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Entry version 154 (13 Feb 2019)
Sequence version 2 (02 Sep 2008)
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Protein

Sodium channel protein type 10 subunit alpha

Gene

SCN10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • voltage-gated ion channel activity Source: UniProtKB-KW
  • voltage-gated sodium channel activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5576892 Phase 0 - rapid depolarisation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y5Y9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel protein type 10 subunit alpha
Alternative name(s):
Peripheral nerve sodium channel 3
Short name:
PN3
Short name:
hPN3
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCN10A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185313.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10582 SCN10A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604427 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5Y9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 125CytoplasmicCuratedAdd BLAST125
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei126 – 149Helical; Name=S1 of repeat ISequence analysisAdd BLAST24
Topological domaini150 – 154ExtracellularCurated5
Transmembranei155 – 174Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini175 – 187CytoplasmicCuratedAdd BLAST13
Transmembranei188 – 206Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini207 – 212ExtracellularCurated6
Transmembranei213 – 232Helical; Voltage-sensor; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini233 – 248CytoplasmicCuratedAdd BLAST16
Transmembranei249 – 272Helical; Name=S5 of repeat ISequence analysisAdd BLAST24
Topological domaini273 – 341ExtracellularCuratedAdd BLAST69
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei342 – 366Pore-formingBy similarityAdd BLAST25
Topological domaini367 – 373ExtracellularCurated7
Transmembranei374 – 399Helical; Name=S6 of repeat ISequence analysisAdd BLAST26
Topological domaini400 – 659CytoplasmicCuratedAdd BLAST260
Transmembranei660 – 684Helical; Name=S1 of repeat IISequence analysisAdd BLAST25
Topological domaini685 – 695ExtracellularCuratedAdd BLAST11
Transmembranei696 – 719Helical; Name=S2 of repeat IISequence analysisAdd BLAST24
Topological domaini720 – 727CytoplasmicCurated8
Transmembranei728 – 747Helical; Name=S3 of repeat IISequence analysisAdd BLAST20
Topological domaini748 – 753ExtracellularCurated6
Transmembranei754 – 773Helical; Voltage-sensor; Name=S4 of repeat IISequence analysisAdd BLAST20
Topological domaini774 – 789CytoplasmicCuratedAdd BLAST16
Transmembranei790 – 810Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini811 – 834ExtracellularCuratedAdd BLAST24
Intramembranei835 – 855Pore-formingBy similarityAdd BLAST21
Topological domaini856 – 864ExtracellularCurated9
Transmembranei865 – 890Helical; Name=S6 of repeat IISequence analysisAdd BLAST26
Topological domaini891 – 1147CytoplasmicCuratedAdd BLAST257
Transmembranei1148 – 1171Helical; Name=S1 of repeat IIISequence analysisAdd BLAST24
Topological domaini1172 – 1184ExtracellularCuratedAdd BLAST13
Transmembranei1185 – 1210Helical; Name=S2 of repeat IIISequence analysisAdd BLAST26
Topological domaini1211 – 1216CytoplasmicCurated6
Transmembranei1217 – 1238Helical; Name=S3 of repeat IIISequence analysisAdd BLAST22
Topological domaini1239 – 1242ExtracellularCurated4
Transmembranei1243 – 1264Helical; Voltage-sensor; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1265 – 1283CytoplasmicCuratedAdd BLAST19
Transmembranei1284 – 1311Helical; Name=S5 of repeat IIISequence analysisAdd BLAST28
Topological domaini1312 – 1353ExtracellularCuratedAdd BLAST42
Intramembranei1354 – 1375Pore-formingBy similarityAdd BLAST22
Topological domaini1376 – 1391ExtracellularCuratedAdd BLAST16
Transmembranei1392 – 1418Helical; Name=S6 of repeat IIISequence analysisAdd BLAST27
Topological domaini1419 – 1471CytoplasmicCuratedAdd BLAST53
Transmembranei1472 – 1495Helical; Name=S1 of repeat IVSequence analysisAdd BLAST24
Topological domaini1496 – 1506ExtracellularCuratedAdd BLAST11
Transmembranei1507 – 1530Helical; Name=S2 of repeat IVSequence analysisAdd BLAST24
Topological domaini1531 – 1536CytoplasmicCurated6
Transmembranei1537 – 1560Helical; Name=S3 of repeat IVSequence analysisAdd BLAST24
Topological domaini1561 – 1572ExtracellularCuratedAdd BLAST12
Transmembranei1573 – 1594Helical; Voltage-sensor; Name=S4 of repeat IVSequence analysisAdd BLAST22
Topological domaini1595 – 1609CytoplasmicCuratedAdd BLAST15
Transmembranei1610 – 1632Helical; Name=S5 of repeat IVSequence analysisAdd BLAST23
Topological domaini1633 – 1646ExtracellularCuratedAdd BLAST14
Intramembranei1647 – 1669Pore-formingBy similarityAdd BLAST23
Topological domaini1670 – 1697ExtracellularCuratedAdd BLAST28
Transmembranei1698 – 1722Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1723 – 1956CytoplasmicCuratedAdd BLAST234

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Episodic pain syndrome, familial, 2 (FEPS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurologic disorder characterized by adult-onset of paroxysmal pain mainly affecting the distal lower extremities.
See also OMIM:615551
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070878554L → P in FEPS2; increases the excitability of small DRG neurons. 1 PublicationCorresponds to variant dbSNP:rs138404783EnsemblClinVar.1
Natural variantiVAR_0708821304A → T in FEPS2; increases the excitability of small DRG neurons. 1 PublicationCorresponds to variant dbSNP:rs142173735EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6336

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SCN10A

MalaCards human disease database

More...
MalaCardsi
SCN10A
MIMi615551 phenotype

Open Targets

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OpenTargetsi
ENSG00000185313

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
130 Brugada syndrome
88642 Channelopathy-associated congenital insensitivity to pain
46348 Paroxysmal extreme pain disorder
90026 Primary erythromelalgia
101016 Romano-Ward syndrome
306577 Sodium channelopathy-related small fiber neuropathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35000

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5451

Drug and drug target database

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DrugBanki
DB01086 Benzocaine
DB00297 Bupivacaine
DB01161 Chloroprocaine
DB00527 Cinchocaine
DB00907 Cocaine
DB00645 Dyclonine
DB00473 Hexylcaine
DB06218 Lacosamide
DB01002 Levobupivacaine
DB00281 Lidocaine
DB00961 Mepivacaine
DB01173 Orphenadrine
DB00892 Oxybuprocaine
DB00721 Procaine
DB00807 Proparacaine
DB00296 Ropivacaine
DB00313 Valproic Acid

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
585

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SCN10A

Domain mapping of disease mutations (DMDM)

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DMDMi
205371821

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485071 – 1956Sodium channel protein type 10 subunit alphaAdd BLAST1956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi276 ↔ 319By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei441PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1
Modified residuei479PhosphoserineBy similarity1
Modified residuei612PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1
Glycosylationi819N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi857 ↔ 866By similarity
Glycosylationi1312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1336N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1451Phosphoserine; by PKCBy similarity1
Glycosylationi1686N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by NEDD4L; which promotes its endocytosis.By similarity
Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity
Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5Y9

PeptideAtlas

More...
PeptideAtlasi
Q9Y5Y9

PRoteomics IDEntifications database

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PRIDEi
Q9Y5Y9

ProteomicsDB human proteome resource

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ProteomicsDBi
86545

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5Y9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5Y9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the dorsal root ganglia and sciatic nerve.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185313 Expressed in 78 organ(s), highest expression level in occipital lobe

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y5Y9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y5Y9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000390600

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y5Y9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y5Y9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y5Y9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati116 – 405ICuratedAdd BLAST290
Repeati647 – 911IICuratedAdd BLAST265
Repeati1140 – 1449IIICuratedAdd BLAST310
Repeati1458 – 1757IVCuratedAdd BLAST300
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1851 – 1880IQAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231755

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053100

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y5Y9

KEGG Orthology (KO)

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KOi
K04842

Identification of Orthologs from Complete Genome Data

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OMAi
DCIIVTV

Database of Orthologous Groups

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OrthoDBi
609083at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y5Y9

TreeFam database of animal gene trees

More...
TreeFami
TF323985

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10037:SF208 PTHR10037:SF208, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00170 NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y5Y9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK
60 70 80 90 100
PRPQLDLKAC NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT
110 120 130 140 150
ISRFSATRAL WLFSPFNLIR RTAIKVSVHS WFSLFITVTI LVNCVCMTRT
160 170 180 190 200
DLPEKIEYVF TVIYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA
210 220 230 240 250
YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVKKLADVT
260 270 280 290 300
ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN
310 320 330 340 350
KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF
360 370 380 390 400
RLMTQDSWER LYQQTLRTSG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY
410 420 430 440 450
EEQNQATTDE IEAKEKKFQE ALEMLRKEQE VLAALGIDTT SLHSHNGSPL
460 470 480 490 500
TSKNASERRH RIKPRVSEGS TEDNKSPRSD PYNQRRMSFL GLASGKRRAS
510 520 530 540 550
HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG GGAGQQGPLP
560 570 580 590 600
RSPLPQPSNP DSRHGEDEHQ PPPTSELAPG AVDVSAFDAG QKKTFLSAEY
610 620 630 640 650
LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLSQ KYLIWDCCPM
660 670 680 690 700
WVKLKTILFG LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG
710 720 730 740 750
NIVFTIFFTA EMVFKIIAFD PYYYFQKKWN IFDCIIVTVS LLELGVAKKG
760 770 780 790 800
SLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TIILAIIVFV
810 820 830 840 850
FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL IVFRILCGEW
860 870 880 890 900
IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA
910 920 930 940 950
PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRSCPFPQ PKAEPELVVK
960 970 980 990 1000
LPLSSSKAEN HIAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA
1010 1020 1030 1040 1050
EGESDLDDLE DDGGEDAQSF QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT
1060 1070 1080 1090 1100
GTSSEDLAPS LGETWKDESV PQVPAEGVDD TSSSEGSTVD CLDPEEILRK
1110 1120 1130 1140 1150
IPELADDLEE PDDCFTEGCI RHCPCCKLDT TKSPWDVGWQ VRKTCYRIVE
1160 1170 1180 1190 1200
HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE
1210 1220 1230 1240 1250
MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR
1260 1270 1280 1290 1300
TLRALRPLRA LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV
1310 1320 1330 1340 1350
NLFAGKFWRC INYTDGEFSL VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF
1360 1370 1380 1390 1400
DNVAMGYLAL LQVATFKGWM DIMYAAVDSR EVNMQPKWED NVYMYLYFVI
1410 1420 1430 1440 1450
FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK KYYNAMKKLG
1460 1470 1480 1490 1500
SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ
1510 1520 1530 1540 1550
SEEKTKILGK INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVVLS
1560 1570 1580 1590 1600
IASLIFSAIL KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL
1610 1620 1630 1640 1650
MMSLPALFNI GLLLFLVMFI YSIFGMSSFP HVRWEAGIDD MFNFQTFANS
1660 1670 1680 1690 1700
MLCLFQITTS AGWDGLLSPI LNTGPPYCDP NLPNSNGTRG DCGSPAVGII
1710 1720 1730 1740 1750
FFTTYIIISF LIMVNMYIAV ILENFNVATE ESTEPLSEDD FDMFYETWEK
1760 1770 1780 1790 1800
FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC
1810 1820 1830 1840 1850
LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ
1860 1870 1880 1890 1900
EDISATVIQK AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN
1910 1920 1930 1940 1950
ENCVLPDKSE TASATSFPPS YESVTRGLSD RVNMRTSSSI QNEDEATSME

LIAPGP
Length:1,956
Mass (Da):220,626
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A4A2C5E135B6685
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6J6A0A2R8Y6J6_HUMAN
Sodium channel protein
SCN10A
1,955Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7H0A0A2R8Y7H0_HUMAN
Sodium channel protein
SCN10A
1,956Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020605509S → P. Corresponds to variant dbSNP:rs7630989EnsemblClinVar.1
Natural variantiVAR_070878554L → P in FEPS2; increases the excitability of small DRG neurons. 1 PublicationCorresponds to variant dbSNP:rs138404783EnsemblClinVar.1
Natural variantiVAR_048696590G → R. Corresponds to variant dbSNP:rs35332705EnsemblClinVar.1
Natural variantiVAR_064748916R → W Found in a renal cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs370208223Ensembl.1
Natural variantiVAR_070879939P → L1 PublicationCorresponds to variant dbSNP:rs202174472EnsemblClinVar.1
Natural variantiVAR_070880940Q → L1 Publication1
Natural variantiVAR_0708811056D → N1 PublicationCorresponds to variant dbSNP:rs751574392Ensembl.1
Natural variantiVAR_0206061073V → A1 PublicationCorresponds to variant dbSNP:rs6795970EnsemblClinVar.1
Natural variantiVAR_0206071092L → P. Corresponds to variant dbSNP:rs12632942EnsemblClinVar.1
Natural variantiVAR_0708821304A → T in FEPS2; increases the excitability of small DRG neurons. 1 PublicationCorresponds to variant dbSNP:rs142173735EnsemblClinVar.1
Natural variantiVAR_0708831523C → Y No gain in function in response to depolarization. 1 PublicationCorresponds to variant dbSNP:rs142217269EnsemblClinVar.1
Natural variantiVAR_0708841662G → S1 PublicationCorresponds to variant dbSNP:rs151090729EnsemblClinVar.1
Natural variantiVAR_0206081713M → V1 PublicationCorresponds to variant dbSNP:rs6599241Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF117907 mRNA Translation: AAD30863.1
AC116038 Genomic DNA No translation available.
AC137625 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS33736.1

NCBI Reference Sequences

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RefSeqi
NP_001280235.2, NM_001293306.2
NP_001280236.2, NM_001293307.2
NP_006505.3, NM_006514.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.250443

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000449082; ENSP00000390600; ENSG00000185313
ENST00000644826; ENSP00000494789; ENSG00000185313

Database of genes from NCBI RefSeq genomes

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GeneIDi
6336

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6336

UCSC genome browser

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UCSCi
uc003ciq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117907 mRNA Translation: AAD30863.1
AC116038 Genomic DNA No translation available.
AC137625 Genomic DNA No translation available.
CCDSiCCDS33736.1
RefSeqiNP_001280235.2, NM_001293306.2
NP_001280236.2, NM_001293307.2
NP_006505.3, NM_006514.3
UniGeneiHs.250443

3D structure databases

ProteinModelPortaliQ9Y5Y9
SMRiQ9Y5Y9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000390600

Chemistry databases

BindingDBiQ9Y5Y9
ChEMBLiCHEMBL5451
DrugBankiDB01086 Benzocaine
DB00297 Bupivacaine
DB01161 Chloroprocaine
DB00527 Cinchocaine
DB00907 Cocaine
DB00645 Dyclonine
DB00473 Hexylcaine
DB06218 Lacosamide
DB01002 Levobupivacaine
DB00281 Lidocaine
DB00961 Mepivacaine
DB01173 Orphenadrine
DB00892 Oxybuprocaine
DB00721 Procaine
DB00807 Proparacaine
DB00296 Ropivacaine
DB00313 Valproic Acid
GuidetoPHARMACOLOGYi585

PTM databases

iPTMnetiQ9Y5Y9
PhosphoSitePlusiQ9Y5Y9

Polymorphism and mutation databases

BioMutaiSCN10A
DMDMi205371821

Proteomic databases

PaxDbiQ9Y5Y9
PeptideAtlasiQ9Y5Y9
PRIDEiQ9Y5Y9
ProteomicsDBi86545

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449082; ENSP00000390600; ENSG00000185313
ENST00000644826; ENSP00000494789; ENSG00000185313
GeneIDi6336
KEGGihsa:6336
UCSCiuc003ciq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6336
DisGeNETi6336
EuPathDBiHostDB:ENSG00000185313.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SCN10A
GeneReviewsiSCN10A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0030722
HGNCiHGNC:10582 SCN10A
MalaCardsiSCN10A
MIMi604427 gene
615551 phenotype
neXtProtiNX_Q9Y5Y9
OpenTargetsiENSG00000185313
Orphaneti130 Brugada syndrome
88642 Channelopathy-associated congenital insensitivity to pain
46348 Paroxysmal extreme pain disorder
90026 Primary erythromelalgia
101016 Romano-Ward syndrome
306577 Sodium channelopathy-related small fiber neuropathy
PharmGKBiPA35000

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00940000154992
HOGENOMiHOG000231755
HOVERGENiHBG053100
InParanoidiQ9Y5Y9
KOiK04842
OMAiDCIIVTV
OrthoDBi609083at2759
PhylomeDBiQ9Y5Y9
TreeFamiTF323985

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5576892 Phase 0 - rapid depolarisation
SIGNORiQ9Y5Y9

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SCN10A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6336

Protein Ontology

More...
PROi
PR:Q9Y5Y9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185313 Expressed in 78 organ(s), highest expression level in occipital lobe
ExpressionAtlasiQ9Y5Y9 baseline and differential
GenevisibleiQ9Y5Y9 HS

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF208 PTHR10037:SF208, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCNAA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5Y9
Secondary accession number(s): A6NDQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: September 2, 2008
Last modified: February 13, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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