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UniProtKB - Q9Y5Y3 (GPR45_HUMAN)

Entry version 152 (10 Feb 2021)
Sequence version 2 (22 Nov 2005)
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Protein

Probable G-protein coupled receptor 45

Gene

GPR45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor. May play a role in brain function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y5Y3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y5Y3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 45
Alternative name(s):
PSP24-1
PSP24-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4503, GPR45

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604838, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y5Y3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135973.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 75CytoplasmicSequence analysisAdd BLAST16
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 109ExtracellularSequence analysisAdd BLAST13
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 149CytoplasmicSequence analysisAdd BLAST19
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 198ExtracellularSequence analysisAdd BLAST28
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 268CytoplasmicSequence analysisAdd BLAST49
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 305ExtracellularSequence analysisAdd BLAST16
Transmembranei306 – 326Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini327 – 372CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11250

Open Targets

More...OpenTargetsi		ENSG00000135973

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28892

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y5Y3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR45

Domain mapping of disease mutations (DMDM)

More...DMDMi		82654940

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695741 – 372Probable G-protein coupled receptor 45Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y5Y3

PeptideAtlas

More...PeptideAtlasi		Q9Y5Y3

PRoteomics IDEntifications database

More...PRIDEi		Q9Y5Y3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86539

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y5Y3, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y5Y3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y5Y3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135973, Expressed in cortical plate and 45 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y5Y3, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135973, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116411, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q9Y5Y3, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258456

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y5Y3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_3_9_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y5Y3

Identification of Orthologs from Complete Genome Data

More...OMAi		CMPFTAI

Database of Orthologous Groups

More...OrthoDBi		742446at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y5Y3

TreeFam database of animal gene trees

More...TreeFami		TF338633

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y5Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACNSTSLEA YTYLLLNTSN ASDSGSTQLP APLRISLAIV MLLMTVVGFL 
        60         70         80         90        100
GNTVVCIIVY QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAVTLITVRW 
       110        120        130        140        150
HFGDHFCRLS ATLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPRRAKV 
       160        170        180        190        200
IIAVSWVLSF CIAGPSLTGW TLVEVPARAP QCVLGYTELP ADRAYVVTLV 
       210        220        230        240        250
VAVFFAPFGV MLCAYMCILN TVRKNAVRVH NQSDSLDLRQ LTRAGLRRLQ 
       260        270        280        290        300
RQQQVSVDLS FKTKAFTTIL ILFVGFSLCW LPHSVYSLLS VFSQRFYCGS 
       310        320        330        340        350
SFYATSTCVL WLSYLKSVFN PIVYCWRIKK FREACIELLP QTFQILPKVP 
       360        370 
ERIRRRIQPS TVYVCNENQS AV
Length:372
Mass (Da):41,967
Last modified:November 22, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA54EC7AE7E80193
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti270L → P in AAH67455 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0357597S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049394312L → F1 PublicationCorresponds to variant dbSNP:rs35946826Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF118266 Genomic DNA Translation: AAD21056.1
AC012360 Genomic DNA Translation: AAY15009.1
BC066879 mRNA Translation: AAH66879.1
BC066880 mRNA Translation: AAH66880.1
BC067455 mRNA Translation: AAH67455.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2066.1

NCBI Reference Sequences

More...RefSeqi		NP_009158.3, NM_007227.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258456; ENSP00000258456; ENSG00000135973

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11250

UCSC genome browser

More...UCSCi		uc002tco.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118266 Genomic DNA Translation: AAD21056.1
AC012360 Genomic DNA Translation: AAY15009.1
BC066879 mRNA Translation: AAH66879.1
BC066880 mRNA Translation: AAH66880.1
BC067455 mRNA Translation: AAH67455.1
CCDSiCCDS2066.1
RefSeqiNP_009158.3, NM_007227.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116411, 1 interactor
IntActiQ9Y5Y3, 5 interactors
STRINGi9606.ENSP00000258456

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ9Y5Y3, 3 sites
iPTMnetiQ9Y5Y3
PhosphoSitePlusiQ9Y5Y3

Genetic variation databases

BioMutaiGPR45
DMDMi82654940

Proteomic databases

PaxDbiQ9Y5Y3
PeptideAtlasiQ9Y5Y3
PRIDEiQ9Y5Y3
ProteomicsDBi86539

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17832, 176 antibodies

The DNASU plasmid repository

More...DNASUi		11250

Genome annotation databases

EnsembliENST00000258456; ENSP00000258456; ENSG00000135973
GeneIDi11250
KEGGihsa:11250
UCSCiuc002tco.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11250
DisGeNETi11250

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR45
HGNCiHGNC:4503, GPR45
HPAiENSG00000135973, Tissue enriched (brain)
MIMi604838, gene
neXtProtiNX_Q9Y5Y3
OpenTargetsiENSG00000135973
PharmGKBiPA28892
VEuPathDBiHostDB:ENSG00000135973.2

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00950000183001
HOGENOMiCLU_009579_3_9_1
InParanoidiQ9Y5Y3
OMAiCMPFTAI
OrthoDBi742446at2759
PhylomeDBiQ9Y5Y3
TreeFamiTF338633

Enzyme and pathway databases

PathwayCommonsiQ9Y5Y3
ReactomeiR-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SignaLinkiQ9Y5Y3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11250, 12 hits in 870 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR45

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11250
PharosiQ9Y5Y3, Tbio

Protein Ontology

More...PROi		PR:Q9Y5Y3
RNActiQ9Y5Y3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135973, Expressed in cortical plate and 45 other tissues
ExpressionAtlasiQ9Y5Y3, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPR45_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5Y3
Secondary accession number(s): Q6NWS4, Q6NXU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 22, 2005
Last modified: February 10, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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