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Protein

Sorting nexin-11

Gene

SNX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Phosphatidylinositol 3-phosphate1
Binding sitei85Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei99Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol phosphate binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: GO_Central
  • intracellular protein transport Source: InterPro
  • vesicle organization Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-11
Gene namesi
Name:SNX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000002919.14
HGNCiHGNC:14975 SNX11
MIMi614906 gene
neXtProtiNX_Q9Y5W9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59R → A: Abolishes lipid-binding. 1 Publication1
Mutagenesisi135 – 139IEACV → AAAAA: Impairs function in membrane trafficking. 1 Publication5

Organism-specific databases

OpenTargetsiENSG00000002919
PharmGKBiPA37951

Polymorphism and mutation databases

BioMutaiSNX11
DMDMi14916716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138561 – 270Sorting nexin-11Add BLAST270

Proteomic databases

EPDiQ9Y5W9
PaxDbiQ9Y5W9
PeptideAtlasiQ9Y5W9
PRIDEiQ9Y5W9
ProteomicsDBi86524

PTM databases

iPTMnetiQ9Y5W9
PhosphoSitePlusiQ9Y5W9
SwissPalmiQ9Y5W9

Expressioni

Gene expression databases

BgeeiENSG00000002919
CleanExiHS_SNX11
ExpressionAtlasiQ9Y5W9 baseline and differential
GenevisibleiQ9Y5W9 HS

Organism-specific databases

HPAiHPA044787
HPA054660

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118960, 23 interactors
IntActiQ9Y5W9, 11 interactors
STRINGi9606.ENSP00000352175

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 28Combined sources12
Beta strandi35 – 44Combined sources10
Beta strandi53 – 55Combined sources3
Helixi60 – 67Combined sources8
Helixi70 – 73Combined sources4
Beta strandi89 – 91Combined sources3
Helixi92 – 97Combined sources6
Helixi100 – 108Combined sources9
Helixi114 – 117Combined sources4
Helixi120 – 127Combined sources8
Helixi132 – 139Combined sources8
Beta strandi143 – 145Combined sources3
Helixi147 – 156Combined sources10

3D structure databases

ProteinModelPortaliQ9Y5W9
SMRiQ9Y5W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 132PXPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Important for membrane trafficking5

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2527 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00650000093174
HOGENOMiHOG000231108
HOVERGENiHBG054994
InParanoidiQ9Y5W9
KOiK17924
OMAiSCCFLPR
OrthoDBiEOG091G0NL7
PhylomeDBiQ9Y5W9
TreeFamiTF332117

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR028655 SNX11
PANTHERiPTHR10555:SF36 PTHR10555:SF36, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT
60 70 80 90 100
AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR
110 120 130 140 150
QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA
160 170 180 190 200
ILRYAMSNCG WAQEERQSSS HLAKGDQPKS CCFLPRSGRR SSPSPPPSEE
210 220 230 240 250
KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG TSTLQSVRRA
260 270
VGGDHAVPLD PGQLETVLEK
Length:270
Mass (Da):30,433
Last modified:July 11, 2001 - v2
Checksum:iE6839B7415F1724F
GO
Isoform 2 (identifier: Q9Y5W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGFWCRMSENQEQE → MVCREQ

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,423
Checksum:i4DC0C01993F8151D
GO

Sequence cautioni

The sequence AAD27834 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565941 – 14MGFWC…NQEQE → MVCREQ in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121861 mRNA Translation: AAD27834.1 Different initiation.
BT006723 mRNA Translation: AAP35369.1
AK023932 mRNA Translation: BAB14732.1
AK091852 mRNA Translation: BAG52428.1
AK298551 mRNA Translation: BAG60747.1
AK316374 mRNA Translation: BAH14745.1
AC006468 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94754.1
BC000768 mRNA Translation: AAH00768.1
BC103721 mRNA Translation: AAI03722.1
CCDSiCCDS11526.1 [Q9Y5W9-1]
CCDS82152.1 [Q9Y5W9-2]
RefSeqiNP_001317249.1, NM_001330320.1 [Q9Y5W9-2]
NP_037455.2, NM_013323.2 [Q9Y5W9-1]
NP_689450.1, NM_152244.1 [Q9Y5W9-1]
XP_005257317.1, XM_005257260.3 [Q9Y5W9-1]
XP_005257319.1, XM_005257262.3 [Q9Y5W9-2]
XP_011522999.1, XM_011524697.2 [Q9Y5W9-1]
UniGeneiHs.15827

Genome annotation databases

EnsembliENST00000359238; ENSP00000352175; ENSG00000002919 [Q9Y5W9-1]
ENST00000393405; ENSP00000377059; ENSG00000002919 [Q9Y5W9-1]
ENST00000580219; ENSP00000462188; ENSG00000002919 [Q9Y5W9-2]
ENST00000582104; ENSP00000463948; ENSG00000002919 [Q9Y5W9-2]
GeneIDi29916
KEGGihsa:29916
UCSCiuc002inf.2 human [Q9Y5W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNX11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W9
Secondary accession number(s): B3KRL6
, B4DPY5, D3DTV0, Q53YC0, Q9H885
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2001
Last modified: July 18, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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