UniProtKB - Q9Y5Y3 (GPR45_HUMAN)
Protein
Probable G-protein coupled receptor 45
Gene
GPR45
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor. May play a role in brain function.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5Y3 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | Q9Y5Y3 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 45Alternative name(s): PSP24-1 PSP24-alpha |
Gene namesi | Name:GPR45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4503, GPR45 |
MIMi | 604838, gene |
neXtProti | NX_Q9Y5Y3 |
VEuPathDBi | HostDB:ENSG00000135973.2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 75 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 76 – 96 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 109 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 110 – 130 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 149 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 150 – 170 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 198 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 199 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 268 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 269 – 289 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 305 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 306 – 326 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 372 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11250 |
OpenTargetsi | ENSG00000135973 |
PharmGKBi | PA28892 |
Miscellaneous databases
Pharosi | Q9Y5Y3, Tbio |
Genetic variation databases
BioMutai | GPR45 |
DMDMi | 82654940 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069574 | 1 – 372 | Probable G-protein coupled receptor 45Add BLAST | 372 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 17 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 20 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9Y5Y3 |
PeptideAtlasi | Q9Y5Y3 |
PRIDEi | Q9Y5Y3 |
ProteomicsDBi | 86539 |
PTM databases
GlyGeni | Q9Y5Y3, 3 sites |
iPTMneti | Q9Y5Y3 |
PhosphoSitePlusi | Q9Y5Y3 |
Expressioni
Tissue specificityi
Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.
Gene expression databases
Bgeei | ENSG00000135973, Expressed in cortical plate and 45 other tissues |
ExpressionAtlasi | Q9Y5Y3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000135973, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Q9Y5Y3
With | #Exp. | IntAct |
---|---|---|
OTX2 - isoform 2 [P32243-2] | 3 | EBI-1751869,EBI-9087860 |
Protein-protein interaction databases
BioGRIDi | 116411, 1 interactor |
IntActi | Q9Y5Y3, 5 interactors |
STRINGi | 9606.ENSP00000258456 |
Miscellaneous databases
RNActi | Q9Y5Y3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000183001 |
HOGENOMi | CLU_009579_3_9_1 |
InParanoidi | Q9Y5Y3 |
OMAi | CMPFTAI |
OrthoDBi | 742446at2759 |
PhylomeDBi | Q9Y5Y3 |
TreeFami | TF338633 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y5Y3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACNSTSLEA YTYLLLNTSN ASDSGSTQLP APLRISLAIV MLLMTVVGFL
60 70 80 90 100
GNTVVCIIVY QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAVTLITVRW
110 120 130 140 150
HFGDHFCRLS ATLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPRRAKV
160 170 180 190 200
IIAVSWVLSF CIAGPSLTGW TLVEVPARAP QCVLGYTELP ADRAYVVTLV
210 220 230 240 250
VAVFFAPFGV MLCAYMCILN TVRKNAVRVH NQSDSLDLRQ LTRAGLRRLQ
260 270 280 290 300
RQQQVSVDLS FKTKAFTTIL ILFVGFSLCW LPHSVYSLLS VFSQRFYCGS
310 320 330 340 350
SFYATSTCVL WLSYLKSVFN PIVYCWRIKK FREACIELLP QTFQILPKVP
360 370
ERIRRRIQPS TVYVCNENQS AV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 270 | L → P in AAH67455 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035759 | 7 | S → C in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_049394 | 312 | L → F1 PublicationCorresponds to variant dbSNP:rs35946826Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118266 Genomic DNA Translation: AAD21056.1 AC012360 Genomic DNA Translation: AAY15009.1 BC066879 mRNA Translation: AAH66879.1 BC066880 mRNA Translation: AAH66880.1 BC067455 mRNA Translation: AAH67455.1 |
CCDSi | CCDS2066.1 |
RefSeqi | NP_009158.3, NM_007227.3 |
Genome annotation databases
Ensembli | ENST00000258456; ENSP00000258456; ENSG00000135973 |
GeneIDi | 11250 |
KEGGi | hsa:11250 |
UCSCi | uc002tco.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118266 Genomic DNA Translation: AAD21056.1 AC012360 Genomic DNA Translation: AAY15009.1 BC066879 mRNA Translation: AAH66879.1 BC066880 mRNA Translation: AAH66880.1 BC067455 mRNA Translation: AAH67455.1 |
CCDSi | CCDS2066.1 |
RefSeqi | NP_009158.3, NM_007227.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116411, 1 interactor |
IntActi | Q9Y5Y3, 5 interactors |
STRINGi | 9606.ENSP00000258456 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9Y5Y3, 3 sites |
iPTMneti | Q9Y5Y3 |
PhosphoSitePlusi | Q9Y5Y3 |
Genetic variation databases
BioMutai | GPR45 |
DMDMi | 82654940 |
Proteomic databases
PaxDbi | Q9Y5Y3 |
PeptideAtlasi | Q9Y5Y3 |
PRIDEi | Q9Y5Y3 |
ProteomicsDBi | 86539 |
Protocols and materials databases
Antibodypediai | 17832, 176 antibodies |
DNASUi | 11250 |
Genome annotation databases
Ensembli | ENST00000258456; ENSP00000258456; ENSG00000135973 |
GeneIDi | 11250 |
KEGGi | hsa:11250 |
UCSCi | uc002tco.2, human |
Organism-specific databases
CTDi | 11250 |
DisGeNETi | 11250 |
GeneCardsi | GPR45 |
HGNCi | HGNC:4503, GPR45 |
HPAi | ENSG00000135973, Tissue enriched (brain) |
MIMi | 604838, gene |
neXtProti | NX_Q9Y5Y3 |
OpenTargetsi | ENSG00000135973 |
PharmGKBi | PA28892 |
VEuPathDBi | HostDB:ENSG00000135973.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000183001 |
HOGENOMi | CLU_009579_3_9_1 |
InParanoidi | Q9Y5Y3 |
OMAi | CMPFTAI |
OrthoDBi | 742446at2759 |
PhylomeDBi | Q9Y5Y3 |
TreeFami | TF338633 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5Y3 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | Q9Y5Y3 |
Miscellaneous databases
BioGRID-ORCSi | 11250, 12 hits in 870 CRISPR screens |
GeneWikii | GPR45 |
GenomeRNAii | 11250 |
Pharosi | Q9Y5Y3, Tbio |
PROi | PR:Q9Y5Y3 |
RNActi | Q9Y5Y3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135973, Expressed in cortical plate and 45 other tissues |
ExpressionAtlasi | Q9Y5Y3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR45_HUMAN | |
Accessioni | Q9Y5Y3Primary (citable) accession number: Q9Y5Y3 Secondary accession number(s): Q6NWS4, Q6NXU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | November 22, 2005 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families