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Protein

Prostaglandin D2 receptor 2

Gene

PTGDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-418594 G alpha (i) signalling events

Chemistry databases

SwissLipidsiSLP:000001575

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor 2
Alternative name(s):
Chemoattractant receptor-homologous molecule expressed on Th2 cells
G-protein coupled receptor 44
CD_antigen: CD294
Gene namesi
Name:PTGDR2
Synonyms:CRTH2, DL1R, GPR44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000183134.4
HGNCiHGNC:4502 PTGDR2
MIMi604837 gene
neXtProtiNX_Q9Y5Y4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 56Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini57 – 67CytoplasmicSequence analysisAdd BLAST11
Transmembranei68 – 89Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini90 – 106ExtracellularSequence analysisAdd BLAST17
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 168Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini169 – 210ExtracellularSequence analysisAdd BLAST42
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 247CytoplasmicSequence analysisAdd BLAST16
Transmembranei248 – 269Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini270 – 288ExtracellularSequence analysisAdd BLAST19
Transmembranei289 – 308Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini309 – 395CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi330D → A: 45% increases internalization of PTGDR2. 1 Publication1
Mutagenesisi331S → A: 45% increases internalization of PTGDR2. 1 Publication1
Mutagenesisi332E → A: 45% increases internalization of PTGDR2. 1 Publication1
Mutagenesisi333L → A: 45% increase in internalization of PTGDR2. 1 Publication1
Mutagenesisi347T → A: Decreases in PKC-induced internalization of PTGDR2. 1 Publication1

Organism-specific databases

DisGeNETi11251
OpenTargetsiENSG00000183134
PharmGKBiPA28891

Chemistry databases

ChEMBLiCHEMBL5071
DrugBankiDB00328 Indomethacin
DB00605 Sulindac
DB04828 Zomepirac
GuidetoPHARMACOLOGYi339

Polymorphism and mutation databases

BioMutaiPTGDR2
DMDMi296439334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695721 – 395Prostaglandin D2 receptor 2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation
Modified residuei331PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y5Y4
PeptideAtlasiQ9Y5Y4
PRIDEiQ9Y5Y4
ProteomicsDBi86540

PTM databases

iPTMnetiQ9Y5Y4
PhosphoSitePlusiQ9Y5Y4

Expressioni

Tissue specificityi

Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.4 Publications

Gene expression databases

BgeeiENSG00000183134 Expressed in 71 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_GPR44
GenevisibleiQ9Y5Y4 HS

Organism-specific databases

HPAiHPA014259

Interactioni

Protein-protein interaction databases

BioGridi116412, 4 interactors
STRINGi9606.ENSP00000332812

Chemistry databases

BindingDBiQ9Y5Y4

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi330 – 333Involved in the recycling of CRTH24

Domaini

The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV6V Eukaryota
ENOG410YAX7 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG099857
InParanoidiQ9Y5Y4
KOiK06715
OMAiQTVVTTW
OrthoDBiEOG091G0FTA
PhylomeDBiQ9Y5Y4
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y5Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANATLKPL CPILEQMSRL QSHSNTSIRY IDHAAVLLHG LASLLGLVEN
60 70 80 90 100
GVILFVVGCR MRQTVVTTWV LHLALSDLLA SASLPFFTYF LAVGHSWELG
110 120 130 140 150
TTFCKLHSSI FFLNMFASGF LLSAISLDRC LQVVRPVWAQ NHRTVAAAHK
160 170 180 190 200
VCLVLWALAV LNTVPYFVFR DTISRLDGRI MCYYNVLLLN PGPDRDATCN
210 220 230 240 250
SRQVALAVSK FLLAFLVPLA IIASSHAAVS LRLQHRGRRR PGRFVRLVAA
260 270 280 290 300
VVAAFALCWG PYHVFSLLEA RAHANPGLRP LVWRGLPFVT SLAFFNSVAN
310 320 330 340 350
PVLYVLTCPD MLRKLRRSLR TVLESVLVDD SELGGAGSSR RRRTSSTARS
360 370 380 390
ASPLALCSRP EEPRGPARLL GWLLGSCAAS PQTGPLNRAL SSTSS
Length:395
Mass (Da):43,268
Last modified:May 18, 2010 - v3
Checksum:i99A63CBDA418DEC9
GO

Sequence cautioni

The sequence AAD21055 differs from that shown. Reason: Frameshift at position 375.Curated
The sequence AAD21055 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063131204V → A5 PublicationsCorresponds to variant dbSNP:rs2467642Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118265 Genomic DNA Translation: AAD21055.1 Sequence problems.
AB008535 mRNA Translation: BAA74518.1
AF144308 mRNA Translation: AAD34539.1
AY507142 mRNA Translation: AAR92484.1
AP000777 Genomic DNA No translation available.
BC096841 mRNA Translation: AAH96841.1
CCDSiCCDS7994.1
RefSeqiNP_004769.2, NM_004778.2
UniGeneiHs.299567

Genome annotation databases

EnsembliENST00000332539; ENSP00000332812; ENSG00000183134
GeneIDi11251
KEGGihsa:11251
UCSCiuc001nqc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPD2R2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y4
Secondary accession number(s): O94765, Q4QRI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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