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Entry version 144 (13 Feb 2019)
Sequence version 2 (02 Sep 2008)
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Protein

Sorting nexin-10

Gene

SNX10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53Phosphatidylinositol 3-phosphateCurated1
Binding sitei79Phosphatidylinositol 3-phosphateCurated1
Binding sitei94Phosphatidylinositol 3-phosphateCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • ATPase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000086300.15

Human Gene Nomenclature Database

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HGNCi
HGNC:14974 SNX10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614780 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y5X0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Osteopetrosis, autosomal recessive 8 (OPTB8)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB8 is clinically characterized by dense bones with no distinction between outer and inner plates, due to extensive encroachment of cortical bone into the medullary space, increased head circumference, broad open fontanelle, frontal bossing, and hepatosplenomegaly. Osteoclasts number is low and their bone resorptive capacity is impaired.
See also OMIM:615085
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06929916R → L in OPTB8. 1 PublicationCorresponds to variant dbSNP:rs779298714Ensembl.1
Natural variantiVAR_06930032Y → S in OPTB8. 1 PublicationCorresponds to variant dbSNP:rs771038257Ensembl.1
Natural variantiVAR_06930151R → P in OPTB8. 1 Publication1
Natural variantiVAR_06930251R → Q in OPTB8; increased expression, produces extensive cytoplasmic vacuolation and impairs bone resorptive function. 1 PublicationCorresponds to variant dbSNP:rs398123011EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi53R → A: Abolishes vacuolization induced by overexpression. 1 Publication1
Mutagenesisi79K → A: Slightly reduced vacuolization induced by overexpression. 1 Publication1
Mutagenesisi94R → A: Reduced vacuolization induced by overexpression. 1 Publication1

Keywords - Diseasei

Disease mutation, Osteopetrosis

Organism-specific databases

DisGeNET

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DisGeNETi
29887

MalaCards human disease database

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MalaCardsi
SNX10
MIMi615085 phenotype

Open Targets

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OpenTargetsi
ENSG00000086300

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
667 Autosomal recessive malignant osteopetrosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37950

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SNX10

Domain mapping of disease mutations (DMDM)

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DMDMi
205371824

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138541 – 201Sorting nexin-10Add BLAST201

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y5X0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y5X0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y5X0

PeptideAtlas

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PeptideAtlasi
Q9Y5X0

PRoteomics IDEntifications database

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PRIDEi
Q9Y5X0

ProteomicsDB human proteome resource

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ProteomicsDBi
86525

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y5X0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y5X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000086300 Expressed in 209 organ(s), highest expression level in lateral nuclear group of thalamus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y5X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y5X0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015605
HPA064782

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATP6V1D; may play a role in ciliogenesis.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150415EBI-10329478,EBI-714543

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118940, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9Y5X0, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000343709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ON3X-ray2.60A/B1-201[»]
4PZGX-ray2.80A/B1-201[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y5X0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y5X0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 127PXPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni8 – 125Required for interaction with ATP6V1D1 PublicationAdd BLAST118

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2527 Eukaryota
COG5391 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156007

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231108

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054994

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y5X0

KEGG Orthology (KO)

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KOi
K17924

Database of Orthologous Groups

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OrthoDBi
24858at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y5X0

TreeFam database of animal gene trees

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TreeFami
TF332117

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR039358 Sorting_nexin-like

The PANTHER Classification System

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PANTHERi
PTHR10555 PTHR10555, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00787 PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00312 PX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV
60 70 80 90 100
RRRYREFVWL RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED
110 120 130 140 150
FLRKVLQNAL LLSDSSLHLF LQSHLNSEDI EACVSGQTKY SVEEAIHKFA
160 170 180 190 200
LMNRRFPEED EEGKKENDID YDSESSSSGL GHSSDDSSSH GCKVNTAPQE

S
Length:201
Mass (Da):23,598
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i665B80734D5E5C72
GO
Isoform 2 (identifier: Q9Y5X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):13,181
Checksum:i1AE71FD546A428CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQ16C9JQ16_HUMAN
Sorting nexin-10
SNX10
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9H5G5E9H5_HUMAN
Sorting nexin 10, isoform CRA_c
SNX10 hCG_38389
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUJ3A0A087WUJ3_HUMAN
Sorting nexin-10
SNX10
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUQ6C9JUQ6_HUMAN
Sorting nexin-10
SNX10
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06929916R → L in OPTB8. 1 PublicationCorresponds to variant dbSNP:rs779298714Ensembl.1
Natural variantiVAR_06930032Y → S in OPTB8. 1 PublicationCorresponds to variant dbSNP:rs771038257Ensembl.1
Natural variantiVAR_06930151R → P in OPTB8. 1 Publication1
Natural variantiVAR_06930251R → Q in OPTB8; increased expression, produces extensive cytoplasmic vacuolation and impairs bone resorptive function. 1 PublicationCorresponds to variant dbSNP:rs398123011EnsemblClinVar.1
Natural variantiVAR_046098187S → I1 PublicationCorresponds to variant dbSNP:rs1053042Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0459201 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF121860 mRNA Translation: AAD27833.1
AK309162 mRNA No translation available.
AK312850 mRNA Translation: BAG35703.1
AC004540 Genomic DNA No translation available.
AC010677 Genomic DNA No translation available.
AC074295 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24234.1
CH471073 Genomic DNA Translation: EAW93849.1
BC034992 mRNA Translation: AAH34992.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5399.1 [Q9Y5X0-1]
CCDS56470.1 [Q9Y5X0-2]

NCBI Reference Sequences

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RefSeqi
NP_001186764.1, NM_001199835.1 [Q9Y5X0-1]
NP_001186766.1, NM_001199837.1
NP_001186767.1, NM_001199838.1 [Q9Y5X0-2]
NP_001305127.1, NM_001318198.1
NP_001305128.1, NM_001318199.1 [Q9Y5X0-1]
NP_037454.2, NM_013322.2 [Q9Y5X0-1]
XP_006715775.1, XM_006715712.2 [Q9Y5X0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.741316

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338523; ENSP00000343709; ENSG00000086300 [Q9Y5X0-1]
ENST00000396376; ENSP00000379661; ENSG00000086300 [Q9Y5X0-1]
ENST00000409838; ENSP00000386540; ENSG00000086300 [Q9Y5X0-2]
ENST00000446848; ENSP00000395474; ENSG00000086300 [Q9Y5X0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29887

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29887

UCSC genome browser

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UCSCi
uc003sxx.4 human [Q9Y5X0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121860 mRNA Translation: AAD27833.1
AK309162 mRNA No translation available.
AK312850 mRNA Translation: BAG35703.1
AC004540 Genomic DNA No translation available.
AC010677 Genomic DNA No translation available.
AC074295 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24234.1
CH471073 Genomic DNA Translation: EAW93849.1
BC034992 mRNA Translation: AAH34992.1
CCDSiCCDS5399.1 [Q9Y5X0-1]
CCDS56470.1 [Q9Y5X0-2]
RefSeqiNP_001186764.1, NM_001199835.1 [Q9Y5X0-1]
NP_001186766.1, NM_001199837.1
NP_001186767.1, NM_001199838.1 [Q9Y5X0-2]
NP_001305127.1, NM_001318198.1
NP_001305128.1, NM_001318199.1 [Q9Y5X0-1]
NP_037454.2, NM_013322.2 [Q9Y5X0-1]
XP_006715775.1, XM_006715712.2 [Q9Y5X0-1]
UniGeneiHs.741316

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ON3X-ray2.60A/B1-201[»]
4PZGX-ray2.80A/B1-201[»]
ProteinModelPortaliQ9Y5X0
SMRiQ9Y5X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118940, 3 interactors
IntActiQ9Y5X0, 3 interactors
STRINGi9606.ENSP00000343709

PTM databases

iPTMnetiQ9Y5X0
PhosphoSitePlusiQ9Y5X0

Polymorphism and mutation databases

BioMutaiSNX10
DMDMi205371824

Proteomic databases

EPDiQ9Y5X0
jPOSTiQ9Y5X0
PaxDbiQ9Y5X0
PeptideAtlasiQ9Y5X0
PRIDEiQ9Y5X0
ProteomicsDBi86525

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29887
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338523; ENSP00000343709; ENSG00000086300 [Q9Y5X0-1]
ENST00000396376; ENSP00000379661; ENSG00000086300 [Q9Y5X0-1]
ENST00000409838; ENSP00000386540; ENSG00000086300 [Q9Y5X0-2]
ENST00000446848; ENSP00000395474; ENSG00000086300 [Q9Y5X0-1]
GeneIDi29887
KEGGihsa:29887
UCSCiuc003sxx.4 human [Q9Y5X0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29887
DisGeNETi29887
EuPathDBiHostDB:ENSG00000086300.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SNX10
HGNCiHGNC:14974 SNX10
HPAiHPA015605
HPA064782
MalaCardsiSNX10
MIMi614780 gene
615085 phenotype
neXtProtiNX_Q9Y5X0
OpenTargetsiENSG00000086300
Orphaneti667 Autosomal recessive malignant osteopetrosis
PharmGKBiPA37950

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2527 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00940000156007
HOGENOMiHOG000231108
HOVERGENiHBG054994
InParanoidiQ9Y5X0
KOiK17924
OrthoDBi24858at2759
PhylomeDBiQ9Y5X0
TreeFamiTF332117

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNX10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29887

Protein Ontology

More...
PROi
PR:Q9Y5X0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000086300 Expressed in 209 organ(s), highest expression level in lateral nuclear group of thalamus
ExpressionAtlasiQ9Y5X0 baseline and differential
GenevisibleiQ9Y5X0 HS

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR039358 Sorting_nexin-like
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5X0
Secondary accession number(s): E9PFH5, Q8IYT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 2, 2008
Last modified: February 13, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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