UniProtKB - Q9Y5Y0 (FLVC1_HUMAN)
Feline leukemia virus subgroup C receptor-related protein 1
FLVCR1
Functioni
Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.
4 PublicationsHeme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.
GO - Molecular functioni
- heme binding Source: GO_Central
- heme transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- blood vessel development Source: Ensembl
- cellular iron ion homeostasis Source: Reactome
- embryonic digit morphogenesis Source: Ensembl
- embryonic skeletal system morphogenesis Source: Ensembl
- erythrocyte differentiation Source: MGI
- erythrocyte maturation Source: UniProtKB-KW
- head morphogenesis Source: Ensembl
- heme biosynthetic process Source: Reactome
- heme export Source: UniProtKB
- heme transport Source: MGI
- in utero embryonic development Source: Ensembl
- mitochondrial transport Source: MGI
- multicellular organism growth Source: Ensembl
- regulation of organ growth Source: Ensembl
- spleen development Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Erythrocyte maturation, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5Y0 |
Reactomei | R-HSA-189451, Heme biosynthesis R-HSA-917937, Iron uptake and transport [Q9Y5Y0-1] |
SignaLinki | Q9Y5Y0 |
Protein family/group databases
TCDBi | 2.A.1.28.1, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Feline leukemia virus subgroup C receptor-related protein 1Short name: Feline leukemia virus subgroup C receptor Short name: hFLVCR |
Gene namesi | Name:FLVCR1 Synonyms:FLVCR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24682, FLVCR1 |
MIMi | 609144, gene |
neXtProti | NX_Q9Y5Y0 |
VEuPathDBi | HostDB:ENSG00000162769 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- Mitochondrion membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrion Source: MGI
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 107 | CytoplasmicSequence analysisAdd BLAST | 107 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 147 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 148 – 168 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 169 – 174 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 196 – 199 | ExtracellularSequence analysis | 4 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 240 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 275 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 276 – 296 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 331 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 332 – 352 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 372 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 401 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 424 | ExtracellularSequence analysis | 2 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 459 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 460 – 480 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 481 – 490 | ExtracellularSequence analysis | 10 | |
Transmembranei | 491 – 511 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 512 – 555 | CytoplasmicSequence analysisAdd BLAST | 44 |
Keywords - Cellular componenti
Cell membrane, Membrane, MitochondrionPathology & Biotechi
Involvement in diseasei
Posterior column ataxia with retinitis pigmentosa (PCARP)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065158 | 121 | N → D in PCARP. 1 PublicationCorresponds to variant dbSNP:rs267606820EnsemblClinVar. | 1 | |
Natural variantiVAR_065159 | 192 | C → R in PCARP; also found in a patient with sensory neuropathy and pain insensitivity. 2 PublicationsCorresponds to variant dbSNP:rs267606821EnsemblClinVar. | 1 | |
Natural variantiVAR_065160 | 241 | A → T in PCARP. 1 PublicationCorresponds to variant dbSNP:rs267606819EnsemblClinVar. | 1 | |
Natural variantiVAR_065161 | 493 | G → R in PCARP. 1 PublicationCorresponds to variant dbSNP:rs1558121050EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Neurodegeneration, Neuropathy, Retinitis pigmentosaOrganism-specific databases
DisGeNETi | 28982 |
MalaCardsi | FLVCR1 |
MIMi | 609033, phenotype |
OpenTargetsi | ENSG00000162769 |
Orphaneti | 88628, Posterior column ataxia-retinitis pigmentosa syndrome |
PharmGKBi | PA162388695 |
Miscellaneous databases
Pharosi | Q9Y5Y0, Tbio |
Genetic variation databases
BioMutai | FLVCR1 |
DMDMi | 46396053 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084844 | 1 – 555 | Feline leukemia virus subgroup C receptor-related protein 1Add BLAST | 555 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 536 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9Y5Y0 |
jPOSTi | Q9Y5Y0 |
MassIVEi | Q9Y5Y0 |
MaxQBi | Q9Y5Y0 |
PaxDbi | Q9Y5Y0 |
PeptideAtlasi | Q9Y5Y0 |
PRIDEi | Q9Y5Y0 |
ProteomicsDBi | 86537 [Q9Y5Y0-1] |
PTM databases
GlyGeni | Q9Y5Y0, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y5Y0 |
PhosphoSitePlusi | Q9Y5Y0 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000162769, Expressed in jejunal mucosa and 202 other tissues |
ExpressionAtlasi | Q9Y5Y0, baseline and differential |
Genevisiblei | Q9Y5Y0, HS |
Organism-specific databases
HPAi | ENSG00000162769, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Interacts with HPX.
1 PublicationProtein-protein interaction databases
BioGRIDi | 118803, 87 interactors |
IntActi | Q9Y5Y0, 26 interactors |
MINTi | Q9Y5Y0 |
STRINGi | 9606.ENSP00000355938 |
Miscellaneous databases
RNActi | Q9Y5Y0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 535 – 555 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 541 – 555 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2563, Eukaryota |
GeneTreei | ENSGT01030000234625 |
InParanoidi | Q9Y5Y0 |
OMAi | EKPQYPP |
PhylomeDBi | Q9Y5Y0 |
TreeFami | TF314292 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARPDDEEGA AVAPGHPLAK GYLPLPRGAP VGKESVELQN GPKAGTFPVN
60 70 80 90 100
GAPRDSLAAA SGVLGGPQTP LAPEEETQAR LLPAGAGAET PGAESSPLPL
110 120 130 140 150
TALSPRRFVV LLIFSLYSLV NAFQWIQYSI ISNVFEGFYG VTLLHIDWLS
160 170 180 190 200
MVYMLAYVPL IFPATWLLDT RGLRLTALLG SGLNCLGAWI KCGSVQQHLF
210 220 230 240 250
WVTMLGQCLC SVAQVFILGL PSRIASVWFG PKEVSTACAT AVLGNQLGTA
260 270 280 290 300
VGFLLPPVLV PNTQNDTNLL ACNISTMFYG TSAVATLLFI LTAIAFKEKP
310 320 330 340 350
RYPPSQAQAA LQDSPPEEYS YKKSIRNLFK NIPFVLLLIT YGIMTGAFYS
360 370 380 390 400
VSTLLNQMIL TYYEGEEVNA GRIGLTLVVA GMVGSILCGL WLDYTKTYKQ
410 420 430 440 450
TTLIVYILSF IGMVIFTFTL DLRYIIIVFV TGGVLGFFMT GYLPLGFEFA
460 470 480 490 500
VEITYPESEG TSSGLLNASA QIFGILFTLA QGKLTSDYGP KAGNIFLCVW
510 520 530 540 550
MFIGIILTAL IKSDLRRHNI NIGITNVDVK AIPADSPTDQ EPKTVMLSKQ
SESAI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C3Z2 | H7C3Z2_HUMAN | Feline leukemia virus subgroup C re... | FLVCR1 | 354 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050297 | 52 | A → P1 PublicationCorresponds to variant dbSNP:rs11120047EnsemblClinVar. | 1 | |
Natural variantiVAR_065158 | 121 | N → D in PCARP. 1 PublicationCorresponds to variant dbSNP:rs267606820EnsemblClinVar. | 1 | |
Natural variantiVAR_065159 | 192 | C → R in PCARP; also found in a patient with sensory neuropathy and pain insensitivity. 2 PublicationsCorresponds to variant dbSNP:rs267606821EnsemblClinVar. | 1 | |
Natural variantiVAR_077884 | 221 | P → S Probable disease-associated variant found in a patient with sensory neuropathy and pain insensitivity. 1 PublicationCorresponds to variant dbSNP:rs753000469Ensembl. | 1 | |
Natural variantiVAR_065160 | 241 | A → T in PCARP. 1 PublicationCorresponds to variant dbSNP:rs267606819EnsemblClinVar. | 1 | |
Natural variantiVAR_065161 | 493 | G → R in PCARP. 1 PublicationCorresponds to variant dbSNP:rs1558121050EnsemblClinVar. | 1 | |
Natural variantiVAR_050298 | 544 | T → M1 PublicationCorresponds to variant dbSNP:rs3207090EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047866 | 1 – 276 | Missing in isoform 2. 2 PublicationsAdd BLAST | 276 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118637 mRNA Translation: AAD45243.1 AK001419 mRNA Translation: BAA91679.1 DQ496107 Genomic DNA Translation: ABF47096.1 CH471100 Genomic DNA Translation: EAW93374.1 BC048312 mRNA Translation: AAH48312.1 |
CCDSi | CCDS1510.1 [Q9Y5Y0-1] |
RefSeqi | NP_054772.1, NM_014053.3 [Q9Y5Y0-1] |
Genome annotation databases
Ensembli | ENST00000366971; ENSP00000355938; ENSG00000162769 |
GeneIDi | 28982 |
KEGGi | hsa:28982 |
MANE-Selecti | ENST00000366971.9; ENSP00000355938.4; NM_014053.4; NP_054772.1 |
UCSCi | uc001hjt.3, human [Q9Y5Y0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118637 mRNA Translation: AAD45243.1 AK001419 mRNA Translation: BAA91679.1 DQ496107 Genomic DNA Translation: ABF47096.1 CH471100 Genomic DNA Translation: EAW93374.1 BC048312 mRNA Translation: AAH48312.1 |
CCDSi | CCDS1510.1 [Q9Y5Y0-1] |
RefSeqi | NP_054772.1, NM_014053.3 [Q9Y5Y0-1] |
3D structure databases
SMRi | Q9Y5Y0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118803, 87 interactors |
IntActi | Q9Y5Y0, 26 interactors |
MINTi | Q9Y5Y0 |
STRINGi | 9606.ENSP00000355938 |
Protein family/group databases
TCDBi | 2.A.1.28.1, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q9Y5Y0, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y5Y0 |
PhosphoSitePlusi | Q9Y5Y0 |
Genetic variation databases
BioMutai | FLVCR1 |
DMDMi | 46396053 |
Proteomic databases
EPDi | Q9Y5Y0 |
jPOSTi | Q9Y5Y0 |
MassIVEi | Q9Y5Y0 |
MaxQBi | Q9Y5Y0 |
PaxDbi | Q9Y5Y0 |
PeptideAtlasi | Q9Y5Y0 |
PRIDEi | Q9Y5Y0 |
ProteomicsDBi | 86537 [Q9Y5Y0-1] |
Protocols and materials databases
Antibodypediai | 20720, 178 antibodies from 32 providers |
DNASUi | 28982 |
Genome annotation databases
Ensembli | ENST00000366971; ENSP00000355938; ENSG00000162769 |
GeneIDi | 28982 |
KEGGi | hsa:28982 |
MANE-Selecti | ENST00000366971.9; ENSP00000355938.4; NM_014053.4; NP_054772.1 |
UCSCi | uc001hjt.3, human [Q9Y5Y0-1] |
Organism-specific databases
CTDi | 28982 |
DisGeNETi | 28982 |
GeneCardsi | FLVCR1 |
HGNCi | HGNC:24682, FLVCR1 |
HPAi | ENSG00000162769, Tissue enhanced (intestine) |
MalaCardsi | FLVCR1 |
MIMi | 609033, phenotype 609144, gene |
neXtProti | NX_Q9Y5Y0 |
OpenTargetsi | ENSG00000162769 |
Orphaneti | 88628, Posterior column ataxia-retinitis pigmentosa syndrome |
PharmGKBi | PA162388695 |
VEuPathDBi | HostDB:ENSG00000162769 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2563, Eukaryota |
GeneTreei | ENSGT01030000234625 |
InParanoidi | Q9Y5Y0 |
OMAi | EKPQYPP |
PhylomeDBi | Q9Y5Y0 |
TreeFami | TF314292 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y5Y0 |
Reactomei | R-HSA-189451, Heme biosynthesis R-HSA-917937, Iron uptake and transport [Q9Y5Y0-1] |
SignaLinki | Q9Y5Y0 |
Miscellaneous databases
BioGRID-ORCSi | 28982, 24 hits in 1051 CRISPR screens |
ChiTaRSi | FLVCR1, human |
GeneWikii | FLVCR1 |
GenomeRNAii | 28982 |
Pharosi | Q9Y5Y0, Tbio |
PROi | PR:Q9Y5Y0 |
RNActi | Q9Y5Y0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162769, Expressed in jejunal mucosa and 202 other tissues |
ExpressionAtlasi | Q9Y5Y0, baseline and differential |
Genevisiblei | Q9Y5Y0, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FLVC1_HUMAN | |
Accessioni | Q9Y5Y0Primary (citable) accession number: Q9Y5Y0 Secondary accession number(s): Q1HE16, Q86XY9, Q9NVR9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families