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UniProtKB - Q9Y5Z0 (BACE2_HUMAN)

Entry version 185 (11 Dec 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Beta-secretase 2

Gene

BACE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1101
Active sitei3031

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:G66-33964-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.23.45 2681

Protein family/group databases

MEROPS protease database

More...MEROPSi		A01.041

Transport Classification Database

More...TCDBi		8.A.32.1.2 the Beta-amyloid cleaving enzyme (bace1) family
8.A.32.1.3 the Beta-amyloid cleaving enzyme (bace1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-secretase 2 (EC:3.4.23.451 Publication)
Alternative name(s):
Aspartic-like protease 56 kDa
Aspartyl protease 1
Short name:
ASP1
Short name:
Asp 1
Beta-site amyloid precursor protein cleaving enzyme 2
Short name:
Beta-site APP cleaving enzyme 2
Down region aspartic protease
Short name:
DRAP
Memapsin-1
Membrane-associated aspartic protease 1
Theta-secretase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BACE2
Synonyms:AEPLC, ALP56, ASP21
ORF Names:CDA13, UNQ418/PRO852
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000182240.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:934 BACE2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605668 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5Z0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 473ExtracellularSequence analysisAdd BLAST453
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 518CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi110D → A or N: Loss of autoproteolytic cleavage. 2 Publications1
Mutagenesisi303D → A: Loss of autoproteolytic cleavage. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		25825

Open Targets

More...OpenTargetsi		ENSG00000182240

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25233

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5Z0 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2525

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2331

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BACE2

Domain mapping of disease mutations (DMDM)

More...DMDMi		6685260

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002594521 – 625 PublicationsAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002594663 – 518Beta-secretase 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi233 ↔ 4331 Publication
Disulfide bondi292 ↔ 4571 Publication
Disulfide bondi344 ↔ 3931 Publication
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes autoproteolytic cleavage.2 Publications
Glycosylated.2 Publications

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y5Z0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y5Z0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5Z0

PeptideAtlas

More...PeptideAtlasi		Q9Y5Z0

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5Z0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86546 [Q9Y5Z0-1]
86547 [Q9Y5Z0-2]
86548 [Q9Y5Z0-3]
86549 [Q9Y5Z0-4]
86550 [Q9Y5Z0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5Z0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5Z0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.7 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in primary breast and colon tumors and liver metastasis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182240 Expressed in 210 organ(s), highest expression level in parotid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y5Z0 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035416

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts ith RTN3 and RTN4.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P109973EBI-11282723,EBI-8526679

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117353, 18 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y5Z0, 19 interactors

Molecular INTeraction database

More...MINTi		Q9Y5Z0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332979

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y5Z0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5Z0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1518
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y5Z0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y5Z0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 429Peptidase A1PROSITE-ProRule annotationAdd BLAST338

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1339 Eukaryota
ENOG410XNV7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159548

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5Z0

KEGG Orthology (KO)

More...KOi		K07747

Identification of Orthologs from Complete Genome Data

More...OMAi		EWYYQVE

Database of Orthologous Groups

More...OrthoDBi		826997at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5Z0

TreeFam database of animal gene trees

More...TreeFami		TF329595

Family and domain databases

Conserved Domains Database

More...CDDi		cd05473 beta_secretase_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.70.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR009119 BACE
IPR009121 BACE2
IPR033874 Memapsin-like
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13683 PTHR13683, 1 hit
PTHR13683:SF262 PTHR13683:SF262, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00026 Asp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01817 BACE2
PR01815 BACEFAMILY
PR00792 PEPSIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50630 SSF50630, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y5Z0-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG 
        60         70         80         90        100
TPAERHADGL ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT 
       110        120        130        140        150
PPQKLQILVD TGSSNFAVAG TPHSYIDTYF DTERSSTYRS KGFDVTVKYT 
       160        170        180        190        200
QGSWTGFVGE DLVTIPKGFN TSFLVNIATI FESENFFLPG IKWNGILGLA 
       210        220        230        240        250
YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA GSGTNGGSLV 
       260        270        280        290        300
LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA 
       310        320        330        340        350
IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET 
       360        370        380        390        400
PWSYFPKISI YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP 
       410        420        430        440        450
STNALVIGAT VMEGFYVIFD RAQKRVGFAA SPCAEIAGAA VSEISGPFST 
       460        470        480        490        500
EDVASNCVPA QSLSEPILWI VSYALMSVCG AILLVLIVLL LLPFRCQRRP 
       510 
RDPEVVNDES SLVRHRWK
Length:518
Mass (Da):56,180
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E903150823760D3
GO
Isoform 2 (identifier: Q9Y5Z0-2) [UniParc]FASTAAdd to basket
Also known as: Isoform C

The sequence of this isoform differs from the canonical sequence as follows:
     329-378: Missing.

Show »
Length:468
Mass (Da):50,325
Checksum:i717E0920126A0142
GO
Isoform 3 (identifier: Q9Y5Z0-3) [UniParc]FASTAAdd to basket
Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
     379-396: LYIQPMMGAGLNYECYRF → KLQVLQCLKFPGLSQQRM
     397-518: Missing.

Show »
Length:396
Mass (Da):42,985
Checksum:iEDB3A7AF391CEACA
GO
Isoform 4 (identifier: Q9Y5Z0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:439
Mass (Da):48,275
Checksum:i02EC0E0E50F11602
GO
Isoform 5 (identifier: Q9Y5Z0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:423
Mass (Da):46,476
Checksum:i675FBF380B57CE7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36A → T in AAF13714 (PubMed:10677483).Curated1
Sequence conflicti184E → G in BAC11682 (PubMed:14702039).Curated1
Sequence conflicti192K → Q in BAC11682 (PubMed:14702039).Curated1
Sequence conflicti233C → R in BAC11682 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q9Y5Z0-3)
Sequence conflicti381Q → R in AAF35836 (PubMed:10965118).Curated1
Sequence conflicti396M → F in AAF35836 (PubMed:10965118).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380231 – 95Missing in isoform 5. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0380241 – 79Missing in isoform 4. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_038025329 – 378Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_038026379 – 396LYIQP…ECYRF → KLQVLQCLKFPGLSQQRM in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_038027397 – 518Missing in isoform 3. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF200342 mRNA Translation: AAF17078.1
AF117892 mRNA Translation: AAD45240.1
AF178532 mRNA Translation: AAF29494.1
AF188276 mRNA Translation: AAF35835.1
AF188277 mRNA Translation: AAF35836.1
AF050171 mRNA Translation: AAD45963.1
AF204944 mRNA Translation: AAF26368.1
AF200192 mRNA Translation: AAF13714.1
AF212252 mRNA Translation: AAG41783.1
AY358927 mRNA Translation: AAQ89286.1
AK075539 mRNA Translation: BAC11682.1
AK292056 mRNA Translation: BAF84745.1
AL163284 Genomic DNA Translation: CAB90458.1
AL163285 Genomic DNA Translation: CAB90554.1
CH471079 Genomic DNA Translation: EAX09611.1
CH471079 Genomic DNA Translation: EAX09613.1
BC014453 mRNA Translation: AAH14453.1
AY769996 Genomic DNA Translation: AAX14808.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13668.1 [Q9Y5Z0-1]
CCDS13669.1 [Q9Y5Z0-2]
CCDS13670.1 [Q9Y5Z0-3]

NCBI Reference Sequences

More...RefSeqi		NP_036237.2, NM_012105.4 [Q9Y5Z0-1]
NP_620476.1, NM_138991.2 [Q9Y5Z0-2]
NP_620477.1, NM_138992.2 [Q9Y5Z0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328735; ENSP00000333854; ENSG00000182240 [Q9Y5Z0-3]
ENST00000330333; ENSP00000332979; ENSG00000182240 [Q9Y5Z0-1]
ENST00000347667; ENSP00000327528; ENSG00000182240 [Q9Y5Z0-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25825

UCSC genome browser

More...UCSCi		uc002yyw.5 human [Q9Y5Z0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200342 mRNA Translation: AAF17078.1
AF117892 mRNA Translation: AAD45240.1
AF178532 mRNA Translation: AAF29494.1
AF188276 mRNA Translation: AAF35835.1
AF188277 mRNA Translation: AAF35836.1
AF050171 mRNA Translation: AAD45963.1
AF204944 mRNA Translation: AAF26368.1
AF200192 mRNA Translation: AAF13714.1
AF212252 mRNA Translation: AAG41783.1
AY358927 mRNA Translation: AAQ89286.1
AK075539 mRNA Translation: BAC11682.1
AK292056 mRNA Translation: BAF84745.1
AL163284 Genomic DNA Translation: CAB90458.1
AL163285 Genomic DNA Translation: CAB90554.1
CH471079 Genomic DNA Translation: EAX09611.1
CH471079 Genomic DNA Translation: EAX09613.1
BC014453 mRNA Translation: AAH14453.1
AY769996 Genomic DNA Translation: AAX14808.1
CCDSiCCDS13668.1 [Q9Y5Z0-1]
CCDS13669.1 [Q9Y5Z0-2]
CCDS13670.1 [Q9Y5Z0-3]
RefSeqiNP_036237.2, NM_012105.4 [Q9Y5Z0-1]
NP_620476.1, NM_138991.2 [Q9Y5Z0-2]
NP_620477.1, NM_138992.2 [Q9Y5Z0-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EWYX-ray3.10A/B/C/D78-460[»]
3ZKGX-ray1.90A/B75-460[»]
3ZKIX-ray2.40A/B75-460[»]
3ZKMX-ray1.85A/B75-460[»]
3ZKNX-ray2.00A/B75-460[»]
3ZKQX-ray1.51A75-460[»]
3ZKSX-ray2.11A75-460[»]
3ZKXX-ray2.37A75-460[»]
3ZL7X-ray3.20A75-460[»]
3ZLQX-ray2.10A/B75-460[»]
4BELX-ray1.85A/B75-460[»]
4BFBX-ray2.21A/B75-460[»]
6JSZX-ray1.53A75-460[»]
SMRiQ9Y5Z0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117353, 18 interactors
IntActiQ9Y5Z0, 19 interactors
MINTiQ9Y5Z0
STRINGi9606.ENSP00000332979

Chemistry databases

BindingDBiQ9Y5Z0
ChEMBLiCHEMBL2525
GuidetoPHARMACOLOGYi2331

Protein family/group databases

MEROPSiA01.041
TCDBi8.A.32.1.2 the Beta-amyloid cleaving enzyme (bace1) family
8.A.32.1.3 the Beta-amyloid cleaving enzyme (bace1) family

PTM databases

iPTMnetiQ9Y5Z0
PhosphoSitePlusiQ9Y5Z0

Polymorphism and mutation databases

BioMutaiBACE2
DMDMi6685260

Proteomic databases

jPOSTiQ9Y5Z0
MassIVEiQ9Y5Z0
PaxDbiQ9Y5Z0
PeptideAtlasiQ9Y5Z0
PRIDEiQ9Y5Z0
ProteomicsDBi86546 [Q9Y5Z0-1]
86547 [Q9Y5Z0-2]
86548 [Q9Y5Z0-3]
86549 [Q9Y5Z0-4]
86550 [Q9Y5Z0-5]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9Y5Z0

The DNASU plasmid repository

More...DNASUi		25825

Genome annotation databases

EnsembliENST00000328735; ENSP00000333854; ENSG00000182240 [Q9Y5Z0-3]
ENST00000330333; ENSP00000332979; ENSG00000182240 [Q9Y5Z0-1]
ENST00000347667; ENSP00000327528; ENSG00000182240 [Q9Y5Z0-2]
GeneIDi25825
KEGGihsa:25825
UCSCiuc002yyw.5 human [Q9Y5Z0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25825
DisGeNETi25825
EuPathDBiHostDB:ENSG00000182240.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		BACE2
HGNCiHGNC:934 BACE2
HPAiHPA035416
MIMi605668 gene
neXtProtiNX_Q9Y5Z0
OpenTargetsiENSG00000182240
PharmGKBiPA25233

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00940000159548
InParanoidiQ9Y5Z0
KOiK07747
OMAiEWYYQVE
OrthoDBi826997at2759
PhylomeDBiQ9Y5Z0
TreeFamiTF329595

Enzyme and pathway databases

BioCyciMetaCyc:G66-33964-MONOMER
BRENDAi3.4.23.45 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BACE2 human
EvolutionaryTraceiQ9Y5Z0

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Beta-secretase_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25825
PharosiQ9Y5Z0 Tchem

Protein Ontology

More...PROi		PR:Q9Y5Z0
RNActiQ9Y5Z0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182240 Expressed in 210 organ(s), highest expression level in parotid gland
GenevisibleiQ9Y5Z0 HS

Family and domain databases

CDDicd05473 beta_secretase_like, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR009119 BACE
IPR009121 BACE2
IPR033874 Memapsin-like
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF262 PTHR13683:SF262, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR01817 BACE2
PR01815 BACEFAMILY
PR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBACE2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5Z0
Secondary accession number(s): A8K7P1
, Q5DIH8, Q8N2D4, Q9H2V8, Q9NZL1, Q9NZL2, Q9UJT6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: December 11, 2019
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Peptidase families
    Classification of peptidase families and list of entries
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