 620 630 640 650
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR
660 670 680 690 700
FRVAAINGCG IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP
710 720 730 740 750
TSPSGNILEY SAYLAIRTAQ IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN
760 770 780 790
AHIDYTSRPA IVFRISAKNE KGYGPATQVR WLQGNNKKAP LN
Length:792
Mass (Da):86,779
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEADF5FF25F70856C
GO
Isoform 2 (identifier: Q9Y5Z7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-412: GV → DQ
     413-792: Missing.

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):45,828
Checksum:i2EA7A06A247B3BCC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU09F8VU09_HUMAN
Host cell factor 2
HCFC2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05004446A → S. Corresponds to variant dbSNP:rs2700500Ensembl.1
Natural variantiVAR_033984268G → A. Corresponds to variant dbSNP:rs17035206Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057024411 – 412GV → DQ in isoform 2. 1 Publication2
Alternative sequenceiVSP_057025413 – 792Missing in isoform 2. 1 PublicationAdd BLAST380

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF117210 mRNA Translation: AAD27814.1
AK313466 mRNA Translation: BAG36252.1
AC078819 Genomic DNA No translation available.
AC084359 Genomic DNA No translation available.
AC089983 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97736.1
CH471054 Genomic DNA Translation: EAW97737.1
BC006558 mRNA Translation: AAH06558.1
BC033799 mRNA Translation: AAH33799.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9097.1 [Q9Y5Z7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_037452.1, NM_013320.2 [Q9Y5Z7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229330; ENSP00000229330; ENSG00000111727 [Q9Y5Z7-1]
ENST00000544223; ENSP00000442942; ENSG00000111727 [Q9Y5Z7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29915

UCSC genome browser

More...
UCSCi
uc001tkj.5 human [Q9Y5Z7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117210 mRNA Translation: AAD27814.1
AK313466 mRNA Translation: BAG36252.1
AC078819 Genomic DNA No translation available.
AC084359 Genomic DNA No translation available.
AC089983 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97736.1
CH471054 Genomic DNA Translation: EAW97737.1
BC006558 mRNA Translation: AAH06558.1
BC033799 mRNA Translation: AAH33799.1
CCDSiCCDS9097.1 [Q9Y5Z7-1]
RefSeqiNP_037452.1, NM_013320.2 [Q9Y5Z7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi118959, 38 interactors
CORUMiQ9Y5Z7
IntActiQ9Y5Z7, 17 interactors
STRINGi9606.ENSP00000229330

PTM databases

iPTMnetiQ9Y5Z7
PhosphoSitePlusiQ9Y5Z7

Polymorphism and mutation databases

BioMutaiHCFC2
DMDMi62900381

Proteomic databases

EPDiQ9Y5Z7
jPOSTiQ9Y5Z7
PaxDbiQ9Y5Z7
PeptideAtlasiQ9Y5Z7
PRIDEiQ9Y5Z7
ProteomicsDBi86554

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29915
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229330; ENSP00000229330; ENSG00000111727 [Q9Y5Z7-1]
ENST00000544223; ENSP00000442942; ENSG00000111727 [Q9Y5Z7-2]
GeneIDi29915
KEGGihsa:29915
UCSCiuc001tkj.5 human [Q9Y5Z7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29915
DisGeNETi29915

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HCFC2
HGNCiHGNC:24972 HCFC2
HPAiHPA006227
MIMi607926 gene
neXtProtiNX_Q9Y5Z7
OpenTargetsiENSG00000111727
PharmGKBiPA134868925

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4152 Eukaryota
ENOG410Y5AC LUCA
GeneTreeiENSGT00940000160733
HOGENOMiHOG000021205
InParanoidiQ9Y5Z7
KOiK14966
OMAiHNSCVVD
OrthoDBi416932at2759
PhylomeDBiQ9Y5Z7
TreeFamiTF314757

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HCFC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29915

Protein Ontology

More...
PROi
PR:Q9Y5Z7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111727 Expressed in 199 organ(s), highest expression level in testis
ExpressionAtlasiQ9Y5Z7 baseline and differential
GenevisibleiQ9Y5Z7 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.120.10.80, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR011043 Gal_Oxase/kelch_b-propeller
IPR037932 HCFC2
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller
PANTHERiPTHR46003:SF2 PTHR46003:SF2, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 1 hit
SSF50965 SSF50965, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCFC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5Z7
Secondary accession number(s): B2R8Q5, C0H5X3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: May 8, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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