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Protein

Sorting nexin-8

Gene

SNX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei135Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei148Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • early endosome to Golgi transport Source: UniProtKB
  • endocytosis Source: GO_Central
  • intracellular protein transport Source: UniProtKB
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-8
Gene namesi
Name:SNX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106266.8
HGNCiHGNC:14972 SNX8
MIMi614905 gene
neXtProtiNX_Q9Y5X2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106266
PharmGKBiPA37948

Polymorphism and mutation databases

BioMutaiSNX8
DMDMi10720288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138511 – 465Sorting nexin-8Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei452PhosphothreonineCombined sources1
Modified residuei456PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y5X2
MaxQBiQ9Y5X2
PaxDbiQ9Y5X2
PeptideAtlasiQ9Y5X2
PRIDEiQ9Y5X2
ProteomicsDBi86527

PTM databases

iPTMnetiQ9Y5X2
PhosphoSitePlusiQ9Y5X2

Expressioni

Gene expression databases

BgeeiENSG00000106266
CleanExiHS_SNX8
ExpressionAtlasiQ9Y5X2 baseline and differential
GenevisibleiQ9Y5X2 HS

Organism-specific databases

HPAiHPA057296
HPA060194

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi118939, 15 interactors
IntActiQ9Y5X2, 14 interactors
MINTiQ9Y5X2
STRINGi9606.ENSP00000222990

Structurei

3D structure databases

ProteinModelPortaliQ9Y5X2
SMRiQ9Y5X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 181PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00460000041594
HOGENOMiHOG000252992
HOVERGENiHBG017827
InParanoidiQ9Y5X2
KOiK17922
OMAiIRNIYNS
OrthoDBiEOG091G0NVM
PhylomeDBiQ9Y5X2
TreeFamiTF314082

Family and domain databases

CDDicd06866 PX_SNX8_Mvp1p_like, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR028662 SNX8/Mvp1
IPR035704 SNX8/Mvp1_PX
PANTHERiPTHR10555:SF165 PTHR10555:SF165, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y5X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA
60 70 80 90 100
PSRMQMPQGN PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ
110 120 130 140 150
RFKSSVYRRY NDFVVFQEML LHKFPYRMVP ALPPKRMLGA DREFIEARRR
160 170 180 190 200
ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS DVQNKLKESA QCVGDEFLNC
210 220 230 240 250
KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE RIASRAIDNA
260 270 280 290 300
ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD
310 320 330 340 350
KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS
360 370 380 390 400
LMKRQMMSAT AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE
410 420 430 440 450
TQLIHVYLPL TSHILRAFVN SQIQGHKEMS KVWNDLRPKL SCLFAGPHST
460
LTPPCSPPED GLCPH
Length:465
Mass (Da):52,569
Last modified:November 1, 1999 - v1
Checksum:i90C5EDB761C31E88
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036259147A → G in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121858 mRNA Translation: AAD27831.1
CH236953 Genomic DNA Translation: EAL23950.1
CH471144 Genomic DNA Translation: EAW87235.1
BC007785 mRNA Translation: AAH07785.2
BC021565 mRNA Translation: AAH21565.1
CCDSiCCDS5331.1
RefSeqiNP_037453.1, NM_013321.3
UniGeneiHs.584900

Genome annotation databases

EnsembliENST00000222990; ENSP00000222990; ENSG00000106266
GeneIDi29886
KEGGihsa:29886
UCSCiuc003slw.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNX8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5X2
Secondary accession number(s): A4D207, Q96I67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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