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Protein

Heme-binding protein 2

Gene

HEBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.1 Publication

Caution

Has been described as heme-binding protein in mouse, but His-42, a residue essential for heme binding in mouse, is not conserved in all orthologs, or in the heme-binding family member HEBP1.Curated

GO - Molecular functioni

  • heme binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 2
Alternative name(s):
Placental protein 23
Short name:
PP23
Protein SOUL
Gene namesi
Name:HEBP2
Synonyms:C6orf34, SOUL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000051620.10
HGNCiHGNC:15716 HEBP2
MIMi605825 gene
neXtProtiNX_Q9Y5Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi23593
OpenTargetsiENSG00000051620
PharmGKBiPA25935

Polymorphism and mutation databases

BioMutaiHEBP2
DMDMi74753513

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001169002 – 205Heme-binding protein 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei181PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y5Z4
PaxDbiQ9Y5Z4
PeptideAtlasiQ9Y5Z4
PRIDEiQ9Y5Z4
ProteomicsDBi86551
86552 [Q9Y5Z4-2]

PTM databases

iPTMnetiQ9Y5Z4
PhosphoSitePlusiQ9Y5Z4

Expressioni

Tissue specificityi

Detected in placenta.1 Publication

Gene expression databases

BgeeiENSG00000051620 Expressed in 230 organ(s), highest expression level in amniotic fluid
CleanExiHS_HEBP2
ExpressionAtlasiQ9Y5Z4 baseline and differential
GenevisibleiQ9Y5Z4 HS

Organism-specific databases

HPAiHPA016928

Interactioni

Subunit structurei

Monomer. Interacts with LRPPRC (PubMed:11827465). May interact with BCL2L1; an interaction with BCL2L1 was observed using a peptide, but not with the full-length protein (PubMed:21639858). The full-length protein would have to undergo a major conformation change for the interaction to occur (PubMed:21639858). Interacts with PDCD6 (PubMed:27784779).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDCD6O753406EBI-741593,EBI-352915

Protein-protein interaction databases

BioGridi117128, 5 interactors
IntActiQ9Y5Z4, 3 interactors
STRINGi9606.ENSP00000058691

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y5Z4
SMRiQ9Y5Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.1 Publication

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IZTQ Eukaryota
ENOG410ZWW6 LUCA
GeneTreeiENSGT00530000063312
HOVERGENiHBG097982
InParanoidiQ9Y5Z4
OMAiTAYVRTY
OrthoDBiEOG091G0ZIG
PhylomeDBiQ9Y5Z4
TreeFamiTF328887

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPLQPDPG AAEDAAAQAV ETPGWKAPED AGPQPGSYEI RHYGPAKWVS
60 70 80 90 100
TSVESMDWDS AIQTGFTKLN SYIQGKNEKE MKIKMTAPVT SYVEPGSGPF
110 120 130 140 150
SESTITISLY IPSEQQFDPP RPLESDVFIE DRAEMTVFVR SFDGFSSAQK
160 170 180 190 200
NQEQLLTLAS ILREDGKVFD EKVYYTAGYN SPVKLLNRNN EVWLIQKNEP

TKENE
Length:205
Mass (Da):22,875
Last modified:November 1, 1999 - v1
Checksum:iA0B5131F94783E07
GO
Isoform 2 (identifier: Q9Y5Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-33: AEDAAAQAVETPGWKAPEDAGP → F

Show »
Length:184
Mass (Da):20,859
Checksum:iE9AD02AF9E32C67B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5THN1Q5THN1_HUMAN
Heme-binding protein 2
HEBP2
116Annotation score:
C9IZA0C9IZA0_HUMAN
Heme-binding protein 2
HEBP2
127Annotation score:
H7C0N7H7C0N7_HUMAN
Heme-binding protein 2
HEBP2
45Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053364140R → Q. Corresponds to variant dbSNP:rs3734303Ensembl.1
Natural variantiVAR_053365191E → A. Corresponds to variant dbSNP:rs14812Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01705712 – 33AEDAA…EDAGP → F in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117616 mRNA Translation: AAD32099.1
AF411610 mRNA Translation: AAL07394.1
AY427823 mRNA Translation: AAR88624.1
AL031003 Genomic DNA No translation available.
BC008205 mRNA Translation: AAH08205.1
BC010290 mRNA Translation: AAH10290.1
BC093037 mRNA Translation: AAH93037.1
CCDSiCCDS5191.1 [Q9Y5Z4-1]
RefSeqiNP_055135.1, NM_014320.2 [Q9Y5Z4-1]
UniGeneiHs.486589

Genome annotation databases

EnsembliENST00000607197; ENSP00000475750; ENSG00000051620 [Q9Y5Z4-1]
GeneIDi23593
KEGGihsa:23593
UCSCiuc003qhw.2 human [Q9Y5Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117616 mRNA Translation: AAD32099.1
AF411610 mRNA Translation: AAL07394.1
AY427823 mRNA Translation: AAR88624.1
AL031003 Genomic DNA No translation available.
BC008205 mRNA Translation: AAH08205.1
BC010290 mRNA Translation: AAH10290.1
BC093037 mRNA Translation: AAH93037.1
CCDSiCCDS5191.1 [Q9Y5Z4-1]
RefSeqiNP_055135.1, NM_014320.2 [Q9Y5Z4-1]
UniGeneiHs.486589

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R85X-ray1.95E/F/G/H147-172[»]
3R8JX-ray1.60A/B2-205[»]
3R8KX-ray2.85A/B/C/D2-205[»]
4AYZX-ray3.50A/B1-205[»]
4B0YX-ray3.50A1-205[»]
5GQQX-ray2.20A/B20-197[»]
ProteinModelPortaliQ9Y5Z4
SMRiQ9Y5Z4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117128, 5 interactors
IntActiQ9Y5Z4, 3 interactors
STRINGi9606.ENSP00000058691

PTM databases

iPTMnetiQ9Y5Z4
PhosphoSitePlusiQ9Y5Z4

Polymorphism and mutation databases

BioMutaiHEBP2
DMDMi74753513

Proteomic databases

EPDiQ9Y5Z4
PaxDbiQ9Y5Z4
PeptideAtlasiQ9Y5Z4
PRIDEiQ9Y5Z4
ProteomicsDBi86551
86552 [Q9Y5Z4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000607197; ENSP00000475750; ENSG00000051620 [Q9Y5Z4-1]
GeneIDi23593
KEGGihsa:23593
UCSCiuc003qhw.2 human [Q9Y5Z4-1]

Organism-specific databases

CTDi23593
DisGeNETi23593
EuPathDBiHostDB:ENSG00000051620.10
GeneCardsiHEBP2
HGNCiHGNC:15716 HEBP2
HPAiHPA016928
MIMi605825 gene
neXtProtiNX_Q9Y5Z4
OpenTargetsiENSG00000051620
PharmGKBiPA25935
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZTQ Eukaryota
ENOG410ZWW6 LUCA
GeneTreeiENSGT00530000063312
HOVERGENiHBG097982
InParanoidiQ9Y5Z4
OMAiTAYVRTY
OrthoDBiEOG091G0ZIG
PhylomeDBiQ9Y5Z4
TreeFamiTF328887

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiHEBP2 human
GeneWikiiHEBP2
GenomeRNAii23593
PROiPR:Q9Y5Z4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000051620 Expressed in 230 organ(s), highest expression level in amniotic fluid
CleanExiHS_HEBP2
ExpressionAtlasiQ9Y5Z4 baseline and differential
GenevisibleiQ9Y5Z4 HS

Family and domain databases

Gene3Di3.20.80.10, 1 hit
InterProiView protein in InterPro
IPR011256 Reg_factor_effector_dom_sf
IPR006917 SOUL_haem-bd
PANTHERiPTHR11220 PTHR11220, 1 hit
PfamiView protein in Pfam
PF04832 SOUL, 1 hit
SUPFAMiSSF55136 SSF55136, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Z4
Secondary accession number(s): Q96P57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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